Currently, very little detailed information on the epidemiological distribution and specificities of severely burned patients during the coronavirus disease 2019 (COVID-19) pandemic is available. This retrospective study aims to describe and compare this specific patient population based on 114patients who were treated between March 2019 and March 2021 at the Center for Severe Burn Injuries at the Medical University of Vienna. To answer the research questions, aretrospective cohort study has been conducted over aperiod of 24months, starting in March 2019 and ending in March 2021. To evaluate the epidemiological differences, the patients were divided into 2observation periods of 12months each. In the period from 12 March 2020 to 11 March 2021, atotal of 62patients were admitted to the Center for Severe Burn Injuries. In comparison, only 52patients were admitted in the same period of the previous year, which corresponds to an increase of 19.2%. In addition, it was noted that during the 2019-2020 observation period, 27% of patients were female and 73% male, whereas during the pandemic the gender distribution was 42% female and only 58% male. During the pre-pandemic observational period, 13out of 52patients admitted died (25%), whereas during the pandemic, 17out of 62patients succumbed to their injuries (27%). Although the severity of the COVID-19 pandemic seems to be decreasing, especially due to the increasing availability of vaccines, there is aneed for more data on the impact of the crisis on severely burned patients. In contrast to the current literature, we have seen agreater number of inpatient admissions to the Center for Severe Burn Injuries, as well as significant differences in gender distribution. Our data also suggest that the circumstances of the pandemic have no influence on the likelihood of survival for patients with severe burns.