Background of the Study: Physical activity and exercise part of maintaining good health. Its benefits are associated with improved life quality in the physical, psychological, and social sectors. Physical exercise is therefore essential to the recovery of amputees. A person’s quality of life might suffer when a limb is amputated. The quality of life for amputees in order to improve health, though, is little understood. The primary objective of this study was to look into the quality of life and physical activity of male adults and adolescents who had lower limb prosthesis. Methodology: Lower-limb amputees participated in the cross-sectional, descriptive study. investigation.72 Adolescents (5-17 years) and male adults (18-40 years) with unilateral transtibial and transfemoral amputees participated. The World Health Organization Quality of Life scale (WHOQOL) self-administration questionnaire was used to evaluate quality of life. Whereas, to check lower extremity conditions in the participants, The Lower Extremity functionality Scale was used. Results: Low Extremity Functions had significant positive relationship with overall Quality of Life with mean 32.45±9.44 and the strength of the correlation was .24*. Moreover, components of Quality-of-Life Environmental Health and Physical Health shows significant positive relationship with Lower Extremity Functions. Physical Health and Social Relationship showed non-significant correlation with lower Extremity Function. Conclusion: It was concluded that the age group differences were not significant with the Quality of Life, Physical health, Psychological health, social relationship and environmental health. However, the results showed that the quality of life and the lower extremity functional scale had a positive relationship. If the QOL of the individual increases that LEFS also increases. The social relationships and the psychological health do not correlate with the lower extremity functions but, the physical health and the environmental health has a significant impact on it.