Life In Breast Cancer Patients Research Articles

Quality of life of breast cancer patients

WHO in 2019 has reported 2.09 million cases and 62, 7000 deaths of breast cancer in women. It affects women in the developing and developed countries across the globe. In our country, breast cancer is the most common form of cancer, among women which begins in the early thirties and peaks at 60-65 years of age. Breast cancer if detected early can be treated. The study was done to assess Quality of Life among breast Cancer patients. Using Sister Callista Roy’s General system theory this descriptive study was done on 100 Breast Cancer patients in Oncology OPD using QOL tool. Study findings revealed that with all treatment and follow-up regimes too only 54% had a good QOL rest being affected with disease and having some or other issues. To conclude even if there are extensive advancements in treatment modalities related to the Breast cancer still the fears, finances and social activities are widely affected.

Breast cancer and body image: The roles of the male partner

Background: Cancer is a group of diseases with different causes, manifestations, treatment, and prognosis, characterized with an uncontrolled growth of abnormal cell. In women; cancer of the breast is the second most common cancer after cervical cancer and the second leading cancer’s death following lung cancer among women in Sub-Saharan Africa. In Nigeria, it has become the most common female malignancy with a prevalence of 12.5%. However, the same treatment that offers better cure rates may also result in a serious decrease in quality of life, psychological problems, as well as provoking changes in their bodies. Societal behavior towards breast cancer patients makes a woman that is newly diagnosed with breast cancer become tearful, ashamed, and discouraged. Aims: To examine breast cancer, body image and the roles of the male partner. Methods: The data for this review paper are from published studies. Electronic databases of Medline, Scopus, PubMed, CINAHL, and Google Scholar were searched using the keywords: breast cancer, body image, roles of the male partner and literature were retrieved and screened for eligibility. The date limit considered in the literature search was from 2016-2021 to capture only the variables identified in this seminar objective. The author defined the topic of interest and the goal was to address the objective of the seminar topic. Results: Four themes (issues) emerged which are: (1) The Model of Whole-Person Caring, (2) Disturbed Body Image, (3) Psycho-Social Impact of Breast Cancer and (4) Roles of the Male Partner. Conclusion: Breast cancer poses a significant financial and psychosocial burden not only on patients, but also on their spouses, families, and broader social network. Breast cancer disease usually changes spousal roles as the women’s husbands take over their responsibilities. The disease influenced both partners and made stress a common factor shared by them. Husband plays a vital role in the lives of breast cancer patients through managing the finance, decision-making, providing emotional support, and remaining involved throughout the disease. Therefore, involving the husband in planned psycho-social interventions produces better results than merely patient-focused strategies. Male partners have a great role to play and should be encouraged and allow partaking in the treatment process of their spouses as this will positively influence their recovery.

Quality of life in breast cancer patients after immediate two-stage reconstruction

Quality of life in breast cancer patients after immediate two-stage reconstruction

Sleep quality, mental health, and quality of life in women with breast cancer.

Breast cancer is the most frequent malignancy among women and its prevalence keeps growing. Today, it is important to optimize the quality of life of breast cancer patients because the survival rates increase with early diagnosis and treatments. Our aim was to examine the sleep quality of patients with breast cancer, compare them with the healthy control group, and evaluate the relationship between quality of life and mental health. This cross-sectional study included 125 patients diagnosed with breast cancer and 125 healthy control patients who were admitted to the general surgery department of a university. In 60.8% of breast cancer patients, sleep quality was poor and sleep subscale scores were high. In addition, these patients had a poorer sleep quality, higher score of anxiety and depression, and lower quality of life (in terms of physical subcomponent) compared with the control group. Moreover, although age, marital status, education status, time of cancer diagnosis, menopausal status, surgical method did not have any effect on sleep quality in patient group; low income, accompanying chronic diseases, and increased levels of anxiety and depression worsened sleep quality and increased the risk. In patients with breast cancer, poor sleep quality, score of anxiety and depression were higher, and worsened the quality of life. In addition, low income, presence of concomitant chronic diseases, and anxiety score posed an increased risk for poor sleep quality. Therefore, physical and mental evaluation of breast cancer patients during and after treatment should not be ignored.

Factors Affecting the Quality of Life in Breast Cancer Patients Undergoing Radiotherapy

Factors Affecting the Quality of Life in Breast Cancer Patients Undergoing Radiotherapy

Diagnostic delay in breast cancer diagnosis: the role of health practitioners

Breast cancer is a significant health concern for women in Pakistan, with one in nine women facing a high lifetime risk of being diagnosed with the disease. Accessing timely and appropriate healthcare services for breast cancer patients can be challenging in Pakistan, and understanding the role of different health practitioners is essential to understand the functioning of the informal referral system. Therefore, this study aimed to explore the different aspects of patients' consultations with various health practitioners for diagnosing breast cancer symptoms. Data were collected from 168 breast cancer patients who had consulted local health practitioners before being diagnosed with breast cancer. Descriptive statistics, the Kruskal‒Wallis H test, and post hoc tests were used to analyze the data. The study found that most patients consulted general practitioners (59.52%) and pir (56.55%) for their health-related concerns. Consultants referred most patients to diagnostic centers, while pir and hakim referred no patients. Patients visited pir and general practitioners the most, but the average number of visits to pir and hakim was higher than that to other health practitioners (p < 0.05). Moreover, pir (130 days) and hakim (120 days) had longer treatment periods than other health practitioners, with hakim charging the highest consultation fees [i.e., Pakistani rupees (PKR) 18,000] and patients incurring the highest travel expenses to visit pir (p < 0.05). Our study highlights the challenges faced by breast cancer patients in seeking timely and effective healthcare services. The absence of a formal referral system resulted in prolonged diagnosis times, extensive travel, and financial burdens on the patients. The findings suggest the need to improve general public awareness regarding breast cancer symptoms and establish an active cancer referral system to achieve early diagnosis, timely treatment, and improved quality of life for breast cancer patients, especially those with a lower socioeconomic status.

The synergistic effect of physical activity and nutrition to improve the quality of life in breast cancer patients: a systemic review.

Medical recommendations for balanced control of exercise, physical activity, and nutritional intake after breast cancer diagnosis remain unclear. Therefore, this review aims to summarize effective exercise methods and dietary opinions by reviewing clinical trial results. We systematically reviewed studies that evaluated 1) the relationship between exercise methods and quality of life improvement in patients with breast cancer and 2) the recommendations for physical activity, exercise, nutrition, and potential ways to improve life after breast cancer. To conduct this literature review, we searched the PubMed database for articles published until October 1, 2022, using the terms "physical activity OR exercise," "breast cancer," and "nutrition." After a primary review of the retrieved articles, we included clinical trials in this systematic review. We hypothesized that physical activity improves the quality of life after the onset of breast cancer, suggesting that a balanced approach to aerobic exercise and resistance exercise increases the efficacy of anticancer treatment. From a nutritional point of view, it is recommended that both physical activity and diet management are necessary for patients with breast cancer. Customized exercise and diet can help with weight loss, the reduction of cancer-induced fatigue, the regulation of hormonal changes, the reduction of inflammatory factors, and the improvement of mental health and vitality. Understanding the integrated mechanisms of physical activity and nutritional balance will improve the quality of life of patients with breast cancer. Therefore, it is necessary to continuously advance exercise programs and develop an alimentary balance control program.

Self-care behaviors mediates the relationship between resilience and quality of life in breast cancer patients

Previous studies have shown that resilience could play an important role in enhancing the quality of life in women with breast cancer; however, the mediating role of self-care behaviors have not been studied. This study aims to explore the mediating role of self-care behaviors in the relationship between resilience and quality of life in breast cancer patients. A sample of 195 women with breast cancer (aged from 21 to 60 years; M = 45.32 ± 8.2) from three hospitals in Tehran, Iran completed online questionnaires measuring resilience, self-care and quality of life. The results of structural equation modeling showed that resilience (β = 0.546, p < .01) and self-care behaviors (β = 0.621, p < .01) positively predicted the quality of life in breast cancer patients. The bootstrapping analysis showed that self-care behaviors acted as a partial mediator between resilience and quality of life. The present study brings to light an underlying mechanism of the relationship between resilience and quality of life via the mediating variable of self-care behaviors for patients with breast cancer.

Impact and Association of Anaemia Severity and Its Treatment With Quality of Life of Breast Cancer Patients in Malaysia

Anaemia is a crucial issue among cancer patients and need to be treated properly. High incidence of anaemia in patients with cancer have been associated with several physiological manifestations, leading to decreased quality of life (QOL). The current study aimed to assess the severity of anaemia, evaluate the current treatment guideline of anaemia, and to determine the association between the level of anaemia and its treatment on quality of life of breast cancer patients in Malaysia. This prospective study conducted among breast cancer patients in multicancer centers in Malaysia including three follow ups after receiving their chemotherapy. Clinical data were collected from their medical records and at each follow up, they asked to fill up a functional assessment chronic therapy (FACT-An) questionnaire. Descriptive and inferential statistical analysis were done using SPSS. The mean age of participants was 52 ± 11 years old, and out of 120 participants, 32% received anti-anaemic treatments including 87% of them were prescribed with iron supplementation and only 13% received combination of blood transfusion and iron therapy. Surprisingly, none of the participants received erythropoietin stimulating agents (ESAs). Statistical tests also indicated a significant association between anti-anaemic treatments with haemoglobin level and QOL scores. However, this association was insufficient to significantly improve QOL or palliate anaemia severity among participants. This study showed a great evidence that, the current practice of anaemia treatment (iron therapy) among breast cancer patients in Malaysia’s healthcare setting, was not sufficient to palliate anaemia severity or to improve patients’ QOL. There is still a lot of gaps to improve in the management of anaemia among breast cancer patients to show a significant improvement in haemoglobin level. Therefore, respective organisations and oncologists are required to raise awareness about the optimal treatment of anaemia among breast cancer patients, as a result, improve their general wellbeing

Improving the quality of life in a breast cancer patient and caregiver: Protocol for the application of the integrative medical service model

Patients with chronic diseases require ongoing treatment, and caregivers face financial burdens as well as psychological and physical difficulties. However, the current healthcare system does not provide adequate systems or services to address the difficulties that patients and caregivers face. The purpose of this study was to conduct an observational case study in order to evaluate and improve the application of an integrative healthcare service model developed for distress management and improved quality of life in breast cancer (BC) patients and caregivers. The integrative healthcare service model was intensively applied to a patient-caregiver pair in this observational study. This was followed by gathering feedback from participants and experts, as well as reflecting on the content of the feedback in order to improve the model further. This study will then modify and improve the program with feedback and provide integrative medical services to a BC patient and caregiver. This study used the BC patients' pain management and quality of life enhancement model, aiming to provide basic data for the establishment of a healthcare service system for patients suffering from chronic pain due to diseases such as BC by systematically integrating previously applied interventions into the current healthcare system and soliciting feedback from patients and caregivers.

Radiation pneumonitis in relation to pulmonary function, dosimetric factors, TGFβ1 expression, and quality of life in breast cancer patients receiving post-operative radiotherapy: a prospective 6-month follow-up study.

To investigate development of radiation pneumonitis (RP) in relation to pulmonary function, dosimetric factors, and transforming growth factor beta-1 (TGFβ1) expression in irradiated breast cancer patients. A total of 49 breast cancer patients who received post-operative radiotherapy (RT) were evaluated in terms of pulmonary function tests (PFTs), quality of life (QoL), development of RP, dosimetric factors, cytokine levels, and lung high-resolution computed tomography (HRCT) before and after RT. ROC analysis was performed for performance of dosimetric factors in predicting RP, while frequencies of single nucleotide polymorphisms (SNPs) genotyped for TGFβ1 (rs11466345 and rs1800470) were also evaluated. All cases with RP (10.2%) recovered clinically at the end of third post-RT month. PFT and HRCT parameters were similar before and after RT overall, as well as by RP and the radiation field subgroups. ROC analysis revealed the significant role of the ipsilateral V5 (cutoff value of 45.9%, p = 0.039), V10 (29.4%, p = 0.015), V20 (23%, p = 0.017), and MLD (1200cGy, p = 0.030) in predicting RP. Higher post-RT TGFβ1 levels (p = 0.037) were noted overall and in patients with RP. Patient and control groups were similar in terms of frequencies of SNPs genotyped for TGFβ1 (rs11466345 and rs1800470). EORTC QLQ-C30 and QLQ-BR-23 scores were similar in patients with vs. without RP. Our findings revealed significant role of dosimetric factors including MLD, V20 as well as the low dose-volume metrics in predicting the risk of RP among breast cancer patients who received post-operative RT. Implementation of RT, extent of radiation field or the presence of RP had no significant impact on PFTs.

Intervening Fatigue Program on Fatigue, Self-Esteem, Body Image, Life Quality on Breast Cancer Survivors

The incidence of breast cancer in Indonesia is the highest among other cancers in women, with an estimated prevalence of fatigue between 25-99%. The current study is a 6-week mixed methods action study on fatigue in breast cancer patients. This study aimed to develop a self-management intervention program to reduce empowerment-based fatigue with telenursing strategies and to seek evidence of its effect on fatigue levels, self-esteem, body image, and quality of life. The first stage describes the problem with a qualitative method by exploring the fatigue problem in the survivor's perception. The second stage is the intervention development stage, and the third stage is testing the effectiveness of the intervention, carried out in a quasi-experimental study with a pre-posttest control group design. The first stage produces five themes, and the second stage produces nursing interventions based on transitional nursing theory and telenursing strategies. The third stage of the study proved that the fatigue management intervention (IPK) effectively reduced fatigue levels, increased self-esteem and body image, and improved the quality of life in breast cancer patients. This study recommends oncology nurses consider empowering survivors using this intervention so that the transition period for breast cancer survivors achieves healthy physical and psychological health, achieving optimal health after a cancer diagnosis.

Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art.

Breast cancer is the most common type of cancer in women and is the second leading cause of cancer-related deaths worldwide. Early diagnosis and effective therapeutic interventions are critical determinants that can improve survival and quality of life in breast cancer patients. Nanotheranostics are emerging interventions that offer the dual benefit of in vivo diagnosis and therapeutics through a single nano-sized carrier. Rare earth metal-doped upconversion nanoparticles (UCNPs) with their ability to convert near-infrared light to visible light or UV light in vivo settings have gained special attraction due to their unique luminescence and tumor-targeting properties. In this review, we have discussed applications of UCNPs in drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and tumor targeting in breast cancer. Further, present challenges and future opportunities for UCNPs in breast cancer treatment have also been mentioned.

Effectiveness of Peer Support on Quality of Life and Anxiety in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Background: Breast cancer patients report high levels of psychosocial maladjustment after hospital discharge. Peer support may play an important role in improving anxiety and quality of life in breast cancer patients. This study aimed to assess the effect of peer support on quality of life and anxiety in breast cancer patients. Method: A systematic review and meta-analysis of randomized controlled studies were conducted, using data sourced from PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, SinoMed, China Science and Technology Periodical Database, China National Knowledge Infrastructure, and Wanfang Data for randomized controlled trials (RCTs) from inception to October 15, 2021. The RCTs reporting the effect of peer support intervention on quality of life and anxiety in breast cancer patients were included. The quality of evidence was assessed using the Cochrane risk of bias tool, that is, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for the pooled effect size. Results: A total of 14 studies were included in the systematic review and 11 in the meta-analysis. The pooled results revealed that peer support significantly improved quality of life (SMD = 0.69, 95% CI = 0.28–1.11) and anxiety (SMD = −0.45, 95% CI = −0.88 to −0.02) in breast cancer patients. The quality of evidence was low as all studies showed the risk of bias and inconsistency. Conclusion: Peer support intervention has the potential to effectively improve psychosocial adaptations in breast cancer patients. Future studies with a robust design and larger sample size are needed to investigate the potential factors associated with the beneficial effects of peer support.

Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies.

Bone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast cancer patients. Studies have revealed that bone metastasis is related to interactions between tumor cells and the bone microenvironment, and involves complex molecular biological mechanisms, including colonization, osteolytic destruction, and an immunosuppressive bone microenvironment. Agents inhibiting bone metastasis (such as bisphosphate and denosumab) alleviate bone destruction and improve the quality of life of breast cancer patients with bone metastasis. However, the prognosis of these patients remains poor, and the specific biological mechanism of bone metastasis is incompletely understood. Additional basic and clinical studies are urgently needed, to further explore the mechanism of bone metastasis and develop new therapeutic drugs. This review presents a summary of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, aiming to improve the quality of life and prognosis of breast cancer patients and provide a reference for future research directions.

Hubungan Asupan Makanan, Status Gizi, Lama Menjalani Kemoterapi dan Dukungan Keluarga dengan Kualitas Hidup Pasien Kanker Payudara (Studi di Rumah Sakit Umum Daerah Ulin Kota Banjarmasin)

Background: Breast cancer certainly has a big impact on the sufferer, physically, psychologically, socially, spiritually and other aspects of life. This certainly affects the quality of life of breast cancer patients. Objective: To analyze the relationshipbetween food intake, nutritional status, duration of chemotherapy and family support with the quality of life of breast cancer patients at Ulin Hospital Banjarmasin. Methods: observational analytic using a cross sectional research design. The population was all breast cancer patients at Ulin Hospital Banjarmasin were 92 people based on data in December 2019. The sample was taken using a non-probability sampling technique based on inclusion and exclusion criteria as many as 48 people. Primary data were obtained through interviews and anthropometric measurements. Data analysis used Spearman Rank correlation test with 95% confidence level. Results: Energy intake deficit (70.9%), protein intake deficit (54.1%), fat intake deficit (68.8%), carbohydrate intake deficit (66.7%), nutritional status normal (47.9% ), chemotherapy 3 months (72.9%), good family support (91.7%) and moderate quality of life (75%). Conclusion: There is a relationship between food intake, nutritional status and duration of chemotherapy with the quality of life of breast cancer patients at Ulin Hospital Banjarmasin and there is no relationship between family support and quality of life of breast cancer patients at Ulin Hospital Banjarmasin. Suggestion: Nutritionists are expected to provide nutritional consultation regarding food intake for cancer patients, respondents are expected to increase food intake, and respondent’s families are expected to pay attention to the patient's diet and provide information support.

A study on prevalence of psychiatric morbidity in advanced breast cancer patients at a tertiary cancer hospital in South India

Breast cancer is one of the most common cancers among women globally as well in India. Breast cancer patients may suffer from psychological morbidity. Psychological problems like depression, anxiety, may affect the quality of life of breast cancer patients. To study the psychiatric morbidity in diagnosed advanced breast cancer patients.A cross sectional study was done in the department of Psychiatry, over a period of one and half years from January 2014 to June 2015 at Osmania Medical College Allied Hospitals (M.N.J Institute of Oncology &amp; Regional Cancer Centre and Osmania General Hospital), Hyderabad, Telangana. Breast cancer patient cases and controls were studied by the General health questionnaire -28 (GHQ-28)Mini International Neuropsychiatric Interview- plus (mini- plus).This difference in the proportion of psychiatric disorders was statistically significant.By using MINI plus, 26.7% of breast cancer patients reported psychiatric illness and this percentage was 10% in controls. This difference was not statistically significant at p value of 0.05 (Chi square value 2.78, p value 0.18). The most common psychiatric morbidities were Dysthymia, and MDD seen in 3 (10%) women each.Adjustment disorder unspecified was found in 2 (6.7%) women. There are statistically significant differences between cases and controls and these differences are circumscribed to domains of recall and language and orientation. The mean total score obtained by cases is 28.60 with a standard deviation of 1.354 and that obtained by the control group is 29.70 with a standard deviation of 0.535. The difference between the two groups is highly significant (p&amp;#60;0.001).The study brings out the need for identifying psychiatric problems at proper time, referral of breast cancer patients to Psychiatrists and points out the need for establishing psychiatric units in Cancer Institutes.

Effect of a novel pilot support group on distress and quality of life in breast cancer patients in Nigeria.

To assess the effect of a new breast cancer support group (BCSG) on breast cancer patients' self-reported distress and quality of life. A single arm pre-post trial providing an eight session healthcare provider led BCSG. Primary outcome variables were distress and quality of life assessed using the National Comprehensive Cancer Network Distress Thermometer (DT) and The Functional Assessment of Cancer Therapy - Breast plus Arm Morbidity (FACT-B+4), respectively. Topics in each session addressed a wide range of issues some of which were pre-selected by the patients themselves. Paired sample t-test was used for data analysis on International Business Machine Statistical Package for the Social Sciences 21. The participants (N=18) had a mean age of 51. Most had secondary school level education (54%), were traders (59%) and had stage 3 or 4 disease (67%). A larger proportion (78% or n=14) of the patients lived in rural areas, while 4 (22%) of the patients lived in Ibadan. Out of the 8 sessions, 12 (67%) of the participants attended 1-3 sessions while 6 (33%) attended 4-8 sessions. There were, significant improvements in emotional wellbeing (t=-4.253; p<0.05) and functional wellbeing (t=-2.191; p<0.05) on the FACT-B+4. There was a significant reduction in the DT score (t=2.345; p<0.05) but the number of items on the problem list were not significantly reduced (t=1.191; p>0.05). Majority (75%) of the patients rated the support group activities as satisfactory. These data show that the support group can benefit breast cancer patients in terms of reduced distress levels along with satisfaction and improvement in the functional and emotional wellbeing indices of quality of life.

Prediction of radiation-induced acute skin toxicity in breast cancer patients using data encapsulation screening and dose-gradient-based multi-region radiomics technique: A multicenter study.

Radiation-induced dermatitis is one of the most common side effects for breast cancer patients treated with radiation therapy (RT). Acute complications can have a considerable impact on tumor control and quality of life for breast cancer patients. In this study, we aimed to develop a novel quantitative high-accuracy machine learning tool for prediction of radiation-induced dermatitis (grade ≥ 2) (RD 2+) before RT by using data encapsulation screening and multi-region dose-gradient-based radiomics techniques, based on the pre-treatment planning computed tomography (CT) images, clinical and dosimetric information of breast cancer patients. 214 patients with breast cancer who underwent RT between 2018 and 2021 were retrospectively collected from 3 cancer centers in China. The CT images, as well as the clinical and dosimetric information of patients were retrieved from the medical records. 3 PTV dose related ROIs, including irradiation volume covered by 100%, 105%, and 108% of prescribed dose, combined with 3 skin dose-related ROIs, including irradiation volume covered by 20-Gy, 30-Gy, 40-Gy isodose lines within skin, were contoured for radiomics feature extraction. A total of 4280 radiomics features were extracted from all 6 ROIs. Meanwhile, 29 clinical and dosimetric characteristics were included in the data analysis. A data encapsulation screening algorithm was applied for data cleaning. Multiple-variable logistic regression and 5-fold-cross-validation gradient boosting decision tree (GBDT) were employed for modeling training and validation, which was evaluated by using receiver operating characteristic analysis. The best predictors for symptomatic RD 2+ were the combination of 20 radiomics features, 8 clinical and dosimetric variables, achieving an area under the curve (AUC) of 0.998 [95% CI: 0.996-1.0] and an AUC of 0.911 [95% CI: 0.838-0.983] in the training and validation dataset, respectively, in the 5-fold-cross-validation GBDT model. Meanwhile, the top 12 most important characteristics as well as their corresponding importance measures for RD 2+ prediction in the GBDT machine learning process were identified and calculated. A novel multi-region dose-gradient-based GBDT machine learning framework with a random forest based data encapsulation screening method integrated can achieve a high-accuracy prediction of acute RD 2+ in breast cancer patients.

Relationship between family support, serum lipid knowledge and quality of life in Chinese breast cancer women with adjuvant endocrine therapy.

Serum lipid management is an important health management goal for breast cancer patients with endocrine therapy, and serum lipid knowledge is a substantial factor influencing patients' serum lipid management behavior. The aim of this study was to explore the relationship between family support, serum lipid knowledge and quality of life in breast cancer women with endocrine therapy. Through convenience sampling, 301 women who had been treated in the First Affiliated Hospital of China Medical University and Liaoning Cancer Hospital were selected to fill in the questionnaire of knowledge-attitude-practice (KAP) on serum lipids, family support questionnaire (FSQ), and the functional assessment of cancer therapy-breast cancer (FACT-B). Pearson correlation coefficient was used to analyze the correlation between the three. Multiple linear regression model was used to analyze the influencing factors of quality of life in breast cancer patients with endocrine therapy. The average score of KAP on serum lipids was 42.62 ± 7.333, the average score of family support was 12.55 ± 2.390, and the average score of quality of life was 97.13 ± 21.347, all above the medium level. Family support of breast cancer women with endocrine therapy was positively correlated with serum lipid knowledge and quality of life. Disease stage, family support, and serum lipid knowledge were the influencing factors of quality of life of breast cancer women with endocrine therapy. Good family support is associated with better serum lipid knowledge in breast cancer women with endocrine therapy. Therefore, interventions that aim to improve the level of family support may be one way to improve the knowledge level of serum lipid, prevent cardiovascular and cerebrovascular diseases, and improve the quality of life.