Hb Levels Research Articles

Impact of Hemoglobin Level, White Blood Cell Count, Renal Dysfunction, and Staphylococcus as the Causative Organism on Prediction of In-Hospital Mortality from Infective Endocarditis.

Infective endocarditis (IE) is a highly fatal disease in cases of delayed diagnosis and treatment, although its incidence is low. However, there have been few single-center studies in which the risk of in-hospital death from IE was stratified according to laboratory findings on admission and the organism responsible for IE. In this study, a total of 162 patients who were admitted to our hospital during the period from 2009 to 2021, who were suspected of having IE according to the modified Duke classification, and for whom IE was confirmed by transesophageal echocardiography were retrospectively analyzed. Patients were observed for a mean-period of 43.7 days with the primary endpoint being in-hospital death. The in-hospital death group had a lower level of hemoglobin (Hb), higher white blood cell (WBC) count, lower level of estimated glomerular filtration rate (eGFR), and higher frequency of Staphylococcus being the causative agent than those in the non-in-hospital death group. In overall multivariate analysis, Hb, WBC count, eGFR, and Staphylococcus as the causative agent were identified to be significant prognostic determinants. IE patients with Hb < 10.6 g/dL, WBC count > 1.4 × 104/μL, eGFR < 28.1 mL/minute/1.7 m2, and Staphylococcus as the causative agent had significantly and synergistically increased in-hospital death rates compared to those in other IE patients. Low level of Hb, high WBC count, low eGFR, and Staphylococcus as the causative agent of IE were independent predictors of in-hospital mortality, suggesting that these 4 parameters may be combined to additively stratify the risk of in-hospital mortality.

The epidemiology of gestational diabetes, gestation hypertension, and anemia in North Palestine from 2018 to 2020: A retrospective study.

In Palestine, women face a challenging environment and a demanding lifestyle, which puts them at a higher risk of experiencing complications during pregnancy. This study aimed to examine the risk factors linked with abnormal hemoglobin (Hb) levels, gestational diabetes (GD), and gestational hypertension (GH) among pregnant women. The results was compared between women residing in cities or villages areas and those in refugee camps. Medical records (N = 7889) for pregnant women at primary healthcare centers in the North West Bank were reviewed for sociodemographic and medical data along with the reported fasting blood sugar, hemoglobin, and blood pressure in the first and second trimesters from July 2018 to July 2020. However, only 6640 were included in the analysis as 1249 were excluded for having multiple pregnancy or lost to follow up. Complications and risk factors were defined according to the available global guidelines. Then, descriptive analysis was used to show the percentages of different risk factors and complications among them. The correlation between the several characteristics and variables with these complications was assessed by calculating the odds ratios (OR) using logistic regression. P-values of <0.05 were considered significant. The prevalence of adolescent pregnancy was the highest among women living in rural areas (9.8%) and grand multigravidity among refugee women (22%). The overall prevalence of anemia was higher in the second-trimester (16.2%) than in the first-trimester (11.2%), with anemic women in the first-trimester being more likely to be anemic in the second-trimester (OR = 8.223, P-value<0.001). Although anemia was less common in the first-trimester among refugees than among women living in urban areas (OR = 0.768, P-value = 0.006), it was more prevalent in the second-trimester (OR = 1.352, P-value<0.001). Moreover, refugee women were at lower risk than women living in urban areas of having GD (OR = 0.687, P-value<0.001) and diabetes mellitus (OR = 0.472, P-value<0.001) in the second-trimester. GH was associated with GD (OR = 1.401, P-value = 0.003) and DM (OR = 1.966, P-value<0.001). The findings of this study provide evidence-based data on the considerable prevalence of pregnancy complications, anemia, GD, and GH among Palestinian pregnant women living in the north of the West Bank. Multi gravida, gestational age, Hb levels, and the type of settings were strong predictors of pregnancy complications. Therefore, a national plan is needed to ensure adequate maternal care for all, especially disadvantaged women, those in rural areas and refugee camps.

Relationship between Food and Iron Intake and Hemoglobin Levels among Medical Students: A Cross-sectional Study at Indonesian Christian University, Class of 2021

Background: Lack of protein intake will result in hampered iron transport and reduce the formation of hemoglobin (Hb). Hemoglobin is a protein compound found in red blood cells and is useful for transporting oxygen (O2) and carbon dioxide CO2 in the body. The level of protein consumption is closely related to hemoglobin, where the protein binds to iron in the body. If iron intake is lacking, it can cause red blood cell production to be disrupted and cause anemia. The world's population with anemia is around 30% or 2.20 billion people and the global prevalence of anemia is around 51%. This study was conducted to determine the relationship between iron intake and hemoglobin (Hb) levels. Aims: This research was conducted to determine the relationship between food or iron intake and hemoglobin (Hb) levels. Methodology: This research uses a descriptive-analytical research design with a cross-sectional approach and uses primary data as a research instrument, which was obtained from the results of blood sampling from students from the Faculty of Medicine, Indonesian Christian University Class of 2021 for laboratory examination using the Hematology Analyzer method and a 2x24 hour Food Recall form. The purposive sampling method was used to obtain 72 samples in this study. Results: The study showed 59 students (81.9%) were not anemic, and 13 (18.1%) were anemic. A total of 12 students (16.7%) had a low iron adequacy score, and 60 students (83.3%) had a sufficient iron adequacy score. There is a relationship between food/iron intake and hemoglobin levels (p &lt; 0.05). Conclusion: there is a significant relationship between iron intake and hemoglobin levels.

The Effects Of Acute Kidney Injury On The Outcomes Of Patients With Gastrointestinal Bleeding

Objective: To determine the clinical outcomes of patients with acute kidney injury in patients with upper gastrointestinal bleeding (UGIB), as it is a very frequently encountered condition with high morbidity and treatment costs. We aimed to study the differences in clinical outcomes in patients with UGIB who developed acute kidney injury (AKI) and those who did not. Methods: This cross-sectional study was conducted between Jan 1 and Jun 30, 2023, at a private hospital in Karachi. 200 cases with upper gastrointestinal bleeding were recruited by non-probability sampling after participant assent. 100 patients comprised the acute kidney injury (AKI group) and 100 patients were without AKI. Participants documented age, gender, and co-morbidities in a self-structured questionnaire. Clinical outcomes i.e. hypoalbuminemia, hospital stay and mortality were evaluated and compared. Results: Mean age was 45.03+9.17 years in AKI group and 45.57+9.31 years in without AKI, p-value=0.680, albumin levels in AKI was 2.74+0.43 and without AKI 3.18+0.31, p-value=0.00, Hb level in AKI group was 9.07+0.83 and without AKI 9.54+1.04, p-value=0.001, mean hospital stay in AKI group was 5.21+1.00 and without AKI group 4.20+0.96 days, p-value=0.000. A comparison of the two groups regarding gender and clinical outcome shows that 58 (58%) in AKI and 56%(56) without AKI were male whereas 42 (42%) in AKI and 44 (44%) without AKI were females, mortality in AKI group was 27(27%) and in without AKI group 8(8%) cases, p-value=0.000. Conclusion: We concluded that the rate of clinical outcome in terms of hospital stay, hypoalbuminemia and mortality was adverse in upper gastrointestinal bleeding with AKI than those without AKI. Keywords: Acute kidney injury, gastrointestinal bleeding, clinical outcome.

Efficacy of Drumstick Tree (Moringa oleifera) Leaves Powder on Lipid Profile and Hematological Indices in Chickens on a High Fat Diet

Moringa oleifera belongs to the Moringaceae family and genus Moringa. Moringa oleifera has many beneficial pharmaceutical and nutritional properties. The present study aimed to investigate the effects of dietary supplements of Moringa oleifera leaves powder after consumption of a high-fat diet on cholesterol TG, HDL, LDL, VLDL and hematological parameters such as Hb, MCV, MCH, MCHC, PCV, RBCs, WBCs, PLT neutrophil, heterophil and lymphocytes count in chicks. Golden Misri Chickens were divided into 4 groups: Group 1 (the Control group) was given Feed-13. Group 2 (Experimental Group) was given Feed-13 and mustard oil (high-fat diet) Group 3 (experimental Group) was given Feed-13 + mustard oil and 1.5% Moringa oleifera leaves powder. Group 4 (experimental Group) was given Feed-13 and 1.5% of Moringa oleifera leaves powder for four weeks. The results of the current study showed a significant (p &lt; 0.05) increase in body weight in Experimental Group 3. Experimental group 3 showed a significant increase in levels of HDL, TG, RBCs, and Hb, while significantly decreased (p &gt; 0.05) in LDL, TLC, WBCs, MCHC, MCV, MCH, TC, TP, Monocytes count, neutrophil count, and platelet counts. Moringa oleifera supplementation showed a significant reduction in cholesterol, LDL, and TC levels. The findings of this study demonstrated that powdered Moringa oleifera is a beneficial and effective dietary supplement that increases HDL, TG, Hb, and RBCs, and decreases cholesterol levels.

MENSTRUAL CYCLE AND THE INCIDENT OF ANEMIA IN TEENAGE WOMEN

The prevalence of anaemia in Indonesia is still high, especially in adolescent girls. This is due to nutritional status, stress levels, knowledge and menstrual disorders. Menstrual disorders are related to the cycle or duration of menstruation or the amount of blood that comes out. The impact that occurs adolescents will feel weak, tired, lethargic, difficult to concentrate and for the long term related to fertility, and there is a possibility to deliver baby with weight and premature birth. The purpose of the study was to determine the relationship between the menstrual cycle and the incidence of anaemia in adolescent girls. Correlational descriptive research method with cross sectional approach. The sample was 68 respondents with total sampling. Data were collected through questionnaires in the form of fill-in sheets for menstrual cycles and anemia using easy touch to determine Hb levels. The results showed that respondents who experienced a normal cycle as many as 41 respondents (60.3%), 16 respondents (23.5%) experienced a long cycle and as many as 11 respondents (16.2%) experienced a short cycle. Respondents who experienced anemia as many as 36 respondents (52.9%) and did not have anemia as many as 32 respondents (47.1%). The results of the statistical test obtained a ρ value of 0.000. The conclusion of this study is that there is a relationship between the menstrual cycle and the incidence of anemia in adolescent girls. It is recommended for the nursing profession to provide information through health counseling in collaboration with the community and schools about anemia and its causative factors to improve the health status of adolescent girls

Insight into antiphospholipid syndrome: the role and clinical utility of neutrophils extracellular traps formation

Antiphospholipid syndrome (APLS) is a systemic immune dysregulation distinguished by repetitive complications and pregnancy loss in the absence of definite etiology. Most research focuses on the laboratory detection and clinical features of APLS, but its precise etiology remains to be deeply explored. NETosis is a newly developed theory in the pathophysiology of APLS which may serve as the missing bridge between coagulation and inflammation reaching the disease progression and severity. We aimed in this study to navigate the prognostic role of NETosis in thrombotic APLS. Our study included 49 newly diagnosed APLS patients (both 1ry and 2ry) who met clinical and laboratory criteria as per the international consensus statement on the update of the classification criteria for definite APLS and were sub-classified according to the occurrence of thrombotic events in thrombotic and non-thrombotic types. In addition, 20 sex and age-matched reactive subjects and 20 sex and age-matched healthy volunteer controls were enrolled. NETosis formation was assessed by measuring serum Myeloperoxidase (MPO) and Histones level using the enzyme-linked immunosorbent assay (ELISA) technique. Both MPO and Histones levels were able to discriminate among APLS cases from normal controls, showing significant cutoffs of > 2.09 ng/ml for MPO and > 1.45 ng/ml for Histones (AUC values were 0.987and 1.000, respectively). These values can be used as predictors for NETosis pathophysiology in APLS patients. Additionally, these markers demonstrated a significant association with several prognostic indicators, including thrombosis, higher PT and INR, and lower hemoglobin (Hb) levels which are supposed to be ameliorated by using NETs inhibitors. In conclusion, we suggest that measuring NETosis markers, MPO, and Histones, in the early course of APLS using proposed cutoff values will facilitate the timely initiation of anti-NETosis therapy and improve the overall prognosis, particularly for patients with thrombotic APLS.

Hematological parameters of sheep and goats fed diets containing various amounts of water hyacinth (Eichhornia crassipes).

A major global barrier to increased animal output is nutrition. The use of aquatic plants, which were previously considered to be waste and needed a lot of labor to eliminate, has recently come to light due to the lack of feed during the dry season in the majority of tropical regions of Africa. The objectives of this study were therefore to see how different dietary Eichhornia crassipise inclusion rates affect the hematological indicators of Ethiopian Doyogena sheep and Woyto-Guji goats. Blood samples were taken from the jugular veins of 12 Doyogena sheep and 12 Woyto-Guji goats in a 2 × 4 randomized crossover design with two animal species, four diets, and four random periods (15 - day adaption period followed by a 7- day experimental diet in each period). The dietary inclusion rates E. crassipise were 0, 25, 50, and 75% that was used as a replacement for commercial concentrate mix diet in the treatment groups. The data was analyzed using the SAS software programme PROC GLM, and Pearson's correlation coefficient was calculated between hematological markers. The hemoglobin (Hb), red blood cell count (RBC), packed cell volume (PCV), mean corpuscular volume (MCH), and mean corpuscular hemoglobin (MCHC) results revealed substantial, RDW-SD, and WBC differences between animal species (P < 0.001). Sheep had greater WBC, Hb, RBC, PCV, RDW-SD, and RDW-CV levels, while goats had higher MCH and MCHC values (P < 0.001). For the analyzed hematological measures, the Pearson's correlation coefficient ranged from low to strong in terms of positive and negative associations (P < 0.05). Since all hematological indicators were closer to those of clinically healthy native Ethiopian sheep and goat breeds, feeding water hyacinth to sheep and goats up to a 75% inclusion level in diets without producing sickness may provide a remedy for adverse feed shortages.

An Assessment of the Nutritional Status and its Predictors amongst Women in a Rural Community of Dharwad Taluk, Karnataka, India

The connection between food insecurity and health is becoming more widely acknowledged, as it plays a major role in the onset and advancement of non-communicable illnesses. The family's overall well-being and health are directly impacted by the health status of the female. Rural women play a dominant role in the country’s economy and their nutritional status has direct bearing on the whole family. Hence the present study was conducted with the objective to assess nutritional status and to identify the predictors of poor nutrition among rural women of Dharwad taluk, Karnataka. The sample of the study included 500 rural women in the age group of 16-80 years. A self structured questionnaire, SES Agarwal 2005, Anthropometric measurements were used to assess BMI, Hb level, knowledge level and morbidity status. More than one third of the rural women were selected were in the age group of 40-80 years, were illiterates and involved in agriculture. Majority belong to social tribes and staying in nuclear families. Two third of the selected rural womenconsume non-vegetarian food. More than half of the families belonged to upper middle socio economic status. Majority of them had health related problems and were in mild to moderate anemia category. Low SES, low nutritional knowledge, non working status, morbidity condition, middle age group, anemia status and poor protein diet were found to be the risk factors of poor nutritional status among rural women. Low SES was found to be 2.6 times riskier; anemia condition was 4.68 times risk when compared to normal Hemoglobin level.

Parasitological and serological detection of Trypanosoma evansi on Bali cattle at the Pesanggaran slaughterhouse, Denpasar, Indonesia using hematological profile

Abstract. Apsari IAP, Suratma NA, Swacita IBN, Soma IG, Sari TK, Putra IPC, Sudipa PH. 2024. Parasitological and serological detection of Trypanosoma evansi on Bali cattle at the Pesanggaran slaughterhouse, Denpasar, Indonesia using hematological profile. Biodiversitas 25: 1057-1062. Bali cattle (Bos sondaicus Blyth, 1842 syn. Bos javanicus domesticus Wilckens, 1905) are vulnerable to blood protozoan infections like Trypanosoma evansi. Indonesia's warm and moist environment provides ideal conditions for blood-sucking flies such as Stomoxys calcitrans, Haematobia irritans, and Hipobosca sp. to thrive and spread. These flies act as carriers of T. evansi, which can then infect Bali cattle. This study aims to detect the presence of T. evansi in Bali cattle. Blood samples were collected from 275 Bali cattle at the Pesanggaran slaughterhouse, Denpasar City, Bali, Indonesia. The samples were examined using the Giemsa-Staining Blood Smear (GSBS) method and hematology profile examination using Hematology Analyzer RT-7600 for Vet. Serum samples were also collected for serologic examination using the Card Agglutination Test for Trypanosomiasis (CATT) method. The hematological profile data obtained were analyzed descriptively, and the Mann-Whitney U test was used to determine the significance of hematological values between female and male cattle seropositive to T. evansi. The results showed that the T. evansi parasite was not detected in the blood smear examination. However, the serological detection with CATT revealed that 6.54% (18/275) of Bali cattle were positive for T. evansi. The hematological profiles of T. evansi seropositive cattle remained within the normal range, except for neutrophil percentage. White Blood Cell (WBC), Hemoglobin (Hb) levels, and hematocrit (PCV) values of male cattle were significantly (P?0.05) lower than those of females. Therefore, based on serological examination, it can be concluded that the protozoa T. evansi is present in 6.54% of Bali cattle at the Pesanggaran slaughterhouse.

Adjusting Current Hemoglobin Thresholds: A Way to Improve Outcome in Women Undergoing Major Surgery.

Background/Objective: In the perioperative setting, a suboptimal total hemoglobin (Hb) mass puts women and men at an unreasonable disadvantage. Anemia is an independent risk factor for transfusion, postoperative complications, and mortality. The Hb cut-off value for women was set at <12.0 g/dL by the World Health Organization (WHO) and has been rigorously debated for decades. The aim of this study was to elucidate the risk for postoperative complications in female patients with Hb levels < 12.0, 12.0-12.9, and ≥13.0 g/dL. Material and Methods: Single-center retrospective analysis of female patients undergoing major surgery. Results: In total, 6,516 patients ≥18 years of age had major surgery between 2018 and 2019 and 2,446 female patients were included in analysis. Mean age was 67.4 ± 16.6, 66.4 ± 15.6, and 64.5 ± 15.5 years in female patients with preoperative Hb levels <12.0, 12.0-12.9 and ≥13.0 g/dL, respectively. The transfusion rate of red blood cells (RBCs) was significantly higher in female patients with Hb <12.0 g/dL (53%) and with Hb 12.0-12.9 g/dL (31%) compared to female patients ≥13.0 g/dL (22%). Rates of pneumonia, acute kidney injury, and sepsis were significantly higher in patients with Hb <12.0 and 12.0-12.9 g/dL compared to patients with Hb ≥13.0 g/dL. Total length of hospital stay was significantly longer in female patients with Hb <12.0 g/dL than patients with Hb 12.0-12.9 g/dL and Hb ≥13.0 g/dL (10 days vs. 8 days). Conclusion: Taken together, our data show that Hb values below 12.9 g/dL are associated with increased probability of RBC transfusions and increased risk of postoperative complications. In addition, our results indicate that postoperative outcomes for women might be optimized by increasing cut-off values for anemia. The call to revise the anemia threshold for women by the WHO can no longer be disregarded.

Erythrocyte and iron profiles in soil-transmitted helminth-infected children in a rural area in Banten, Indonesia

BACKGROUND Soil-transmitted helminth (STH) infection, frequently caused by Ascaris lumbricoides, Trichuris trichiura, and hookworms (Ancylostoma duodenale and Necator americanus), often gives rise to malabsorption of nutrients that form hemoglobin (Hb) thereby causing anemia. This study aimed to know the difference in erythrocyte profile in children with and without STH infections. METHODS This cross-sectional study involved 205 children from two Panimbang Jaya elementary schools in Pandeglang, Banten, Indonesia. Blood and stool samples were collected from a previous study conducted from November 2021 to May 2022. Erythrocyte parameters were Hb concentration, erythrocyte count, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and red cell distribution width (RDW). The iron profile included serum iron, total iron-biding capacity (TIBC), and ferritin. Worm infestation was detected by direct stool microscopical examination. Statistical analysis was performed using SPSS software version 20. RESULTS The prevalence of STH infection in Pandeglang was 44.4%, primarily characterized by mild intensity STH infection (79%). The identified STH species were A. lumbricoides, T. trichiura, and combination of both. The median differences between erythrocyte count, MCV, and MCH, and the mean differences of TIBC and serum iron were not statistically significant (p = 0.388, 0.098, and 0.057, and p = 0.304 and 0.455). However, children with STH infection had lower Hb (12.57 versus 12.95 g/dl) and ferritin (19.60 versus 30.57 µg/dl) levels but higher RDW (13.20 versus 13.10%). CONCLUSIONS A high prevalence of STH infection was identified among schoolchildren, but their erythrocyte profiles were similar regardless of STH infection status.

Investigation Few Biomarkers for Pantoea Infection with Systemic Lupus Erythematosus Patients

Background: Systemic lupus erythematosus (SLE) is a disease known as systemic lupus erythematosus. SLE is an autoimmune condition in which the immune system attacks the body’s own tissues, leading to extensive tissue damage and inflammation in other organs. One of the most frequent causes of death and morbidity in SLE patients is infection. Patients with SLE may contract a genus of gram-negative bacteria called Pantoea. This study aims to find biomarkers for Pantoea infection in SLE patients in Iraq’s Najaf Governorate. Methods: About 60 individuals with systemic lupus erythematosus from Al-Sader Medical City in Al-Najaf Province had blood samples taken at a specialized rheumatology and nephrology center between September 2022 and February 2023. Some bio-markers has been evaluated. Results: The results of microbiological analyses indicate that 26/60 samples contain bacteria. Pantoea was discovered in 3 (11.6%) of the 26 specimens. Despite SLE, increased autoantibody levels in patients. The results of this analysis indicate a significant decrease in Hb, WBC, and platelet levels. In contrast to the control group, the serum levels of CD69, IL-21, and IL-35 increased significantly. Conclusion: Pantoea produces elevated diagnostic and immunological parameters in SLE patients. Consequently, it is necessary to conduct assays to identify bacterial infections in patients, with a significant increase in CD69, IL-21, and IL-35 in the event that SLE patients are infected with bacteria.

A Cross-Sectional Study on The Prevalence of Anemia in Maintenance Hemodialysis and Peritoneal Dialysis Patients and Its Related Factors

Objective: To study the prevalence of anemia, the proportion of hemoglobin (Hb) levels, the treatment methods, and the influencing factors of Hb levels in maintenance hemodialysis (MHD) and peritoneal dialysis patients. Methods: In this study, 602 patients with maintenance hemodialysis and continuous ambulatory peritoneal dialysis were enrolled from December 2020 to December 2022 in our hospital, and their medical records were collected and summarized. The main contents included the patient’s gender, age, primary disease, dialysis duration, dialysis method, the use of erythropoietic stimulating agents (ESA), intravenous iron, and laboratory tests. A Hb index exceeding 110 g/L was set as the standard for the prevalence of anemia. Results: The rate of anemia in patients undergoing blood purification was 83%. The proportion of ESA use was 84.1%, and the proportion of iron use was 76.7%, of which the proportion of intravenous iron used was 17.0%, and the proportion of folic acid used was 28.3%. Conclusion: The incidence of anemia in MHD patients was relatively high, with a low proportion of patients reaching the standard Hb levels. Risk factors include albumin (ALB) levels, iron storage, white blood cells, C-reactive protein, cholesterol, etc. Nutritional support, iron supplementation, and prevention of micro-inflammatory reactions can effectively promote the improvement of Hb indicators in dialysis patients to prevent anemia.

The impact of inflammatory biomarkers on amputation rates in patients with diabetic foot ulcers.

Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non-amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Statistical analyses were performed using independent sample t-tests, Mann-Whitney U test and logistic regression. The univariate analysis showed no significant difference in BMI, DM duration or DFU duration between groups. However, significant differences were noted in PCT, Hb, ESR, ALB, HbA1c and WBC levels, and in inflammatory ratios (NLR, PLR and LMR). Multivariate logistic regression identified CRP, NLR and PLR as independent risk factors for amputation. The study highlights CRP, PLR and NLR as key independent risk factors for amputation in patients with DFUs. These easily obtainable markers from routine blood tests can effectively aid in predicting the risk of osteomyelitis and amputation, enhancing clinical decision making and patient care strategies.

Association between maternal hemoglobin concentration and educational attainment in mid-childhood in a high-resource obstetric setting: a prospective cohort study

BackgroundAlthough maternal Hb levels during pregnancy are commonly associated with perinatal outcomes, their link to childhood neurodevelopment remains uncertain. ObjectiveThis study aimed to examine the associations between maternal hemoglobin (Hb) in early and late pregnancy with offspring mid-childhood educational attainment in a high-resource obstetric setting. Study DesignPregnancy data from a prospective birth cohort (Pregnancy Outcome Prediction Study, Cambridge, UK, 2008-2012, N=3285) were linked to mid-childhood educational outcomes (Department for Education, UK). Regression models adjusted for maternal, child, and socioeconomic factors were used to determine associations between maternal Hb, pregnancy complications, and offspring educational outcomes (ages 5-7). ResultsNo association was observed between maternal Hb at 12 weeks and the likelihood of either adverse pregnancy outcomes or children meeting expected educational standards between ages 5-7. Higher maternal Hb at 28 weeks was associated with an increased risk of small-for-gestational age infants (aOR1.26, 95%CI 1.11-1.59; p=0.002) and preterm birth (aOR1.38, 95%CI 1.11-1.81; p=0.005). There were no adverse birth outcomes associated with anemia. However children of mothers who were anaemic at 28 weeks had ∼40% increased risk of not attaining expected educational standards at age 5 (aOR1.42, 95%CI 1.03-1.95; p=0.03). There was no association between maternal anemia at 28 weeks and educational performance at ages 6-7. No associations were found between high maternal Hb concentrations (top decile) or change Hb concentrations between 12-28 weeks and childhood educational attainment. ConclusionsMaternal anemia at 28 weeks of pregnancy is associated with reduced educational attainment aged 5, but not at older ages (6-7 years). A proactive approach to increasing maternal hemoglobin in high-resource settings is unlikely to impact on long-term childhood educational attainment.

Low Hemoglobin Level and Elevated Inflammatory Hematological Ratios Associated With Depression and Sleep Disturbance.

The relationship between blood cell profiles, including hemoglobin (Hb) levels and inflammatory hematological ratios, and mental health problems currently remains unclear. This study aimed to investigate the relationship between blood cell profiles and mental health issues, including depressive state and sleep disturbance, while adjusting for potential demographic confounders. This retrospective, cross-sectional, observational study used a population-based medical database from the Tohoku Medical Megabank Project with more than 60,000 volunteers. Data on age, sex, daily tobacco use, body mass index, and self-reported scores on the Kessler Psychological Distress Scale (K6), Athens Insomnia Scale (AIS), and the Center for Epidemiologic Studies Depression Scale (CES-D) were collected. A total of 62,796 volunteers (23,663 males and 39,133 females), aged ≥20 years at the time of the blood test, agreed to participate in this study. Among the evaluated blood cell profiles, Hb, hematocrit, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were significantly correlated with the K6, AIS, and CES-D scores, with strong statistical significance (p<0.0001 for all) in bivariate correlation analyses. A significant adjusted odds ratio (aOR) of the Hb level for elevated CES-D scores (aOR=0.965 [95% CI: 0.949-0.981], p<0.0001) was confirmed after adjusting for demographic data and daily tobacco use using a logistic regression model. Sensitivity analyses revealed that these associations existed in both males and females but were more prominent in the former. In male participants, a low Hb level was significantly associated with an elevated AIS score. The evaluated inflammatory hematological ratios, including NLR, PLR, and monocyte-to-lymphocyte ratio (MLR), also showed significant aORs with the K6, AIS, and CES-D scores after adjusting for demographic background. Low Hb levels and elevated inflammatory hematological ratios (NLR, MLR, and PLR) were associated with depressive state and sleep disturbances in the general population.

HUBUNGAN PARITAS DAN ANEMIA DENGAN PERSALINAN PREMATUR

Premature birth is the main cause of high perinatal mortality rates. The lower the birth weight, the higher the incidence of morbidity and mortality. WHO says there are 15 million babies born prematurely every year throughout the world. Of the 15 million premature babies, 1.1 million babies were reported to have died due to various complications. Premature birth and complications in labor are always associated, such as asphyxia, infection and birth defects, which are the cause of most neonatal deaths. The aim of this study was to determine the relationship between parity and anemia with the incidence of preterm labor. This research is a quantitative observational analytical study with an individual matched case-control design, a retrospective approach using secondary data from mothers giving birth in the Obstetrics and Obstetrics Department of Arifin Achmad Hospital Riau for the period January 2016 – December 2018 which was carried out in May – June 2023. The sample size was 259 cases and 259 controls. From the parity chi-square test carried out, a p-value of 0.855 (≥ 0.05) was obtained, where it was concluded that there was no relationship between parity and the incidence of premature labor and from the chi-square test for anemia, a p-value of 0.00 was obtained ( &lt;0.05) so it can be concluded that there is a relationship between anemia in pregnancy and OT at Arifin Achmad Hospital, Riau Province. It is recommended that pregnant women check their HB levels to avoid amenia which can cause premature labor and also to avoid other factors that cause premature labor.

Pengaruh Pendidikan Kesehatan Terhadap Tingkat Pengetahuan Tentang Anemia Pada Remaja Putri di SMA Kesatrian 2 Semarang

Background: Anaemia is a condition with lower-than-normal haemoglobin levels and red blood cells. Iron nutritional anaemia in young women is at higher risk because it causes a person to experience decreased body resistance, making them susceptible to health problems (Anggoro, 2020). Normal Hb levels in female adolescents &gt;12 g/dL, women of childbearing age 12–14 g/dL, pregnant women 11 g/dL, and males &gt;13 g/dL. The prevalence of anaemia among young women in Semarang City is 43.75% (Semarang City Health Office, 2019). Based on preliminary studies at SMA Kesatrian 2 Semarang from class X, XI, and XII representatives, such as BP checks, conjunctival and skin examinations. After a simple examination, it was found that there were 3 class X who experienced symptoms of anaemia. Eight students in class XI experienced symptoms of anemia. In class XII, four people experienced symptoms of anaemia. Purpose: This study aimed to determine the effect of health education on the level of knowledge of anaemia in young female at SMA Kesatrian 2 Semarang.Method: This study used the pre-experimental design method with a one-group pre-test and post-test design approach. The sampling technique used was total sampling with a sample size of 55 respondents, and the research location was at SMA Kesatrian 2 Semarang. The data analysis used was the Wilcoxon test with the Shapiro-Wilk data normality test. Results: Based on data analysis, we obtained good knowledge from 51 (92.7%) respondents. The results of the Wilcoxon statistical test, namely a p-value of 0.000 (&lt;0.005) and a potential health education value of 6.473x, affect the level of knowledge about anaemia in female adolescents. It can be concluded that Ha is accepted, and Ho is rejected; that is, there is an effect of providing health education on the level of knowledge about anaemia in young female at SMA Kesatrian 2 Semarang. Conclusion: Adolescents need to be given additional health education about anaemia to better recognize the signs and symptoms and how to avoid it.

Accurate and reproducible enumeration of CD4 T cell counts and Hemoglobin levels using a point of care system: Comparison with conventional laboratory based testing systems in a clinical reference laboratory in Cameroon.

Measurements of CD4 T cells and hemoglobin (Hb) are conventionally used to determine the immunological state and disease progression for HIV-infected patients. We obtained a small lightweight point-of-care device, the BD FACSPrestoTM in order to demonstrate its ability to deliver CD4 and Hb analysis in comparison with two larger clinical machines the BDFACSCantoTM analyzer and Sysmex XN 1000 haematology analyzer. The advantages of using the POC device include access to HIV patient data in remote and in resource limited settings. The analytical performance of the BD FACSPrestoTM, compared with the FACSCantoTM II flow cytometer and the Sysmex XN 1000 haematology analyzer was evaluated by testing 241 routine clinical specimens collected in EDTA tubes from patients attending the Immunology and Microbiology laboratory of Chantal BIYA International Reference Centre (Yaounde, Cameroon) between January and May 2016. The mean in absolute counts and percentage of CD4 T cells was 606 cells/mL and 25% respectively via the FACSPrestoTM, and 574 cells/mL and 24% respectively via the BD FACSCantoTM II. The mean concentration of Hb levels was 11.90 on the Sysmex XN 1000 and 11.45 via the BD FACSPrestoTM, A high correlation (R2 = 0.95, P < 0.001) of Hb level measurements was noted between the BD FACSPrestoTM and Sysmex XN 1000 hematology analyzer. Overall, a Bland-Altman plot of the differences between the two methods showed an excellent agreement for absolute and percentage CD4 counts and hemoglobin measurements between POC and conventional methods evaluated here. Furthermore, the study demonstrated the ease of use of the BD FACSPrestoTM POC technology in remote areas. The BD FACPrestoTM is a suitable tool for CD4 enumeration in resource-limited settings, specifically providing a deployable, reliable POC testing option. The BD FACSPrestoTM performed appropriately in comparison to the conventional reference standard technologies. The BD FACSPrestoTM, system provides accurate, reliable, precise CD4/%CD4/Hb results on venous blood sampling. The data showed good agreement between the BD FACSPrestoTM, BD FACSCantoTM II and Sysmex XN 1000 XN 1000 systems.