External Exposure Levels Research Articles

Analysis of personal dose monitoring results of occupational external exposure for radiation workers in a hospital

Objective: To analyze and understand the level of occupational external radiation personal dose of radiation workers in a hospital, and provide a reference for radiation protection. Methods: In May 2023, the personal dose monitoring data of all radiation workers in the hospital from 2018 to 2022 were collected, and their occupational external radiation exposure levels were analyzed and evaluated. All radiation workers were divided into radiation diagnosis, radiotherapy, interventional radiology, and nuclear medicine according to their occupational categories. Results: A total of 1626 person-times were monitored from 2018 to 2022, and the average annual effective dose per person (0.13-0.36 mSV) was lower than the national limit of 20 mSv. The average annual dose of nuclear medicine was the highest (0.36 mSv), and interventional radiology was lower (0.13 mSv). The average annual dose of individuals was the highest in 2020 (0.24 mSv) . Conclusion: The average annual effective dose per person of radiation workers in this hospital is lower than the national standard, and it is still necessary to strengthen the inspection of the wearing of personal dosimeters and the using of protective equipment for radiation workers.

Aluminum exposure levels in workers at electrolytic production

Introduction. Occupational exposure to aluminum has been established to lead to accumulation of metal in tissues and create a risk of functional impairment in the central nervous system. The aim of the work was to assess the levels of external and internal aluminum exposure in workers at the electrolytic production of aluminum under modern occupation conditions. Materials and methods. Two hundred fifty measurements of the average shift aluminum oxide concentration were analyzed at various stages of the technological process. The urine aluminum concentration urine was determined by the atomic absorption method. Results. The aluminum oxide concentration in the housings with the unbaked anode technology varied from 0.59 to 17.95 mg/m3. The MPC was exceeded at the electrolyzer workplace in 10% of measurements, the anode maker — in 40%, and the crane operator – in 50%. In housings with a baked anode, the aluminum oxide concentration in all measurements did not exceed the MPC. The highest aluminum emission was observed in occupational groups associated with unbaked anodes. A trend model was constructed for the dependence of urine aluminum concentration on the aluminum dioxide level in the air, which has the form of an exponential curve. The bend in the curve begins with an air aluminum dioxide content of about 4.2 mg/m3. Limitations. The study is limited by the number of examined workers who underwent periodic medical examination. Conclusion. The results of biomonitoring showed the elimination of aluminum with urine to reflect the level of exposure to the toxicant. The equation of the dependence of the urine aluminum concentration on the air aluminum dioxide level was calculated.

Species specific kinetics of imidacloprid and carbendazim in mouse and rat and consequences for biomonitoring

This study aimed to develop physiologically based kinetic (PBK) models to predict the blood concentrations of imidacloprid and carbendazim and their primary metabolites 5-hydroxy-imidacloprid and 2-aminobenzimidazole after single or repeated oral exposure in mouse (Mus musculus), and compare this to corresponding kinetic data in rat (Rattus norvegicus). PBK model constants for conversion of imidacloprid and carbendazim and formation and clearance of their selected primary metabolites were quantified by in vitro mouse liver microsomal and S9 incubations. The performance of the newly developed PBK models was evaluated, based on a comparison to available literature data, showing that the models performed well. Predictions made were also compared to results from PBK model simulations for rats reported previously to obtain insight in species dependent differences in kinetics of these pesticides. The results thus obtained revealed substantial species differences in kinetics for these two pesticides between mouse and rat, especially for imidacloprid and to a lesser extent for carbendazim. Repeated dose PBK model simulations revealed that the models can facilitate estimation of external exposure levels under wildlife conditions based on internal blood concentrations of the parent compound. The rate of conversion and liver volume fraction were shown to influence the accuracy of these predictions with lower values providing less variable outcomes. It is concluded that PBK modeling provides a new approach methodology of use for wildlife biomonitoring studies and that results of the present study facilitate benchmarking of the species and compounds for which kinetics enable this with sufficient accuracy.

Profiling population-wide exposure to environmental chemicals: A case study of naphthalene

Long-term exposure to environmental chemicals can detrimentally impact human health, and understanding the relationship between age distribution and levels of external and internal exposure is crucial. Nonetheless, existing methods for assessing population-wide exposure across age groups are limited. To bridge this research gap, we introduced a modeling approach designed to assess both chronic external and internal exposure to chemicals at the population level. The external and internal exposure assessments were quantified in terms of the average daily dose (ADD) and steady-state blood concentration of the environmental chemical, respectively, which were categorized by age and gender groups. The modeling process was presented within a spreadsheet framework, affording users the capability to execute population-wide exposure analyses across a spectrum of chemicals. Our simulation outcomes underscored a salient trend: younger age groups, particularly infants and children, exhibited markedly higher ADD values and blood concentrations of environmental chemicals compared to their older counterparts. This observation is due to the elevated basal metabolic rate per unit of body weight characteristic of younger individuals, coupled with their diminished biotransformation kinetics of xenobiotics within their livers. These factors collectively contribute to increased intake rates of environmental chemicals per unit of body weight through air and food consumption, along with heightened bioaccumulation of these chemicals within their bodies (e.g., blood). Furthermore, we augmented the precision of the external and internal exposure assessment by incorporating the age distribution across the population. The simulation outcomes unveiled that, to estimate the central tendency of the population's exposure levels, employing the baseline value group (age group 21–30) or the surrogate age of 25 serves as a simple yet dependable approach. However, for comprehensive population protection, our recommendation aligns with conducting exposure assessments for the younger age groups (age group 0–11). Future studies should integrate individual-level exposure assessment, analyze vulnerable population groups, and refine population structures within our developed model.

Biomonitoring for workplace exposure to copper and its compounds is currently not interpretable

This paper sets out to explore the requirements needed to recommend a useable and reliable biomonitoring system for occupational exposure to copper and its inorganic compounds. Whilst workplace environmental monitoring of copper is used to measure ambient air concentrations for comparison against occupational exposure limits, biological monitoring could provide complementary information about the internal dose of workers, taking into account intra-individual variability and exposure from all routes. For biomonitoring to be of reliable use for copper, a biomarker and the analytical ability to measure it with sufficient sensitivity must be identified and this is discussed in a range of matrices. In addition, there needs to be a clear understanding of the dose-response relationship of the biomarker with any health-effect (clinical or sub-clinical) or, between the level of external exposure (by any route) and the level of the copper biomarker in the biological matrix being sampled, together with a knowledge of the half-life in the body to determine accurate sampling times. For many biologically non-essential metals the requirements for reliable biomarkers can be met, however, for ‘essential’ metals such as copper that are under homeostatic control, the relationship between exposure (short- or long-term) and the level of any copper biomarker in the blood or urine is complex, which may limit the use and interpretation of measured levels. There are a number of types of biomarker guidance values currently in use which are discussed in this paper, but no values have yet been determined for copper (or its inorganic compounds) due to the complexity of its essential nature; the US The American Conference of Governmental Industrial Hygienists (ACGIH) has however indicated that it is considering the development of a biological exposure index for copper and its compounds. In light of this, we present a review of the reliability of current copper biomarkers and their potential use in the occupational context to evaluate whether there is value in carrying out human biomonitoring for copper exposure. Based on the available evidence we have concluded that the reliable use of biomonitoring of occupational exposure to copper and its application in risk assessment is not possible at the present time.

Advances in the applications of exposomics in the identification of environmental pollutants and their health hazards

Environmental pollution has become a prominent global problem, and the potential health hazards of pollutants have caused widespread concern. However, revealing the relationship between complex-pollutant exposure and disease development remains an immense challenge. The core of environmental-health research and risk assessment is the identification of contaminants and their effects. Exposomics provides a new approach in the study of the relationship between environmental factors and human health. Both "top-down" and "bottom-up" strategies are employed in exposomics research. The development of new technologies for chemical detection and "multi-omics" has greatly facilitated the implementation of these strategies. Exposomics focuses on the measurement of an individual's lifelong exposure and aims to identify the health effects of such exposure. It involves the dynamic monitoring of external and internal exposure levels at different stages of life through traditional biomonitoring and exposomic methods. It also includes the identification of biomarkers, which indicate specific environmental exposures and the adverse effects of these exposures on health. Compared with traditional environmental-health studies, exposomics can more accurately reflect the diversity of exposure factors such as pollutants, natural factors, and lifestyles in the real environment, as well as the complexity of their in vivo processes and the responses they trigger in an organism. Powerful chemical analytical tools such as high-resolution mass spectrometry (HRMS) are widely used in studies related to the field of exposomics. Liquid chromatography-mass spectrometry (LC-MS) has been applied in the detection and analysis of environmental pollutants. Proteomics and metabolomics, as two important tools for biomarker identification and effects analysis, are widely used to explore the relationship between environmental factors and diseases. Pollutants can lead to pathological changes and even toxic effects by interacting with proteins. In the case of mixed exposure, some contaminants may present joint toxicity. The interaction between contaminants may change their environmental behavior or the amount of each contaminant that enters the human body, which, in turn, affects their health effects.

A Systematic Review of Polycyclic Aromatic Hydrocarbon Derivatives: Occurrences, Levels, Biotransformation, Exposure Biomarkers, and Toxicity.

Polycyclic aromatic hydrocarbon (PAH) derivatives constitute a significant class of emerging contaminants that have been ubiquitously detected in diverse environmental matrixes, with some even exhibiting higher toxicities than their corresponding parent PAHs. To date, compared with parent PAHs, fewer systematic summaries and reanalyses are available for PAH derivatives with great environmental concerns. This review summarizes the current knowledge on the chemical species, levels, biotransformation patterns, chemical analytical methods, internal exposure routes with representative biomarkers, and toxicity of PAH derivatives, primarily focusing on nitrated PAHs (NPAHs), oxygenated PAHs (OPAHs), halogenated PAHs (XPAHs), and alkylated PAHs (APAHs). A collection of 188 compounds from four categories, 44 NPAHs, 36 OPAHs, 56 APAHs, and 52 XPAHs, has been compiled from 114 studies that documented the environmental presence of PAH derivatives. These compounds exhibited weighted average air concentrations that varied from a lower limit of 0.019 pg/m3 to a higher threshold of 4060 pg/m3. Different analytical methods utilizing comprehensive two-dimensional gas chromatography coupled with high-resolution time-of-flight mass spectrometry (GC × GC-TOF-MS), gas chromatography coupled to time-of-flight mass spectrometry (GC-TOF-MS), comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry (GC × GC-QQQ-MS), and Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS), that adopted untargeted strategies for the identification of PAH derivatives are also reviewed here. Additionally, an in-depth analysis of biotransformation patterns for each category is provided, including the likelihood of specific biotransformation reaction types. For the toxicity, we primarily summarized key metabolic activation pathways, which could result in the formation of reactive metabolites capable of covalently bonding with DNA and tissue proteins, and potential health outcomes such as carcinogenicity and genotoxicity, oxidative stress, inflammation and immunotoxicity, and developmental toxicity that might be mediated by the aryl hydrocarbon receptor (AhR). Finally, we pinpoint research challenges and emphasize the need for further studies on identifying PAH derivatives, tracking external exposure levels, evaluating internal exposure levels and associated toxicity, clarifying exposure routes, and considering mixture exposure effects. This review aims to provide a broad understanding of PAH derivatives' identification, environmental occurrence, human exposure, biotransformation, and toxicity, offering a valuable reference for guiding future research in this underexplored area.

Intracranial Cancer Detection by Mobile Phone Electromagnetic Radiation

Cancer is the topping cause of death only after ischemic heart disease in the world. Among cancers, brain tumors are generally one of the hardest to heal. And among the brain tumors, glioblastoma multiforme, which is a very aggressive intracranial cancer, has one of the highest mortality rates. These cancers are rather difficult to diagnose with the lack of manual diagnosis and very aggressive in their progression the disease, thus a later-stage diagnosis would not be much of a benefit. Therefore, medical doctors require advanced medical imaging techniques such as computed tomography and magnetic resonance imaging for intracranial tumors. The Covid-19 pandemic has caused a global lockdown and has put an enormous load on the medical system. Any similar pandemic would almost paralyze the medical system. In this study, the authors investigate the possibility of an early-stage detection of glioblastoma multiforme by use of mobile phone electromagnetic radiation. Since cancer tissue contains more blood vessels because of its intrinsic energy needs, external electromagnetic radiation would affect the cancer tissue faster than the normal tissue. The authors build the model by introducing a hypothetical ellipsoid cancer tissue into the IEEE phantom head SAR model. By applying two different levels of external electromagnetic exposure, the simulations seek to find a discriminatory temperature change, which can be detected externally.

A Review on Tetrabromobisphenol A: Human Biomonitoring, Toxicity, Detection and Treatment in the Environment.

Tetrabromobisphenol A (TBBPA) is a known endocrine disruptor employed in a range of consumer products and has been predominantly found in different environments through industrial processes and in human samples. In this review, we aimed to summarize published scientific evidence on human biomonitoring, toxic effects and mode of action of TBBPA in humans. Interestingly, an overview of various pretreatment methods, emerging detection methods, and treatment methods was elucidated. Studies on exposure routes in humans, a combination of detection methods, adsorbent-based treatments and degradation of TBBPA are in the preliminary phase and have several limitations. Therefore, in-depth studies on these subjects should be considered to enhance the accurate body load of non-invasive matrix, external exposure levels, optimal design of combined detection techniques, and degrading technology of TBBPA. Overall, this review will improve the scientific comprehension of TBBPA in humans as well as the environment, and the breakthrough for treating waste products containing TBBPA.

The overview of neutron-induced 56Mn radioactive microparticle effects in experimental animals and related studies.

Investigation into the risks associated with radiation exposure has been carried out on those exposed to radiation in Hiroshima and Nagasaki, Semipalatinsk and other parts of the world. These risks are used as a guidance standard for the protection for radiation workers and the general public when exposed to radiation, and it sets upper regulatory limits for the amount of radiation exposure. However, the effects of internal exposure to radioactive microparticles have not been considered in these studies. These effects cannot be ignored since the exposure dose increases are inversely proportional to the square of the distance to the vicinity of the particles and can exceed tens of thousands of mGy. So far, only retrospective studies of people who have been exposed to radiation have been conducted, therefore we hypothesized that animal experiments would be necessary to investigate these effects. As a result, we found specific effects of radioactive microparticles. One particularly noteworthy finding was that internal exposure to radioactive microparticles resulted in pathological changes that were more than 20 times greater than those caused by the same level of external exposure. In contrast, there were other results that showed no such effects, and the reasons for this discrepancy need to be clarified. We also conducted RNA expression experiments and found that there was a difference between external exposure to 60Co gamma rays and internal exposure to 56Mn microparticles. In the future, we will need to study the mechanisms behind these findings. If the mechanism can be confirmed, it is expected to lead to the development of protective and therapeutic methods.

Human exposure to BTEX emitted from a typical e-waste recycling industrial park: External and internal exposure levels, sources, and probabilistic risk implications

Benzene, toluene, ethylbenzene, and xylene (BTEX) can be released during extensive activities associated with the disposal of electronic waste (e-waste), which might pose deleterious health effects on workers. In this study, pollution profiles of BTEX in air and their urinary excretive profiles in occupational workers were investigated in a typical e-waste recycling industrial park. The results showed that the workers in the park were generally exposed to high levels of BTEX. The median levels of urinary metabolites were approximately 6-orders of magnitude higher than those of unmetabolized BTEX, indicating that pollutants efficiently metabolize at those occupational levels. The analytes presented differential profiles in external and internal exposure. Among the metabolites, significant correlation (p < 0.05) was observed between N-acetyl-S-benzyl-L-cysteine (S-BMA) concentration and atmospheric individual BTEX derived from the e-waste recycling area, suggesting that S-BMA is a potential marker for BTEX exposure to e-waste occupational workers. Notably, 95.2 % of all the workers showed a cumulative carcinogenic risk induced by BTEX exposure via inhalation, with 99.9 % of the carcinogenic risk distribution based on concentration of benzene metabolite (N-acetyl-S-(phenyl)-L-cysteine) exceeding 1.0E-6. This study holds potential in providing valuable inferences for the development of remediation strategies focusing on BTEX exposure reduction to protect workers’ health at e-waste recycling industries.

Health Risk Assessment of Ortho-Toluidine Utilising Human Biomonitoring Data of Workers and the General Population.

The aim of this work was to demonstrate how human biomonitoring (HBM) data can be used to assess cancer risks for workers and the general population. Ortho-toluidine, OT (CAS 95-53-4) is an aniline derivative which is an animal and human carcinogen and may cause methemoglobinemia. OT is used as a curing agent in epoxy resins and as intermediate in producing herbicides, dyes, and rubber chemicals. A risk assessment was performed for OT by using existing HBM studies. The urinary mass-balance methodology and generic exposure reconstruction PBPK modelling were both used for the estimation of the external intake levels corresponding to observed urinary levels. The external exposures were subsequently compared to cancer risk levels obtained from the evaluation by the Scientific Committee on Occupational Exposure Limits (SCOEL). It was estimated that workers exposed to OT have a cancer risk of 60 to 90:106 in the worst-case scenario (0.9 mg/L in urine). The exposure levels and cancer risk of OT in the general population were orders of magnitude lower when compared to workers. The difference between the output of urinary mass-balance method and the general PBPK model was approximately 30%. The external exposure levels calculated based on HBM data were below the binding occupational exposure level (0.5 mg/m3) set under the EU Carcinogens and Mutagens Directive.

External exposure levels and fluoride content in the urine of workers at aluminium electrolysis

Introduction. In the context of large-scale modernization and intensification of aluminium production, it becomes relevant to assess the actual fluoride loads and the main factors that determine the occupational exposure of workers to fluorides for health risk analysis. Materials and methods. Monitoring studies of the content of hydrofluoride and aerosols of fluoride salts in the air of electrolysis shops were carried out with traditional and modernized technologies for producing aluminium and fluorine in urine in 108 workers of the primary professions and 35 people in the control group. Determination of the concentration of fluorides was carried out by photometric methods, and fluorine in urine - by ionometric methods. Results. The total concentration of fluoride compounds in the air of the modernized shops was 1.4-2.1 times lower than the values in traditional shops. The fluoride content in the urine of workers in these workshops ranged from 0.8 to 4.7 mg/l, 1.1-6.7 times higher than the level of the control group and 1.1-2.3 times the limit value of the biological exposure index. The highest external and internal fluoride loads and associated health risks are found in workers who maintain electrolyzers and anodes. A closer, noticeable (r = 0.644) correlation was found between the content of fluoride in urine and the levels of gaseous hydrofluoride in the air, indicating its predominant effect on workers compared to other determinants (total concentration of fluorides, seniority and age). Conclusion. The studies’ results indicate a high additional informative value and reliability of biomonitoring of fluoride in urine, which, combined with analysis of air pollution with fluorides, provides a completely objective assessment of the risk of exposure to workers. The presence of high levels of hydrofluoride in the air of electrolysis shops creates a higher occupational health risk for workers.

Assessment of exposure to ionizing radiation in Chernobyl tree frogs (Hyla orientalis)

Ionizing radiation can damage organic molecules, causing detrimental effects on human and wildlife health. The accident at the Chernobyl nuclear power plant (1986) represents the largest release of radioactive material to the environment. An accurate estimation of the current exposure to radiation in wildlife, often reduced to ambient dose rate assessments, is crucial to understand the long-term impact of radiation on living organisms. Here, we present an evaluation of the sources and variation of current exposure to radiation in breeding Eastern tree frogs (Hyla orientalis) males living in the Chernobyl Exclusion Zone. Total absorbed dose rates in H. orientalis were highly variable, although generally below widely used thresholds considered harmful for animal health. Internal exposure was the main source of absorbed dose rate (81% on average), with 90Sr being the main contributor (78% of total dose rate, on average). These results highlight the importance of assessing both internal and external exposure levels in order to perform a robust evaluation of the exposure to radiation in wildlife. Further studies incorporating life-history, ecological, and evolutionary traits are needed to fully evaluate the effects that these exposure levels can have in amphibians and other taxa inhabiting radio-contaminated environments.

Assessment of internal exposure to methylsiloxanes in children and associated non-dietary exposure risk

Methylsiloxanes (MSs) are a significant source of indoor environmental pollution due to their high production level and widespread application, and pose a potential health risk. Given the special vulnerability of children to environmental contaminants, assessment of indoor MSs exposure in children is quite essential. In this study, we assessed internal exposure doses and external exposure levels of MSs in children from industrial and residential areas in southwestern China. Indoor air, indoor dust, and personal care product (PCP) samples were collected to evaluate indoor non-dietary MSs exposure in children through various pathways. The concentrations of MSs in indoor environments of industrial areas were approximately one to four orders of magnitude higher than those of residential areas. Sun protection products contained the highest concentrations of MSs. Relatively high levels of cyclic methylsiloxanes (CMSs) were found in plasma of children from industrial areas, which were one to two orders of magnitude higher than those in children from residential areas. The highest MSs levels in plasma were detected in infants (0–1 year), with values of 1.4 × 102 ng/mL and 1.3 × 102 ng/mL for CMSs (D4–D6) and linear methylsiloxanes (LMSs) (L5–L16), respectively. The internal exposure dose of infants in residential areas is driven by major unknown sources of MSs. The average daily doses via inhalation and dust ingestion in children from industrial areas were one to three orders of magnitude higher than in those from residential areas, indicating that these children should be considered a highly exposed population. Inhalation and dust ingestion were both major exposure pathways to MSs for children of all age groups in industrial areas, whereas dermal absorption from PCPs was the predominant exposure pathway for children of all age groups in residential areas (except for infants). Although the exposure risk to D4 and D5 was at an acceptable level for all children studied, the total daily exposure doses of these two cyclic compounds via inhalation for infants in the industrial areas was near the chronic reference dose. Meanwhile, MSs may accumulate in infant plasma within a short period of time (<6 months). Therefore, infants should be the focus of greater attention in future research. As indoor environments may pose high risks for infants in industrial areas, they should be the focus of future research.

Dynamic integration and transmission channels among interest rates and oil price shocks

This paper examines the short term dynamic integration among oil price shocks and interest rates for the U.S.A, Euro area and twelve Asian economies from August 1999 to January 2018 using a Time-Varying Parameter Vector Autoregression (TVP-VAR) with stochastic volatility. First, we found convincing evidence of time variation in the co-movement of interest rates and oil shocks and that the integration levels were highest towards the 2001 financial crisis whereas there is an evidence of decoupling as shown by notable drop in the level of integration during the 2007–2009 economic and Euro-debt crises. In descending order, Singapore, crude oil, Hong Kong, Philippines and the United States are the net-transmitters of shocks while India, Japan and Vietnam are net-receivers. Results from a sub-sample containing highly industrializing economies in Asia, the United States, Euro area and crude oil market suggest that Singapore, Hong Kong and the United States remained top transmitters of shocks whereas the Euro-area, Taiwan, Korea and crude oil market become net receivers of shocks. Results from the analysis of transmission channels suggest that higher integration for the full sample tend to be driven by increasing levels of external exposure through trade and financial linkages, information asymmetry and political stability while financial crisis reduces the level of integration. Lastly, among the highly industrialized markets, time varying integration is also driven by the degree of external exposure as well as both political and financial stability. We also document important policy implications of our findings.

Lead contamination among Paris Fire Brigade firefighters who fought the Notre Dame Cathedral fire in Paris.

On 15th April 2019, the fire at Notre Dame Cathedral, Paris, resulted in the melting of 410 tons of lead. Four hundred fourteen Paris firefighters were involved. For the purpose of preventive medicine, the level of lead contamination among the firefighters was assessed. This study objectives' were to describe the blood lead levels (BLLs) in the firefighters, to study the influence of some parameters such as the function of firefighters and the decrease in BLLs during the follow-up investigations. The emission of 138kg of melted lead from the roof and spire of the Notre Dame Cathedral during the fire was estimated by the National Institute for Industrial Environment and Risks. Three categories were defined according to the estimated levels of external lead exposure and fire proximity: high (category 1, n=170), medium (category 2, n=151), and low (category 3, n=93). Two to three weeks after the fire, blood samples to assess the BLLs were taken from firefighters in category 1 (N=164) and from every female firefighter in category 1 and 2 (N=4). When the BLL was above 50μg/L (95th percentile of reference range concentrations for a sample of the French population), it was checked again at one month later (N=31) and then, if still above 50μg/L, at six months later (N=10). The geometric mean of initial blood lead level was 31.5μg/L (CI 95% [27.7-35.9]; Min-Max: 7.0-307.6μg/L). Twenty-five percent (n=42) of initial BLLs were above 50μg/L, versus 10% (n=16) at 1 month, and 2% (n=3) at 6 months. The French binding biological BLL limit value (400μg/L for men and 300μg/L for women was never exceeded and all BLLs decreased over time. BLLs varied according to the function occupied during the extinguishing of the fire: operators', officers' and those of unknown function. BLLs were significantly higher compared to drivers reflecting their lower distance to fire and fume. The fire at Notre Dame Cathedral, Paris, resulted in moderate lead contamination among firefighters. Individual and collective protection measures probably helped to limit the contamination. Nevertheless, an effort could be made to improve the working conditions by rethinking the respiratory protection.

Accurate assessment of parabens exposure in healthy Chinese female adults: Findings from a multi-pathway exposure assessment coupled with intervention study

Exposure of humans to parabens is widespread and urinary parabens are widely used as exposure biomarkers. However, are the levels of these chemicals suitable to assess exposure to parabens? We conducted an intervention study by controlling the use of personal care products (PCPs) to explore the exposure of parabens. Ten female participants were recruited who were treated with different types of PCPs during the 18-day study period. The concentrations of parabens and their metabolites in matrices of different exposure pathways (dust, drinking water and dietary food) and urine samples were determined. We demonstrated that PCPs were the major sources of parabens, accounting for >99% of total exposure. The metabolites were nonspecific to individual parabens and could not be used as exposure biomarkers. Urinary paraben concentrations were positively correlated with external exposure levels. However, poor reproducibility was observed, with intraclass correlation coefficients (ICC) ranging from 0.125 to 0.295 in unadjusted urinary concentrations. Creatinine-adjusting could not significantly improve the ICC values in random spot samples. After adjusting for both creatinine and kinetic models, the ICC values ranged from 0.695 to 0.886, indicating a good reproducibility. So, toxicokinetic parameters may be taken into consideration for precise monitoring of exposures for the non-persistent pollutants.

Sediment contamination and toxic effects on Violet Goby fish (Gobioides broussonnetii - Gobiidae) from a marine protected area in South Atlantic

The Estuarine-Lagoon Complex of Iguape-Cananéia (ELCIC), a Marine Protected Area (MPA) in Brazil, was the focus of this study that aimed to relate external levels of exposure to contaminants to toxic effects on Gobioides broussonnetii fish. Different anthropogenic contaminants such as metals, polycyclic aromatic hydrocarbons (PAHs) and pharmaceuticals and personal care products (PPCPs) were analyzed in the sediments; and biochemical, histopathological and genotoxicity biomarkers evaluated in fish; in two different seasons at three sites of the estuarine region. Higher contamination of the sediments was observed near the main urban center (Iguape city - IG). Metal concentrations were considered low to moderate, while PAHs concentrations were considered low. The concentrations of PPCPs increased due to the anthropogenic presence and were higher near IG and the Cananéia Island (CI). Contributions from historical mining, agriculture, nautical activities, oil, sewage and waste disposal, biomass and fossil fuels combustion were identified. Higher concentrations of metals and PPCPs were observed during the cold-dry season, suggesting influences of the lower hydrodynamics during the season of lower precipitation. Higher PAHs concentrations occurred in the hot-rainy season, indicating influences of greater human presence in summer. In fish, biological responses followed the same spatial and seasonal pattern. More pronounced changes in antioxidant, biotransformation, histopathological and genotoxic biomarkers were observed in IG and CI. The multivariate analysis and the integrated biomarkers response index (IBR) also evidenced worse environmental conditions in these sites. This result can indicate a negative influence of anthropogenic activities on the contamination of sediments and on the biological responses of fish. This study presented the first ecotoxicological data for the species and suggested that these chronic exposures can cause adverse effects on this fish population. The data contribute to the understanding of local environmental quality and can be applied in the future to the environmental and social management of marine protected areas.

Human exposure to halogenated and organophosphate flame retardants through informal e-waste handling activities - A critical review.

Informal electrical and electronic waste (e-waste) handling activities constitute a potentially important source of halogenated (HFRs) and organophosphate flame retardants (OPFRs) to the environment and humans. In this review, two electronic databases (ScienceDirect and Web of Science Core Collection) were searched for papers that addressed this topic. A total of 82 relevant studies (including 72 studies selected from the two databases and 10 studies located from the references of the first 72 selected studies) were identified that reported on human external and internal exposure to HFRs and OPFRs arising as a result of informal e-waste handling activities. Compared to the general population, higher levels of external exposure (i.e., inhalation, ingestion, and dermal absorption) and internal exposure (i.e., blood serum, hair, breast milk, urine, and other human matrices) to HFRs and OPFRs were identified for e-waste recyclers and residents inhabiting e-waste dismantling and recycling zones, especially for younger adults and children. Food intake and dust ingestion were the dominant exposure pathways for the majority of brominated flame retardants (BFRs) and dechlorane plus (DP); while inhalation was identified as the most significant pathway of human exposure to OPFRs in informal e-waste sites. The majority of research to date has focused on China and thus future studies should be conducted in other regions such as Africa and South Asia. Other suggested foci of future research are: examination of exposure via dermal contact with e-waste, dietary exposure of local populations to OPFRs, confirmation of the existence of and cause(s) of the higher body burdens of females compared with males amongst populations impacted by informal e-waste handling, and characterisation of exposure of such populations to chlorinated paraffins.