Objective: To compare the analgesic effect of commercially available premixed injection of lignocaine 2% and adrenaline in 1:100,000 dilution with that of freshly prepared solution by mixing adrenaline in suitable quantity to 2% plain lignocaine just before the time of injection for tooth extraction in patients of dental caries. Design: Descriptive Interventional Study. Place and Duration: Armed Forces Institute of Dentistry (AFID) Rawalpindi from March 2006 to August 2006. Patients and Methods: A total of 50 patients of dental caries, who were scheduled for tooth extraction, were divided into 2 groups of 25 each. Group A was provided analgesia with commercially available premixed injection of lignocaine and adrenaline and group B was provided analgesia with freshly prepared solution of plain lignocaine and adrenaline. Results: In group A, good quality analgesia sufficient enough for tooth extraction, was achieved in 19 patients whereas in group B good quality analgesia was achieved in 23 patients. Conclusions: Freshly prepared mixture of plain lignocaine and adrenaline gives better analgesic effect than that of commercially available solution of lignocaine with adrenaline.