Methods We studied all patients who had a visit in our outpatient HIV clinic during 2007. The following data were collected: age at diagnosis of HIV infection, gender, country of origin, smoking status, HCV co-infection, HIV risk group, AIDS diagnosis, CD4+ cell count, HIV viral load, fasting glucose and insulin levels, lipid profile, blood pressure, waist circumference, BMI and present HAART. We used the HOMA index to assess insulin resistance, choosing as cut-off point 3.8. The IDF criteria have been used to define increased waist circumference, hypertension, hypertrygliceridemia, low HDL cholesterol and hyperglycemia. We assessed the association of these variables with IR using a multivariate logistic regression predictive model. Blood glucose value was not taken into account in the analysis since it is embedded in the HOMA index. Discriminating power of the model was analyzed by means of a receiver operating curve (ROC). The effect measure was the adjusted odds-ratio with 95% confidence interval (CI).