The combination of fused deposition modeling (FDM) and foaming technology enables the fabrication of complex hierarchical and lightweight parts. However, this approach is hindered by a reduction in the mechanical properties of final parts. To this end, with the aim of addressing the challenge of the fabrication of 3D-printed parts with enhanced mechanical and lightweight features, a micro-extrusion foaming FDM process using CO2 as a blowing agent was hereby established, and the carbon fiber (CF) was selected as a reinforcing filler. Compared to pure polyetherimide (PEI) parts, the longitudinal tensile strength of the PEI/CF parts with 5.0 wt% CF added increased by 30.3 %, while the interfacial bonding strength of PEI/CF-5.0 foamed parts increased by 86.3 % compared to the unfoamed parts. Furthermore, the PEI/CF-5.0 foamed parts, weighing only about 1.7 g, could bear a load of a 60 kg human body in multiple directions. Additionally, focusing on the filler orientation and the enhanced interdiffusion and entanglement of polymer chains at interfaces, the reinforcement mechanisms of the foamed parts fabricated by micro-extrusion foaming FDM process were discussed. The micro-extrusion foaming FDM process demonstrated the capability to produce lightweight parts with enhanced mechanical properties, making it a promising technology for applications in the aerospace and military industries.