Life Scores In Group Research Articles

Comparative assessment of patient’s quality of life under medical and surgical epilepsy treatment: an observational prospective study

Epilepsy has never been a purely medical problem; its social significance is well known. It is a global issue that affects people of all ages, races, and social classes in different countries and occurs in both men and women. Drug-resistant epilepsy is a form of the disease in which seizures persist despite appropriate therapy with two antiepileptic drugs, either as monotherapy or in combination. However, surgical treatment of drug-resistant epilepsy is still underutilized. The purpose of the study is to compare the level of quality of life in patients with drug-resistant epilepsy under medical treatment and 1 year after surgery in order to evaluate the dynamics in the areas of quality of life. The study design was a prospective case-control observation. The study included neurosurgical patients with a confirmed diagnosis of drug-resistant epilepsy divided into two groups: group 1 - patients in the preoperative phase receiving drug therapy with antiepileptic drugs, and group 2 - patients 1 year after surgical treatment of drug-resistant epilepsy. Demographic and clinical parameters were analyzed, and the Quality of Life in Epilepsy Inventory-31 survey was carried out before and 1 year after surgery. The first group consisted of 56 patients (55%), and the second group comprised 46 patients (45%). The overall mean quality of life score in group 1 was 53.5, and in group 2 – 59.9, which was statistically significantly different from group 1 (p=0.05). Of the 7 quality of life indicators, a statistically significant improvement was found in 2: general quality of life (p=0.01) and social functioning (p=0.01). 5 indicators showed no statistical differences between the groups: seizure worry (p=0.06), emotional well-being (p=0.9), energy/fatigue (p=0.5), cognitive function (p=0.7), and medication side effects (p=0.6). A comparative analysis of the quality of life of patients with pharmacoresistant epilepsy showed positive dynamics of quality of life from the first year after surgery in contrast to uncontrolled epilepsy against the background of medical treatment with antiepileptic drugs.

Comparative Study of Vestibular Rehabilitation and Dual Task Training on Balance and Quality of Life in Young Stroke Patients

Question: Is there any impact of vestibular rehabilitation and dual task training alongside conventional therapy on balance and quality of life in young stroke patients.  Design: Quasi-experimental study with treatment duration of 8 weeks. Simple random sampling was used to divide patients into 3 groups.  Participants: 30 subjects in the age group 18-45 years both males and females with diagnoses of unilateral hemiplegia within the previous six months.  Intervention: Group A received vestibular rehabilitation along with conventional therapy; Group B received dual task training alongside conventional therapy and Group C received only conventional therapy. Outcome measures: Assessment using Berg Balance Scale and Stroke Specific Quality of Life was conducted pre- and post-treatment.  Results: The results revealed a significant improvement (p<0.05) in balance and quality of life scores in Group A as compared to Groups B and Group C.  Conclusion: Hence, it was concluded that vestibular rehabilitation along with conventional therapy is more effective in enhancing balance among young stroke patients compared to dual task training along with conventional therapy or conventional therapy alone.  Registration: BFUHS/2K23p-TH/11527.

Quality of Life Comparisons in Strabismic Children Managed Surgically or Conservatively

Abstract
 Introduction & Objectives : Strabismus causes visual impairment due to ocular misalignment, interferes cosmetic appearance, results in negative self-image and impacts quality of life. Studies in adults have shown that successful strabismus surgery improves quality of life, but awareness of strabismus surgery and its benefits are still lacking. Studies regarding the impact of conservative treatment on quality of life are limited, so further study is required.
 Methods : This was an observational study comparing 2 unpaired groups. The method used in this study was cross-sectional and samples were obtained purposefully according to medical records and consecutively based on outpatient visits.
 Results : Thirty-six subjects in group A, who had undergone strabismus surgery and 33 subjects in group B who were still managed conservatively were included in this study. Both groups had similar demographic characteristics, except parental education background (p=0.048). Comparative test of2 unpaired groups in this study showed higher quality of life scores in group A (p=0.0001).
 Conclusion : The quality of life in subjects who had undergone strabismus surgery was better than that in those who were still managed conservatively.

Clinical Effect of PRP with DPASB on Full-Thickness Rotator Cuff Tears and Its Role in VAS, SST, and Constant Scores of Patients.

The aim of the study is to probe the effects of platelet-rich plasma (PRP) plus double-row anchor suture bridge (DRASB) under shoulder arthroscopy on the postoperative VAS, SST and Constant scores, rotator cuff tendonbone healing, and re-tear of patients with full-thickness rotator cuff tear (RCT). A total of 60 patients with full-thickness RCT treated in our institution from August 2019 to January 2020 were picked and assigned to either group A (n = 30) or group B (n = 30) on a voluntary basis. Group B received DRASB under shoulder arthroscopy, whereas group A underwent DRASB under shoulder arthroscopy plus PRP. We compared the curative effects of both groups. Week 2, 4, 8, 12 after surgery and 6 months after surgery, VAS scores of patients in both groups declined saliently, whereas SST and Constant scores elevated, and the decrease/increase amplitude of patients in group A was sharply higher than that in group B (p < 0.05). At T2 and T3, abduction 90° external rotation, abduction 90° internal rotation, abduction and anteflexion in both groups increased strikingly, and group A harbored a brilliantly higher increase than group B (p < 0.05). At T2 and T3, serum NO and IL-6 contents were prominently dwindled in both groups, and group A held a plainly higher decrease than group B (p < 0.05). At T3, in comparison to group B, the rotator cuff tendonbone healing rate and quality of life scores in group A were higher (p < 0.05), whereas retear rate was dramatically lower (p < 0.05). DRASB under shoulder arthroscopy plus PRP therapy can blatantly meliorate the curative effect of patients with full-thickness tear, improve the shoulder joint function and tendonbone healing rate, reduce the postoperative pain degree and the incidence of retear, and can be more broadly promoted and applied clinically.

Intratumoral hyperthermic chemotherapy injection in peripheral non-small cell lung cancer

BackgroundIntratumoral chemotherapy (ITC) has been used by many groups; the combination of heat and cytotoxic drugs increases the ability to destroy the malignant cells. The aim of this study was to assess the efficacy and safety of percutaneous injection of hyperthermic chemotherapy in conjunction with systemic chemotherapy as a palliative management of peripheral inoperable non-small cell lung cancer (NSCLC) compared to conventional systemic chemotherapy.ResultsThere was a statistically significant improvement in quality of life score in group A and B, but deterioration in group C after 6 months. As regards radiology, after 6 months in group A, one patient (10%) showed complete response, 6 patients (60%) showed partial response, one patient (10%) stable response, and two patients (20%) showed progression; in group B, 6 patients (60%) showed partial response, two patients (20%) showed stable response, and two patients (20%) showed progression; and in group C, 7 patients (70%) showed progression, two patients (20%) showed partial response, and one patient (10%) showed stable response. There were few controllable complications. Median survival in group A was 16 months, in group B was 15 months, and in group C was 8 months.ConclusionIntratumoral hyperthermic chemotherapy is a promising, effective, harmless palliative therapy for inoperable peripheral NSCLC.

The clinical significance of gabapentin in combination with opioids in controlling outbreak of pain in cancer patients.

e24142 Background: This study compared the pain relief effects of opioids combined with gabapentin and opioids alone after an outbreak of pain in patients with opioid-tolerant cancer pain to explore better cancer pain management. Methods: A total of 60 patients with moderate and severe cancer pain from September 2016 to April 2017 in the Department of Oncology of the Fourth Hospital of Hebei Medical University. They were randomly divided into two groups when they experienced an outbreak of pain, only oxycodone hydrochloride sustained-release tablets group (A group) 30 cases and gabapentin capsule combined with oxycodone hydrochloride sustained-release tablets group (B group) 30 cases, The degree of pain relief before and after treatment, the consumption of oxycodone hydrochloride sustained-release tablets, quality of life scores and adverse reactions, and nighttime sleep time were compared between the two groups. Results: 1. The NRS score in group B after treatment was significantly lower than that in group A after treatment (1.83±0.46 vs. 2.30±0.75). There was a statistically significant difference (P &lt; 0.05). 2. The consumption of oxycodone hydrochloride sustained-release tablet in group B was lower than that in group A (19.000±6.074 vs. 25.667±10.063). There was statistical significance (P = 0.003). 3. The quality score was higher than before, and the quality of life score in group B was higher than that in group A (P &lt; 0.05). 4. The main adverse reactions in both groups were constipation, nausea, vomiting and dizziness. The incidence was 86.67% vs. 50.00%、33.33% vs. 23.33%, 20.00% vs. 16.67%, respectively, there was no significant difference (P &gt; 0.05). The nighttime sleep time of both groups was higher than that before treatment (6.017±0.636 vs. 5.167±0.735, 6.433±0.583 vs. 5.167±0.661). 5. The nighttime sleep time of Group B was longer than that of Group A after treatment (6.433±0.583 vs. 6.017±0.636). The difference was statistically significant (P &lt; 0.05). Conclusions: Opioids combined with gabapentin are superior to opioids alone in the treatment of cancer pain with analgesic efficacy, improved quality of life, reduced opioid consumption, adverse drug reactions, and effective night time sleep.

Neuroprotective effect of surround needling combined with acupoint injection on acute herpetic neuralgia

To explore the effect and mechanism of surround needling combined with acupoint injection on acute herpetic neuralgia (AHN). Ninety-nine patients with T6-T10 segment AHN were randomly divided into 3 groups, 33 cases in each group, including 2 cases dropped off in the surround needling group, 4 cases dropped off in the acupoint injection group, and 3 cases dropped off in the combined group. Oral valacyclovir was given in each group, 0.3 g each time, 2 times a day for 10 days. Oblique insertion of needle used at ashi points around the herpes in the surround needling group, and continuous wave was stimulated to tolerance for 20 min; the same acupoints were selected as the surround needling group, stimulated with the mixture injection of mecobalamin and lidocaine in the acupoint injection group; After the surround needling, acupoint injection was performed in the combined group. The treatment was given once a day, 14 times for a course, and one course was needed in all groups. The skin healing conditions (blistering, crusting, and dislocation time) of each group were compared after treatment. The pain scores, pain area and quality of life scores in each group were observed before and after treatment. The levels of neuron specific enolase (NSE), substance P (SP) and calcitonin gene-related peptide (CGRP) in the local blister fluid were measured before and after treatment in all groups. The blistering, crusting and dislocation time in the combined group were earlier than the other two groups (all P<0.05). The pain score and pain area in the each group were significantly lower than those before treatment, and the quality of life score was significantly higher than that before treatment (all P<0.05). The improvements of pain score and quality of life score in the combined group were more obvious than the other two groups (all P<0.05). After treatment, the levels of NSE, SP and CGRP in the local blister fluid in each groups were significantly lower than those before treatment (all P<0.05). The indexes in the combined group were significantly lower than those in the other two groups (all P<0.05). Both surround needling and acupoint injection have an adjuvant effect on AHN. The combination of the two is better, the skin is healed quickly, the analgesia is significant, and the contents of local NSE, SP and CGRP are significantly decreased. The mechanism of action is to exert neuroprotective effects.

Effect of thyroid function on COPD exacerbation frequency: a preliminary study

Background: Frequent exacerbations of chronic obstructive pulmonary disease (COPD) have negative effects on quality of life and survival. Thus, factors related to exacerbations should be determined. We aimed to evaluate the effects of thyroid function on quality of life and exacerbation frequency in COPD patients. Methods: The study population (n = 128) was divided into 3 groups (Group 1: COPD patients with hypothyroidism (n = 44); Group 2: COPD patients with normal thyroid function tests (n = 44); Group 3: Healthy subjects (n = 40)). Pulmonary function tests, maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) measurements were performed. Quality of life questionnaire (Short Form 36, SF-36) was carried out. Patients were followed up for one year and number of exacerbations was recorded. Results: FVC, FEV1/FVC, and FEF 25–75% measurements were statistically different between group 1 and 2 (p = 0.041, p = 0.001, p = 0.009 respectively). Although MEP values were significantly different between group 1 and 2 (p = 0.006), there was no significant difference in MIP values between groups (p = 0.77). Quality of life scores in group 1 and 2 were significantly lower than control group. Exacerbation frequency was significantly higher in group 1 than in group 2 (p = 0.017). TSH values and exacerbation frequency had positive correlation (p &lt; 0.0001; r = 0.82). Conclusions: The results of the present study suggest that thyroid function has an effect in exacerbation frequency of COPD. Decrease in exacerbation numbers with early detection of impairment in thyroid function will have positive contribution on quality of life in COPD patients.

Effect of thyroid function on COPD exacerbation frequency: a preliminary study

BackgroundFrequent exacerbations of chronic obstructive pulmonary disease (COPD) have negative effects on quality of life and survival. Thus, factors related to exacerbations should be determined. We aimed to evaluate the effects of thyroid function on quality of life and exacerbation frequency in COPD patients.MethodsThe study population (n = 128) was divided into 3 groups (Group 1: COPD patients with hypothyroidism (n = 44); Group 2: COPD patients with normal thyroid function tests (n = 44); Group 3: Healthy subjects (n = 40)). Pulmonary function tests, maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) measurements were performed. Quality of life questionnaire (Short Form 36, SF-36) was carried out. Patients were followed up for one year and number of exacerbations was recorded.ResultsFVC, FEV1/FVC, and FEF 25–75% measurements were statistically different between group 1 and 2 (p = 0.041, p = 0.001, p = 0.009 respectively). Although MEP values were significantly different between group 1 and 2 (p = 0.006), there was no significant difference in MIP values between groups (p = 0.77). Quality of life scores in group 1 and 2 were significantly lower than control group. Exacerbation frequency was significantly higher in group 1 than in group 2 (p = 0.017). TSH values and exacerbation frequency had positive correlation (p < 0.0001; r = 0.82).ConclusionsThe results of the present study suggest that thyroid function has an effect in exacerbation frequency of COPD. Decrease in exacerbation numbers with early detection of impairment in thyroid function will have positive contribution on quality of life in COPD patients.