High Level Of Sensitivity Research Articles

TIMS2Rescore: A Data Dependent Acquisition-Parallel Accumulation and Serial Fragmentation-Optimized Data-Driven Rescoring Pipeline Based on MS2Rescore.

The high throughput analysis of proteins with mass spectrometry (MS) is highly valuable for understanding human biology, discovering disease biomarkers, identifying therapeutic targets, and exploring pathogen interactions. To achieve these goals, specialized proteomics subfields, including plasma proteomics, immunopeptidomics, and metaproteomics, must tackle specific analytical challenges, such as an increased identification ambiguity compared to routine proteomics experiments. Technical advancements in MS instrumentation can mitigate these issues by acquiring more discerning information at higher sensitivity levels. This is exemplified by the incorporation of ion mobility and parallel accumulation and serial fragmentation (PASEF) technologies in timsTOF instruments. In addition, AI-based bioinformatics solutions can help overcome ambiguity issues by integrating more data into the identification workflow. Here, we introduce TIMS2Rescore, a data-driven rescoring workflow optimized for DDA-PASEF data from timsTOF instruments. This platform includes new timsTOF MS2PIP spectrum prediction models and IM2Deep, a new deep learning-based peptide ion mobility predictor. Furthermore, to fully streamline data throughput, TIMS2Rescore directly accepts Bruker raw mass spectrometry data and search results from ProteoScape and many other search engines, including Sage and PEAKS. We showcase TIMS2Rescore performance on plasma proteomics, immunopeptidomics (HLA class I and II), and metaproteomics data sets. TIMS2Rescore is open-source and freely available at https://github.com/compomics/tims2rescore.

Unusual symptoms reveal a rare splenic lymphoma: a case report of PS-DLBCL with neck and shoulder pain as the initial presentation

The rare occurrence of diffuse large B-cell lymphoma (DLBCL) limited to the spleen presents difficulties in diagnosis. A case report details a patient whose initial symptoms were neck and shoulder pain, subsequently diagnosed as spontaneous spleen rupture, a rare complication of primary splenic lymphoma. Following a splenectomy, the patient was confirmed to have primary splenic DLBCL and made a good postoperative recovery. This report highlights the diagnostic dilemmas in atypical presentations, where neck and shoulder pain may be the only early sign of a neglected spleen rupture, lacking typical symptoms of the underlying disease. In cases of patients who are not stable, the recommended first imaging method is a focused assessment using sonography for trauma (FAST), as CT scans have a high level of sensitivity. Treatment is determined by hemodynamic status, with conservative management for stable patients and surgical intervention for unstable patients. The importance of recognizing spontaneous spleen rupture as a critical yet uncommon possibility in acute abdominal cases, especially in instances of primary splenic DLBCL, is emphasized in the report.

Echocardiographic predictors of surgical outcomes in pulmonary atresia with intact ventricular septum and development of a discriminatory calculator: an Australian tertiary institution experience.

Pulmonary atresia with intact ventricular septum is a rare congenital cardiac lesion with significant anatomical heterogeneity. Surgical planning of borderline cases remains challenging and is primarily based on echocardiography. The aim was to identify echocardiographic parameters that correlate with surgical outcome and to develop a discriminatory calculator. Retrospective review of all pulmonary atresia with intact ventricular septum cases at a statewide tertiary paediatric cardiac centre was performed between 2004 and 2020. Demographic, clinical, and echocardiographic data were collected. Logistic regression was used to develop a discriminatory tool for prediction of biventricular repair. Forty patients were included. Overall mortality was 27.5% (n = 11) and confined to patients managed as univentricular (11 vs 0, p = 0.027). Patients who underwent univentricular palliation were more likely to have an associated coronary artery abnormality (17 vs 3, p = 0.001). Fifteen surviving patients (51.7%) achieved biventricular circulation while 14 (48.3%) required one-and-a-half or univentricular palliation. Nineteen patients (47.5%) underwent percutaneous pulmonary valve perforation. No patients without tricuspid regurgitation achieved biventricular repair. The combination of tricuspid valve/mitral valve annulus dimension ratio and right ventricle/left ventricle length ratio identified biventricular management with a sensitivity of 93% and specificity of 96%. An online calculator has been made available. Pulmonary atresia with intact ventricular septum is a challenging condition with significant early and interstage morbidity and mortality risk. Patient outcomes were comparable to internationally reported data. Right ventricle/left ventricle length and tricuspid valve/mitral valve annulus dimension ratios identified a biventricular pathway with a high level of sensitivity and specificity. Absent tricuspid regurgitation was associated with a univentricular outcome.

Sensory processing patterns and their relationships to coping and occupational engagement in mental health service users.

Mental health service users often have sensory processing difficulties hampering their ability to cope with mental health problems and occupational engagement. However, there is little knowledge of sensory processing and its relation to these factors. Hence, this current study aims to investigate sensory processing patterns in relation to coping and occupational engagement for the target group. This cross-sectional study involved 97 mental health service users. Sociodemographic information and self-rated questionnaires were administered; Adolescent/Adult Sensory Profile (AASP), Coping Orientation to Problems Experienced Inventory scale (short version) (Brief-COPE), and Profiles of Occupational Engagement among people with Severe mental illness (POES). Statistical analysis included descriptive statistics and multiple linear regression models. This study sits within an RCT project where parts were designed collaboratively with research-educated service users. The result showed strong relationships between sensory processing patterns and occupational engagement. Low levels of occupational engagement were related to high levels of sensory sensitivity, sensation avoiding, and low registration. Whereas, high levels of occupational engagement were related to high levels of sensation-seeking. Concerning coping styles, high levels of emotion-focused coping were related to high levels of low registration, while high levels of avoidant coping styles were related to high levels of sensation-seeking. The findings indicate that occupational engagement and coping styles are related to outcomes of the sensory profile and thus affect how a person with severe mental health problems interprets and reacts to sensory stimuli in daily life.

Two-step-7-Pink Rule: A Practical Tool for the Dermoscopic Evaluation of Fully Amelanotic Skin Lesions

Introduction: The diagnosis of fully amelanotic skin tumors is difficult on clinical and dermoscopic examination. Objective: We sought to identify an accurate and user-friendly dermoscopic algorithm to differentiate between benign and malignant pink lesions. Methods: The database of 1 referral center was retrospectively reviewed for images of non-inflammatory fully amelanotic skin lesions. Two dermatologists jointly assessed a validation set of images for dermoscopic criteria and constructed a diagnostic algorithm, the 2-step 7-pink rule (2S-7PR). Two external clinicians, with different skills in dermoscopy and blinded to the final diagnosis, separately evaluated images from the validation test sets using the prevalent criterion method and the new 2S-7PR algorithm. Results: A total of 763 lesions from 652 patients were included in the validation set database, of which 68.3% were malignant and 31.7% were benign. Three suspicious dermoscopic criteria were included in the first step of the 2S-7PR: polymorphous or sharply focused vessels, scales or crusts, and erosions or ulcerations; and 4 non-suspicious criteria were included in the second: white collarette, white scar-like area, vascular lacunae, and necklace pinpoint vessels. High levels of specificity and sensitivity were calculated in the validation and test phases for both the expert and non-expert evaluators, the former achieving higher levels of both sensitivity and specificity by employing the 2S-7PR compared to the prevalent method, and the latter only improved specificity. Conclusions: The present study showed that an algorithm focused on a few reproducible and easily recognizable criteria could improve diagnostic accuracy in the management of amelanotic lesions.

Advances in RNA editing in hematopoiesis and associated malignancies.

Adenosine-to-inosine (A-to-I) RNA editing is a prevalent RNA modification essential for cell survival. The process is catalyzed by the Adenosine Deaminase Acting on RNA (ADAR) enzyme family that converts adenosines in double-stranded RNAs (dsRNAs) into inosines, which are read as guanosines during translation. Deep sequencing has helped to reveal that A-to-I editing occurs across various types of RNAs to affect their functions. RNA editing detection is now so sophisticated that we can achieve a high level of accuracy and sensitivity to identify low abundance edited events. Consequently, A-to-I editing has been implicated in various biological processes, including immune and stress responses, cancer progression and stem cell fate determination. In particular, a crucial role for this process has been recently reported in hematopoietic cell development and hematologic malignancy progression. Results from genetic mouse models have demonstrated the impact of ADARs' catalytic activity on hematopoietic cells, complemented by insights from human cell studies. Meanwhile clinical studies have implicated ADAR enzymes and RNA editing events in hematologic malignancies and highlighted their potential as prognostic indicators. In this review, we outline the regulatory mechanisms of RNA editing in both normal hematopoiesis and hematologic malignancies. We then speculate on how targeting ADAR expression and site-specific RNA substrates might serve as a therapeutic avenue for affected patients.

Development and Validation of an RPA Assay for Detecting Xanthomonas citri subsp. citri A, A* and Aw and X. fuscans subsp. aurantifolii B and C

Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc) and X. fuscans subsp. aurantifolii (Xfa), is a destructive disease of citrus. It is sparsely distributed in the Caribbean, and effective biosecurity measures, including accurate pathogen detection systems, are essential to prevent further spread. Current in-field screening methods rely on visual symptom identification and serological tools like Agdia’s X. axonopodis subsp. citri (Xac) ImmunoStrips®. However, they failed to detect the Aw and C pathotypes in this study. Nucleic acid amplification is the gold standard for confirming detection but is resource-intensive and less accessible in Caribbean plant diagnostic laboratories and regulatory services. To address this, a rapid recombinase polymerase amplification (RPA) assay was developed using a portable fluorometer and primers designed to detect all canker-causing pathotypes. The RPA assay accurately detected all five citrus canker pathotypes and was selective against Xanthomonas euvesicatoria pv. citrumelonis, the fastidious citrus greening bacteria Candidatus Liberibacter asiaticus, and the xylem-limited bacterial pathogen Xylella fastidiosa. However, X. perforans, X. citri pv. glycines, and X. citri pv. phaseoli, pathogens unrelated to citrus and unlikely to be present in citrus, were detected. Real-time detection was completed in 25 minutes with high sensitivity levels of 0.001 pg/µl (Xcc A), 0.1 pg/µl (Xfa B), and 1 pg/µl (Xfa C) of DNA. This RPA assay offers a robust, in-field detection method, combining molecular sensitivity and specificity with the field-friendly simplicity of crude extraction and single-tube reactions.

A handheld biofluorometric system for acetone detection in exhaled breath condensates.

As a marker of human metabolism, acetone is important for lipid metabolism monitoring and early detection of diabetes. In this study, we developed a handheld biosensor for acetone based on fluorescence detection by utilizing the enzymatic reaction of secondary alcohol dehydrogenase (S-ADH) with β-nicotinamide adenine dinucleotide (NADH, λex = 340 nm, λem = 490 nm). In the reaction, NADH is oxidized when acetone is reduced to 2-propanol by S-ADH, and the acetone concentration can be measured by detecting the amount of NADH consumed in this reaction. First, we constructed a compact and light-weight fluorometric NADH detection system (209 g for the sensing system and 342 g for the PC), which worked using battery power. Then, sensor characteristics were evaluated after optimization of the working conditions. The developed system was able to quantify acetone in a range of 510 nM-1 mM within 1 minute. The developed battery-operated acetone biosensor demonstrated its ability to measure the acetone concentration in the exhaled breath condensate of 10 healthy subjects at rest (23.4 ± 15.1 μM) and after 16 h of fasting (37.7 ± 14.7 μM) and it distinguished the results with significant differences (p = 0.011). With the advantages of handheld portability, and high levels of sensitivity and selectivity, this sensor is expected to be widely used in clinical diagnosis and wearable biochemical sensors in the future.

Home Respiratory Polygraphy to Detect Obstructive Sleep Apnea Syndrome after Supracricoid Partial Laryngectomy.

Introduction Supracricoid partial laryngectomy is a surgical treatment for advanced laryngeal cancer which is implemented to preserve organ function, but it may cause obstructive sleep apnea syndrome (OSAS) due to anatomical changes after surgery that may be neglected by clinicians. Although the gold standard for the diagnosis of OSAS is polysomnography, respiratory polygraphy is an alternative valid method with a high level of diagnostic sensitivity and specificity; since the equipment is portable, it can be used at home, with no need for hospitalization. Objective To describe the polygraphy result of patients submitted to supracricoid partial laryngectomy. Methods The present study included 13 patients, and we collected data on age, date of the surgery, body mass index, cardiovascular risk factors, Epworth score, and apnea-hypopnea index (AHI). Results The 13 patients were all male, with a mean age of 62 years. As for the AHI, one patient was classified as severe, six, as moderate, and three patients, as mild; moreover, 3 patients were simple snorers. While 77% of the sample presented OSAS, only 23% presented symptoms of drowsiness. Conclusion The study group, who underwent supracricoid partial laryngectomy, did not present self-reported symptoms of OSAS. Nevertheless, polygraphy was a useful tool in this group, and we recommend its systematic use after decannulation to avoid leaving OSAS undiagnosed. Level of evidence 4; case series study.

Using routinely available electronic health record data elements to develop and validate a digital divide risk score.

Digital health (patient portals, remote monitoring devices, video visits) is a routine part of health care, though the digital divide may affect access. To test and validate an electronic health record (EHR) screening tool to identify patients at risk of the digital divide. We conducted a retrospective EHR data extraction and cross-sectional survey of participants within 1 health care system. We identified 4 potential digital divide markers from the EHR: (1) mobile phone number, (2) email address, (3) active patient portal, and (4) >2 patient portal logins in the last year. We mailed surveys to patients at higher risk (missing all 4 markers), intermediate risk (missing 1-3 markers), or lower risk (missing no markers). Combining EHR and survey data, we summarized the markers into risk scores and evaluated its association with patients' report of lack of Internet access. Then, we assessed the association of EHR markers and eHealth Literacy Scale survey outcomes. A total of 249 patients (39.4%) completed the survey (53%>65 years, 51% female, 50% minority race, 55% rural/small town residents, 46% private insurance, 45% Medicare). Individually, the 4 EHR markers had high sensitivity (range 81%-95%) and specificity (range 65%-79%) compared with survey responses. The EHR marker-based score (high risk, intermediate risk, low risk) predicted absence of Internet access (receiver operator characteristics c-statistic=0.77). Mean digital health literacy scores significantly decreased as her marker digital divide risk increased (P <.001). Each of the four EHR markers (Cell phone, email address, patient portal active, and patient portal actively used) compared with self-report yielded high levels of sensitivity, specificity, and overall accuracy. Using these markers, health care systems could target interventions and implementation strategies to support equitable patient access to digital health.

Опыт зарубежных исследований в области акустических архитектурных решений в школах для детей с аутизмом

Nowadays, teaching children with autism in secondary schools is a new practice for Russia. Its implementation requires special knowledge and skills from all involved specialists. It also requires special architectural and design practices at all construction stages: from the project to the object itself. After competent planning decisions, the most important element is acoustic comfort in speech therapy and other rooms for inclusive purposes. Students with special educational needs, including autism, have a high level of sensitivity to noise with strong tonal, impulsive, or intermittent characteristics. A correct controlled acoustic environment is necessary to preserve the normotypic behavior of students with autism in the schools. Indeed, we should consider their needs when performing functional zoning and avoid artificial formation of a quiet environment for the learning process. Hence, generalising communication skills in an acoustically unchanged environment will ensure maximum students’ integration into social interactions both inside and outside the school.

Synthesis of triclosan-derived coumarins as potent, biocompatible, broad-spectrum antimicrobial agents

Objective: Various personal care products previously used triclosan, a chlorinated antimicrobial agent. However, safety and environmental concerns have grown, forbidding its application. Given this fact, the present work aims to repurpose this out-of-use chemical by including it as a precursor for synthesizing nineteen triclosan-based coumarins (TBCs). Methods: The spectrophotometric methods applied to confirm the chemical structures of TBCs were FTIR, 1H-NMR, 13C-NMR, and HRMS. The antimicrobial investigations were run through using broth microdilution methodology and many pathogenic microbes. These include six aerobic and four anaerobic ATCC-approved bacterial strains, as well as two fungal strains. We validated the results by comparing them with three standards: ciprofloxacin, metronidazole, and nystatin, which were based on the tested microbe. On the other hand, the biocompatibility investigations determined the ability of TBCs to inhibit the normal growth of three microbiome strains. Results: The results revealed several conclusive points, including the bactericidal impact of the synthesized TBCs on both pathogenic and microbiome strains tested, with low and high MIC values, respectively. The impact of the synthesized TBCs on pathogenic bacteria was dependent on the number and type of substitutes on the D ring, but this was not the case for microbiome bacteria, where these two factors were of low importance. These factors also influence the activity of the synthesized TBCs against pathogenic fungi. The latter microbes exhibit a high level of sensitivity to the synthetic intermediate, which contains a carboxylic acid moiety within its structure. We concluded from these findings that the number of chlorides that deactivated the D ring directly promoted the anti-aerobic bacterial activity. The same holds true for the anti-anaerobic bacteria, albeit with the addition of nitro groups. Conclusion: the results could provide insights into how the structure of the synthesized TBCs influences their antimicrobial activity. This renders them highly promising as potential future medicines that are robust, safe, and effective against a broad spectrum of microbes.

Pay-for-performance and corporate R&D

ABSTRACT We examine the association between CEO pay-performance sensitivity and innovation activity. We find that pay-performance sensitivity positively influences the investment in knowledge capital, but a too high level of pay-performance sensitivity is detrimental to investment in knowledge capital. At high pay-for-performance, managers will likely focus more on the current earnings to sustain the firm’s stock price, consistent with managerial myopia. We find evidence of incentive alignment at low pay-performance sensitivity, such that R&D investment increases in pay-performance sensitivity. We find an inverted U-shaped relation between management pay-performance sensitivity and R&D investment. Our findings suggest that a lower pay-for-performance gives the managers a greater tolerance for failure such that management pay fluctuates less with the stock return volatility, boosting the firm’s innovation activity.

Role of Psychological Factors in Migraine.

Migraine, marked by moderate to severe headaches, is frequently accompanied by reversible neurological symptoms. Recent studies have revealed a complex and significant relationship between psychological factors and the onset and progression of migraine. Personality traits, such as neuroticism and harm avoidance, play a crucial role in the development, progression, and treatment outcomes of migraines. Migraine patients often experience comorbid mental health conditions, such as depression and anxiety, which contribute to a diminished quality of life by exacerbating migraine-related disability and impaired occupational functioning. In particular, high levels of pain catastrophizing and anxiety sensitivity in migraine sufferers reflect their negative cognitive beliefs, which are closely linked to both their personality traits and vulnerability to mental disorders. This article explores the pathophysiological mechanisms underlying the relationship between migraine and psychological factors, including genetic influences, overlapping brain regions, 5-hydroxytryptamine (5-HT) dysfunction, and neurogenic inflammation. While traditional pharmacological treatments for migraine are often influenced by psychological factors and may have limited efficacy, psychotherapy, such as cognitive behavioral therapy and positive thinking therapy, has been increasingly recognized for its role in alleviating the psychological symptoms associated with migraine and enhancing overall therapeutic outcomes.

Spatiotemporal Mapping of Lymphatic Metastases in Gastric Cancer Using Tumor-Trackable and Enzyme-Activatable Near-Infrared Fluorescent Nanoprobes.

Sentinel lymph node biopsy holds significant importance in cancer management, yet the challenge persists in early detection and precise resection of metastasis lymph nodes (LNs) due to the absence of specific and sensitive optical probes. This study reports metastatic LN reporters (MLRs) with an activatable optical output for accurate spatiotemporal mapping of lymphatic metastases in gastric cancer. MLRs are self-assembled entities incorporating mixed amphiphiles with a lipophilic tail and a tumor-targeting ligand or a fluorescent moiety that is caged with a switch cleavable by tumor-specific β-galactosidase (β-Gal). After draining into LNs, MLRs selectively activate their near-infrared fluorescence in the presence of spreading tumor cells. In orthotopic gastric cancer mouse models, the representative reporter MLR1 distinguishes macro/micrometastatic LNs from benign LNs and enables early detection of skip LNs metastasis patterns in a spatial-dependent manner. Such an active sensing mechanism provides a high level of sensitivity and specificity comparable to those of flow cytometry analysis. In surgically resected patient specimens, MLR1 differentiates cancerous tissues and metastatic LNs from normal tissues and benign LNs within 1 h. This study thus presents NIRF nanoprobes that permit facile detection of LN metastases in GC patient samples and highlights a generic translatable nanoprobe design for understanding metastatic progression.

Distribution of values of indicators of minimum suppressive concentrations of antibiotics in relation to gram-negative bacterial strains isolated from cystic fibrosis

Introduction. Cystic fibrosis is a severe chronic genetic disease, in which the microbiological status of the patient plays an important role, because it will determine the severity of the respiratory infection. In recent years, representatives of non-fermenting gram-negative bacteria (NFGNB) - P. aeruginosa, B. cenocepacia, Axylosoxidans; as well as representatives of the order Flavobacteriales - have become of great clinical importance in patients with cystic fibrosis. A feature of some representatives of NFGNB is the formation of resistance to antibacterial drugs, due to prolonged antimicrobial therapy. In addition to the acquired, there is a high level of natural resistance, and therefore the possibilities of using antibacterial drugs are significantly limited.Aim. To estimate the distribution of the values of the minimum suppressive concentrations (MSC) of cefepim / sulbactam, piperacillin / tazobactam, biapenem in relation to 100 strains of Gram-negative bacteria isolated from respiratory samples from patients with cystic fibrosis.Materials and methods. To date, new compounds have appeared with potential activity against the strains under consideration - cefepim / sulbactam, piperacillin / tazobactam, biapenem. We selected 100 bacterial strains isolated from respiratory samples from patients with cystic fibrosis from various regions of the Russian Federation. Among them, 69 strains are Pseudomonas aeruginosa, 6 - Achromobacter xylosoxidans, 14 - Burkholderia cenocepacia, 10 - Chryseobacterium spp., 1 - Elizabethkingia miricola. MSC values were determined for 3 antimicrobial drugs: cefepim / sulbactam, piperacillin / tazobactam, biapenem.Results and discussions. According to the data obtained, it was found that most strains of Pseudomonas aeruginosa, Achromobacter xylosoxidans have a high level of sensitivity to cefepim/sulbactam, piperacillin/tazobactam. The criteria for evaluating the MSC indicators of the studied drugs in relation to Burkholderia cenocepacia and representatives of the order Flavobacteriales have not been determined, however, it is worth noting that most isolates have demonstrated an achievable value of MSC indicators. This suggests the possibility of practical application of antimicrobial drugs under test.Conclusions. The data obtained indicate the microbiological efficacy of the drugs: cefepim/sulbactam, piperacillin/tazobactam, biapenem relative to NFGNB isolated from patients with cystic fibrosis.

The effects of buy now, pay later (BNPL) on customers’ online purchase behavior

The effects of buy now, pay later (BNPL) on customers’ online purchase behavior

A hydrogel film microarray stabilizes very short structure switching aptamer duplexes to achieve enhanced sensing of small molecules

A hydrogel film microarray stabilizes very short structure switching aptamer duplexes to achieve enhanced sensing of small molecules

TEACHERS’ PERCEPTIONS OF SOCIAL JUSTICE IN EDUCATION AND SELF-EFFICACY ON IMPLEMENTATION OF INCLUSIVE PRACTICES

Social justice in education refers to the commitment of schools to safeguard the rights of all students, to combat discrimination and inequality, and to provide equitable opportunities in an inclusive environment. The purpose of the study was to explore the correlation between teachers' perceptions of social justice and their self-efficacy in promoting and implementing effective inclusion of all students with disabilities. In addition, the study investigated whether demographic factors and teachers' professional profiles influence their attitudes about social justice and teaching self-efficacy. The research sample comprised of 172 primary and secondary school teachers. For the purposes of the study, the (a) Social Justice Scale - SJS (Torres-Harding, Siers &amp;amp; Olson, 2012), (b) Teaching Students with Disability Efficacy-TSDES (Dawson &amp;amp; Scott, 2013) were utilized. The study concluded that teachers demonstrate positive attitudes towards the implementation of social justice in the educational process. Educators with high levels of social sensitivity demonstrated greater ability to support children with disabilities as well as optimal guidance of all students to facilitate inclusion, and simultaneously, demonstrated greater professionalism in implementing this policy. It also emerged that female educators had more positive attitudes and showed greater sensitivity regarding the importance of implementing social justice, while younger teachers appear to be overall more positive compared to older teachers. The most important factor that influences perceptions and attitudes on social justice is specialized studies in special education. Spearman correlation coefficient showed a strong positive correlation between the positive attitudes of teachers towards social justice and their teaching self-efficacy. Linear regression analysis, showed that perceived social behavioral control and the intention of future social justice implementation are firmly indicative of high effectiveness in effectively promoting and implementing behavioral practices. The study highlights the importance for educational institutions to incorporate social justice education into curricula and promote the use of equitable and effective educational practices to address inequities.&lt;p&gt; &lt;/p&gt;&lt;p&gt;&lt;strong&gt; Article visualizations:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;img src="/-counters-/soc/0295/a.php" alt="Hit counter" /&gt;&lt;/p&gt;

Correlation between ethical sensitivity and humanistic care ability among undergraduate nursing students: a cross-sectional study

BackgroundIn nursing practice, a high level of ethical sensitivity and humanistic care ability must always be maintained. A limited number of studies have investigated the correlation between the level of ethical sensitivity and humanistic care ability of nursing students.MethodsA survey study was conducted from November 2023 to January 2024 among 656 undergraduate nursing students using the General Information Questionnaire, Ethical Sensitivity Questionnaire For Nursing Students, and Humanistic Care Ability Inventory.ResultsThe total ethical sensitivity score of nursing students (36.01 ± 6.31) was positively correlated with the total humanistic care ability score (r = 0.426, P < 0.01), and the results of the multivariate linear regression analysis showed that grade, relationship with parents, liking of the nursing major, willingness to work in nursing, experiences in learning nursing ethics, experience of caring for patients, and humanistic care ability are the main influencing factors of nursing students’ ethical sensitivity.ConclusionThe ethical sensitivity of undergraduate nursing students is at a moderate level, which shows a moderate and significant correlation with their humanistic care ability. College nursing educators and administrators should focus on integrating humanistic care ability education while increasing ethical education to cultivate excellent nursing students with comprehensive abilities.