Location determines not only the climatic condition but also the structural loads that the structure must withstand. Given the broad variety of climatic and seismic requirements of Chile, the design of lightweight timber buildings considering both energy and seismic design parameters and boundary conditions becomes a difficult task. The main objective of this research is to analyze and quantify the effect of climates, seismic loads, lateral anchorage, and story number on the optimal energy design solutions, including the seismic behavior in a light-frame timber building. Furthermore, the optimal design was parametrically analyzed considering five Chilean cities that consider different climates, seismic zone, number of stories, and lateral anchorage systems to prevent rocking (overturning) due to lateral seismic forces. The optimal wall insulation thickness, stud spacing, and thermal mass exhibited significant variations depending on the buildings' number of stories, lateral anchorage system, climate, and seismic zone. Therefore, the results of this investigation reinforce the necessity of integrating energy and seismic designs for light-frame timber buildings. The optimal designs obtained in this investigation showed considerable variations depending on the combination of climatic and seismic loads as well as the number of stories and anchoring systems. The article's main contributions are the evidence of the structural and energy design interconnection of light-frame timber buildings and how design variables, such as stud spacing, floor concrete thickness layer, and wall insulation thickness, are related and change according to the different climates, seismic loads, lateral anchorage, and story number.