BackgroundResearch on the association between chronic inflammatory airway diseases (CIADs), defined as asthma, chronic obstructive pulmonary disease, and impaired lung function, and long-term exposure of outdoor air pollutants for adults has been scarce. Research questionEffects of long-term exposure for outdoor air pollutants to the risk of CIADs in adults. Materials and methodsApplying data from Taiwan Biobank, 10-year accumulative exposure of major outdoor air pollutants, PM2.5, PM10, NO2, SO2, CO, and O3, was estimated by Kriging's interpolation, based on 76 nationwide air pollution monitoring stations linked to residency information at township or district level at baseline interview for volunteered community participants older than 30 years old. Eligible cases and randomly selected healthy controls constructed a nested case-control study with frequency matching on age and sex at a ratio of 1:4. We adopted logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of outdoor air pollutants to the risk of CIADs for univariable and multivariable analyses. For detecting potential interactions among critical covariates, we used the generalized multifactor dimensionality reduction method. ResultsHigher 10-year cumulative exposure of NO2 and SO2 put people at a significantly elevated relative risk of CIADs after confounding control, showing adjusted ORs of 1.07 (95% CI: 1.01, 1.14) for NO2 and 1.23 (95% CI: 1.15, 1.31) for SO2 for each increment of standard deviation. Furthermore, a significant synergistic interaction (P-value < 0.01 for interaction term) between PM10 and CO in tertiles was detected with an adjusted OR of 5.01 (95% CI: 2.95, 8.49) for the highest tertiles of PM10 and CO combined, relative to the group of lowest tertile combination. ConclusionOur outcomes contributed to a more profound understanding on the effects of long-term exposure of air pollutants to CIADs in etiology, highlighting a synergistic interaction between PM10 and CO.
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