Level Of Alertness Research Articles

Baseline levels of alertness influence tES effects along different age-related directions

Normal aging is usually accompanied by several structural and functional physiological changes of the brain, which are closely related to alterations of cognitive functions (e.g., visual short-term memory). As the average age of the population increases, it has become crucial to identify cognitive-behavioural interventions to maintain a healthy level of cognitive performance. Among a variety of approaches, the targeting of specific intrinsic alertness mechanisms has shown a solid rationale and beneficial effects in both healthy and pathological ageing. In a similar vein, the use of non-invasive transcranial electrical stimulation (tES) represents another promising approach to induce an alerting state that can produce advantages in the information processing in the brain and therefore behaviour. Here, we investigated whether time-locked bursts of tES (i.e., transcranial random noise stimulation) were effective in inducing behavioural and physiological changes, consistently with an alertness increase, in both young and older healthy adults. Namely, we expected to find a beneficial alerting effect on visual short-term memory performance as a function of stimulus perceptual salience and tES. The initial results showed that the performance of younger adults was not affected by tES, while older adults scored lower correct responses for high-salience stimuli during real tES with respect to sham stimulation. However, after including a baseline measure of subjective level of alertness in the analyses, a tES-induced memory improvement did emerge in the less alerted younger adults, while only the more alerted older adults were subject to the worsening effect by tES. We discuss these results in consideration of the evidence on critical age-related differences as well as the interaction between neurostimulation and baseline alerting mechanisms.

What's your name again? A review of the superior longitudinal and arcuate fasciculus evolving nomenclature.

Studies of the superior longitudinal fasciculus (SLF) have multiplied in recent decades owing to methodological advances, but the absence of a convention for nomenclature remains a source of confusion. Here, we have reviewed existing nomenclatures in the context of the research studies that generated them and we have identified their agreements and disagreements. A literature search was conducted using PubMed/MEDLINE, Web-of-Science, Embase, and a review of seminal publications, without restrictions regarding publication date. Our search revealed that diffusion imaging, autoradiography, and fiber dissection have been the main methods contributing to tract designation. The first two have been particularly influential in systematizing the horizontal elements distant from the lateral sulcus. Twelve approaches to naming were identified, eight of them differing considerably from each other. The terms SLF and arcuate fasciculus (AF) were often used as synonyms until the second half of the 20th century. During the last 15 years, this has ceased to be the case in a growing number of publications. The term AF has been used to refer to the assembly of three different segments, or exclusively to long frontotemporal fibers. Similarly, the term SLF has been employed to denote the whole superior longitudinal associative system, or only the horizontal frontoparietal parts. As only partial correspondence can be identified among the available nomenclatures, and in the absence of an official designation of all anatomical structures that can be encountered in clinical practice, a high level of vigilance regarding the effectiveness of every oral or written act of communication is mandatory.

Uncovering the factors behind new ventures’ international performance: Capabilities, alertness and technological turbulence

This research is based on the perception that the explanation of International New Ventures' (INVs) performance demands a process view, going deeper than the standard approach, in empirical papers, of testing a direct relationship between company-level antecedents and performance. A three-tier model was developed to investigate the process leading to INVs international performance, emphasizing the role of entrepreneurial alertness. Based on the dynamic capabilities framework, entrepreneurial alertness was envisaged as the mediating element between firms' capabilities and their international performance. Empirical research confirmed the hypothesized model. Firms' capabilities (entrepreneurial orientation, foreign market knowledge, and absorptive capacity) significantly influence the level of entrepreneurial alertness, which impacts on the levels of self-reported satisfaction with the company's international performance. The paper makes four contributions to International Entrepreneurship literature. First, it highlights the key role played by entrepreneurial alertness in explaining INVs' international performance. This is convergent with the dynamic capabilities view on firms' ability to sense and seize specific international business opportunities. Second, this study considers entrepreneurial alertness as a capability that is not limited to the entrepreneur, but it is an organizational capability. Third, it shows that entrepreneurial alertness does not exist in the vacuum, is based on a set of base capabilities, namely entrepreneurial orientation, foreign market knowledge, and absorptive capacity, that simultaneously leverage the INVs to sense possible opportunities and constrain the focus of opportunities to international markets, as a key element to foster INVs' higher performance. Fourth, it underlines the role of technological turbulence as a moderator of the relationship between entrepreneurial alertness and INVs' international performance.

Challenges of Emergency Management in Nigeria: A Case Study of Federal Capital Territory (FCT) (FEMA)

The study examined the challenges of emergency management and response in Nigeria; a case study of FCT Emergency Management Agency (FEMA), FCT Nigeria. The study assesses the nature and trend of disasters and emergency situations prevalent in the Federal Capital Territory (FCT), the effectiveness of FEMA’s response to emergency situations in the FCT, and highlights the challenges of the Federal Environmental Management Agency of FCT. Both primary and secondary methods of data collection were used. Descriptive statistics were used to analyze the data. The findings of the study revealed that road crashes and flooding are the highest emergency situations recorded in the area. The trend shows that in 2014, 40 emergency situations were recorded, 26 in 2016, and 49 the highest in 2019. In terms of the effectiveness of FEMA’s response to emergencies, the study findings revealed that from 2014 to 2019, 215 emergency situations were recorded, 740 lives were saved as a result of FEMA’s response time of 3 to 15 minutes. The study also revealed that FCT FEMA synergies with other emergency stakeholders in emergency management and response. Training of staffs was periodically carried out to improve productivity and level of alertness of the staff. Some of the humanitarian services of FCT FEMA include the distribution of relief materials and school enrolment for internally displaced persons (IDPs). These notwithstanding, the activities of the agency have been constrained by inadequate funding, poor logistics, wrong address from callers, lack of proper maintenance of infrastructure and equipment, improper vulnerability assessment, and inadequate and ineffective legal and regulatory framework. Based on the findings, the study recommends adequate funding, use of other means of transportation, public enlightenment, and increase synergies among emergency management stakeholders.

Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled trial

Background and objectivesFatigue and sleep disturbance are debilitating problems following brain injury and there are no established treatments. Building on demonstrated efficacy of blue light delivered via a lightbox in reducing fatigue and daytime sleepiness after TBI, this study evaluated the efficacy of a novel in-home light intervention in alleviating fatigue, sleep disturbance, daytime sleepiness and depressive symptoms, and in improving psychomotor vigilance and participation in daily productive activity, following injuryMethodsThe impact of exposure to a dynamic light intervention (Treatment) was compared to usual lighting (Control) in a randomized within-subject, crossover trial. Outcomes were fatigue (primary outcome), daytime sleepiness, sleep disturbance, insomnia symptoms, psychomotor vigilance, mood and activity levels. Participants (N = 24, M ± SDage = 44.3 ± 11.4) had mild-severe TBI or stroke > 3 months previously, and self-reported fatigue (Fatigue Severity Scale ≥ 4). Following 2-week baseline, participants completed each condition for 2 months in counter-balanced order, with 1-month follow-up. Treatment comprised daytime blue-enriched white light (CCT > 5000 K) and blue-depleted light (< 3000 K) 3 h prior to sleep.ResultsRandom-effects mixed-model analysis showed no significantly greater change in fatigue on the Brief Fatigue Inventory during Treatment, but a medium effect size of improvement (p = .33, d = -0.42). There were significantly greater decreases in sleep disturbance (p = .004), insomnia symptoms (p = .036), reaction time (p = .004) and improvements in productive activity (p = .005) at end of Treatment relative to Control, with large effect sizes (d > 0.80). Changes in other outcomes were non-significant.ConclusionsThis pilot study provides preliminary support for in-home dynamic light therapy to address sleep-related symptoms in acquired brain injury.Trial registrationThis trial was registered with the Australian and New Zealand Clinical Trials Registry on 13 June 2017, www.anzctr.org.au, ACTRN12617000866303.

Age-Related Changes in Circadian Rhythms and Their Effects on Cognition and Psychological Well-Being: A Literature Review

Introduction: Circadian rhythms, the internal “clocks” that control a variety of physiological processes, have been found to change considerably throughout one’s lifetime. Young adults tend to be more “evening” people, while older adults tend to be more “morning” people due to age-related changes in their sleep-wake cycles. This review aims to discuss the corresponding physiological and psychological changes that occur due to the changing circadian rhythms that come with age. Methods: A literature search was conducted using the databases PubMed, PsycINFO, and AgeLine. Keywords included variations of “circadian rhythms”, “aging”, “chronotype”, “cognition”, “depression”, “mood”, “bipolar disorder”, and “anxiety”. Studies were selected and findings regarding the physiological and psychological changes due to circadian rhythms and aging were reviewed. Results: Research shows that age-related disruptions in circadian rhythms are associated with cognitive and psychological decline. Diminished sleep quality is associated with older age, due to the aforementioned underlying dysregulated circadian rhythms. Sleep deprivation is associated with increased levels of fatigue, stress, and overall mood disturbances. Moreover, circadian rhythm abnormalities associated with old age are related to greater mood disturbances, depression, and anxiety. Discussion: Poor sleep and older age are important factors that can negatively affect one’s mood and emotional well-being. It is imperative that healthcare providers consider these factors when consulting and treating patients. Populations such as shift workers have been found to have impaired levels of alertness, mood, memory, and cognitive performance due to their dysregulated circadian rhythms. Furthermore, time of day plays a crucial role in the educational success of children and adolescents. Young individuals with an evening chronotype are put at a disadvantage for early school start times due to their opposing optimal times of performance. Conclusion: Circadian rhythm dysfunction that is commonly associated with aging has the potential to contribute to adverse outcomes in human health, including cognitive deficits and pathological conditions. Future research efforts should concentrate on further clarifying the relationship between changing circadian rhythms and its impact on psychological well-being.

Sound Effects on Physiological State and Behavior of Drivers in a Highway Tunnel.

Driving behavior in a highway tunnel could be affected by external environmental factors like light, traffic flow, and acoustic environments, significantly when these factors suddenly change at the moment before and after entering a tunnel. It will cause tremendous physiological pressure on drivers because of the reduction of information and the narrow environment. The risks in driving behavior will increase, making drivers more vulnerable than driving on the regular highways. This research focuses on the usually neglected acoustic environment and its effect on drivers' physiological state and driving behavior. Based on the SIMLAB driving simulation platform of a highway tunnel, 45 drivers participated in the experiment. Five different sound scenarios were tested: original highway tunnel sound and a mix of it with four other sounds (slow music, fast music, voice prompt, and siren, respectively). The subjects' physiological state and driving behavior data were collected through heart rate variability (HRV) and electroencephalography (EEG). Also, vehicle operational data, including vehicle speed, steering wheel angle, brake pedal depth, and accelerator pedal depth, were collected. The results indicated that different sound scenarios in the highway tunnel showed significant differences in vehicle speed (p = 0.000, η2 = 0.167) and steering wheel angle (p = 0.007, η2 = 0.126). At the same time, they had no significant difference in HRV and EEG indicators. According to the results, slow music was the best kind of sound related to driving comfort, while the siren sound produced the strongest driver reaction in terms of mental alertness and stress level. The voice-prompt sound most likely caused driver fatigue and overload, but it was the most effective sound affecting safety. The subjective opinion of the drivers indicated that the best sound scenario for the overall experience was slow music (63%), followed by fast music (21%), original highway tunnel sound environment (13%), and voice-prompt sound (3%). The findings of this study will be valuable in improving acoustic environment quality and driving safety in highway tunnels.

Impact of shift work on excessive daytime sleepiness among healthcare professionals and its association with medical incidents: A review

Sleep disorders, especially excessive daytime sleepiness (EDS), is a common complaint among medical professionals such as physicians and nurses. EDS is associated with decreased level of alertness in everyday life and thus leads to road accidents, workspace errors, and lack of concentration in people. We reviewed the literature to know the influence of shift work in the development of EDS and to scrutinize the relation between EDS and medical incidents. In association with EDS, shift work is defined as major risk factors. As health-care professionals are regularly involved in shift work to complete the 24 h services, they were more prone to experience EDS and may cause occupational incidents. Even though it is apparent that working in long shifts leads to sleep disorders, as the body clock is unbalanced, ample or apt research is required to collect reliable evidence. Various studies have reported occupational errors among nurses on comparatively longer work hours like drug administration errors, needlestick injuries, and operational errors in the past 12 months. In conclusion, these variables, that is, shift work, EDS, and occupational errors are directly related to each other. Further studies are required to explore the scenario between these factors.

Optimal sleep and work schedules to maximize alertness.

Working outside the conventional "9-to-5" shift may lead to reduced sleep and alertness impairment. Here, we developed an optimization algorithm to identify sleep and work schedules that minimize alertness impairment during work hours, while reducing impairment during non-work hours. The optimization algorithm searches among a large number of possible sleep and work schedules and estimates their effectiveness in mitigating alertness impairment using the Unified Model of Performance (UMP). To this end, the UMP, and its extensions to estimate sleep latency and sleep duration, predicts the time course of alertness of each potential schedule and their physiological feasibility. We assessed the algorithm by simulating four experimental studies, where we compared alertness levels during work periods for sleep schedules proposed by the algorithm against those used in the studies. In addition, in one of the studies we assessed the algorithm's ability to simultaneously optimize sleep and work schedules. Using the same amount of sleep as in the studies but distributing it optimally, the sleep schedules proposed by the optimization algorithm reduced alertness impairment during work periods by an average of 29%. Similarly, simultaneously optimized sleep and work schedules, for a recovery period following a chronic sleep restriction challenge, accelerated the return to baseline levels by two days when compared to the conventional 9-to-5 work schedule. Our work provides the first quantitative tool to optimize sleep and work schedules and extends the capabilities of existing fatigue-management tools.

The feminine target: Gender expression in same-sex relationships as a predictor of experiences with public displays of affection

The extent to which sexual minority individuals present publicly as masculine, feminine, or both has been associated with their perceptions of threat and safety in public spaces. The current study investigates the role of gender expression in men and women’s experiences of public displays of affection (PDAs) in same-sex relationships. Participants (N = 528) reported their own gender expression as well as that of their partner, perceptions of support for PDAs, PDA-related vigilance, general vigilance and overall PDA frequency. Men in same-sex relationships reported less frequent PDAs and greater PDA-related vigilance than women, while women reported greater overall variability in their gender expression than men. Multiple regression analyses show femininity within the participant (for men) or their partner (for both men and women) was associated with greater general and PDA-related vigilance. These findings align with previous research on femmephobia, in which femininity is described as making individuals feel ‘targeted’ for other forms of oppression (e.g., homophobia, sexism, transphobia; Hoskin, 2019 ). Although femininity was associated with greater vigilance, the association between masculinity within a same-sex relationship and vigilance was more tenuous, demonstrating evidence of masculinity serving as both a potential target for homophobic violence as well as a source of protection. The dual nature of masculinity was particularly salient among women in same-sex relationships, where masculinity tempered by femininity was associated with greater perceived support for PDAs but for women with partners low in femininity, the more masculine their partner, the greater their reported levels of vigilance.

COVID-19 DALAM KAJIAN QAWAID FIQHIYAH

This study tries to assess the level of danger of covid-19 in the study of qawaid fiqhiyah. So that the level of vigilance is found based on the study of fiqh. There are several fiqhiyah principles that serve as basic guidelines in fostering human behavior in dealing with COVID-19, there are also some changes in the basic provisions (hukum ashal) to new provisions, which changes according to the level of the virus. The fiqhiyah rules that are relevant to this study are; 1) التيسير تجلب المشقة (difficulty can bring fast), which this rule describes the difficulties obtained from the process of spreading COVID-19 can abort obligations and change the basic provisions. 2) الضرورة تبيح المحظورات (the condition of the dharurat allows something that is forbidden), from the other side this rule also describes the same thing as the rule above, where dharurah is an excuse to fail an obligation and may do things that were originally prohibited. 3) ما أبيح للضرورة يقدر بقدرها (Something What is Allowed because dharurah is Measured According to the Level of ‘Endanger’), this rule describes the level of permissibility or legal relief that arises due to the spread of COVID-19 not absolutely, but it is adjusted to the level of the spread zone. 4), الضرر يزال (‘Endanger’ must be eliminated), in the spread of COVID-19, this rule becomes the basic guide for the new obligations, namely eliminating harm caused by the spread of COVID-19 by following health protocols. 5) قد نزلت منز لة الضرورة عامة كانت أو خاصة الحاجة (hajah;pretention Occasionally Occupies Emergency Positions either General or Special), this rule describes the desire with special criteria parallel to dharurah independently, such as hajah means, isolation of dharurah as a washilah to keep other people from being exposed.

The effect of a hypothetical psychological counseling of health care on the development of mental alertness and self-efficacy corona Pande

PurposeThe level of mental alertness among students who are in need of study in the preparatory year – Imam Abdul Rahman Bin Faisal University. The level of self-competence of female students who are in need of study in the preparatory year – Imam Abdul Rahman Bin Faisal University. To learn about the relationship between mental alertness and self-competence among students who are in need of study in the preparatory year – Imam Abdul Rahman Bin Faisal University.Design/methodology/approachThe researchers used the experimental method by following the experimental design with two measurements, tribal and posterior, for two groups, one experimental and the other control, due to its suitability to the nature of this research. Research sample: the research community included female students stumbling in the scientific path of Rayyan, the second semester of the academic year 2020–2021 AD, where the researchers selected the research sample in a deliberate manner from the stalled students of 25 students and a random sample of 10 female students was withdrawn to conduct the exploratory study. The number of the basic research sample is 15 female students. Reasons for selecting the search sample: all of the sample members are female students stumbling in the scientific path of Al-Rayyan for the academic year 2020–2021 and all sample members agree to apply the research.FindingsThe researchers refer to this to the virtual psychological guidance program-specific objectives, as well as the follow-up of the scientific principles and principles and the legalization of the measurement tools used in the research and the diversity of the program within the parts of the program and the training sought to develop the ability to manage pressures and emotions and training in social skills, awareness and self-awareness and the use of exercises relaxation, breathing and modern self-help, as well as the use of different methods and techniques such as the method of dialogue, discussion, awareness of feelings and problem-solving, which led to a change in behavior and personal characteristics, which led to a change in behavior and personal characteristics, leading to the development of behavior and personal characteristics.Originality/valueThe study aims to design a hypothetical psychological counseling program as a method of health care and its effect on the level of mental alertness and the level of self-efficacy of students who have struggled to study at the Deanship of the preparatory year – Imam Abdul Rahman bin Faisal University. The researchers used the experimental approach and applied this study on a sample of 25 students from the students who failed to study at the Deanship of the preparatory year for the second semester of the academic year 2020–2021 AD and the most important results were that the psychological counseling program as a method of health care had a positive effect on improving the level of mental alertness and the level of self-efficacy among the students who had failed to study. There is a positive correlation between the level of mental alertness and self-efficacy of struggling students as a way of health care.

Human disturbances increase vigilance levels in sika deer (Cervus nippon): A preliminary observation by camera-trapping

Human disturbances increase vigilance levels in sika deer (Cervus nippon): A preliminary observation by camera-trapping

The Impact of Organizational Support on Strategic Vigilance in Ministry of Civil Service in Sultanate Oman

The study aimed to examine the impact of organizational support on strategic vigilance of Ministry of Civil Services in Sultanate Oman. The organizational support consisted of four dimensions: leadership support, organizational justice, decision-making participation and rewards. Meanwhile the strategic vigilance also consisted of four dimensions: technological vigilance, marketing vigilance, competitive vigilance and environmental vigilance. The study was conducted on a sample consisting of (147) managers. The study indicated that there are medium levels of organizational support and strategic vigilance, and that there is a significant impact of organizational support on strategic vigilance, and that there is an impact of organizational support on all types of strategic vigilance.

Classroom Movement Breaks Reduce Sedentary Behavior and Increase Concentration, Alertness and Enjoyment during University Classes: A Mixed-Methods Feasibility Study.

This mixed-methods study aimed to determine the feasibility of incorporating movement breaks into university classes in terms of acceptability (disruption, engagement, satisfaction), practicality (ease of scheduling and conducting breaks) and efficacy (sedentary time, concentration, alertness, enjoyment). Movement breaks of five to 10 min duration were scheduled after 20 min of sedentary time during 2-h classes. Classes without movement breaks were used as a comparison. Data were collected using surveys, objective physical activity monitoring and focus group interviews of students (n = 85) and tutors (n = 6). Descriptive statistics (quantitative data) and independent coding and thematic analysis (qualitative data) were completed. Students (mean age 23 ± 2 years, 69% female) actively engaged in movement breaks with no adverse events. Movement breaks were perceived to be beneficial for concentration, engagement and productivity. Timing of the break was perceived to be important to enhance the benefit and reduce disruption. Students preferred outdoor or competitive movement breaks. Students spent 13 min less time sitting (95%CI 10 to 17), took 834 more steps (95%CI 675 to 994) and had higher levels of concentration, alertness and enjoyment (p < 0.001) in classes with movement breaks compared to classes without. Classroom movement breaks are feasible and may be considered for incorporation into university classes to reduce sedentary behaviour and increase physical activity, alertness, concentration and enjoyment.

A novel convolutional neural network method for subject-independent driver drowsiness detection based on single-channel data and EEG alpha spindles.

A significant number of fatal accidents are caused by drowsy drivers worldwide. Driver drowsiness detection based on electroencephalography (EEG) signals has high accuracy and is known as a reference method for evaluating drowsiness. Among brain waves, EEG alpha spindle activity is a silent feature of decreasing alertness levels. In this paper, based on the detection of EEG alpha spindles, a novel driver drowsiness detection method is presented. The EEG spindles were detected using Continuous Wavelet Transform (CWT) analysis and the Morlet function. To do so, the signal is divided into 30-s epochs, and the observer rating of drowsiness determines the drowsiness level in each epoch. Tests were conducted on 17 healthy males in a driving simulator with a monotonous driving scenario. The Convolutional Neural Network (CNN) is used for classifying EEG signals and automatically learns features of the early drowsy state. The subject-independent classification results for single-channel P4 show 94% accuracy.

The impact of shift work on the wellbeing and subjective levels of alertness and sleepiness in firefighters and rescue service workers

Shift work can be associated with health and sleep problems which may lead to cognitive impairment. This study investigated effects of shift work on sleep, health behaviours and cognitive functions of polish rescue service workers. We tested 18 paramedics working 12-hour shifts, 15 firefighters working 24-hours shifts, and 17 daytime workers. We measured general sleepiness, workload during shifts, an occurrence of health behaviours. Additionally we measured attention, executive functions and subjective alertness. Paramedics showed lower average sleep duration and quality, and fewer health behaviours than firefighters and control group. However, no differences in performance in cognitive tests between the groups and between the measures were found. The results indicate that the differences in job specificity may contribute to the effects of shift-work on sleep and health of the workers.

Single agent activity of ONC201 in non-midline H3 K27M-mutant diffuse gliomas.

e14037 Background: H3 K27M-mutant diffuse midline glioma is an invariably lethal form of brain cancer that disproportionately affects children and young adults and has no effective treatment following front-line radiation. The initial disease definition in the 2016 WHO Classification of Tumors of the Central Nervous System regarded the H3 K27M mutation as pathognomonic, though the definition was updated in 2018 restricting the diagnosis to histologically diffuse gliomas that involve midline CNS structures (cIMPACT-NOW update 2). ONC201 is an investigational anti-cancer small molecule, DRD2 antagonist and ClpP agonist that has induced durable tumor regressions by RANO-HGG criteria in a registration cohort of recurrent diffuse midline glioma, H3 K27M-mutant patients treated with single agent ONC201. Methods: We present 7 patients with H3 K27M-mutant diffuse gliomas were enrolled in ONC201 clinical studies, though excluded from the registration cohort due to involvement of non-midline CNS structures, all within the cerebral hemispheres (3 frontal, 1 temporal, 1 frontotemporal, 1 parietal, and 1 corona radiata). Results: Two of the 7 patients underwent objective responses by RANO-HGG criteria as assessed by investigator, which was associated with clinical benefit that included increased mobility and level of alertness. Conclusions: These results demonstrate that H3 K27M-mutant diffuse gliomas occur outside of midline CNS structures, and suggest that ONC201 has single agent activity in H3 K27M-mutant gliomas irrespective of CNS location.

Impaired Attentional Processing During Parabolic Flight.

Previous studies suggest that altered gravity levels during parabolic flight maneuvers affect spatial updating. Little is known about the impact of the experimental setting and psychological stressors associated with parabolic flight experiments on attentional processes. To address this gap, we investigated the level of alertness, selective and sustained attention in 1 and 0 g using a Go/No-Go Continuous Performance Task. We also identified several parameters associated with the experimental set-up of a parabolic flight that could be expected to affect attentional processing. These included the use of scopolamine, sleep quality prior to the flight day, participant’s stress level as well as mood and anxiety state before and after the parabolic flight. We observed a deterioration in attentional processing prior to the first parabola that was further aggravated in weightlessness and returned to baseline after the last parabola. Reaction Time, Hit and False Alarm Rate were moderately correlated with self-reported anxiety state, but not cortisol levels or emotional states. The use of scopolamine had minor effects on Reaction Time. Our results confirm previous studies reporting impairments of cognitive performance in 0 g, and highlight important aspects that should be considered for the design of behavioral research experiments in future parabolic flight campaigns.

FMRI-based detection of alertness predicts behavioral response variability.

Levels of alertness are closely linked with human behavior and cognition. However, while functional magnetic resonance imaging (fMRI) allows for investigating whole-brain dynamics during behavior and task engagement, concurrent measures of alertness (such as EEG or pupillometry) are often unavailable. Here, we extract a continuous, time-resolved marker of alertness from fMRI data alone. We demonstrate that this fMRI alertness marker, calculated in a short pre-stimulus interval, captures trial-to-trial behavioral responses to incoming sensory stimuli. In addition, we find that the prediction of both EEG and behavioral responses during the task may be accomplished using only a small fraction of fMRI voxels. Furthermore, we observe that accounting for alertness appears to increase the statistical detection of task-activated brain areas. These findings have broad implications for augmenting a large body of existing datasets with information about ongoing arousal states, enriching fMRI studies of neural variability in health and disease.