College is an important context for young adults to cultivate developmental assets, solidify vocational plans, and nurture meaningful relationships. National data from Gallup have highlighted key experiences that positively impact a student’s experience while at college and their life after graduation. These “Big Six” experiences, including relationships with faculty and mentors and participation in high-impact practices, predict student success. Similarly, both theory and research underscore the importance of relationships, active engagement, and exploration in cultivating purpose and long-term aims. Little work has examined the cumulative and relative value of the “Big Six” experiences in explaining purpose development in college. The present cross-sectional and exploratory study sought to address this gap. Specifically, this study utilized hierarchical linear regression to examine the impact of different experiences and relationships on college student purpose at a small, liberal arts university in the Southeast region of the United States (n = 758). The results indicated that a greater number of “Big Six” experiences were predictive of a stronger purpose. Furthermore, experiences centered on relationships mattered relatively more in fostering purpose among college students than participation in high-impact practices. The findings are discussed in the context of the literature and recommendations for higher-education institutions are made.