Life Questionnaire For Patients Research Articles

Comparative Evaluation of Health-Related Quality of Life Questionnaires in Patients With Heart Failure Undergoing Cardiac Rehabilitation: A Psychometric Study

ObjectiveTo compare the psychometric properties of 2 heart failure (HF)-specific quality of life questionnaires and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) in patients with HF. DesignA methodological study based on 3-month follow-up data for evaluating psychometric properties of health-related quality of life (HRQOL) questionnaires. SettingCardiac rehabilitation center at a cardiovascular research institute. ParticipantsEligible patients with HF (N=60). InterventionsExercise training in cardiac rehabilitation. Main Outcome MeasuresThe SF-36, the MacNew Heart Disease questionnaire, and the Minnesota Living With Heart Failure Questionnaire (MLHFQ) and New York Heart Association functional classification. ResultsItems from the MLHFQ and the MacNew questionnaire had acceptable correlations (r>.30, P<.05). Internal consistency and test-retest reliability were adequate at ≥0.7 for the MLHFQ subscales. Correlations for the MLHFQ and the MacNew with SF-36 similar items ranged from .28 to .50 and from .26 to .60, respectively. Similar scales from the MacNew and MLHFQ showed strong correlations at baseline and follow-up, supporting the convergent validity. Improvement in HRQOL was significant for all MLHFQ subscales (P<.001) and the MacNew emotional (P<.05) and social (P<.001) subscales. The MLHFQ demonstrated the most responsiveness to changes and discriminated disease severity the best. The follow-up scores for all MLHFQ and 2 MacNew subscales were significantly greater in patients who improved compared with those who showed no change or deteriorated. ConclusionsThe MLHFQ was more responsive to changes of HRQOL than the MacNew questionnaire over time in patients with HF. The MacNew questionnaire was more responsive to changes than the SF-36.

Reproducibility and Reliability of the Quality of Life Questionnaire in Patients With Atrial Fibrillation.

BackgroundStudies have shown the impact of atrial fibrillation (AF) on the patients' quality of life. Specific questionnaires enable the evaluation of relevant events. We previously developed a questionnaire to assess the quality of life of patients with AF (AFQLQ version 1), which was reviewed in this study, and new domains were added.ObjectiveTo demonstrate the reproducibility of the AFQLQ version 2 (AFQLQ v.2), which included the domains of fatigue, illness perception and well-being.MethodsWe applied 160 questionnaires (AFQLQ v.2 and SF-36) to 40 patients, at baseline and 15 days after, to measure inter- and intraobserver reproducibility. The analysis of quality of life stability was determined by test-retest, applying the Bartko intraclass correlation coefficient (ICC). Internal consistency was assessed by Cronbach's alpha test.ResultsThe total score of the test-retest (n = 40) had an ICC of 0.98 in the AFQLQ v.2, and of 0.94 in the SF36. In assessing the intra- and interobserver reproducibility of the AFQLQ v.2, the ICC reliability was 0.98 and 0.97, respectively. The internal consistency had a Cronbach's alpha coefficient of 0.82, compatible with good agreement of the AFQLQ v.2.ConclusionThe AFQLQ v.2 performed better than its previous version. Similarly, the domains added contributed to make it more comprehensive and robust to assess the quality of life of patients with AF.

Analysis and correlation of physical therapy tests, pain, function and quality of life questionnaires in patients from parqve (project arhtritis recovering quality of life by means of education)

Analysis and correlation of physical therapy tests, pain, function and quality of life questionnaires in patients from parqve (project arhtritis recovering quality of life by means of education)

Evaluation of the clinical usefulness of a health-related quality of life questionnaire in patients with prostate cancer

ObjectivesThe PROSQoLI questionnaire evaluates health-related quality of life in patients with advanced prostate cancer. Although its utility in different clinical settings has never been assessed, its brevity and good measurement properties make its use recommendable in clinical practice. The objective is to evaluate the clinical usefulness of PROSQoLI in clinical treatment decision-making in patients with prostate cancer. Materials and methodsAn observational, prospective longitudinal and multi-center study conducted in different Spanish centers. Sociodemographic and clinical data of patients and researchers were collected. Each patient fulfilled PROSQoLI questionnaire in each visit. Besides, physicians answered a survey about clinical usefulness of PROSQoLI questionnaire. ResultsThe mean age of patients was 74.7 (7.4) years (standard deviation) and of researchers 51.8 (9.7) years. The usefulness in clinical decision-making was considered high by 66.1% of physicians; regarding questionnaire characteristics 71.3% of physicians considered it highly useful and 73.4% of them regarding doctor–patient communication. ConclusionsThe use of health-related quality of life questionnaires improves doctor–patient communication. It is demonstrated that PROSQoLI can be an additional tool in clinical decision-making as well as a means of facilitating doctor–patient communication.

The MacNew Heart Disease Health-Related Quality of Life Questionnaire: A Scandinavian Validation Study

The aim of this study is to validate the Danish, Norwegian and Swedish versions of the self-administered MacNew Heart Disease Health-related Quality of Life questionnaire in patients with ischemic heart disease. The MacNew questionnaire, the Short Form SF-36, and the Hospital Anxiety and Depression Scale were completed at baseline by 976 patients (Denmark n = 353, Norway n = 328, Sweden n = 295) with a diagnosis of angina (n = 335), myocardial infarction (n = 352), or heart failure (n = 289). Each language version of the MacNew satisfied reliability criteria with Cronbach’s α values for the total group data (0.90–0.94) as well as the diagnostic group data (0.91–0.96). The test–retest correlations exceeded the criteria for group comparison (r ≥ 0.70) in Danish and Norwegian patients. The multidimensionality of the MacNew was confirmed although the original three-factor solution did not fully meet the criteria for good fit. Convergent and discriminative validity were confirmed in each language and diagnosis group with the exception of discriminative validity in Swedish angina patients. The psychometric properties of the Danish, Norwegian, and Swedish versions of the MacNew are largely confirmed. The MacNew can be recommended as a specific instrument for assessing and evaluating HRQL in Danish, Norwegian, and Swedish patients with angina, MI, and heart failure. However, the MacNew factor structure needs to be revisited in future studies.

Assessment of early and late dysphagia using videofluoroscopy and quality of life questionnaires in patients with head and neck cancer treated with radiation therapy.

BackgorundThe aim of this study was to evaluate dysphagia in patients with head and neck cancer (HNC) undergoing three-dimensional conformal radiation therapy using objective and subjective tools simultaneously and to associate the clinical correlates of dysphagia with dosimetric parameters.MethodsTwenty patients were included in the study. The primary tumor and the involved lymph nodes (LN) were treated with 66-70 Gy, the uninvolved LN were treated with 46-50 Gy. Six swallowing structures were identified: the superior pharyngeal constrictor muscle (SPCM), the middle pharyngeal constrictor muscle (MPCM), the inferior pharyngeal constrictor muscle (IPCM), the base of tongue (BOT), the larynx and the proximal esophageal sphincter (PES). Dysphagia was evaluated using videofluoroscopy and European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaire (QLQ-C30) and supplemental EORTC QoL module for HNC (QLQ-H&N35). The evaluations were performed before treatment, at 3 months and at 6 months following treatment.ResultsOn objective evaluation, the Dmax for the larynx and the sub-structures of the PCM were correlated with impaired lingual movement, BOT weakness and proximal esophageal stricture at 3 months, whereas the V65, the V70and the Dmax for the larynx was correlated with BOT weakness and the V65, the V70, the Dmax or the Dmean for the sub-structures of the PCM were correlated with impaired lingual movement, BOT weakness, reduced laryngeal elevation, reduced epiglottic inversion and aspiration at 6 months following treatment. On subjective evaluation, the V60, the Dmax and the Dmean for SPCM were correlated with QoL scores for HNSO at 3 months, whereas the V70 for SPCM were correlated with QoL scores for HNPA and the V60, the V65, the V70, the Dmax and the Dmean for SPCM were correlated with QoL scores for HNSO at 6 months following treatment.ConclusionsThe use of multiple dysphagia-related endpoints to complement eachother rather than to overlap with one another, as well as the use of multiple evaluations over time to represent a scale of early to late findings might provide a better insight in terms of the association of the clinical correlates of dysphagia with the dose-volume data for the dysphagia-related anatomical structures.

Validation and perspectives of the Russian version of the quality of life questionnaire in patients with diabetic peripheral polyneuropathy

Background. Quality of life is a multivariate indicator of patient?s perception of various aspects of his/her own life. Questionnaires (specific and non-specific) are used to assess it. Objective. . To validate the Russian version of the specific quality of life questionnaire ?NeuroQol? in diabetic patients with peripheral polyneuropathy. Materials and Methods. A total of 371 diabetic patients participated in the study. All patients were screened for the signs of peripheral neuropathy and limb ischemia. The examination results were used to evaluate the eligibility of a patient; the eligible patients were then asked to fill in the quality of life questionnaire. The validation included translation, pilot testing and assessment of reliability and validity. Results. Cronbach?s alpha coefficient of internal consistency exceeded 0.8 in all scales and proved the high reliability of the questionnaire. Criterion validity was analyzed by Spearmen correlation (r) coefficient between the domains and external parameters. The results obtained revealed significant correlation between NeuroQol domains and neuropathy severity, which indicates adequate criterion validity. The psychometric assessment (construct validity) was performed using factor analysis. The physical and psychosocial factors contributing to the quality of life were identified; they confirmed the validity of the questionnaire structure. Conclusion. The results demonstrate that the Russian version of the NeuroQol questionnaire is valid and reliable. This questionnaire enables one to assess quality of life in patients with the signs of peripheral diabetic polyneuropathy, including evaluation of the efficiency of various treatment strategies for complications. The lack of social life and psychological conditions of patients affect their quality of life more than physical complications do. These parameters must become the focus of specialists' attention in their efforts to improve the quality of life in this category of patients.

The reliability and validity of the Iranian version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for patients with Bone Metastases: the EORTC QLQ-BM22

The aim of the present study was to evaluate the psychometric properties of the measure among a sample of Iranian patients with bone metastases. One hundred and seventy-seven patients with bone metastases undergoing various treatments were recruited from Imam Khomeini Hospital in Tehran to participate in the study. The coefficient alpha affirmed internal consistency reliability of the Quality of Life Questionnaire for patients with Bone Metastases (QLQ-BM22). This measure discriminated well between subgroups of the patients based on performance status and responding to treatment. Confirmatory factor analysis confirmed the factorial validity of the four hypothesized QLQ-BM22 scales. Patients in this study had a similar interpretation of the items on the QLQ-BM22 regardless of gender. All scales of the QLQ-BM22 were sensitive to change after treatment over a month’s follow-up, with the exception of psychosocial aspects. The Persian version of the EORTC QLQ-BM22 was highly reliable and is valid for use among patients with bone metastases who are undergoing various treatment regimes.

Statistical or Clinical Improvement? Determining the Minimally Important Difference for the Vascular Quality of Life Questionnaire in Patients with Critical Limb Ischemia

Interpreting whether changes in quality of life (Qol) in patients with peripheral arterial disease (PAD) are not only statistically significant but also clinically relevant, may be difficult. This study introduces the concept of the minimally important difference (MID) to vascular surgeons using Qol outcomes of patients treated for chronic critical limb ischemia (CLI). The Vascular Quality of Life (VascuQol) questionnaire was recorded at baseline before treatment and after 6 months follow-up in consecutive patients with CLI treated between May 2007 and May 2010. Statistical significance of change in VascuQol score was tested with the Wilcoxon Signed Rank test. The MID for the VascuQol score was determined using a clinical anchor-based method and a distribution-based method. A total of 127 patients with CLI completed the VascuQol after 6 months. The VascuQol sum scores improved from 3.0 (range 1.1-5.9) at baseline to 4.0 (range 1.2-6.7) at 6 months (p < .001). The MID on the VascuQol sumscore indicating a clinically important change determined with the anchor-based method was 0.36, and with the distribution-based method was 0.48. On an individual level, depending on the method of determining the MID, this resulted in 60% to 68% of the patients with an important benefit. Expression of changes in Qol by means of the MID provides better insight into clinically important changes than statistical significance.

AB0398 Responsiveness of a generic and disease specific health related quality of life questionnaire in patients with systemic lupus erythematosus.

BackgroundLittle is published on comparative responsiveness of generic and disease specific Patients reported outcomes (PRO) tool in systemic lupus erythematosus (SLE).ObjectivesTo determine and compare the responsiveness and minimally clinical important...

Validation of the Hebrew Version of the MacNew Heart Disease Healthrelated Quality of Life Questionnaire in Patients Undergoing Coronary Artery Bypass Surgery

Background: The MacNew questionnaire is a disease-specific health-related quality of life (HRQL) measure designed for patients with heart disease. We aimed to assess the psychometric property of the MacNew questionnaire in Hebrew-speaking patients undergoing coronary artery bypass grafting (CABG) surgery. Methods: The study sample comprised of 775 Hebrew-speaking patients undergoing CABG surgery. Patients were assessed twice: before CABG surgery and 12-months thereafter. They completed the MacNew, the Short Form-36 Health Survey (SF-36), the Hospital Anxiety and Depression Scale, and a questionnaire on demographic and lifestyle habits. Results: 775 patients completed the questionnaires at study entry, 599 (77%) of whom also provided data after 12 months. The internal consistency of the MacNew sub-scales was high (alpha coefficients: 0.88-0.94). There were moderate to high correlations between sub-scales of the MacNew and similar domains of the SF-36 (0.66-0.80). The MacNew scales discriminated between men and women, patients with and without congestive heart failure and between individuals with clinically significant symptoms of depression or anxiety and all other patients. The original three-factor structure was generally supported as most loadings met the 0.40 threshold on the expected factor. Patients attending cardiac rehabilitation programs after CABG surgery showed greater improvement in all the MacNew scales, particularly in physical functioning, compared to patients who had not participated in cardiac rehabilitation programmes. Conclusions: The Hebrew version of MacNew was found to be a reliable and valid HRQL tool which is sensitive to change in patients undergoing CABG surgery. This instrument offers clinicians and researchers a useful tool for understanding the impact of heart disease and its treatment from the patient‘s perspective.

Nazal Polipli Hastalarda Bilgisayarlı Tomografi ve Endoskopi Skorlarının Yaşam Kalitesi Ölçekleri ile Korelasyonunun Araştırılması

Nazal Polipli Hastalarda Bilgisayarlı Tomografi ve Endoskopi Skorlarının Yaşam Kalitesi Ölçekleri ile Korelasyonunun Araştırılması

Health Related Quality of Life for Stone Formers

Urolithiasis is a common urological condition that causes significant pain and suffering. Until recently few studies had been done to examine how quality of life is affected in stone formers. We hypothesized that patients with multiple recurrent episodes of urolithiasis have worse health related quality of life. Thus, we identified specific factors that impact health related quality of life in patients with urolithiasis. In an institutional review board approved study we recruited 386 patients through mailings and through the outpatient clinic who were evaluated at our institution for urolithiasis in the last 5 years. Each patient was asked to answer questionnaires on stone disease, including SF-36®, a validated 36-item health care quality of life survey. Of the 386 patients recruited for study 115 responded to our inquiry. Variables such as surgical complications, time from last stone episode, number of emergency room visits and number of surgeries correlated with the SF-36 domains. Urolithiasis is associated with severe physical and psychological effects that lead to clinically significant impairment in quality of life. Our findings confirm and expand the findings of previous groups showing the many ways in which stone formation can affect patient quality of life. Appreciation of these effects in the acute and chronic treatment settings may change the way that the disease is approached.

P-0277 Validation of the Filipino Version of Stoma-Qol Questionnaire for Colorectal Cancer Patients With Stoma

ABSTRACT Introduction Stoma Quality of Life Scale (Stoma-QoL), a twenty-item quality of life questionnaire for patients with intestinal stomas, has been translated into sixteen languages but has never been validated. This study aims to translate the questionnaire into Filipino and to test its validity and reliability among colorectal cancer patients with stomal appliance. Methods Stoma-QoL questionnaire was translated into Filipino using the World Health Organization (WHO) Guidelines on Process of Translation and Adaptation of Instruments: forward translation, summary of recommendations by an expert panel, back translation and pre-testing. Expert panel was composed of the translator, two health professionals and a representative from the University of the Philippines Manila Sentro ng Wika. After cognitive debriefing, pre-testing was done on ten respondents. The final translated version was then administered twice, one week apart, to 108 eligible patients at the Colorectal Cancer Multidisciplinary Clinic of Philippine General Hospital. Results There was no significant difference on the median QoL score between the two visits (Spearman's correlation coefficient 0.733, p=0.916). Cronbach's α coefficient of the Filipino Stoma QoL is 0.91, which exceeded the recommended value of 0.70, indicating good internal consistency reliability. Five domains were extracted after factor analysis was done which explain 66.4% of the total variance. Conclusion The Filipino Stoma QoL is a reliable and valid quality of life tool which can be used among colorectal cancer patients with intestinal stomas.

Validity of A Short-Term Quality of Life Questionnaire in Patients Undergoing Joint Replacement: The Quality of Recovery–40

One hundred thirty-two patients undergoing total hip or knee arthroplasty were evaluated before and after surgery with the Quality of Recovery–40 (QoR-40) and the Short Form 12 (SF-12) questionnaires seven times over a 4-month period, with the objective of comparing their psychometric properties. Physical dimensions of the QoR-40 and SF-12 were not related in the days after surgery but moderately related over the first month. Only the change in score for the physical independence dimension of the QoR-40 exceeded measurement error. Effect sizes were larger for the QoR-40 within the first month post-surgery and larger for the SF-12 past 1 month. Effect sizes were larger for the physical dimensions of both instruments compared to the psychological dimensions. Only the physical independence dimension of the QoR-40 appears useful to assess the quality of life in the first month following surgery.

Quality of life questionnaire in patients with coeliac disease

Background: The incidence of coeliac disease (CD) has been increased in the latest years. Several patients don't have serious gastrointestinal symptoms at all and the diagnosis is often delayed. Patients with few, moderate symptoms or without symptoms doubt on the necessity of the life-long diet and the control examinations. Aim: To evaluate the lifestyle, the dietary habits and the attitude toward CD by a questionnaire in patients with CD. Patients and methods: The questionnaires were filled by our patients with CD who are registered in our department. Results: The total number of the cases were 74 (female: 64, male: 10; mean age: 41.7 years). 76% (56/74) of the patients reside in cities while 24% (18/74) live in villages. The time interval between the first signs or symptoms and the diagnosis was more than one year in 41% (30/74) of the cases. Other diseases associated with CD were found in 57% (42/74) of them. CD was diagnosed in one third of the patient's relatives as well. 96% (71/74) of the patients know the point of the diet but only 85% (63/74) comply with it correctly. 76% (56/74) of the cases complain about abstaining from various food. 96% (71/74) of patients are aware of the fact that it is a life-long diet. 63% (47/74) of the cases appear at regular control examinations. Conclusion: Although almost 100% of the patients are fully aware of the properties of coeliac disease, not all of them keep the diet correctly and about only half of them come to control examinations. Providing wider range of information and explanation CD would improve this situation.

Phase 3 Efficacy and Tolerability Study of OnabotulinumtoxinA for Urinary Incontinence From Neurogenic Detrusor Overactivity

We assessed the efficacy, safety and effects on quality of life of onabotulinumtoxinA in patients with neurogenic detrusor overactivity. In this 52-week, international, multicenter, double-blind, randomized, placebo controlled trial 416 patients with neurogenic detrusor overactivity and urinary incontinence (14 or more episodes per week) resulting from multiple sclerosis (227) and spinal cord injury (189) were treated with intradetrusor injections of onabotulinumtoxinA (200 or 300 U) or placebo. The primary end point was the change from baseline in the mean number of urinary incontinence episodes per week at week 6. Maximum cystometric capacity, maximum detrusor pressure during the first involuntary detrusor contraction and Incontinence Quality of Life total score were secondary end points. Adverse events were monitored. OnabotulinumtoxinA at a dose of 200 U in 135 patients and 300 U in 132 decreased mean urinary incontinence at week 6 by 21 and 23 episodes per week, respectively, vs 9 episodes per week in 149 on placebo (each dose p<0.001). Also, maximum cystometric capacity, maximum detrusor pressure during the first involuntary detrusor contraction and Incontinence Quality of Life score were significantly improved over values in the placebo group (each dose p<0.001). Median time to patient re-treatment request was greater for onabotulinumtoxinA 200 and 300 U than for placebo (256 and 254 days, respectively, vs 92). The most common adverse events were urinary tract infection and urinary retention. Of patients who did not catheterize at baseline 10% on placebo, 35% on 200 U and 42% on 300 U initiated catheterization due to urinary retention. OnabotulinumtoxinA significantly improved neurogenic detrusor overactivity symptoms vs placebo. Clean intermittent catheterization initiation due to urinary retention appeared to increase in a dose dependent fashion. No clinically relevant benefit in efficacy or duration was identified for the 300 U dose over the 200 U dose.

Comparison of the EORTC QLQ-BM22 and the FACT-BP for assessment of quality of life in cancer patients with bone metastases

Introduction: Maintenance or improvement in quality of life (QoL) is the main goal of palliative treatments for bone metastases. Validated and comprehensive tools assessing QoL for specific patient subgroups are required in order to accurately assess and make informed decisions about palliative treatments. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for patients with bone metastases (QLQ-BM22) and the Functional Assessment of Cancer Therapy Quality of Life Measurement in patients with bone pain (FACT-BP) are the only two palliative QoL tools available that have been validated for use specifically for bone metastases patients. The purpose of this study was to compare the development and characteristics of these two tools, as well as their current use in palliative research. Methods: Studies detailing the development process for the QLQ-BM22 and the FACT-BP were identified. A comparison between both questionnaires in terms of development, characteristics, validation and use was conducted. Results: The QLQ-BM22 was developed with collaboration from patients, healthcare professionals and review of the literature, whereas the FACT-BP was created strictly through interviews with patients. Scoring, organization, response options and item format are different; however, recall period is the same. Both tools showed good internal consistency and construct validity. The QLQ-BM22 showed good test–retest reliability, while this has not been tested with the FACT-BP. The QLQ-BM22 has been internationally validated among a large sample of patients undergoing a variety of treatments, demonstrating its ability of detect meaningful QoL changes in diverse bone metastases populations. On the other hand, the FACT-BP demonstrated high internal consistency at all assessments, indicating that it may be utilized as a stand-alone measure of bone pain. Conclusion: Both the QLQ-BM22 and FACT-BP are designed for assessment of QoL issues specific to cancer patients with bone metastases. Each instrument has unique strengths and weaknesses and choice between these tools is dependent on the investigator and study needs.

Abstract P136: Assessing the Impact of Atrial Fibrillation Symptoms: Whose Perspective Should Be Used to Develop a Health Status Questionnaire?

Background Knowledge on how patients experience atrial fibrilliation (AF) and the effect of AF on their life is needed. While generic health status tools are used in clinical trials where the aim is to get a general picture of how patients rate their health, an AF disease-specific tool is missing. In development of disease-specific tools it is important that both patients and physicians are asked to describe the impact of symptoms of AF, when the goal is to elucidate patients' perspectives on the impact of the symptoms on their life with AF. By means of a systematic literature search, we identified five AF disease-specific self-reported instruments: The Canadian Cardiovascular Society Severity in AF (CCS-SAF); the specific questionnaire for Quality of Life in AF patients (QLAF); the Short Symptom Scale for patients with AF (SSS-AF); The Quality of Life questionnaire for patients with AF (AF-QOL); and finally the Atrial Fibrillation Effect on QualiTy-of-life (AFEQT). Aim The aim of this study was to compare five disease-specific AF self-reported instruments in order to elucidate which one is preferable to validate in a Danish context. The preferable tool is expected to be used in a prospective study on the evaluation of ablation and mini-maze operation due to AF and in a study on the development of a rehabilitation solution for patients with AF. Method A literature study comparing the five tools by text analysis was conducted as suggested by the Danish scholar Leif Becker Jensen. Criteria to determine which tool to validate in a Danish cohort included: a) Purpose of tool, b) Perspective captured in development of the tool, d) Content of the tool including length and type of questions, items, domains, e) Validation of the tool. Results a) Purpose of tool b) Perspective captured in development of the tool c) Content of the tool d) Validation of the tool CCS-SAF - Canada Designed for use in clinical practice. Not well designed for clinical trials to elucidate patients' perspective on the impact of symptoms on their life. Expert perspective only Consists of three steps; symptoms, association, functionality, and finally rating of the patients in Five classes (0-4). à designed for doctors to fill out Short Form 36, University of Toronto Atrial Fibrillation Severity Scale QLAF - Brazil Designed for clinical trials. Can also be used in the clinical practice context. Expert perspective only Consists of seven domains and 22 questions and is to be filled out by patients. Short Form 36 SSS-AF - Sweden Designed for use in clinical practice. Not well designed for clinical trials to elucidate patients' perspective on symptoms impact on their life. Expert perspective only Consists of six items which the patient rates on a scale from 0-100 Toronto AF symptom checklist, Short Form 36. AF-QOL - Spain Designed for clinical trials. Can also be used in the clinical practice context. Both patient and expert perspective were involved. Patients were involved during the process by focus group interviews Consists of 18 questions divided into three domains and is designed to be filled out by the patients Short Form 36 AFEQT - US Designed for clinical trials. Can also be used in the clinical practice context. Both patient and expert perspectives were involved. Patients were involved during the process by personal interviews and by having patients' rate relevant items. Consists of 21 questions divided into two sections and is also designed for the patients to fill out Short Form 36, EuroQOL - 5D, Symptom Checklist: Frequency and Severity, University of Toronto Atrial Fibrillation Severity Scale. Generalized Anxiety Disorder (GAD-7), Atrial Fibrillation Patients and Physician Global Change Forms Conclusion AFEQT and AF-QOL meet the criteria specified and by the fact that AFEQT is validated against more tools than AF-QOL it is preferred and will be translated into a Danish context for use in future Danish studies mentioned in the aim section of this study.

The MacNew Heart Disease Health-Related Quality of Life Questionnaire in Patients with Angina and Patients with Ischemic Heart Failure

ObjectivePatient-reported outcomes including health-related quality of life are important in clinical care and research studies. The MacNew Heart Disease health-related quality of life questionnaire has been validated in English-speaking patients with myocardial infarction. The aim of this study was to validate the MacNew in English-speaking patients with angina or ischemic heart failure. MethodsCanadian and American patients with angina or ischemic heart failure completed the MacNew, the Short Form-36 Health Survey, and the Hospital Anxiety and Depression Scale. ResultsWe administered questionnaires to 276 patients with angina (mean age, 65.9 years) and 155 patients with ischemic heart failure (mean age, 70.3 years). The mean ± SD MacNew global score in patients with ischemic heart failure (5.1 ± 1.2) was statistically (P < 0.001), but not clinically, poorer than in patients with angina (5.3 ± 1.1). The three-factor measurement model explained 46.1% of the observed variance in the MacNew in patients with angina and 46.5% in patients with ischemic heart failure. Internal consistency was ≥0.90, and test-retest reliability was ≥0.70 for each MacNew scale and the a priori convergent and discriminative validity hypotheses were confirmed in both diagnoses. The MacNew was highly accepted by patients with little respondent or administrative burden. ConclusionsThe English version of the MacNew is reliable and valid in patients with angina or ischemic heart failure. This permits health-related quality of life outcome comparisons in patients with angina, ischemic heart failure, and myocardial infarction with the MacNew and provides a better understanding of the full range of health-related quality of life outcomes.