Question In the practice of the author astounding improvements of systemic complaints which accompanied apparently rheumatic, neuralgic and other chronically inflammatory systemic diseases are consistently observed after cleaning pain-free edentulous areas of the jaw. These are marked by fatty-degenerative osteonecrosis of the cancellous bone (NICO). Where is the connection between the local surgery of the jaw bone and the systemic results? Methods of research In order to clarify systemic interrelations of NICO, samples of cancellous bone have been extracted from six subjects. The specimens were then analyzed by bead-based multiplex technology and tested for 27 immune messengers. Results All six specimens concordantly showed highest concentration for IL 1-ra (Interleukin-1-receptor antagonist) and RANTES. In addition, in all samples FGF-basic and PDGF-bb have been distinctly evidenced. A statistically high concentration on RANTES is noticeable here. The samples’ small distribution and specific concentration RANTES, despite the high number of 27 tested mediators, is a striking figure. The present research is the first to analyze immune messengers within the scope of a screening of processed samples of degenerated jaw bone tissue (NICO). There is no study with similar purpose known to the authors. Clinical and systemic conclusion The author develops an immunological-based explanatory model of systemic phenomena with two case histories: one case had pain in the knee joints with previous diagnosis rheumatic arthritis and previous prescription of Prednisolon/Metotrexat. Case two had asthma with previous treatment of cortisone. After surgical cleaning of NICO jaw sites both lost symptoms and needed no cortisone any more. The author approaches to a mediator-based hypothesis of systemic-causal relations and a pathogenetic aspect of chronic-inflammatory NICO lesions based on elevated levels of RANTES: removal of NICO lesions often results in disappearance of various inflammatory symptoms in chronic diseases. Additionally proinflammatory RANTES is discussed to play a role in development of MS, cancer and as a messenger in maligne cancer metastasis. Thus NICO and RANTES give a possible complementary and integrative aspect of systemic diseases. Download high-res image (289KB) Download full-size image