Stress Levels Research Articles

The impact of psychospiritual program on state of depression, anxiety and stress among female juvenile delinquents

The participation of teenagers in inappropriate social actions is linked to the disregard for their mental health. This research was carried out to assess how a psychospiritual program impacts the reduction of depression, anxiety, and stress among delinquent adolescents. The study employed a quasi-experimental design, utilizing a single group for pretest-posttest evaluation. In this study, 36 delinquent adolescents who were females (N=36) and were enrolled in an Approved School in Terengganu, Malaysia, participated. The analysis was conducted through paired sample t-tests. The level of depression, anxiety, and stress before and after the psychospiritual program was assessed using the clinical scale for depression, anxiety, and stress (DASS-21). The results showed that the level of depression, anxiety and stress had decreased as much as 0.7619, 1.4643 and 0.7937 respectively after joining the program which was less than 0.05 (p=0.000 ≤0.05). This implies that the psychospiritual program exerts a significant influence in reducing depression, anxiety, and stress levels among adolescent delinquents. As a result, it is prudent to explore the psychospiritual approach as a potential alternative to the conventional allopathic intervention for addressing depression, anxiety, and stress problems especially among female delinquent adolescents at approved schools who have similar criterion.

Installation of open-ended piles: A numerical investigation into the effects on the state of silica sand

Up to this day, there are great uncertainties in the design procedures of monopiles, especially concerning the soil state condition and penetration response during their installation. A numerical model, based on the Coupled Eulerian method and using the hypoplastic law with intergranular strain, is proposed and validated in this paper, after which a series of open-ended pile installation tests have been carried out numerically, to investigate the influence of the jacked installation on the initial conditions for three types of silica sand. A range of soil densities and pile diameters is considered in this analysis. A full investigation of the installation forces, stress level, changes in volume-stress level and voids ratio is conducted. The numerical solution provided a correlation between the penetration resistance and the granulometric properties of the studied sands. Subsequently, the radial stresses in the surrounding soil mass are correlated with the type of sand and its relative density. The stress-volume state of a set of points in the soil domain during installation is presented and discussed from the critical state framework, revealing the contribution of the in-situ state in the pile installation. Finally, the lateral earth pressure resulting after installation is presented.

Physiology and transcriptome analysis of Artemisia argyi adaptation and accumulation to soil cadmium

The soil pollution caused by cadmium (Cd) poses a significant threat to the environment. Therefore, identifying plants that can effectively remediate Cd-contaminated soils is urgently needed. In this study, physiological, cytological, and transcriptome analyses were performed to comprehensively understand the changes in Artemisia argyi under Cd stress. Physiological and cytological analyses indicated that A. argyi maintained normal growth with intact cell structure under Cd stress levels up to 10 mg/kg. Cytological analysis showed that Cd precipitation in leaf cells occurred in the cytoplasm and intercellular spaces. As the levels of Cd stress increased, proline accumulation in leaves increased, whereas soluble protein and soluble sugar initially increased, followed by a subsequent decline. The translocation factor was above 1 under 0.6 mg/kg Cd stress but decreased when it exceeded this concentration. Transcriptome analyses revealed several crucial Cd-influenced pathways, including amino acid, terpenoid, flavonoid, and sugar metabolisms. This study not only proved that A. argyi could enrich Cd in soil but also revealed the response of A. argyi to Cd and its resistance mechanisms, which provided insight into the cleaner production of A. argyi and the remediation of Cd-contaminated soil.

Evaluation of Flavonoid-rich Fraction of Portulaca Grandiflora Aerial Part Extract in Atherogenic Diet-induced Atherosclerosis.

Portulaca grandiflora is a tiny, upright herb that contains a variety of chemical components, including alkaloids, glycosides, mucilage, proteins, tannins, flavonoids, saponins, polysaccharides, and triterpenoids possessing properties that may help with atherosclerosis. The reported pharmacological properties of Portulaca grandiflora are antioxidant, antidiabetic, antiasthmatic, antibacterial, antiulcer and anti-inflammatory properties. The yield of methanol extract is higher than that of ethanol and acetone, and its phytoconstituents, like flavonoids and polyphenols, and has potent antioxidant properties. In order to determine the effectiveness ofPortulaca grandiflora methanol extract fraction against high-fat diet (HFD)-induced hyperlipidemia, hemodynamic change, antioxidant levels, and vascular dysfunction in rats, a study was carried out on a flavonoid-rich methanol extract fraction of the aerial part of Portulaca grandiflora Hook. This method involves a study of 30 days involving male Wistar rats (240-250 g) (n=5) that were fed with an Ath diet. Study groups were divided into (i) The Control Group, (ii) the Diseases Control Group, (iii) Disease + Standard drug (Atorvastatin 20mg/kg, orally, (iv) Disease + Test Extract dose 1 (Portulaca grandiflora 200mg/kg orally), and (v) Disease + Test Extract dose 2 (Portulaca grandiflora 400mg/kg orally). Both the test drug Portulaca grandiflora and the standard drug Atorvastatin were given orally for 30 days. At the end of the study, blood samples were taken to measure the serum lipid profile, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and levels of oxidative tissue stress. Hemodynamic parameters and aortic staining were performed. Portulaca grandiflora treatment improved the lipid profile and considerably reduced oxidative stress levels. Aortic staining examination revealed a marked reduction in atherosclerotic lesions. These results revealed that Portulaca grandiflora is an effective treatment approach in preventing atherosclerotic lesion progression, which is attributed to its protection against oxidative stress and various enzymatic activities in the Atherogenic model.

Evaluating the Antidepressant-like Properties of Melatonin and Vitamin D3 Combination in Mice Subjected to Restraint Stress: Investigating the Involvement of Oxidative Stress

Background: Increased levels of oxidative stress are connected with depression. Due to the melatonin's antioxidant effects and Vitamin D3 (Vit D3)'s regulatory effect on the biosynthesis of neurotransmitters and neurotrophic factors, the present study investigated the possible protective effect of melatonin and Vit D3 combination on restraint stress-induced depression-like behaviors in mice. Methods: After being subjected to restraint stress, mice were divided into six groups using a randomization process. These groups included non-stressed and stressed vehicle-treated groups, as well as groups treated with Vit D3 (25 μg/kg/day), melatonin (10 mg/kg) or fluoxetine. A group also received a combination of both melatonin and Vit D3. The Forced Swimming Test (FST), and Open Field Test (OFT) were conducted to evaluate behavioural changes. The Malondialdehyde (MDA) level and Catalase (CAT), Superoxide Dismutase (SOD) activity, and ADP/ATP ratio were evaluated in the hippocampus of mice. Results: Restraint stress lengthened the immobility period in FST, while melatonin, Vit D3, and their combination all significantly reversed this impact. Co-administration of melatonin and Vit D3 was more effective than melatonin or Vit D3 administration alone at reducing immobility time. The exposure of mice to restraint stress has been linked to an elevation in the ADP/ATP ratio and oxidative stress in their hippocampus; however, these effects are reversed by the administration of melatonin and Vit D3 (10 mg/kg) alone or in combination. Melatonin and Vit D3 combination increased the hippocampus CAT activity compared with melatonin and Vit D3 alone. Conclusion: The current study's findings suggested that Vit D3 may enhance melatonin's potential as an antidepressant in FST.

Antioxidants, Hormetic Nutrition, and Autism.

Autism spectrum disorder (ASD) includes a heterogeneous group of complex neurodevelopmental disorders characterized by atypical behaviors with two core pathological manifestations: deficits in social interaction/communication and repetitive behaviors, which are associated with disturbed redox homeostasis. Modulation of cellular resilience mechanisms induced by low levels of stressors represents a novel approach for the development of therapeutic strategies, and in this context, neuroprotective effects of a wide range of polyphenol compounds have been demonstrated in several in vitro and in vivo studies and thoroughly reviewed. Mushrooms have been used in traditional medicine for many years and have been associated with a long list of therapeutic properties, including antitumor, immunomodulatory, antioxidant, antiviral, antibacterial, and hepatoprotective effects. Our recent studies have strikingly indicated the presence of polyphenols in nutritional mushrooms and demonstrated their protective effects in different models of neurodegenerative disorders in humans and rats. Although their therapeutic effects are exerted through multiple mechanisms, increasing attention is focusing on their capacity to induce endogenous defense systems by modulating cellular signaling processes such as nuclear factor erythroid 2 related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) pathways. Here we discuss the protective role of hormesis and its modulation by hormetic nutrients in ASD.

Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis.

This study aimed to investigate the changes in oxidative stress, adenosine monophosphate-activated protein kinase (AMPK), connexin43 (Cx43), nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression, and extracellular matrix (ECM) in the gastric smooth muscle tissues of rats with diabetic gastroparesis (DGP) and high glucose-cultured gastric smooth muscle cells, determine the existence of oxidative stress-AMPK-Cx43-NLRP3 pathway under high glucose condition, and the involvement of this pathway in ECM remodeling in DGP rats. The results showed that with increasing duration of diabetes, oxidation stress levels gradually increased, the AMPK activity decreased first and then increased, NLRP3, CX43 expression, and membrane/cytoplasmratio of Cx43 expression were increased in the gastric smooth muscle tissues of diabetic rats. Changes in ECM of gastric smooth muscle cells wereobserved in DGP rats. The DGP group showed higher collagen type I content, increased expression of Caspase-1, transforming growth factor-beta 3 (TGF-β3), and matrix metalloproteinase-2 (MMP-2), decreased tissue inhibitor of metalloproteinase-1 (TIMP-1) expression, and higher interleukin-1betacontent when compared with the control group. For gastric smooth muscle cells cultured under higher glucose, the MMP-2 and TGF-β3 expression wasdecreased, TGF-β1 and TIMP-1 expression was increased, the interleukin-1betacontent was decreased in cells after inhibition of NLRP3 expression; the NLRP3 and Caspase-1expression was decreased, and adenosine triphosphate content was lower after inhibition of Cx43; the expression of NLRP3, Caspase-1, P2X7, and the membrane/cytoplasm ratio of CX43 expression was decreased in cells after inhibition of AMPK and oxidative stress, the phospho-AMPK expression was also decreased after suppressing oxidative stress. Our findings suggest that high glucose induced the activation of the AMPK-Cx43-NLRP3 pathway through oxidative stress, and this pathway was involved in the ECM remodeling of gastric smooth muscles in DGP rats by regulating the biological functions of TGF-β3, TGF-β1, MMP-2, and TIMP-1.

A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing

Hyaluronic acid (HA)-based biopolymer hydrogels are promising therapeutic dressings for various wounds but still underperform in treating diabetic wounds. These wounds are extremely difficult to heal and undergo a prolonged and severe inflammatory process due to bacterial infection, overexpression of reactive oxygen species (ROS), and insufficient synthesis of NO. In this study, a dynamic crosslinked hyaluronic acid (HA) hydrogel dressing (Gel-HAB) loaded with allomelanin (AMNP)-N, N′-dis-sec-butyl-N, N′-dinitroso-1, 4-phenylenediamine (BNN6) nanoparticles (AMNP-BNN6) was developed for healing diabetic wounds. The dynamic acylhydrazone bond formed between hydrazide-modified HA (HA-ADH) and oxidized HA (OHA) makes the hydrogel injectable, self-healing, and biocompatible. The hydrogel, loaded with AMNP-BNN6 nanoparticles, exhibits promising ROS scavenging ability and on-demand release of nitric oxide (NO) under near-infrared (NIR) laser irradiation to achieve mild photothermal antibacterial therapy (PTAT) (∼ 48 °C). Notably, the Gel-HAB hydrogel effectively reduced the oxidative stress level, controlled infections, accelerated vascular regeneration, and promoted angiogenesis, thereby achieving rapid healing of diabetic wounds. The injectable self-healing nanocomposite hydrogel could serve as a mild photothermal-enhanced antibacterial, antioxidant, and nitric oxide release platform for the treatment of diabetic wounds.

The effectiveness of a recovery program on some biological variables and stress levels for Beginners in gymnastics

The effectiveness of a recovery program on some biological variables and stress levels for Beginners in gymnastics

A Study of Retirement Preparedness among Malaysian Female Millennials

The purpose of this study is to examine the effect of financial literacy, financial stress, financial management practices, saving behaviour, household size and income adequacy, on Malaysian female millennials’ retirement preparedness. A total of 268 questionnaires were self-administered and collected from Malaysian female millennials residing and working in the Klang Valley aged between 26 to 41 years old using a purposive stratified sampling method. Regression analyses were performed using SPSS software to determine the influence of variables investigated on retirement preparedness. Findings indicate that financial literacy level (β = 0.154, t-statistic = 2.669), financial stress level (β = 0.108, t-statistic = 2.207), saving behaviour (β = 0.281, t-statistic = 5.713) and household size (β = 0.242, t-statistic = 2.616), have significant positive effects on retirement preparedness. Income adequacy (β = – 0.298, t-statistic = – 2.595) on the other hand, is significantly and negatively associated with retirement preparedness, while financial management practices are found to have no influence. This study contributes to extant literature by examining the increasingly significant segment of the working population in our country. Hence, our findings should provide more insights to interested stakeholders in designing new or improving existing financial planning programs or mechanisms, particularly those related to retirement to better promote sound retirement planning among Malaysian female millennials.

Determination of Covid-19 stress level in intensive care nurses after pandemic

Determination of Covid-19 stress level in intensive care nurses after pandemic

Stress Detection in IT Professionals Using Machine Learning

Abstract: In today's fast-paced technology landscape, stress management. The work environment in the IT field is often characterized by long hrs, and high expectations, which can leading to elevated stress levels. Unchecked stress not only impacts the health and well-being of professionals but also affects in job satisfaction. This study aims to predicting the stress levels of IT professionals using machine learning techniques, thereby aiding in proactive stress management. We utilize a range of features indicative of work stress, including Heart Rate, Skin Conductivity, Hours Worked, Number of Emails Sent, and Meetings Attended. These features provide a physiological and work-related factors that contribute to stress. The application of [ML] in this context serves as an innovative approach to an increasingly pertinent issue. By leveraging the power of data analytics, this model aims to organizations. Individuals we can use for self-monitoring and early intervention, while organizations can utilize them to identify high-stress environments or roles, thereby allocating resources or interventions more effectively. Our preliminary results indicate a strong correlation between the chosen features and stress levels, demonstrating the viability of using ml for stress prediction in IT professionals. This study stands as a crucial step towards a more data-driven approach to mental health condition

The Correlation Between Systemic Factors, Citizenship Behaviors, Misbehaviors, and Work Stress in Female Arab Teachers in Israel

The study investigates the correlation among systemic factors including educational system reforms and managerial leadership style, stress levels, and their effects on job performance, work-family balance, and workplace functionality of Arab mothers who are teachers in Israel. However, the study involved 546 Israeli-Arab mothers working as secondary education teachers, who completed questionnaires focusing on conflict expressions, systemic factors, and their effects on work performance indicators. The examination of the results - among others, suggests that the perception of work stress among participants was related to a high level of the two types of conflict as well as to the high prevalence of withdrawal behavior. The second result showed that actively managing was associated with a lower occurrence of withdrawal behavior at all three levels, while also being associated with a higher prevalence of citizenship behavior. On the other hand, workload related to work or family was not a predictor of a higher prevalence of withdrawal behaviors and a low prevalence of citizenship behavior. In an understudied field, the current research presents the multi-factorial complexity of the systemic factors in Arab schools in Israel and their impact on work functioning. The practical outcomes are both organizational and social and they concern both the managers and the family environment of the teachers. The study shows that the manager’s support is a crucial factor in mitigating the Work-family conflict. Thus, it is suggested to encourage school managers’ willingness to give teachers support and a more lenient work environment to help mitigate their work-related stress.

Stress and Mental Health Detection using Machine Learning

Abstract: The precise determination of psychological health and stress levels substantial involvement in the course of a patient's therapy, Especially during the initial phases of the condition, it's crucial to remain vigilant as there's a potential for health risks to emerge for the patient. Deep Learning (DL) has emerged as a prevalent technique utilized to detect stress and mental health conditions, aiding in their identification. in a timely manner. Here, we provide mental health prediction utilizing KNN, Random Forest, and Logistic Regression whereas CNN for stress detection to aid in the timely identification of the illness. The website we created compiles the patient/person dataset. It aids When forecasting the outcome of the event, patient's or person's mental health and stress levels once the necessary training procedures have been completed.

Structural Analysis and Optimization of Washing Machine Spider, Drum and Shaft

Abstract: This project's thesis centers on identifying diverse loading scenarios and leveraging their outcomes to optimize two components of a washing machine. The initial phase of this report involves generating a numerical model of a washing machine. This encompasses assembling it in a mechanical software program (ANSYS) and defining specific boundary conditions and material properties for the problem. Decisions on simulation parameters, such as mesh size, types of elements, and the number of iterations in the calculations, will also be made. An examination of various loading scenarios is conducted to gain an overall understanding of the problem and select four specific cases for application in reconstructing the target parts (Spider and front cover). This examination involves calculating the worst relative angle between the Spider and the resultant force for two opposing loads inside the drum. The resulting angle is found to be 35º between the arm and the direction of the resultant force. By applying these diverse loading conditions to the model, the mechanical behavior of the parts will be determined, and this information will be utilized in the reconstruction. Mechanical behavior, in this context, refers to understanding the maximum levels of stress (tension, compression, and shear) and deformation (displacement and strain). Once the critical points of stress in the Spider and front cover are identified, various new shapes are created. The reconstruction parameters considered include volume reduction, stress level reduction, and deformation. Two of these shapes are selected and tested in the numerical model as a validation process.

Life Integrate: Unify Your Life, Simplify Your Success

Abstract: Efficient management and organization of personal and commercial data is critical for reducing stress and increasing productivity in the fast-paced digital environment we live in. An inventive smartphone software called "Life Integrate" attempts to meet this requirement by effectively managing duties and merging different facets of life. The project aims to mimic the effectiveness of an AI personal assistant by bridging the gap between contemporary lives and efficient organizing. The software smoothly distinguishes between personal and professional data by utilizing technologies like machine learning and natural language processing, which improves the user experience and efficiency. One to three clicks can easily share data with the app, which adds to its effectiveness and user-friendliness. Aiming to streamline processes, key features include real-time editing, interactive chats, speech-activated assistants, and contextual awareness. The project's emphasis on developing a personal bot that excels at data collection and generates intelligent ideas based on collected data exemplifies an intriguing combination of customization and artificial intelligence. With its 13 primary sub-tabs and extensive questionnaires for storing both personal and professional data, the app offers an approach to organization and management that is user-centric. Effective app development and deployment are ensured by the use of the Flutter and Dart platforms. In general, "Life Integrate" seeks to transform the information landscape, making it easier to acquire and use, and facilitating more enjoyable interactions between humans and machines. With this project, we hope to create a future in which people can easily incorporate technology into their daily lives, increasing productivity and lowering stress levels

Secondary Adrenal Insufficiency : A Case Report

Introduction: Insufficient pituitary hormone output is referred to as hypopituitarism. Individuals experiencing lethargy, dizziness, orthostatic hypotension, hypoglycemia, nausea, vomiting, or generalized abdominal pain may be diagnosed with acute adrenocorticotropic hormone (ACTH) insufficiency. This report detailed a unique instance of hypopituitarism in a patient who complained of nausea, vomiting, hypotension, hypoglycemia, and overall abdominal pain and soreness. Case presentation: A 65-year-old male presented to the outpatient department with complaints of a cough of 1-day duration on August 9/03/21 associated with 4 to 5 episodes of vomiting and pain in the abdomen, in addition to that whole body darkening, fatigue, and appetite loss of 6 months. weight loss intermittent sweating, and eyebrow and axillary hair loss. SOB with mild activity and also bilateral breast pain but no mass. Discussion: The diagnosis of hypothyroidism and inexplicable fatigue made us believe that there was an adrenal deficiency, which might be treated with cortisol around eight o’clock. Even though the patient with a high stress level the cortisol was immeasurable; so the diagnosis, of adrenal insufficiency, could be made. Other tests including ACTH and Imaging are usually needed to discover the subtype of insufficiency. The follow-up after 1 month showed no signs or symptoms left and a much better condition. Conclusion: When treating individuals who have fatigue that cannot be attributed to anything else, especially when weight loss and muscle weakness are present, adrenal insufficiency should be taken into consideration. A secondary adrenal insufficiency may exist even in the absence of skin pigmentation, which frequently triggers anxieties and ideas about Addison’s disease. If it is not identified promptly, it may potentially result in an adrenal crisis in situations with high-stress levels. Our patient presented with vague and largely mild symptoms related to early secondary adrenal insufficiency. These included nausea and vomiting, as well as fatigue. Laboratory studies indicated new hyponatremia and urine studies showed inappropriately normal urine sodium and osmolality. His morning serum cortisol was low, with borderline low ACTH, consistent with a secondary cause.

Stress and work engagement among nurses in intensive care units: Palestinian perspective

Purpose Work engagement denotes to a state of positive and affective motivation of elevated power joined with high educational levels and a great concentration on occupation and it is negatively affected by psychological problems. This study aims to assess the stress and work engagement among Palestinian nurses working in intensive care units. Design/methodology/approach A cross-sectional design was adopted. A convenience sample consisting of 225 intensive care nurses from governmental hospitals was recruited to participate. Data collection used the Nursing Stress Scale and Utrecht Work Engagement Scale-9, and demographic data were used to gather data throughout the period from February 10 to March 30, 2023. Findings Findings demonstrated that nurses’ stress levels were high (M = 105.9 ± standard deviation [SD] = 11.91). Concerning work engagement, the nurses endorsed moderate work engagement levels with a mean of 3.7 (SD = 0.4). Regarding work engagement subscales, the mean of vigor was 3.7 (0.6), dedication with a mean of 3.7 (0.6) and absorption with a mean of 3.7 (0.6). Also, the findings showed that stress, gender and monthly income were predictors of work engagement (p < 0.05). Research limitations/implications Despite the significant results, this study had the following limitations: the design was cross-sectional, which limits the ability to explore the cause and effect of the study variables, thus longitudinal studies are recommended. In addition, the study adopted a self-reported questionnaire based on participants’ understanding, culture and work context which could influence their responses. Originality/value The intensive care nurses had high stress levels and moderate work engagement. Stress, gender and monthly income were predictors of the work engagement. Thus, interventions should be encouraged to minimize stress, which has a significant influence on work engagement.

Effectiveness of a mobile-based return to work programfor decent return to work. fatigue, stress, and quality of working life among cancer survivors.

This study aimed to develop a smartphone mobile application-based supportive return to work (RTW) program for cancer survivors and evaluate its effects on their RTW, fatigue, stress, and quality of working life. This program was developed through a comprehensive process involving literature review, interviews with cancer survivors, and consultations with experts. A non-equivalent control group pre- and post-test design was used, with 41 participants assigned to the experimental (n = 18) and control (n = 23) groups based on recruitment timing. The experimental group received a 6-week smartphone mobile application-based supportive RTW program comprising "Counseling and Education" and "Self-Management." Participants completed assessments of decent RTW, fatigue, stress, and quality of working life at baseline and 6months later. The experimental group completed an additional post-program completion survey. During the 6-week program, no experimental group participants dropped out. The program's impact on decent RTW remains unclear. Fatigue (F = 2.52, p = 0.095) and quality of working life (F = 0.86, p = 0.434) did not show statistically significant differences. However, there was a significant reduction in stress (F = 4.59, p = 0.017). The smartphone application-based RTW program, focusing on self-management and counseling, effectively reduced participants' stress levels. To further evaluate the effectiveness of the program, a more diverse range of interventions and ongoing programs should be implemented. This study underscores the importance of tailored digital interventions to support the RTW of cancer survivors. The use of mobile smartphone applications allows temporal and spatial flexibility in program participation. Interventions involving various activities should be implemented to ensure ongoing participation.

ABI3 promotes auxin signalling by regulating SHY2 expression to control primary root growth in response to dehydration stress.

Plants combat dehydration stress through several adaptive measures including root architectural changes. Here we show that when exposed to varying levels of dehydration stress, primary root growth in Arabidopsis is modulated by regulating root meristem activity. ABA in concert with auxin signalling perceives the stress level and adapts primary root growth accordingly. ABI3, the ABA responsive transcription factor stands at the intersection of ABA and auxin signalling and fine tunes primary root growth in response to dehydration stress. Under low ABA or dehydration stress, induction of ABI3 expression promotes auxin signalling by decreasing expression of SHY2, a negative regulator of auxin response. This further enhances the expression of auxin transporter gene PIN1 and cell cycle gene CYCB1;1, resulting in an increase in primary root meristem size and root length. Higher levels of dehydration stress or ABA repress ABI3 expression and promote ABI5 expression. This elevates SHY2 expression, thereby impairing primary root meristem activity and retarding root growth. Notably, ABI5 can promote SHY2 expression only in the absence of ABI3. Such ABA concentration dependent expression of ABI3 therefore functions as a regulatory sensor of dehydration stress levels and orchestrates primary root growth by coordinating its downstream regulon.