National Research Laboratory of Chirotechnology, Department of Chemistry, Division of Molecular and Life Sciences,Pohang University of Science and Technology, Kyungbuk 790-784, KoreaReceived March 11, 2004An efficient dynamic kinetic resolution of racemic β-hydroxyalkylferrocene and 1,1'-bis(β-hydroxyalkyl)-ferrocene derivatives was achieved using lipase/ruthenium-catalyzed transesterification in the presence of anacyl donor. The racemic β-hydroxyalkylferrocene derivatives were successfully transformed to thecorresponding chiral acetates of high optical purities in high yields.Key Words : Dynamic kinetic resolution (DKR), Enzyme/metal bicatalysis, Lipase, β-HydroxyalkylferroceneIntroductionThe chiral ferrocene derivatives have been widely used aschiral ligands in asymmetric synthesis,