Lifetime Basis Research Articles

Childhood Bullying as a Predictor of Suicidality in Young Adults in a Nationwide Population-Based Health Examination Study

Objective Having been bullied at school in childhood links to suicidality. We aimed at verifying earlier findings and delivering diverse data from a representative population-based sample of young adults to characterize the impacts beyond childhood. Method A random sample of adults, aged 18–28 years and representative of the general population living in Finland, participated in a nationwide health examination study. Adverse childhood experiences before the age of 16 years were analyzed for 779 participants in relation to lifetime suicidality (suicidal ideation, suicide attempts), current suicidal thoughts (HSCL-25), mental disorders (self-reports for lifetime, M-CIDI for DSM-IV during the past 12 months), current usage of mental health services, current usage of prescription medicines (ATC codes), current psychological distress (GHQ-12), and current work capacity and work ability. Results Having been bullied in childhood contributed to greater suicidality (p < 0.001), more frequent current usage of antipsychotics (p < 0.001) as well as antidepressants (p < 0.001), greater current psychological distress (p < 0.001), and poorer current work capacity (p < 0.001) as well as work ability (p < 0.001). Of the self-reported mental disorders on lifetime basis, psychosis had the strongest association (p = 0.03) with having been bullied, whereas the interview-based diagnosis of mental disorders during the past 12 months had no significant association. Conclusions Having been bullied at school before the age of 16 years was independently associated not only with suicidality, but also with the self-report of psychosis as well as a range of indicators of poorer mental health at the age of 18–28 years.

Artificial neural networks based multimodal device for autism spectrum disorder.

The neuro developmental condition known as Autism Spectrum Disorder (ASD) affects people on a lifetime basis and exhibits itself in a wide range of ways. In this research work a brand-new semi-supervised training method for the recognition of discrete multi-modal autism spectrum disorder is proposed. At the coarse-grained level, we consider that various methodologies are anticipated to explore equivalent information about child autism. To build DC AlexNet, this combines two small network branches and a large network (trunk network). The network trunk is programmed just to become familiar with the distinguishing characteristics shared by face images at different resolutions. It is built using recently suggested residential components. To project images to a place where their ranges are as little as possible, two branch networks are programmed to learn coupled-mappings (CMs) that are particular to a given resolution. The suggested technique is properly assessed utilizing the databases for the OMEGE and DIAEMO datasets by evaluating it to state-of-the-art techniques in terms of many parameters. Deep Coupled AlexNet is developed to obtain 98.13 % of accuracy, 95.1 % of precision, 94.3 % of recall and 95.4 of F1-score for OMEGE dataset. Moreover, 98.6 % of accuracy, 97.2 % of precision, 98.5 of recall and 97.5 % of F1-score for DIAEMO dataset (Tab. 8, Fig. 10, Ref. 16). Keywords: autism spectrum disorder, artificial neural networks, emotion recognition, interaction design, multimodal factors.

Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores

BackgroundBipolar disorder (BD) has the greatest suicide risk among mental and physical disorders. A recent genome-wide association study (GWAS) of European ancestry (EUR) samples revealed that the genetic etiology of suicide attempt (SA) was not only polygenic but also, in part, diagnosis-specific. The authors aimed to examine whether the polygenic risk score (PRS) for SA derived from that study is associated with SA or repeated attempts in Korean patients with BD. This study also investigated the shared heritability of SA and mental disorders which showed an increased risk of SA and a high genetic correlation with BD.MethodsThe study participants were 383 patients with BD. The history of SA was assessed on a lifetime basis. PRSs for reference disorders were calculated using the aforementioned GWAS data for SA and the Psychiatric Genomics Consortium data of BD, schizophrenia, major depressive disorder (MDD), and obsessive–compulsive disorder (OCD).ResultsThe PRS for SA was significantly associated with lifetime SA in the current subjects (Nagelkerke’s R2 = 2.73%, odds ratio [OR] = 1.36, p = 0.007). Among other PRSs, only the PRS for OCD was significantly associated with lifetime SA (Nagelkerke’s R2 = 2.72%, OR = 1.36, p = 0.007). The PRS for OCD was higher in multiple attempters than in single attempters (Nagelkerke’s R2 = 4.91%, OR = 1.53, p = 0.043).ConclusionThe PRS for SA derived from EUR data was generalized to SA in Korean patients with BD. The PRS for OCD seemed to affect repeated attempts. Genetic studies on suicide could benefit from focusing on specific psychiatric diagnoses and refined sub-phenotypes, as well as from utilizing multiple PRSs for related disorders.

Characterization and Lifetime Dietary Risk Assessment of Eighteen Pyrrolizidine Alkaloids and Pyrrolizidine Alkaloid N-Oxides in New Zealand Honey.

Pyrrolizidine alkaloids (PAs) are a large group of botanical toxins of concern, as they are considered genotoxic carcinogens, with long-term dietary exposure presenting an elevated risk of liver cancer. PAs can contaminate honey through honeybees visiting the flowers of PA-containing plant species. A program of monitoring New Zealand honey has been undertaken over several years to build a comprehensive dataset on the concentration, regional and seasonal distribution, and botanical origin of 18 PAs and PA N-oxides. A bespoke probabilistic exposure model has then been used to assess the averaged lifetime dietary risk to honey consumers, with exposures at each percentile of the model characterized for risk using a margin of exposure from the Joint World Health Organization and United Nations Food and Agriculture Organization Expert Committee on Food Additives (JECFA) Benchmark Dose. Survey findings identify the typical PA types for New Zealand honey as lycopsamine, echimidine, retrorsine and senecionine. Regional and seasonal variation is evident in the types and levels of total PAs, linked to the ranges and flowering times of certain plants. Over a lifetime basis, the average exposure an individual will receive through honey consumption is considered within tolerable levels, although there are uncertainties over high and brand-loyal consumers, and other dietary contributors. An average lifetime risk to the general population from PAs in honey is not expected. However, given the uncertainties in the assessment, risk management approaches to limit or reduce exposures through honey are still of value.

The Growing Socioeconomic Gap in Lifetime Social Security Retirement Benefits: Current and Future Retirees.

Increasing socioeconomic disparities, including in life expectancy, have important implications for the U.S. Social Security program. This study examined inter- and intracohort trends in Social Security retirement benefits, paying special attention to how lifetime benefit trajectories by socioeconomic circumstance shift across cohorts encompassing current and future retirees. Using a dynamic microsimulation model based on representative survey data linked to administrative records, we developed a set of cohort-specific projections that estimate monthly and lifetime Social Security retirement benefits for retirees spanning the early baby boom (1945-1954) to Generation X (1965-1974) cohorts. We found a widening socioeconomic gap in projected monthly and lifetime benefits for men and women, especially on a lifetime basis. This divergence is associated with stagnation of benefit levels among lower socioeconomic status groups coupled with upward shifts among higher strata groups. Distributional changes are linked with increasing differential mortality, but other factors also likely play a role such as rising education premiums, growing earnings inequality, and changes in women's work and relationship histories. Widening mortality differentials can lead to distributional changes in the U.S. Social Security program. Microsimulation methodology lends insights into how the socioeconomic gap in monthly and lifetime benefit distributions may change among future older Americans in the context of differential mortality and other demographic changes. Moving forward in time, these complex patterns could offset some of the progressivity built into the system.

Relationships among feed efficiency traits across production segments and production cycles in cattle.

Understanding the relationships between feed efficiency traits measured in different stages of production is necessary to improve feed efficiency across the beef value chain. The objective of this study was to evaluate relationships among feed efficiency traits measured as growing heifers and breeding females and in their progeny in three full production cycles, and relationships of dam residual feed intake (RFI) with lifetime and lifecycle cow efficiency traits. Data were collected on 160 mixed-breed heifers from 240 d of age to weaning of their third progeny, and postweaning performance of progeny until harvest in experiments initiated in 1953, 1954, 1959, 1964, 1969, and 1974. Individual feed offered was recorded daily, and feed refusals measured every 28 d. Milk yield was measured at 14-d intervals throughout lactation by machine or hand milking. Females and progeny were weighed at 28-d intervals and progeny were harvested at a constant endpoint of live grade or age depending upon the experiment. Feed efficiency traits of RFI and residual BW gain (RG) were computed as the residual from linear regression for developing heifers, dams (RFI and residual energy-corrected milk [RECM]), and postweaning progeny. Feed:gain ratio (FCR) was computed for developing heifers and postweaning progeny, and feed:milk energy ratio (FME) was computed for dams. Various measures of cow efficiency were calculated on either a life cycle or lifetime basis using ratios of progeny and dam weight outputs to progeny and dam feed inputs. Pearson correlations were computed among traits adjusted for a random year-breed-diet group effect. Heifer RFI (0.74) and RG (−0.32) were correlated (P ≤ 0.05) with dam RFI in parity 1 only, but were not correlated (P > 0.05) with dam RECM in any parity. Heifer RFI was correlated (P ≤ 0.05) with progeny RFI (0.17) in parity 3 only. Heifer FCR was not correlated with dam FME or progeny FCR in any parity. Dam RFI was weakly correlated (r = 0.25 to 0.36; P ≤ 0.05) among parities, whereas dam FME and RECM were strongly correlated (r = 0.49 to 0.72; P ≤ 0.05) among parities. Dam RFI in parity 1 and 2 was weakly correlated (r = −0.20 to −0.33; P ≤ 0.05) with cow efficiency ratios that included dam weight as an output, whereas dam RFI in parity 3 was not correlated with any cow efficiency ratio. In conclusion, feed efficiency traits were poorly correlated across production segments, but moderately repeatable across production cycles.

Association between the Arylalkylamine N-Acetyltransferase (AANAT) Gene and Seasonality in Patients with Bipolar Disorder.

Objective Bipolar disorder (BD) is complex genetic disorder. Therefore, approaches using clinical phenotypes such as biological rhythm disruption could be an alternative. In this study, we explored the relationship between melatonin pathway genes with circadian and seasonal rhythms of BD. Methods We recruited clinically stable patients with BD (n=324). We measured the seasonal variation of mood and behavior (seasonality), and circadian preference, on a lifetime basis. We analyzed 34 variants in four genes (MTNR1a, MTNR1b, AANAT, ASMT) involved in the melatonin pathway. Results Four variants were nominally associated with seasonality and circadian preference. After multiple test corrections, the rs116879618 in AANAT remained significantly associated with seasonality (corrected p=0.0151). When analyzing additional variants of AANAT through imputation, the rs117849139, rs77121614 and rs28936679 (corrected p=0.0086, 0.0154, and 0.0092) also showed a significant association with seasonality. Conclusion This is the first study reporting the relationship between variants of AANAT and seasonality in patients with BD. Since AANAT controls the level of melatonin production in accordance with light and darkness, this study suggests that melatonin may be involved in the pathogenesis of BD, which frequently shows a seasonality of behaviors and symptom manifestations.

Herd life, lifetime production, and profitability of Viking Red-sired and Montbéliarde-sired crossbred cows compared with their Holstein herdmates

The first 2 generations from a 3-breed rotation of the Viking Red (VR), Montbéliarde (MO), and Holstein (HO) breeds were compared with their HO herdmates in high-performance commercial herds in Minnesota. The designed study enrolled pure HO females in 2008 to initiate a comparison of 3-breed rotational crossbreds with their HO herdmates. Sires of cows were proven artificial insemination bulls selected for high genetic merit in each of the 3 breeds. The first-generation cows calved for a first time from 2010 to 2014 and had 376 VR × HO and 358 MO × HO crossbreds to compare with their 640 HO herdmates. The second-generation cows calved for a first time from 2012 to 2014 and had 109 VR × MO/HO and 117 MO × VR/HO crossbreds to compare with their 250 HO herdmates. Collection of data ceased on December 31, 2017, and all cows studied had the opportunity for 45 mo in the herd after first calving. Production of milk, fat, and protein (kg) during lifetimes of cows was estimated from test-day observations with best prediction. The lifetime profit function included revenue and cost. Revenue was from production, calves, and slaughter of cull cows. Costs included feed cost during lactation, lactating overhead cost, dry cow cost (including feed cost during dry periods), replacement cost, health treatment cost, insemination cost, fertility hormone cost, pregnancy diagnosis cost, hoof trimming cost, and carcass disposal cost. For individual cows with herd life longer than 45 mo after first calving, survival of cows was projected beyond 45 mo after first calving to estimate herd life, production, and profitability. The 2-breed crossbreds had +158 d longer herd life and the 3-breed crossbreds had +147 d longer herd life compared with their respective HO herdmates. Also, 12.4% of the 2-breed crossbreds died up to 45 mo after first calving compared with 16.3% of their HO herdmates. Furthermore, approximately 29% of both the 2-breed and 3-breed crossbreds lived beyond 45 mo after first calving compared with approximately 18% of their respective HO herdmates. On a lifetime basis, the 2-breed and 3-breed crossbreds provided +$122 and +$134, respectively, more cull cow revenue compared with their HO herdmates. For lifetime replacement cost, the 2-breed crossbreds did not differ from their HO herdmates; however, the 3-breed crossbreds had -$28 less lifetime replacement cost compared with their HO herdmates because of their younger age at first calving. The combined 2-breed crossbreds had +$0.473 (+13%) more daily profit (ignoring potential differences for feed efficiency) and the combined 3-breed crossbreds had +$0.342 (+9%) more daily profit compared with their respective HO herdmates. This resulted in +$173 more profit/cow annually for the combined 2-breed crossbreds and +$125 more profit/cow annually for the combined 3-breed crossbreds compared with their respective HO herdmates.

Epidemiology of Recovery From Alcohol Use Disorder

Almost one-third of the U.S. population meets alcohol use disorder (AUD) criteria on a lifetime basis. This review provides an overview of recent research on the prevalence and patterns of alcohol-related improvement and selectively reviews nationally representative surveys and studies that followed risk groups longitudinally with a goal of informing patients with AUD and AUD researchers, clinicians, and policy-makers about patterns of improvement in the population. Based on the research, alcohol use increases during adolescence and early adulthood and then decreases beginning in the mid-20s across the adult life span. Approximately 70% of persons with AUD and alcohol problems improve without interventions (natural recovery), and fewer than 25% utilize alcohol-focused services. Low-risk drinking is a more common outcome in untreated samples, in part because seeking treatment is associated with higher problem severity. Sex differences are more apparent in help-seeking than recovery patterns, and women have lower help-seeking rates than men. Whites are proportionately more likely to utilize services than are Blacks and Hispanics. Improving recovery rates will likely require offering interventions outside of the health care sector to affected communities and utilizing social networks and public health tools to close the longstanding gap between need and utilization of AUD-focused services.

Epidemiology of Recovery From Alcohol Use Disorder.

Almost one-third of the U.S. population meets alcohol use disorder (AUD) criteria on a lifetime basis. This review provides an overview of recent research on the prevalence and patterns of alcohol-related improvement and selectively reviews nationally representative surveys and studies that followed risk groups longitudinally with a goal of informing patients with AUD and AUD researchers, clinicians, and policy-makers about patterns of improvement in the population. Based on the research, alcohol use increases during adolescence and early adulthood and then decreases beginning in the mid-20s across the adult life span. Approximately 70% of persons with AUD and alcohol problems improve without interventions (natural recovery), and fewer than 25% utilize alcohol-focused services. Low-risk drinking is a more common outcome in untreated samples, in part because seeking treatment is associated with higher problem severity. Sex differences are more apparent in help-seeking than recovery patterns, and women have lower help-seeking rates than men. Whites are proportionately more likely to utilize services than are Blacks and Hispanics. Improving recovery rates will likely require offering interventions outside of the health care sector to affected communities and utilizing social networks and public health tools to close the longstanding gap between need and utilization of AUD-focused services.

167 Increasing weaning age: a tool to improve pig performance in a multisite production system

Abstract The objective of this study was to determine the effects of weaning age on pig performance in a multisite production system. A total of 1,176 pigs (PIC 337 × Camborough) were used in a 136-d growth trial with 21 pigs per pen, 14 replications per age on nursery and 10 on finishing phase, in a randomized complete block design with two blocks of nursery and finishing sites. All pigs within each block were weaned in a common day from a 5000-sow farm. Treatments included weaning litters at 19, 22, 25, or 28 d of age. Pen was the experimental unit for data analysis. Increasing weaning age from 19 to 28 d increased ADG (linear, P &lt; 0.001), and ADFI (linear, P &lt; 0.001), decreased removal rate (linear, P = 0.001), tended to increase G:F (linear, P = 0.081), and showed no evidence for difference in mortality rate (P &gt; 0.05) in the initial 42 d after weaning. Finishing ADG also was improved (linear, P = 0.001) by increasing weaning age; however, there was no evidence for difference (P &gt; 0.05) in removal or mortality rate in the finisher. When analyzed the ADG at a common day of life (164 d of age), no evidence for difference (P &gt; 0.05) were found between the four weaning ages tested. In conclusion, the present study suggests increasing weaning age up to 28 d can be an effective management strategy to improve nursery and finishing growth performance in multisite pig production. However, the growth rate on a lifetime basis is not affected by the weaning age.

Life cycle efficiency of beef production: IX. Relationship between residual feed intake of heifers and cow efficiency ratios based on harvest, carcass, and wholesale cut weight outputs.

Data were collected from 1953 through 1980 from identical and fraternal twin beef and dairy females born in 1953, 1954, 1959, 1964, and 1969, from crossbred females born as singles in 1974, and their progeny. Numbers of dams that weaned at least one calf and were included in the first analysis were 37, 45, and 56 in the 1964, 1969, and 1974 data sets, respectively. Respective numbers of dams that weaned three calves and were included in a second analysis were 6, 8, 8, 22, 33, and 33 in the 1953, 1954, 1959, 1964, 1969, and 1974 experiments. Individual feed consumption was measured at 28-d intervals from the time females were placed on the experiment at 240 d of age until three calves were weaned or the dams had reached 5 yr of age. Residual feed intake (RFI) and residual BW gain (RG) of heifers that subsequently became dams were determined based on ADG and DMI from 240 d of age to first calving. Various measures of cow efficiency were calculated on either a life cycle or actual lifetime basis using ratios of progeny and dam weight outputs to progeny and dam feed inputs. The correlation between RFI and DMI was large and positive (r = 0.67; P < 0.0001), and RG was highly correlated with ADG (r = 0.75; P < 0.0001). Correlations of RFI with cow efficiency ratios that included harvest weight, carcass weight, or weight of trimmed wholesale cuts as measures of output ranged from -0.05 (P > 0.10) to -0.17 (P < 0.10), indicating that heifers with better (i.e., more negative) RFI values tended to become slightly more efficient cows. Correlations of RG with life cycle and actual lifetime cow efficiency ratios ranged from 0.08 (P > 0.10) to 0.23 (P < 0.05), demonstrating that heifers with better (i.e., more positive) values for RG were somewhat more efficient as cows. The correlations were stronger when cow salvage value was included in the measures of cow efficiency. Correlations of DMI and mid-test metabolic BW (MMW) with life cycle cow efficiency ratios that did not include cow salvage value as output ranged from -0.15 (P < 0.10) to -0.22 (P < 0.01). Correlations of DMI and MMW with actual lifetime cow efficiency ratios varied from -0.20 (P < 0.05) to -0.36 (P < 0.001). Therefore, smaller heifers that consumed less feed had superior cow efficiency ratios. Correlations of RFI with carcass grade, backfat thickness, marbling score, and kidney fat of progeny indicated that heifers with superior RFI would tend to produce leaner offspring.

The Zlatné bridge - condition survey, temporary remedial works required due to dangerous condition and bridge restoration project

Bridges are and have been designed on lifetime basis, as given in standards applicable at the time of design. The design lifetime for newly designed bridges as given in Eurocodes is 100 years and according to the old Slovak standard it was 80 years only. The first generation of prestressed concrete bridges have been used in Slovakia (formerly part of Czechoslovakia) starting from 1950s, and thus, according to old standards, they approach the end of their design lifetime. Nowadays, due to insufficient maintenance, many of them are in unsatisfactory condition. This paper focuses on the condition survey of the bridge on the road No. I/18 - in the part “Zlatné” of village Strečno and on the design of immediate remedial works which were necessary due to its potentially dangerous condition. Moreover, the design of restoration is also described.

Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study

BackgroundThe efficacy and utility of long-term prophylactic treatment in patients with bipolar disorders (BDs) have not been fully explored. This study aims to estimate the long-term clinical response of patients with BDs to mood stabilizer treatment and to identify the clinical factors associated with that response.MethodsThe study subjects consisted of 80 patients with bipolar I or bipolar II disorder who had been receiving treatment with lithium and/or valproate for more than 2 years at a single bipolar disorder clinic. The long-term response to the best treatment option based on treatment algorithms was evaluated using the Alda scale. Clinical characteristics were evaluated on a lifetime basis. Patients were classified into two response groups based on frequentist mixture analysis using the total Alda scale score.ResultsThirty-four percent of the patients were good responders, with a total Alda score of 5 or higher. The treatment response rate did not differ between the lithium and valproate groups, but lithium and valproate combination therapy was associated with poorer response. The number of previous mixed episodes was associated with a worse response (p = 0.026). Of individual symptoms, delusions during manic episodes (p = 0.008) and increased appetite (p = 0.035) during depressive episodes were more common in moderate/poor responders than in good responders. Co-morbid anxiety disorders were more frequently observed in the moderate/poor response group (p = 0.008).ConclusionsPsychotic, mixed, and atypical features of BDs were found to be correlated with long-term treatment outcomes. Lithium and valproate showed similar efficacy but moderate/poor responders preferred to use polypharmacy.

Profitability Measures as Decision-Making Tools for Québec Dairy Herds

A retrospective cohort study was conducted using production and health records from Quebec dairy herds which were integrated with the objectives of calculating different lifetime profitability measures and developing analyses of the impact of selected reproduction and health variables on profitability. The dataset for the study consisted of lifetime records for a total of 13 668 Holstein cows from 113 herds and in cohorts of cows calving for the first time between 2000 and 2009. To calculate profit, all the revenues and costs were accumulated on a lifetime basis, and cumulative lifetime profit and cumulative lifetime profit adjusted for the opportunity cost of postponed replacement were selected for analysis. There were statistically significant effects in both profit measures because of age at first calving, cumulative number of days in milk, and cumulative number of days dry as well as the number of health events accumulated by animal lifetime (clinical mastitis, reproductive problems, and feet and legs...

Sustainability, Public Procurement and SMEs Challenges and Opportunities

The global value of public procurement spending is enormous. Each year, approximately 19% of the EU GDP is spent by over 250,000 public authorities purchasing services, works and supplies. The sheer scale of public procurement spending and supplier selection decisions can literally create and shape the market, impacting the lives of citizens across countries and regions at large. Over the last decade public procurement experienced wide spread modernization across the globe, both including local and international levels. These days, public procurement is no longer just about buying the cheapest possible supplies or services but, rather, it is understood as a process whereby organizations meet their needs in a way that achieves value for money on a lifetime basis and delivers aspects beyond savings. This includes doing business responsibly, taking a leadership position in the community and ensuring promotion of Small and Medium Enterprises (SMEs) in public procurement. SMEs are considered the backbone of the European economy as they represent around 99,8 percent of all enterprises and produce more than a half of the European GDP. Thus, if more SMEs participate in public procurement, the competition will increase and, consequently, governments will be able to achieve better value for money in their contracts. Also, it has been argued that most innovations originated from small entrepreneurial firms which support the sustainability agenda. The main claim of this article is that sustainability and the promotion of SMEs participation in public procurement do not necessarily contradict each other. It is without doubt that SMEs participation in the procurement context encompasses a number of challenges. To the latter may be accounted the argument that SMEs are too small, have too little money, experience or technical capabilities to participate in public procurement. Yet, it is argued that revised procurement law has the potential to solve some of the challenges and there is still considerable scope for promoting opportunities for SMEs such as reliance on the capabilities of third parties, bidding in form of consortia or subcontracting, the possibility to influence contract specification, and reserved contracts.

Psychiatric Comorbidity in People Who Inject Drugs

Any lifetime history of injection drug use (IDU) is associated with markedly elevated rates of addiction to alcohol and other substances on a lifetime basis. In this population, substance use tends to manifest early in life, as do conduct problems such as school disciplinary problems, theft, fighting, and juvenile arrest. Many people who inject drugs will ultimately merit a diagnosis of antisocial personality disorder. Rates of depressive illness and anxiety disorders are also high in this population, and IDU is associated with high rates of suicidal ideation, suicide attempt, and completed suicide. The severity of social, medical, and psychiatric disability in this population poses significant treatment challenges. [ Psychiatr Ann . 2017;47(1):27–32.]

Life cycle efficiency of beef production: VIII. Relationship between residual feed intake of heifers and subsequent cow efficiency ratios.

Data were collected from 1953 through 1980 from identical and fraternal twin beef and dairy females born in 1953, 1954, 1959, 1964, and 1969, and from crossbred females born as singles in 1974, and their progeny. Numbers of dams that weaned at least 1 calf and were included in the first analysis were 37, 45, and 56 in the 1964, 1969, and 1974 data sets, respectively. Respective numbers of dams that weaned 3 calves and were included in a second analysis were 6, 8, 8, 22, 33, and 33 in the 1953, 1954, 1959, 1964, 1969, and 1974 experiments. Individual feed consumption was measured at 28-d intervals from the time females were placed on the experiment until 3 calves were weaned or the dams had reached 5 yr of age. Residual feed intake (RFI) and residual gain (RG) of the heifers that subsequently became the dams in this study were determined based on ADG and DMI from 240 d of age to first calving. Various measures of cow efficiency were calculated on either a life cycle or actual lifetime basis using ratios of progeny and dam weight outputs to progeny and dam feed inputs. Residual feed intake was phenotypically independent of ADG and metabolic midweight (MMW), whereas the correlation between RFI and DMI was positive and highly significant ( = 0.67; < 0.0001). Residual gain was highly correlated with ADG ( = 0.75; < 0.0001) and had near 0 correlations with DMI and MMW. Correlations indicated that heifers that ate less and had smaller metabolic midweights from 240 d of age to first calving had superior efficiency ratios as cows. Residual feed intake was not significantly correlated with age at puberty, age at calving, or milk production. Results of this study do not indicate any serious antagonisms of postweaning heifer RFI with subsequent cow and progeny performance traits or with life cycle or actual lifetime cow efficiency. In addition, selection for increased RG would result in earlier ages at calving, but would also tend to result in taller and heavier cows.

Cost-effectiveness of eplerenone in NYHA class II chronic heart failure patients with reduced LVEF: an analysis for Greece.

ObjectivesThe aim of the study was to evaluate the cost-effectiveness (CE) of treatment with eplerenone versus standard care in adult patients with New York Heart Association class II chronic heart failure and reduced left ventricular ejection fraction from the perspective of the Greek national health care payer.MethodsA discrete-event model simulating the clinical course and respective outcomes of eplerenone as an add-on to standard therapy versus standard therapy alone based on the pivotal Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF) trial was locally adapted for the Greek setting. Data on medications followed the resource use from eplerenone in mild patients hospitalization and survival study in heart failure and were estimated on a lifetime basis (or until discontinuation). Cost calculations were based on year 2014, event costs (cardiovascular hospitalizations, adverse events, and devices) were sourced from published diagnosis-related groups. A 3% discount rate was applied. In order to test the robustness of the model projections, a range of deterministic and probabilistic sensitivity analyses were carried out.ResultsOver a patient’s lifetime, the addition of eplerenone to standard care compared to standard care alone led to an incremental gain of 1.33 quality-adjusted life-years (QALYs) (6.53 vs 5.20 QALYs, respectively) as well as an increase in the cost of treatment by €2,160; these outcomes produced an incremental CE ratio of €1,624/QALY for the Greek setting. On the basis of probabilistic sensitivity analysis, there was a 100% likelihood of eplerenone being cost-effective versus standard care at a threshold of €3,500/QALY.ConclusionThis analysis indicates that eplerenone may be a cost-effective option versus standard care accompanied by additional clinical benefits and an added incremental cost at an acceptable, if not low, CE ratio. The results are consistent with the previously published studies on the CE of eplerenone as an add-on therapy to standard care, such as those regarding the health care settings of Spain, the UK, and Australia.

Greenhouse gas emission intensity based on lifetime milk production of dairy animals, as affected by ration-balancing program

Smallholder dairying in India and other developing countries relies on low- and medium-productive animals, and the feeding is mainly based on crop residues and other agro-industrial by-products. The diets are generally nutritionally imbalanced, resulting in productive and reproductive inefficiencies. This also negatively affects the emission intensity (Ei). For the past 3 years, the National Dairy Development Board of India has been implementing large-scale ration-balancing (RB) program in field animals. The effect of feeding balanced rations on Ei was explored. A cradle to farm-gate life-cycle assessment, taking into account the lifespan milk production, was conducted on 163 540 lactating cows and 163 550 buffaloes in northern, southern, eastern and western India. The life-cycle assessment boundary included feed production, enteric fermentation and manure management during various stages of life. On the basis of economic allocation, emissions of methane (CH4) from enteric fermentation, CH4 from manure management, nitrous oxide from manure management and greenhouse gas (GHG), i.e. carbon dioxide (CO2), CH4 and nitrous oxide from feed production, contributed 69.9%, 6.3%, 9.6% and 14.2% in cows, and 71.6%, 7.4%, 12.6% and 8.4% in buffaloes, respectively, to the baseline (before RB) lifetime total GHG emissions. Average Ei based on economic, mass and digestibility allocation for ‘baseline versus after RB’ were 1.6 versus 1.1, 1.8 versus 1.2 and 1.7 versus 1.2 kg CO2-equivalent/kg fat and protein-corrected milk in cows and 2.3 versus 1.5, 2.5 versus 1.6 and 2.4 versus 1.5 kg CO2-equivalent/kg fat and protein-corrected milk in buffaloes, respectively. Feeding-balanced rations significantly improved milk production, but reduced Ei of milk on lifetime basis by 31.2% and 34.7% in cows and buffaloes, respectively. Implementation of RB program has shown considerable potential to reduce GHG emission intensity under smallholding dairy production system of India.