Product life-cycle design is a pathway from concept to research and development, from manufacturing to marketing and distribution. In the current approach to product design two objectives are broadly of stakeholders' and customers' interest: product specification and price. Sustainable product design, however, requires that environmental, energy, and safety issues, among others, be addressed. This paper introduces a new methodology employing three sustainability indices related to environment, energy and safety for a variety of applications including product design. The indices can be used individually or together, and it is possible to add other metrics depending on the nature of products and processes. To test the indices, blends of a typical gasoline as a product design case study were investigated.Gasoline blends are good examples of sustainable product design. Different gasoline blend products were modeled by Aspen HYSYS in order to estimate the octane numbers. New sustainability indices involving metrics such as octane number, mileage loss, potential environmental impacts, and safety risk were then applied on the blends and compared to fuel economy using the Analytical Hierarchy Process (AHP) methodology to select the best product. The range of each metric varies from one to another depending on the nature of the metrics, applications, regulations etc.; however, AHP is used for ranking purposes in the range of 0–100%.