Lighting is an essential component of the built environment, affecting the comfort of the indoor environment as well as the energy use. Luminance-based lighting control is expected to both enhance the comfort and energy savings as the luminance distribution is very versatile. In this study, the feasibility of such system is tested using two alternative luminance-based lighting control algorithms. Algorithm 1 applied proportional control to maintain a target desktop illuminance, while Algorithm 2 assigned the most suitable, predefined, scene to maintain the target desktop illuminance. Energy savings of 50% and 70% were achieved, respectively. Algorithm 2 generally outperformed Algorithm 1. Algorithm 2 was better able to maintain the target illuminance and provided a higher uniformity. Accurate commissioning, especially for proportional control, is essential to achieve an acceptable control system. Nevertheless, this study showed that it is feasible to apply luminance-based lighting control, but the performance largely depends on the control system and the commissioning. Additionally, the versatile luminance cameras can easily be equipped with additional functionalities.