Herein, this study describes a promising sunlight-driven photocatalytic system designed for the elimination of antibiotics (e.g., fluoroquinolones and sulfonamides) in real maricultural wastewater. Phosphate-doped porous coralline carbon nitride (P-CCN), synthesized by controlling morphology from two-dimensional block CN, was immobilized onto porous mullite honeycomb to construct a practical and molding photocatalytic system (P-CCN/PMH). By leveraging its microscopic porous coral structure, P-CCN displayed an augmentation in surface-active sites and a notable inner light refraction effect. This enhancement contributed to the high-efficiency performance of P-CCN/PMH system, producing 8.232 mM·h−1·g−1 H2O2 under sunlight, which was 7.21-fold higher than before modification; and its degradation rate constant to enrofloxacin (0.263 min−1) was 39.31-fold higher. The P-CCN/PMH system demonstrated superior capability in terms of adaptability to a wide concentration range, acid-alkali conditions, mineralization, carbon reduction, and challenging ionic surroundings or water matrices. Crucial superoxide radicals have been confirmed through mass-spectrometric technique and theoretical calculations, leading to ring-opening effects. Long-term and continuous-flow experiments were deeply carried out, validating the commendable competence of the P-CCN/PMH photocatalytic system in simulated wastewater treatment scenarios. Ultimately, the aggregate results highlight valuable insights into coralline materials synthesis and modular catalyst construction, presenting potential for addressing challenges related to environmental antibiotics pollution.