Life Of Elderly Population Research Articles

Targeted non-invasive Metformin-Curcumin co-loaded nanohyaluosomes halt osteoarthritis progression and improve articular cartilage structure: A preclinical study

Osteoarthritis (OA) is a degenerative disease that affects the quality of life in elderly and young populations. Current therapies using corticosteroids and non-steroidal anti-inflammatory drugs via parenteral or oral routes show limited ability to retard progression of the disease and achieve long term effectiveness and safety. Herein, the potential of MT-Cur combinatorial nano-formulations in OA management was explored for the first time. MT-Cur loaded nanohyaluosomes (MT-Cur-HL1) were designed for topical administration of the combined therapy in OA. The optimized MT-Cur-HL1 showed particle size 247.7 ± 3.7 nm, zeta potential −37.3 ± 0.4 mV; and entrapment efficiency (%EE) 70.22 %±0.303 and 76.7 %±0.077 for MT and Cur, respectively. MT-Cur-HL1 exhibited sustained drug release over 24 h and were stable over 3 months at 4 °C in terms of P.S., ZP and %EE. A detailed preclinical study, using MIA-induced osteoarthritis rat model, revealed the most significant anti-arthritic effect and halted OA progression of MT-Cur-HL1. This was proved to be mainly through the potentiation of p-AMPK signaling that ultimately led to suppression of its downstream TLR4/ NF-κB signaling pathway with subsequent reduction in MMP13 and ADAMTS5 induced chondrocytes degeneration. This study proved that this trajectory effectively promotes a significant improvement in the articular cartilage structure and reinforcement of joint mobility with an efficient antinociceptive effect. In conclusion, the novel MT-Cur coloaded nanohyaluosomes offer a promising non-invasive approach for the local management of OA.

Oral health inequalities among geriatric population: A systematic review

ABSTRACT As per the World Health Organization, governments should aim to accomplish two significant global milestones by 2030: reducing health disparities and granting universal accessibility to healthcare. The aim of this article was to systematically review the inequalities and understand the multifactorial causation of oral health inequalities among the older adults. Methods: Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) standards were used to carry out the review and is documented in PROSPERO CRD42026695761. Two authors did the search and screening in accordance with the protocol. Electronic databases such as PubMed, Google Scholar, and EBSCOhost articles of the last 10 years were searched for research presenting data on oral health status and oral health related quality of life in the elderly population. Quality assessment was performed using the Newcastle Ottawa Scale (NOS) for retrospective and prospective research. Results: Only 24 studies fulfilled the eligibility criteria and were incorporated into the qualitative synthesis. Multiple aspects of oral health and the related variables influencing disparities in oral health in the elderly population living in institutions have a positive link. Conclusion: The findings support the notion that this demographic consists of weak, dependent individuals who have poor oral health. The vulnerable elderly institutionalized population was recognized and validated, thus helps in providing measures that will eventually focus the risk factors to improve their OHRQoL.

Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention

ObjectivesInnovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity. Methods127 men and women aged between 50 and 80 years with overweight/obesity participated in the study—between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN—and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months. ResultsBoth strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (−4.3 kg; p < 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality. ConclusionThese results support the benefit of precision nutrition approaches for promoting healthy aging and emotional well-being, enhancing the quality of life in aging populations, during the COVID-19 pandemic.

Aging and Autophagy: Roles in Musculoskeletal System Injury.

Aging is a multifactorial process that ultimately leads to a decline in physiological function and a consequent reduction in the health span, and quality of life in elderly population. In musculoskeletal diseases, aging is often associated with a gradual loss of skeletal muscle mass and strength, resulting in reduced functional capacity and an increased risk of chronic metabolic diseases, leading to impaired function and increased mortality. Autophagy is a highly conserved physiological process by which cells, under the regulation of autophagy-related genes, degrade their own organelles and large molecules by lysosomal degradation. This process is unique to eukaryotic cells and is a strict regulator of homeostasis, the maintenance of energy and substance balance. Autophagy plays an important role in a wide range of physiological and pathological processes such as cell homeostasis, aging, immunity, tumorigenesis and neurodegenerative diseases. On the one hand, under mild stress conditions, autophagy mediates the restoration of homeostasis and proliferation, reduction of the rate of aging and delay of the aging process. On the other hand, under more intense stress conditions, an inadequate suppression of autophagy can lead to cellular aging. Conversely, autophagy activity decreases during aging. Due to the interrelationship between aging and autophagy, limited literature exists on this topic. Therefore, the objective of this review is to summarize the current concepts on aging and autophagy in the musculoskeletal system. The aim is to better understand the mechanisms of age-related changes in bone, joint and muscle, as well as the interaction relationship between autophagy and aging. Its goal is to provide a comprehensive perspective for the improvement of diseases of the musculoskeletal system.

The Role of Recreational Activities in Enhancing Quality of Life among the Elderly

Purpose: The general aim of this study was to explore the role of recreational activities in enhancing the quality of life among the elderly. Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library. Findings: The findings reveal that there exists a contextual and methodological gap relating to the role of recreational activities in enhancing the quality of life among the elderly. Preliminary empirical review revealed that regular participation in recreational activities was crucial for improving various aspects of well-being for older adults. Physical activities improved physical health and mobility, social activities reduced feelings of loneliness and isolation, and cognitive and creative activities stimulated the brain and enhanced psychological well-being. The study identified gaps in understanding and access to recreational activities for the elderly, highlighting the need for more research and inclusive programming. Overall, the findings underscored the importance of tailored recreational programs in promoting a better quality of life for elderly individuals. Unique Contribution to Theory, Practice and Policy: Theory of Planned Behavior, Activity Theory and Socioemotional Selectivity Theory may be used to anchor future studies on recreational activities on the quality of life among the elderly. The study made significant contributions to theory, practice, and policy in gerontology and public health. It provided empirical support for existing theories, such as the Theory of Planned Behavior and Socioemotional Selectivity Theory, while offering actionable recommendations for healthcare providers, community organizations, and policymakers. By validating theoretical frameworks, offering practical insights, and informing policy initiatives, the study advanced understanding of how recreational interventions can promote well-being and quality of life in aging populations. Through continued research, practice, and policy efforts, stakeholders could work collaboratively to create supportive environments

A Protocol for Effectiveness of Ayush Rasayana A &amp; B on Quality of Life of elderly population: A cluster-randomised study (Preprint)

A Protocol for Effectiveness of Ayush Rasayana A &amp; B on Quality of Life of elderly population: A cluster-randomised study (Preprint)

ADAM: a robotic companion for enhanced quality of life in aging populations.

One of the major problems of today's society is the rapid aging of its population. Life expectancy is increasing, but the quality of life is not. Faced with the growing number of people who require cognitive or physical assistance, new technological tools are emerging to help them. In this article, we present the ADAM robot, a new robot designed for domestic physical assistance. It mainly consists of a mobile base, two arms with grippers and vision systems. All this allows the performance of physical tasks that require navigation and manipulation of the environment. Among ADAM's features are its modularity, its adaptability to indoor environments and its versatility to function as an experimental platform and for service applications. In addition, it is designed to work respecting the user's personal space and is collaborative, so it can learn from experiences taught by them. We present the design of the robot as well as examples of use in domestic environments both alone and in collaboration with other domestic platforms, demonstrating its potential.

Integrating Physical Media Education into Elderly Care Programs: A Case Study of Enhancing Well-being and Promoting High-Quality Life

This study examined the impact of media education for elderly care programs in China on the well-being and quality of life of elderly population. This study investigated how media education turned older population in techno-savvy and improved the well-being and quality of life of the elderly population. The objectives of the study were to bring forth the role played by media awareness of social media, to examine the challenges associated with it, and to recommend efficient strategies to promote the engagement of older adults in media education of social media and usage of media gadgets that helps them to be techno-savvy and improve their well-being. The qualitative methodology was used and data was collected through semi-structured interviews from a sample of 8 informants comprising caretakers working at Chinese old age homes and senior community centers. Following a thematic analysis, it was revealed that media education in elderly care programs potentially benefits older by improving their self- efficacy, social connectedness, and overall well-being. It was also found that media awareness of older adults significantly assisted them to be techno-savvy and enhanced high-quality life in them. Limited equipment, unwillingness, and inefficient technological knowledge were some significant challenges that hindered the proper integration of media education in elderly care programs. It was recommended that training sessions, workshops, and proper allocation of resources should be enhanced to get the potential benefits of media education for older adults. These outcomes have significant contributions for policy-makers and practitioners of old-age institutions. In addition, this study offers novel contributions to relevant literature within the context of China.

Nutritional Status and Quality of Life among Geriatric Patients in a Tertiary Care Hospital

Background: Wellbeing of the elderly population in terms of their health and nutritional status are often ignored and unidentified in the community. This study aimed at assessing the nutritional status of the geriatric patients and their quality of life (QOL) attending OPD of Mugda Medical College Hospital. Method: This survey was conducted in the OPD of Mugda Medical College Hospital from June to December 2022 through a cross-sectional analytical method. The study tools were the Mini-Nutritional Assessment tool and WHOQOL-BREF questionnaires which were used to observe the level of nutrition and quality of life among geriatric population respectively. Result: Of all the respondents, about half (46%) were at risk for malnutrition and about 28% were malnourished while 26% respondents’ level of nutrition was normal. About 62% respondents had poor QOL, whereas, 31% had fair QOL and only 7% had good QOL. Also, nutritional status and quality of life of the elderly had significant relationship. Conclusion: The impact of poor nutrition on the quality of life and physical ability of geriatric population is remarkably worthy of attention. The ageing process is challenging and raises public health concerns. Reduction of the observed prevalence of malnutrition and thereby upgrading the quality of life of elderly population should be more focused on and proper attention to this issue is crucial in the community as well as national level. J MEDICINE 2024; 25: 29-34

노인의 사회자본이 삶의 만족도에 미치는 영향

The purpose of this study is to identify the association between social capital and life satisfaction among elders, examining the mediation role of empowerment.&#x0D; Among 414 original responses, 408 participants were included in the final analysis using IBM SPSS Statistics 22.0 and AMOS 22.0.&#x0D; According to the results, social capital showed direct effects on the level of life satisfaction. Secondly, it was confirmed that higher awareness of social capital was associated with higher levels of empowerment. Thirdly, it was found that higher levels of empowerment were associated with greater life satisfaction. Lastly, it was found that social capital had a positive effect on life satisfaction through empowerment.&#x0D; The results of the current study highlights practical implications for future support on elderly population. Practical and political efforts are suggested to assist elders form social capital, to ultimately increase empowerment for greater quality of life.&#x0D; The results support and expand the current literature to clarify the association between social capital, satisfaction in life and impact of elderly population. Detailed implications and future research directions are discussed.

Self-reported dual sensory impairment and related factors: a European population-based cross-sectional survey

BackgroundData on population-based self-reported dual vision and hearing impairment are sparse in Europe. We aimed to investigate self-reported dual sensory impairment (DSI) in European population.MethodsA standardised questionnaire was used to...

Mechanical performance of porous biomimetic intervertebral body fusion devices: an in vitro biomechanical study

BackgroundDegenerative disc disease is one of the most common ailments severely affecting the quality of life in elderly population. Cervical intervertebral body fusion devices are utilized to provide stability after surgical intervention for cervical pathology. In this study, we design a biomimetic porous spinal cage, and perform mechanical simulations to study its performances following American Society for Testing and Materials International (ASTM) standards before manufacturing to improve design process and decrease cost and consumption of material.MethodsThe biomimetic porous Ti-6Al-4 V interbody fusion devices were manufactured by selective laser melting (laser powder bed fusion: LPBF in ISO/ASTM 52900 standard) and subsequently post-processed by using hot isostatic pressing (HIP). Chemical composition, microstructure and the surface morphology were studied. Finite element analysis and in vitro biomechanical test were performed.FindingsThe post heat treatment can optimize its mechanical properties, as the stiffness of the cage decreases to reduce the stress shielding effect between two instrumented bodies. After the HIP treatment, the ductility and the fatigue performance are substantially improved. The use of HIP post-processing can be a necessity to improve the physical properties of customized additive manufacturing processed implants.InterpretationIn conclusion, we have successfully designed a biomimetic porous intervertebral device. HIP post-treatment can improve the bulk material properties, optimize the device with reduced stiffness, decreased stress shielding effect, while still provide appropriate space for bone growth.Clinical significanceThe biomechanical performance of 3-D printed biomimetic porous intervertebral device can be optimized. The ductility and the fatigue performance were substantially improved, the simultaneously decreased stiffness reduces the stress shielding effect between two instrumented bodies; while the biomimetic porous structures provide appropriate space for bone growth, which is important in the patients with osteoporosis.

Differential changes in self-reported quality of life in elderly populations after diagnosis of a genitourinary malignancy.

The time of cancer diagnosis is a major event during which quality of life (QOL) can be affected and represents a crucial time to identify patients at high risk of decline. We sought to compare the differential effects of the diagnosis of 3 major urologic malignancies on QOL. The Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database was queried for patients who completed a QOL questionnaire (SF-36 or VR-12) before and after a diagnosis of bladder, kidney, or prostate cancer. Primary outcome measures were the mental component summary (MCS), and physical component summary (PCS) scores. Mixed effects linear regression was performed with cancer diagnosis as the primary variable of interest, with race and cardiovascular comorbidity status included as potentially confounding independent variables. There were 3,258 patients with urologic cancers. Both MCS and PCS scores dropped after diagnosis in all disease states. Bladder and kidney cancer patients demonstrated the greatest decline in MCS score (-1.762 points, 95% CI-2.571 to -0.952, P < 0.001) and PCS score (-3.769 points, 95% CI-5.042 to -2.496, P < 0.001), respectively, after adjustment for potential confounders. By contrast, prostate cancer patients demonstrated the smallest decline in both domains. Race and cardiovascular comorbidity status were independently associated with QOL, with an association 2 to 3 times greater than that of cancer diagnosis. Diagnosis of a urologic cancer was associated with a decline in patient-reported QOL, particularly in those with bladder or kidney cancer. Changes in physical health were more prominent than in mental health. Race and cardiovascular comorbidity status influenced QOL domains to a greater extent than specific urologic cancer diagnosis.

Lower Extremity Muscle Activity When Walking On A Non-motorized Treadmill

Effective interventions for increasing walking speed are important for improving health and quality of life in aging populations. Non-motorized treadmills (NMT) may enhance the ability to develop or improve motor control in gait by requiring the participant to produce and maintain speed as compared to use of a motorized treadmill (MT) which requires one to simply match speed. PURPOSE: The purpose of this project was to compare muscle activation patterns of lower extremity muscles between MT, NMT and overground (OG) walking. METHODS: Twenty healthy adults (24.4 ± 7.2 yrs, 1.75 ± 0.09 m, 75.4 ± 13.1 kg) completed one trial of walking at each of three speeds (2.5, 3.5, 4.5 mph) and three modes (OG, MT, NMT). Surface EMG of the Biceps Femoris (BF), Tibialis Anterior (TA), Gastrocnemius (GA), and Vastus Medialis (VM) was collected at 1000 Hz using electrodes placed longitudinally at the midpoint of the muscle belly. After removing DC bias, EMG RMS was computed using a moving window of 250 ms. Peak EMG RMS within a stride was averaged across 8 consecutive gait cycles identified using vertical acceleration measured with a triaxial accelerometer. Separate 3x3 repeated measures ANOVA’s were used to compare muscle activity across walking speed and mode for each muscle. RESULTS: For all muscles, there was no significant interaction between walking mode and speed. Muscle activity significantly increased with walking speed (p < 0.05). TA, VM, and GA activity was not different between walking modes (p > 0.05). At 2.5 mph, GA muscle activity, was significantly (p < 0.001) higher for NMT (0.44 ± 0.16 mV) than MT (0.33 ± 0.13 mV) and OG (0.31 ± 0.14 mV) but MT and OG were not different. At 3.5 mph, GA muscle activity, was significantly (p < 0.001) higher for NMT (0.49 ± 0.19 mV) than MT (0.36 ± 0.15 mV) and OG (0.36 ± 0.17 mV) but MT and OG were not different. At 4.5 mph, GA muscle activity, was significantly (p < 0.001) higher for NMT (0.58 ± 0.28 mV) than MT (0.47 ± 0.19 mV) and OG (0.44 ± 0.19 mV) but MT and OG were not different. CONCLUSIONS: These data suggest that use of NMT accentuates plantar flexor activity when walking. Given that reduced plantar flexor activity contributes to reduced gait speed in older adults, use of NMT has potential for clinical use in treatment of gait deficiencies in aging adults.

Loneliness, Cognitive Functioning and Quality of Life in Older Adults

Loneliness and cognitive impairment is a serious concern among the older adults and is a significant factor influencing elderly quality of life. The current study aimed to examine the associations among loneliness, cognitive functioning and quality of life in Pakistani older adults. The study is cross sectional study with a non-probability purposive sample comprising of 149 Pakistani older adults of ages 60 years and above. Internationally standardized scales have been used to collect online data. Multiple linear regression results indicate that loneliness (β= -0.23, p&lt;.001) and cognitive functioning (β= 0.32, p&lt;.001) are significant predictors of the quality of life in older adults. Furthermore, older men scored higher on loneliness and cognitive impairment than older women and the overall quality of life was better in women participants as compared to men. There is need for social and health interventions to promote the quality of life of elderly population, especially in times of pandemic, with specific focus on reducing loneliness and cognitive impairment, Keywords: Loneliness, cognitive functioning, quality of life, older adults, gender difference

HAK EKONOMI DAN SOSIAL PADA LANSIA DI INDONESIA

The increasing number of years of population growth in Indonesia is also accompanied by an increase in the number of elderly people or commonly referred to as elderly. Some of the factors that make the elderly population limited are mobility which makes it difficult for the elderly to be productive, unable to meet their needs and need help from others. The elderly cannot be separated from 3 things, namely poverty, neglect and protection. These three things are the main problems that every elderly will find the role of the community such as the existence of social assistance institutions and the formation of legislation and various social welfare programs that have begun to be seen being implemented in the community. However, the implementation is not always right on target, one of which is often found in the problem of social assistance, there are still many in some areas in Indonesia, especially remote areas where the elderly population lives alone without any family paying attention so that their social economic needs are limited. Therefore, the fulfillment of social economic rights for the elderly is very necessary considering that the elderly are a vulnerable group whose human rights must be protected.

The Impact of Nutrition on Cognitive Performance in a Frail Elderly Population Living in Northern Italy

Objectives: There is increasing evidence for a protective role of nutritional factors on cognitive decline. Many studies have reported a preventive effect of specific dietary patterns, in particular of the Mediterranean diet (MD), on the risk of cognitive decline, but only limited evidence is available about its effects on neuropsychological performance. The aim of this work is to evaluate the relationship between nutrition and cognitive performance in a frail elderly population living in Northern Italy. Methods: In this study we have investigated the impact of the Mediterranean dietary pattern on cognitive performance in a frail elderly population (n = 140). Structural equation modeling was applied to highlight the interrelationship between three cognitive domains: i) Verbal Fluency; ii) Attention/executive function; iii) Memory, and two MD factors: i) Nutrition; ii) Anthropometric/physical activity. In addition, the Multiple Correspondence Analysis was performed to detect the food and nutrients with the highest association with MD and nutritional status. Results: In our sample, 54% of subjects have a medium-high adherence to MD and only 4% have a risk of malnutrition. The variable Nutrition was significantly associated (p < 0.001) with the cognitive domain Attention/executive function, with an increase in Nutrition directly associated with a better performance in Attention/executive function. Conclusions: This study provides preliminary evidence of an association between good nutritional status, related to a high adherence to the MD, and cognitive performance in a non-clinical elderly population living in Northern Italy.

Health Behavior of People Over 60 and Their Dependence on Socio-Economic Factors

Health behaviour are human actions which directly or indirectly influence our health. The elderly are a group of people who should especially take care of their health. Taking up this issue is justified by the rising life expectancy of the society and the related increasing costs of social care. Considering the current situation, it seems required to provide the older generation with education in the field of health promotion and health behaviour. The study involved 689 individuals over 60 years of age from Poland. A diagnostic survey was applied in the research. A survey technique was used including the Health Behaviour Inventory (HBI) and own questionnaire. Elderly people have more health behaviour associated with prophylactic measures and a positive mental attitude, but least related to eating habits. Women, people over 75 years of age and better educated people with good financial standing adopt significantly more health behaviour. The subject concerning health behaviour of elderly people needs to be further explored and completed. This study may contribute to better quality of life in elderly population.

Impact of yoga therapy in improving perceived stress, depression, and quality of life in elderly population: A randomized controlled trial

Introduction: Geriatric population is vulnerable to physical and emotional discommodes that requires expert care from a holistic perspective. Depression, stress, anxiety, etc., are the common problems faced by the elderly. Holistic interventions such as yoga are reckoned to be a pillar in alleviating these issues; however, most of the studies in this arena are conducted on elderly who resides in shelter homes. Materials and Methods: Ninety-six participants were randomized to a yoga or waitlisted control group (n = 48 each). Yoga group received a set of yogic practices for 12 weeks. Assessments were done using Perceived Stress Scale (PSS), Geriatric Depression Scale (GDS), and older people quality of life (OPQOL). Results: Yoga group has shown statistically significant reduction in PSS (P < 0.001), GDS (P = 0.001), and improvement in the selected components of OPQOL such as social relationship (P = 0.014), neighborhood (P = 0.001), psychological well-being (P = 0.001), financial circumstances (P = 0.001), and OPQOL – total (P = 0.001). Discussion: The results indicate that yoga can successfully be implemented in the elderly population on an outpatient basis and can produce clinically beneficial effects. Nurses, physicians, and other therapists should consider integrating yoga in the elderly. Conclusion: The results of this study are encouraging to recommend yoga as a stand-alone mind-body rehabilitation program for older adults.

Association of Depression with Cognitive Functions and Quality of Life in Elderly Population

Objective: Population of the world is rapidly aging and facing different physical, social and mental issues that obviously affect their quality of life. This study aimed to determine the association of depression with cognitive functions and quality of life in elderly population. Methodology: It was cross a sectional study in which data was collected from 100 participants of both genders from elderly population. Their age range was 60 to 80 years. Elderly residents of District Rajanpur were surveyed by using Urdu version of standardized tools like Beck Depression Inventory (BDI) scale, World Health Organization-Quality of Life (WHOQOL-BREF) scale and Mini Mental State Examination (MMSE). Pearson correlation test was applied to measure association of depression with cognition and quality of life. The data was statistically analysed by using SPSS version 25. Results: The results revealed a strong negative correlation between depression and quality of life, r (-.672), P= (.000), and weak positive correlation between depression and cognitive functions, r (.316), P= (.001). Conclusion: The findings suggested that there exists a strong negative correlation between depression and quality of life and weak positive correlation between depression and cognitive functions. Keywords: Cognition, Aged, Depression, Quality of Life.