A sustainable strategy to tackle water pollution involves using innovative composites based on MOFs for photodecomposing antibiotic contaminants. A core-shell structure was synthesized using a solvothermal method, combining Cu2S, carbon quantum dots (CQDs), and Ti-TPA-MOF, resulting in a material with excellent visible-light capture capabilities. Spectroscopic (XRD, XPS, BET, DRS, DLS, ESR, and PL), electrochemical (photocurrent), and microscopic (TEM) analyses were performed to characterize the photocatalyst. Adding 20mg of Cu2S and CQDs greatly improved gentamicin photodegradation compared to other prepared photocatalysts. This was due to enhanced electron conductivity, increased photocurrent density, a narrower energy gap, and a longer charge separation lifetime. The heterojunction composites at 150mg/l showed a 2 to 6 times increase in efficiency after 90min, surpassing the pure materials. The outcomes showed evidence of pseudo-first-order kinetics, photocatalytic activity, and excitation by visible light in the photodegradation. The stability of the photocatalytic process is evident after five cycles.