Life In Breast Cancer Patients Research Articles

Psychiatric comorbidities and quality of life in breast cancer patients undergoing radiation treatment: Risk and protective factors.

The primary goal was to evaluate the prevalence of psychiatric comorbidities and changes in psychological distress levels among breast cancer patients receiving radiotherapy (RT). The secondary goal was to determine risk and protective factors for psychiatric comorbidities of these patients. From June 2018 to November 2019, patients were recruited from the hospital, Department of Psychiatry. Patients completed baseline surveys after seeing their radiation oncologist and prior to the first treatment, which was scheduled to take place within 7 days (visit 1, baseline); visit 2 occurred within 7 days after RT completion, and visit 3 occurred at 6 weeks after RT completion. A total of 99 patients participated in the study at visit 1; 56 patients completed the study through visit 3. Although changes in psychiatric comorbidities and overall quality of life were observed in patients with breast cancer prior to, during, and after RT, the differences were not significant among visits. Patients diagnosed with psychiatric comorbidities after RT had exhibited risk factors at previous visits, including preexisting psychiatric comorbidities, functional deterioration, and more severe symptoms related to breast cancer. Based on the results, the psychological characteristics of optimism and resilience can be considered as protective factors for psychiatric comorbidities. The results suggest that early detection and follow-up of psychological distress and poor quality of life at the onset of RT are of paramount importance, and that psychosocial interventions to enhance protective factors (optimism and resilience) may be helpful.

Fatigue, anxiety, and quality of life in breast cancer patients compared to non-cancer controls: a nationwide longitudinal analysis.

Fatigue and anxiety are common and significant symptoms reported by cancer patients. Few studies have examined the trajectory of multidimensional fatigue and anxiety, the relationships between them and with quality of life. Breast cancer patients (n = 580) from community oncology clinics and age-matched controls (n = 364) completed fatigue and anxiety questionnaires prior to chemotherapy (A1), at chemotherapy completion (A2), and six months post-chemotherapy (A3). Linear mixed models (LMM) compared trajectories of fatigue /anxiety over time in patients and controls and estimated their relationship with quality of life. Models adjusted for age, education, race, BMI, marital status, menopausal status, and sleep symptoms. Patients reported greater fatigue and anxiety compared to controls at all time points (p's < 0.001, 35% clinically meaningful anxiety at baseline). From A1 to A2 patients experienced a significant increase in fatigue (β = 8.3 95%CI 6.6,10.0) which returned to A1 values at A3 but remained greater than controls' (p < 0.001). General, mental, and physical fatigue subscales increased from A1 to A2 remaining significantly higher than A1 at A3 (p < 0.001). Anxiety improved over time (A1 to A3 β =  - 4.3 95%CI -2.6,-3.3) but remained higher than controls at A3 (p < 0.001). Among patients, fatigue and anxiety significantly predicted one another and quality of life. Menopausal status, higher BMI, mastectomy, and sleep problems also significantly predicted change in fatigue. Breast cancer patients experience significant fatigue and anxiety up to six months post-chemotherapy that is associated with worse quality of life. Future interventions should simultaneously address anxiety and fatigue, focusing on mental and physical fatigue subdomains.

Assessment of integrative non-pharmacological interventions and quality of life in breast cancer patients using real-world data.

Treatments with non-pharmacological interventions (NPIs), comprising art and exercise therapies, nursing interventions, and educational components, are considered to improve quality of life of cancer patients. The aim of this study was to assess the longitudinal changes in self-reported quality of life of breast cancer patients receiving an integrative medicine program consisting of hospital-based NPIs and standard oncological treatments. This real-world data study was conducted using data from the Network Oncology clinical registry of the Gemeinschaftskrankenhaus Havelhöhe. Primary breast cancer patients of all tumor stages, who answered the European Organization of Research and Treatment Health-Related Quality of Life Core Questionnaire scale (EORTC QLQ-C30) at first diagnosis and 12months later, were included. Association factors between received NPIs and longitudinal EORTC QLQ-C30-changes were analyzed with additive non-parametric regression tests, considering treatment regimens and demographic variables, using the software R. A total of 231 primary breast cancer patients were enrolled and separate regression analyses were carried out. Significant associations between the received NPIs elaborate consultations and life review, nursing compresses, music and eurythmy therapy and improvements of 8-13 points for global health, all five functional EORTC-scales, and symptoms fatigue, dyspnea, insomnia, and financial difficulties were observed. Our findings support the beneficial impact of NPIs for breast cancer patients. Further research could be directed towards synergistic effects of multimodal applied NPIs. Trial registration number DRKS00013335 on 27/11/2017 retrospectively registered.

Understanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets.

Triple-negative breast cancer (TNBC) is a highly malignant subtype of breast cancer. High invasiveness and heterogeneity, as well as a lack of drug targets, are the main factors leading to poor prognosis. Brain metastasis (BM) is a serious event threatening the life of breast cancer patients, especially those with TNBC. Compared with that for hormone receptor-positive and HER2-positive breast cancers, TNBC-derived BM (TNBCBM) occurs earlier and more frequently, and has a worse prognosis. There is no standard treatment for BM to date, and one is urgently required. In this review, we discuss the current knowledge regarding the developmental patterns of TNBCBM, focusing on the key events in BM formation. Specifically, we consider (i) the nature and function of TNBC cells; (ii) how TNBC cells cross the blood–brain barrier and form a fenestrated, more permeable blood–tumor barrier; (iii) the biological characteristics of TNBCBM; and (iv) the infiltration and colonization of the central nervous system (CNS) by TNBC cells, including the establishment of premetastatic niches, immunosurveillance escape, and metabolic adaptations. We also discuss putative therapeutic targets and precision therapy with the greatest potential to treat TNBCBM, and summarize the relevant completed and ongoing clinical trials. These findings may provide new insights into the prevention and treatment of BM in TNBC patients.

Meta Analysis the Effect of Physical Activity on Survival Life in Breast Cancer Patients

Background: Physical activity has a positive role in breast cancer risk. Physical activity inten­sity is often expressed as metabolic equi­valents (METs) and the analytic guidelines for international physical activity question­naires define low activity as 4 METs and high activity as 8 METs. This study aims to estimate the effect of physical activity on the survival of breast cancer survivors based on a number of previous similar studies. Subjects and Method: This study is a syste­matic review and meta-analysis study. The arti­cles used in this study were obtained from seve­ral databases including PubMed, Science Direct, Google Scholar, and Springer Link. The articles used in this study were those published from 2000-2020. The population in the study were breast cancer survivors with an inter­vention in the form of high physical activity. Comparison, namely low physical activity, and an outcome in the form of survival. Keywords for searching articles are as follows: "physical activity" AND "breast cancer survivors" AND "lifesustainability" OR "survival" AND "breast cancer" AND "adjusted hazard ratio" AND "cohort". The articles included in this study are full text articles with a cohort study design. Articles were collected using PRISMA flow dia­grams. Articles were analyzed using the Review Manager 5.3 application. Results: There were 8 articles originating from Denmark, Norway, Canada, Germany and the United States. The results of the meta-ana­lysis showed that physical activity was statisti­cally significant in increasing the survival of breast cancer survivors (HR= 0.74 95% CI= 0.63 to 0.87; p= 0.0003) and I² = 0%. Conclusion: High physical activity increases the survival of breast cancer survivors. Keyword s : High physical activity, survival, breast cancer survivors Correspondence: Enge Surabina Ketaren. Masters Progam in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ketarenenge3@gmail.com. Mobile: 087­838583646. Indonesian Journal of Medicine (2021), 06(01): 32-41 https://doi.org/10.26911/theijmed.2021.06.01.04.

The Mediating Effect of Positive Illness Cognitions on Experiential Avoidance and Quality of Life in Breast Cancer Patients

The Mediating Effect of Positive Illness Cognitions on Experiential Avoidance and Quality of Life in Breast Cancer Patients

The Effect of Self-Acupressure on Peripheral Neuropathy, Disturbance in Daily Activity, and Quality of Life in Breast Cancer Patients undergoing Chemotherapy

The Effect of Self-Acupressure on Peripheral Neuropathy, Disturbance in Daily Activity, and Quality of Life in Breast Cancer Patients undergoing Chemotherapy

Perceived New Normal and Inner Strength on Quality of Life in Breast Cancer Patients Receiving Adjuvant Endocrine Therapy

Perceived New Normal and Inner Strength on Quality of Life in Breast Cancer Patients Receiving Adjuvant Endocrine Therapy

Risk of Anastrozole-related Mood Disturbances and Dizziness among Breast Cancer Patients taking Anastrozole

Background: Anastrozole has been widely utilized in the management of endocrine sensitive post-menopausal breast cancer; however, there is high variability in the adverse reactions associated with its use. Anastrozole-associated mood disturbances and dizziness occur less frequently. However, they can still affect the quality of life of breast cancer patients. The aim of this study was to determine the clinical and demographic factors associated with Anastrozole's adverse events. Materials/Methods: This is a cross-sectional study of oestrogen receptor positive post-menopausal women (n = 97) with stages I to III breast cancer receiving Anastrozole (1mg daily). Multivariate analyses were performed to establish the factors associated with Anastrozole-induced mood disturbance and dizziness. Results: Approximately 20.6% and 13.4% of the subjects experienced mood disturbance and dizziness respectively. Patients who are on Anastrozole treatment for more than three years had higher odds of having mood disturbance (adjusted odds ratio 20.31, confidence interval 1.75 to 235.31, p = 0.016). No significant association was established between serum oestrogen levels and development of mood disturbance and dizziness. Conclusion: Our study confirmed that although mood disturbances and dizziness are not the most commonly reported adverse reactions, the duration of Anastrozole treatment may be a predictor of mood disturbance in these patients.

Perawatan Paliatif terhadap Kualitas Hidup Pasien Kanker Payudara

This study aims to identify the effect of palliative care on breast cancer patients' quality of life. The method used in this study is a literature review. The results showed that palliative care affected breast cancer patients. In conclusion, comprehensive palliative care from various aspects of the patient's life plays a significant role in achieving the maximum quality of life in breast cancer patients and preparing for a dignified death. &#x0D; Keywords: Breast Cancer, Quality of Life, Palliative Care

Estimating the second primary cancer risk due to proton therapy compared to hybrid IMRT for left sided breast cancer

Background and purpose Proton therapy has been proposed as a technique to improve the long-term quality of life of breast cancer patients. This is due to its ability to reduce the dose to healthy tissue compared to conventional X-ray therapy. The aim of this study was to investigate the risk of secondary carcinogenesis due to proton therapy compared to hybrid IMRT for breast treatments. Material and methods In this study, the Pinnacle treatment planning system was used to simulate treatment plans for 15 female left-sided whole breast cancer patients with deep inspiration breath hold scans. Two treatment plans were generated for each patient: hybrid intensity modulated radiotherapy (h-IMRT) and intensity modulated proton therapy (IMPT). Using the dose-volume histograms (DVHs) from these plans, the mean lifetime attributed risk (LAR) for both lungs and the contralateral breast were evaluated using the BEIR VII and Schneider full risk models. Results The results from both risk models show lower LAR estimates for the IMPT treatment plan compared to the h-IMRT treatment plan. This result was observed for all organs of interest and was consistent amongst the two separate risk models. For both treatment plans, the organs from most to least at risk were: ipsilateral lung, contralateral breast, and contralateral lung. In all cases, the risk estimated via the BEIR VII model was higher that the Schneider full risk model. Conclusion The use of proton therapy for breast treatments leads to reduced risk estimates for secondary carcinogenesis. Therefore, proton therapy shows promise in improving the long term treatment outcome of breast patients.

KUALITAS TIDUR PASIEN KANKER PAYUDARA YANG MENJALANI KEMOTERAPI

Background : In the last five years, the prevalence of breast cancer in Indonesia has increased. The usual treatment for breast cancer is chemotherapy, which can cause physical problems that affect sleep quality. Sleep disorders are often experienced by breast cancer patients, where the impact affects the healing of the cancer and the immune system so that the condition and immune system cannot be maintained optimally in repairing body cells. Purpose: to determine the quality of sleep in breast cancer patients undergoing chemotherapy and to see which components have contributed to disturbing sleep quality. Methods: The study used a quantitative descriptive approach. Sampling technique accidental sampling with 100 respondent. The questionnaire used to measure sleep quality was the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The data analysis technique used univariate analysis, there are two interpretations on the PSQI. Sleep quality is good if the score is ≤ 5, sleep quality is bad if the score is&gt; 5. Results: Most of the respondents have poor sleep quality. This research is expected to increase the role of nursing care and educator so that it can improve the quality of life of breast cancer patients undergoing chemotherapy

Korean Translation and Psychometric Evaluation of Korean Version EORTC QLQ-BRECON23.

The purpose of this study was to evaluate the psychometric properties of the Korean version of the European Organization for Research and Treatment of Cancer Quality of Life-QLQ-BRECON23 in women diagnosed and treated for breast cancer undergoing all types of breast reconstruction. Methods: A total of 148 Korean women who underwent breast reconstruction were recruited from the breast cancer center to participate in the study. After performing forward and backward translation of the original English version of the questionnaire into Korean, its validity (construct, known-group validity, concurrent) and reliability were assessed. A structural equation model (SEM) was used to assess construct validity. Results: The mean age of the patients was 52 years, and 89.8% underwent implant-based reconstruction. Construct validity using confirmatory factor analysis showed a good fit, and the effect size was small-to-medium regarding known-group validity. Concurrent validity was confirmed by the significant correlation between the QLQ-BRECON23 and the QLQ-BR23. The reliability of the QLQ-BRECON23 symptom and function scales ranged from 0.61 to 0.87. Conclusion: The Korean QLQ-BRECON23 can be applied to assess quality of life and its related factors, and also to internationally compare the level of quality of life in breast cancer patients undergoing breast reconstruction.

The Influence of Progressive Muscle Relaxation (PMR) On The Improvement Of Body Composition, Depression Status And Quality of Life of Breast Cancer Patients During Chemotherapy In Dr. Mohammad Hoesin Hospital (RSMH) Palembang

ABSTRAK&#x0D; The breast cancer progression and chemotherapy side effects not only cause problems in mental status, but also the patient's physical status. This is related to a deteriorating quality of life and a worse prognosis. Physical exercise can improve physical status, mental status, and quality of life.&#x0D;            Experimental pre- and post intervention research with a control group was conducted on breast cancer patients to determine the effect of progressive muscle relaxation on the improvement of body composition, depression status, and quality of life for breast cancer patients during chemotherapy at RSMH on February 2019 - February 2020.&#x0D;            Progressive muscle relaxation (PMR) can improve body composition (p = 0.000), reduce the degree of depression (p = 0.000), improve global health status (p = 0.013), physical functioning (p = 0.002), emotional functioning (p = 0.009), social functioning (p = 0015), body image (0,000), sexual function (p = 0.05), future perspective (p = 0.006), and decreased fatigue (p = 0.00), nausea and vomiting (p = 0.002 ), pain (0,000), insomnia (0.002), appetite loss (p = 0,000), breast symptoms (p = 0,000), arm symptoms (p = 0,000), hair loss (p = 0,000), and therapy side effects (p = 0.000).

Patient Satisfaction Following Level II Oncoplastic Breast Surgery: A Comparison with Mastectomy Utililizing the Breast-Q Questionnaire will be published in Surgical Oncology

IntroductionOncoplastic breast surgery (OBS) is increasingly used to decrease the deformity in breast conserving therapy (BCT) for breast cancer. We aimed to evaluate patient reported satisfaction following level II OBS and mastectomy utilizing the BREAST-Q questionnaire. MethodsPatients who underwent level II OBS BCT and those who underwent mastectomies were distributed the BREAST-Q post-reduction/mammoplasty module. Clinicopathological data were collected from review of patient charts. Results were scored using the standardized scoring system (Q-score). Results of the OBS group were compared to those in the mastectomy group. ResultsA total of 88 patients who underwent level II OBS and 101 patients who underwent mastectomy completed the questionnaire. Mann-Whitney odds estimator demonstrated higher satisfaction with breasts (1.51, 95% CI [1.04–2.25], p = 0.026) and higher psychosocial well-being (1.51, 95% CI [1.04–2.15], p = 0.022) in those who underwent OBS compared to mastectomy. ConclusionResults demonstrate a high satisfaction with breasts and improved psychosocial wellbeing in patients who underwent level II OBS compared to those undergoing mastectomy. These results demonstrate that OBS should be considered in patients where mastectomy otherwise would be necessary. Further larger multi-institutional studies are necessary to examine the effect of OBS on the quality of life of breast cancer patients.

P.603 Aggression, hostility and stress in relation to quality of life in breast cancer patients

While magnetic resonance imaging-ultrasound fusion targeted biopsy allows for improved detection of clinically significant prostate cancer, a concerning amount of clinically significant disease is still missed. We hypothesized that a number of these misses are due to the learning curve associated with magnetic resonance imaging-ultrasound fusion targeted biopsy. We report the results of repeat magnetic resonance imaging-ultrasound fusion targeted biopsy in men with continued suspicion for cancer and the institutional learning curve in the detection of clinically significant prostate cancer with time.We analyzed the records of 1,813 prostate biopsies in a prospectively acquired cohort of men who presented for prostate biopsy in a 4-year period. All men were offered prebiopsy magnetic resonance imaging and were assigned a maximum PI-RADS™ (Prostate Imaging Reporting and Data System version 2) score. Biopsy outcomes in men with a suspicious region of interest were compared. The relationship between time and clinically significant prostate cancer detection was analyzed.The clinically significant prostate cancer detection rate increased 26% with time in men with a PI-RADS 4/5 region of interest. On repeat magnetic resonance imaging-ultrasound fusion targeted biopsy in men with continued suspicion for cancer 53% of those with a PI-RADS 4/5 region of interest demonstrated clinically significant discordance from the initial magnetic resonance imaging-ultrasound fusion targeted biopsy compared to only 23% with a PI-RADS 1/2 region of interest. Significantly less clinically significant prostate cancer was missed or under graded in the most recent biopsies compared to the earliest biopsies.The high upgrade rate on repeat magnetic resonance imaging-ultrasound fusion targeted biopsy and the increasing cancer detection rate with time show the significant learning curve associated with magnetic resonance imaging-ultrasound fusion targeted biopsy. Men with low risk or negative biopsies with a persistent, concerning region of interest should be promptly rebiopsied. Improved targeting accuracy with operator experience can help decrease the number of missed cases of clinically significant prostate cancer.

37P Correlation between haematological toxicity with quality of life in breast cancer patients after first-cycle chemotherapy

37P Correlation between haematological toxicity with quality of life in breast cancer patients after first-cycle chemotherapy

341P Relationship between muscle mass and quality of life in breast cancer patients who underwent chemotherapy

341P Relationship between muscle mass and quality of life in breast cancer patients who underwent chemotherapy

The effect of cognitive behavioral therapy on the quality of life of breast cancer patients: a systematic review and meta-analysis of randomized controlled trials.

Several lines of clinical research support the efficacy of Cognitive behavioral therapy (CBT) with a large number of population and various disease conditions, however, the true effects of CBT interventions on Quality of Life of breast cancer patients remain unknown. The aim of the study was to evaluate the effect of Cognitive Behavioral Therapy on the Quality of Life of breast cancer patients. A systematic review of articles published using Web of Science (1950-January 2020); Medline via EBSCO (1992-January 2020); Science direct via ELSEVIER (1996-January 2020); SCOPUS (2004-January 2020); and PubMed (1946-January 2020 excluding Medline from 1992-January 2020) were included. Additional studies were included after checking reference lists of all relevant studies; searching ongoing trials and research registers and manual search. Data extraction was conducted by two independent authors and a third independent author checked the data extraction. The PRISMA statement was adopted. Eleven Randomized controlled trials (RCT) with 1690 breast cancer patients were included in this review. The overall effect size of cognitive behavioral therapy on QoL of breast cancer patients was medium 0.39 (95% CI 0.12-0.66, P < 0.00001, I2 = 83%). Five studies had shown statistically significant improvement in functional and symptoms scales in the treatment group than the control group. CBT is effective in improving the Quality of Life of breast cancer patients. In future research, further randomized controlled trials with adequate randomization, allocation concealment, and appropriate blinding may be needed.

Faktor-Faktor yang Berhubungan dengan Kualitas Hidup Pasien Kanker Payudara di RSUD Raden Mattaher Jambi

Breast cancer is a disease that occurs due to excessive growth or uncontrolled development of cells or breast tissue. Quality of life is an important goal in the treatment of cancer, and concerns about physical, psychological, body image disorders. The purpose of this study is to find out the factors related to the quality of life of breast cancer patients at Raden Mattaher Jambi Hospital in 2019. Research uses a coelative descriptive research design with a cross sectional approach. The research population is breast cancer patients who are treating at Raden Mattaher Jambi Hospital. Sampling is done on a sampling quota. Data collection instruments use the respondent's characteristic data questionnaire, coping mechanism, and quality of life questionnaire using the EORTC-QLQ 30 format. The data was analyzed univariate and bivariate with the Kai-Squared test (CI 95%). The results of the study obtained the average age of respondents was 51.8 years, the majority were elementary and high school educated with a proportion of 35.7%, and most did not work as many as 35 people (62.5%). The results of bivariate analysis that there is a relationship between the length of the cancer and the mechanism of coffee and the quality of life of breast cancer patients in Raden Mattaher Jambi Hospital. It is hoped that hospitals can facilitate the interaction activities of cancer patients through the formation of groups for cancer patients so that they can share experiences and information in terms of improving quality of life. For nursing research, it is hoped that this research can be the basic data in carrying out the next research.