Life In Multiple Sclerosis Patients Research Articles

Social support network and quality of life in multiple sclerosis patients.

To analyse the relationship between the social support network (SSN) and health related quality of life (HRQOL) in multiple sclerosis (MS) patients. The sample comprised 150 consecutive MS patients attending our MS clinic. To assess the socio-demographic data, a specifically designed questionnaire was applied. The HRQOL dimensions were measured with the Short-Form Health Survey Questionnaire-SF36 and the SSN with the Medical Outcomes Study Social Support Survey. Spearman's correlation was used to compare the magnitude of the relationship between the SSN and HRQOL. The mean patient age was 41.7 years (± 10.4; range: 18-70 yr); the mean Expanded Disability Status Score was 2.5 (±2.4; range: 0-9). There was a statistically significant correlation between the structure of the SSN and the HRQOL. The composition of the SSN, social group membership and participation in voluntary work have an important role in the HRQOL of patients with MS.

Topical moringin-cream relieves neuropathic pain by suppression of inflammatory pathway and voltage-gated ion channels in murine model of multiple sclerosis.

BackgroundNeuropathic pain represents the major public health burden with a strong impact on quality life in multiple sclerosis patients. Although some advances have been obtained in the last years, the conventional therapies remain poorly effective. Thus, the discovery of innovative approaches to improve the outcomes for multiple sclerosis patients is a goal of primary importance. With this aim, we investigated the efficacy of the 4-(α−L-rhamnopyranosyloxy)benzyl isothiocyanate (moringin), purified from Moringa oleifera seeds and ready-to-use as topical treatment in experimental autoimmune encephalomyelitis, murine model of multiple sclerosis. Female C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG35–55) were topically treated with 2% moringin cream twice daily from the onset of the symptoms until the sacrifice occurred about 21 days after experimental autoimmune encephalomyelitis induction.ResultsOur observations showed the efficacy of 2% moringin cream treatment in reducing clinical and histological disease score, as well as in alleviating neuropathic pain with consequent recovering of the hind limbs and response to mechanical stimuli. In particular, Western blot analysis and immunohistochemical evaluations revealed that 2% moringin cream was able to counteract the inflammatory cascade by reducing the production of pro-inflammatory cytokines (interleukin-17 and interferon-γ) and in parallel by increasing the expression of anti-inflammatory cytokine (interleukin-10). Interestingly, 2% moringin cream treatment was found to modulate the expression of voltage-gated ion channels (results focused on P2X7, Nav 1.7, Nav 1.8 KV4.2, and α2δ-1) as well as metabotropic glutamate receptors (mGluR5 and xCT) involved in neuropathic pain initiation and maintenance.ConclusionsFinally, our evidences suggest 2% moringin cream as a new pharmacological trend in the management of multiple sclerosis-induced neuropathic pain.

Social Support Network and Quality of Life in Multiple Sclerosis Patients

Social Support Network and Quality of Life in Multiple Sclerosis Patients

The Effect of Group Mindfulness-based Stress Reduction and Consciousness Yoga Program on Quality of Life and Fatigue Severity in Patients with MS.

Introduction: The chronic nature of Multiple Sclerosis (MS), have can leave devastating effects on quality of life and fatigue. The present research aimed to study the effect of group Mindfulness-based Stress Reduction (MBSR) and conscious yoga program on the quality of life and fatigue severity among patients with MS. Methods: This study was quasi-experimental with intervention and control groups. The statistical population included all members to MS Society of Tehran Province, 24 of whom diagnosed with MS were selected as the sample based on the inclusion criteria. The subjects were randomly assigned into the test group (12 patients) and the control group (12 patients). MS Quality of Life-54 (MSQOL-54) and Fatigue Severity Scale (FSS) were used for data collection. Subjects in the test group underwent a MBSR and conscious yoga program in 8 two-hour sessions. The data were analyzed using the SPSS ver.13 software. Results: The study findings showed that there was a significant difference between subjects in the experimental and control groups in terms of mean score of some subscales of quality of life including physical health, role limitations due to physical and emotional problems, energy, emotional well-being, health distress, health perception, and satisfaction with sexual function, overall quality of life, and fatigue severity. Conclusion: The results show that the program is effective in reduction of fatigue severity and improving some subscales of quality of life in MS patients. Hence, this supportive method can be used as an effective way for improving quality of life and relieving fatigue in MS patients.

The urinary-specific quality of life of multiple sclerosis patients: Dutch translation and validation of the SF-Qualiveen.

The SF-Qualiveen is a short questionnaire that measures the impact of urinary symptoms on the quality of life of patients with urological dysfunction due to neurological disorders. The aim of this study is to translate, culturally adapt and validate a Dutch version of the SF-Qualiveen for use in Multiple Sclerosis (MS) patients. Cross-cultural adaptation of the original English SF-Qualiveen into Dutch was performed according to standardized guidelines. Adult MS patients with symptomatic urinary disorders who visited the Urology or Rehabilitation outpatient clinic of the Erasmus Medical Center completed the SF-Qualiveen and the Urinary Distress Inventory-6 (UDI-6), that evaluates bother caused by lower urinary tract symptoms and was used as a gold standard, at baseline and 1-2 weeks later. A control group recruited from the Otolaryngology outpatient clinic completed the questionnaires once. Reliability and validity were determined. Fifty MS patients and 50 controls were included. SF-Qualiveen scores in patients were higher than in controls (on a scale of 0-4: 1.73 vs. 0.34; P < 0.001). Internal consistency (Cronbach's alpha >0.8) and reproducibility (Intraclass correlation coefficients >0.8) were good for the total SF-Qualiveen. Content validity was adequate and a significant relationship between SF-Qualiveen and UDI-6 (r = 0.510-0.479, P < 0.001) confirmed good criterion validity. The Dutch SF-Qualiveen showed good measurement properties. We recommend its use to measure urinary-specific quality of life in MS patients in research and clinical practice in the Netherlands.

Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry.

BackgroundThe aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry.MethodsThis was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL.ResultsThe study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160–0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status.ConclusionThe Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to immunomodulatory therapy.

Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology.

Multiple Sclerosis (MS), an idiopathic progressive immune-mediated neurological disorder of the central nervous system (CNS), is characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. It accounts for functional deterioration and lasting disability among young adults. A body of literature demonstrates that physical activity counteracts fatigue and depression and may improve overall quality of life in MS patients. Furthermore, much data indicates that exercise ameliorates chronic neuroinflammation and its related pathologies by tipping cytokine profiles toward an anti-inflammatory signature. Recent data has focused on the direct impact of exercise training on the innate immune system by targeting toll-like receptors (TLRs), signaling pattern recognition receptors that govern the innate immune response, shedding light on the physiological role of TLRs in health and disease. Indeed, TLRs continue to emerge as players in the neuroinflammatory processes underpinning MS. This review will highlight evidence that physical activity and exercise are potential immunomodulatory therapies, targeting innate signaling mechanism(s) to modulate MS symptom development and progression.

PND45 - An Evaluation of Disability Progression and Quality of Life in Multiple Sclerosis Patients in Brazil and Mexico

PND45 - An Evaluation of Disability Progression and Quality of Life in Multiple Sclerosis Patients in Brazil and Mexico

Elevated moral condemnation of third-party violations in multiple sclerosis patients

ABSTRACTRecent research has demonstrated impairments in social cognition associated with multiple sclerosis (MS). The present work asks whether these impairments are associated with atypical moral judgment. Specifically, we assessed whether MS patients are able to integrate information about intentions and outcomes for moral judgment (i.e., appropriateness and punishment judgments) in the case of third-party acts. We found a complex pattern of moral judgments in MS patients: although their moral judgments were comparable to controls’ for specific types of acts (e.g., accidental or intentional harms), they nevertheless judged behaviors to be less appropriate and endorsed more severe punishment across the board, and they were also more likely to report that others’ responses would be congruent with theirs. Further analyses suggested that elevated levels of externally oriented cognition in MS (due to co-occurring alexithymia) explain these effects. Additionally, we found that the distinction between appropriateness and punishment judgments, whereby harmful outcomes influence punishment judgments to a greater extent than appropriateness judgments, was preserved in MS despite the observed disruptions in the affective and motivational components of empathy. The current results inform the two-process model for intent-based moral judgments as well as possible strategies for improving the quality of life in MS patients.

Analyses of measuring tools comparing the quality of life in patients with multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS). It is characterized by degeneration of axons and axal demyelination. Prevalence of multiple sclerosis is 30 per 100 000 people in the world. In this article we aim to analyze and compare the selected measuring tools evaluating the quality of life in patients affected by MS. The studied measuring tools are: the Multiple Sclerosis Quality of Life Inventory (MSQLI), the Health-Related Quality of Life Questionnaire for Multiple Sclerosis (HRQOL-MS), the Multiple Sclerosis Quality of Life (MSQOL), the Functional Assessment of Multiple Sclerosis (FAMS), the Multiple Sclerosis Impact Scale (MSIS), the Multiple Sclerosis Functional Composite (MSFC), the Multiple Sclerosis International Quality of Life (MUSIQOL). Based on the selected studies we aim to compare the quality of life in MS patients. This article is directed towards the patients affected by MS and the specialist public. It aims to facilatate the navigation between the measuring tools evaluating the quality of life with multiple sclerosis.

The Associations Between Fatigue, Disability, and Mobility and the Quality of Life in Patients with Multiple Sclerosis

Background: Multiple sclerosis (MS) is a chronic disease which is caused by demyelination in the central nervous system (CNS) in young adults. This disease affects independence and the ability to participate in family and community activities, thus affecting the quality of life. Objectives: This cross-sectional study was designed to investigate the associations between fatigue, disability, and mobility and the quality of life in patients with MS in the city of Semnan, Iran. Patients and Methods: Sixty-six MS patients completed the Rivermead mobility index (RMI), Guy’s neurological disability scale (GNDS), modified fatigue impact scale (MFIS), and Multiple sclerosis quality of life-54 (MSQL-54) questionnaires, which assessed the physical and mental health of the participants in 12 dimensions. Results: The results of this study showed significant correlations between fatigue (P = 0.002), disability (P 0.05). Conclusions: Our findings indicate that fatigue and disability may affect a patient’s quality of life. Although mobility may affect the overall quality of life in patients with multiple sclerosis, it may also affect the physical health of MS patients. Therefore, the identification of factors affecting the quality of life in MS patients may help in predicting the quality of life, and designing a rehabilitation protocol.

ASSOCIATION BETWEEN DISABILITY AND QUALITY OF LIFE IN MULTIPLE SCLEROSIS PATIENTS IN AHVAZ, IRAN.

Introduction:Multiple Sclerosis (MS) is a neurodegenerative and chronic disease of central nervous system which affected the middle aged people. The disabling nature of this disease can limit the daily activities, restrict the society roles, unemployment and finally lead to decline the quality of life (QoL) in MS patients. So, the main purpose of this study was to determine association between disability and quality of life among MS patients in Ahvaz, Iran.Materials and Methods:One hundred and one MS patients who living in Khouzestan participated in the cross-sectional study. Two questionnaires include the MSQoL-54 and World Health Organization disability assessment schedule 2.0 (WHODAS2.0) were used in order to measure the QoL and disability severity. Descriptive statistics as well as Pearson correlation coefficient and simple linear regression were used to analysis the data.Results:The respondent rate was 100 percent. The disability showed a large and negative association with QoL (p<0.001) but QoL was not significantly associated with EDSS score. Social participation and cognition subscales recognized as QoL predictors according to simple regression results.Conclusion:The cognition and participation, disability subscales, were the most important predicators for QoL. Therefore, increasing employment opportunities, changing society’s attitude and using the psychotherapy programs might improve the MS patient’s QoL.

Managing the Quality of Life in Patients with Multiple Sclerosis: A Literature Review.

The present research attempts to approach a complex concept. The quality of life of multiple sclerosis patients. A literature review was conducted. Based on the finding, it seems that the quality of life for multiple sclerosis patients is influenced by many factors such as self-confidence, which is a direct result of self-ability and mobility, the stage of disease, the social relations as experienced by the patients and the risk of sudden substantial of health deterioration. In addition, telemedicine applications may help either the patients or the health professionals to manage better the provided quality of life to multiple sclerosis patients.

Effect of 8-Week Combined Training (Resistance and Proprioceptive Neuromuscular Facilitation) on Fatigue and Quality of Life in Multiple Sclerosis Patients

Effect of 8-Week Combined Training (Resistance and Proprioceptive Neuromuscular Facilitation) on Fatigue and Quality of Life in Multiple Sclerosis Patients

Relationship between spiritual well-being and quality of life in multiple sclerosis patients

Background and Purpose: Spiritual health is one of the most critical health dimensions with remarkable influence on the life of individuals. Religion and spirituality play a pivotal role incoping with stressful events in life. This study aimed to evaluate the relationship between spiritual health and quality of life in patients with multiple sclerosis (MS). Methods: This cross-sectional study was conducted on 223 patients at Mazandaran Multiple Sclerosis Association (MMSA), Iran in 2015.Participantswere selected via convenience sampling. Data collection tools included Paloutzian's spiritual well-being questionnaire and Multiple Sclerosis Quality of Life (MSQOL-54) scale. Data analysis was performed in SPSS V.18 using ANOVA, T-test, and Pearson's correlation-coefficient. Results: In this study, the majority of MS patients (71.7%, n=160) had average spiritual health, and mean score of quality of life was 50.2±12. Moreover, significant correlationswere observed between the total score of quality of life with dimensions of existential health (P<0.0001, r=0.97), religious health (P<0.0001, r=0.95), and total score ofspiritual health (P<0.0001, r=0.97). Conclusion: According to the results of this study, spiritual health and religious beliefs could improve the quality of life in MS patients. Spiritual health is inherent to the quality of life of patients suffering from chronic diseases, such as MS. In Iran, ideational and religious doctrines remarkably influence people's lives. Therefore, provision of culture-based and meaning-orientated care and adopting a wholesome attitude towards different aspects of MS could help medical professionals to offer the required services for these patients.

Neurophysiological Profile, Walking Performance Tests and Self-Reported Questionnaires in Spastic Patients with MS: A Pilot Study

Nabiximols is currently being used as an add-on therapeutic option to treat severe forms of multiple sclerosis (MS) spasticity, especially in the progressive phase of the disease. The aim of this exploratory study is to evaluate the response to Nabiximols therapy and modifications in neurophysiological profile, improvement in walking performance tests and self-reported questionnaires, as possible further outcome measures of spasticity. 8 MS patients were recruited to start Nabiximols therapy, all responders in terms of significant reduction of numerical rating scale (NRS). The patients underwent measurements of lower limbs H-reflex and F wave before treatment (baseline) and after 4 and 8 weeks (T1 and T2) of treatment with Nabiximols titrated to optimal dosage, along with timed 25-foot walk test (T25FW), six-minute walk test (6MWT) and questionnaires evaluating subjectively reported spasticity, fatigue and walking abilities (MSSS-88, MFIS, MSWS-12). A reduction of the latencies of the H-reflex and F wave was found between baseline and at T1, which was more strongly confirmed at T2 (P=0.04 relative to H-reflex; P=0.05 and P=0.007 relative to minimal and medium F wave latencies). A significant reduction in time to perform T25FW test was observed between baseline and after treatment (P<0.05), together with a trend towards an improvement in the 6MWT. After the treatment period significant variations in part of the self-reported questionnaires administered were found, as a reduction of the MSSS-88 and MFIS total scores (P<0.05). Nabiximols treatment might have an impact in different objective measurements, including neurophysiological and walking performance tests and self-reported questionnaires. Latencies reduction in H-reflex and F-wave may reflect modifications in the generation of spasticity mechanisms. Moreover, spasticity control is related with an improvement in quality of life of MS patients as it may have a positive impact on walking abilities and reduction of global perception of fatigue.

Association of between mental health and spiritual health among students in Shiraz University

AbstractBackground and aim: Spiritual health is one of the most important social – cultural factors that may predict mental health. The main purpose of this study was to assess association between mental health and spiritual health among students in Shiraz University.Materials and Method: A descriptive-correlational design was used for the study.The study was conducted in 2012. A total number of 474 students (237 female and 237 male) were recruited in this study using a cluster sampling method. Data were collected using Goldberg’s Mental Health Questionnaire and Pulutzyn and Ellison spiritual health questionnaires. Data were analyzed by SPSS16 software and two categories of descriptive and inferential statistical methods correlation and regression and t- tests.Findings: The results of the study indicated that there is a significant relationship between mental health and spiritual health scores in both sexes (P<001). Variable of spiritual health, can predict 70 percent mental health in female and male. T-test results showed that there is a difference between the means of spiritual health in boys and girls (p< 0/05).Discussion & Conclusion: Changings in the educational system and paying attention to mental health and spiritual health to meet the needs of students may be necessary. There is a need for further applied research for testing interventions to promote mental health and spiritual health students.Key Words: Mental health, spiritual health, Students REFERENCES Alahbakhshian M Jafarpour - Alavi M, Parvizi S Haghani H (2010). A survey on relationship between spiritual wellbeing and quality of life in multiple sclerosis patients. Zahedan Journal of Research in Medical Science. 12(29-33). Bahrami E Hosseini Vajari K (2003)[ The Relationship Between Religious Coping and Spiritual Happiness with Mental Health in Women]. Master’s thesis,Theran university. (Persian). 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Neurobehavioral burden of multiple sclerosis with nanotheranostics.

Multiple sclerosis (MS) is a chronic demyelinating neurological disorder affecting people worldwide; women are affected more than men. MS results in serious neurological deficits along with behavioral compromise, the mechanisms of which still remain unclear. Behavioral disturbances such as depression, anxiety, cognitive impairment, psychosis, euphoria, sleep disturbances, and fatigue affect the quality of life in MS patients. Among these, depression and psychosis are more common than any other neurological disorders. In addition, depression is associated with other comorbidities. Although anxiety is often misdiagnosed in MS patients, it can induce suicidal ideation if it coexists with depression. An interrelation between sleep abnormalities and fatigue is also reported among MS patients. In addition, therapeutics for MS is always a challenge because of the presence of the blood–brain barrier, adding to the lack of detailed understanding of the disease pathology. In this review, we tried to summarize various behavioral pathologies and their association with MS, followed by its conventional treatment and nanotheranostics.

The relationship between self-efficacy and health-related quality of life in Multiple Sclerosis patients

Background and Objectives Multiple sclerosis (MS) has a broad spectrum of physical, social, psychological effects and significant impact on quality of life (QoL). Several studies has showed the importance of self-efficacy as a predictor of QoL in patients with MS.This study aims at evaluating the robustness of the relationship between self-efficacy and QoL. Specifically it aims to test whether such relation will vanish under the following conditions: using a general measure of self-efficacy and controlling for level of impairment defined as a broad construct dealing with physical, social and working changes due to the illness condition. Methods One hundred-fifty five participants responded to a questionnaire, including QoL and general self-efficacy measures, socio demographic and clinical variables. Two nested structural equation models that differ for the presence or absence of the path connecting self-efficacy and QoL was estimated.Results and Conclusions The hypothesis of the vanishing of the relationship between self-efficacy and QoL had to be rejected. These results support the genuineness of this relation and emphasize the importance of interventions promoting self-efficacy to improve QoL in chronic diseases such as MS. From a methodological perspective this study is an example of the usefulness of formative indicators in QoL studies.

Importance of program physical activity in quality of life in multiple sclerosis patients, six months after the your intervention

Importance of program physical activity in quality of life in multiple sclerosis patients, six months after the your intervention