Sensation Level Research Articles

Parent’s and teacher’s evaluation of aural oral performance of children with hearing aids

Background and Aim: Parents' evaluation of aural/oral performance of children (PEACH) and teachers' evaluation of aural/oral performance of children (TEACH) questionnaires are used to assess the behaviors of hearing-impaired children in real-life situations. This study aims to compare the scores of PEACH and TEACH in children with severe-to-profound sensorineural hearing loss (SNHL) using hearing aids. Methods: This is a double-blind two-period crossover study on 21 children aged 9-72 months with severe-to-profound SNHL using hearing aids. There were two 6-week periods of fitting Phonak Naida Venture SP hearing aids using the fifth version of the Desired Sensation Level (DSL v5) and the National Acoustics Laborato­ries’ nonlinear fitting procedure (NAL-NL2) pre­scriptions. At the end of each trial, the PEACH and TEACH questioners were completed through an interview with the parents and teachers, res­pectively. Results: There was a strong correlation between the PEACH and TEACH in total and subscale scores. There was no significant difference bet­ween the results of DSL v5 and the NAL-NL2 prescriptions for the total score and subscale scores of PEACH and TEACH. Conclusion: The PEACH score has a strong correlation with the TEACH score. These ques­tionnaires are useful tools for indirectly assess­ment of hearing-impaired children’s communi­cation skills. The DSL v5 and the NAL-NL2 prescriptions make no significant difference in the performance of children with severe-to-profound SNHL. Keywords: Aural oral performance; questionnaire; children; parents; hearing loss; functional performance

Cross-frequency weights in normal and impaired hearing: Stimulus factors, stimulus dimensions, and associations with speech recognition.

Previous studies of level discrimination reported that listeners with high-frequency sensorineural hearing loss (SNHL) place greater weight on high frequencies than normal-hearing (NH) listeners. It is not clear whether these results are influenced by stimulus factors (e.g., group differences in presentation levels, cross-frequency discriminability of level differences used to measure weights) and whether such weights generalize to other tasks. Here, NH and SNHL weights were measured for level, duration, and frequency discrimination of two-tone complexes after measuring discriminability just-noticeable differences for each frequency and stimulus dimension. Stimuli were presented at equal sensation level (SL) or equal sound pressure level (SPL). Results showed that weights could change depending on which frequency contained the more discriminable level difference with uncontrolled cross-frequency discriminability. When cross-frequency discriminability was controlled, weights were consistent for level and duration discrimination, but not for frequency discrimination. Comparing equal SL and equal SPL weights indicated greater weight on the higher-level tone for level and duration discrimination. Weights were unrelated to improvements in recognition of low-pass-filtered speech with increasing cutoff frequency. These results suggest that cross-frequency weights and NH and SNHL weighting differences are influenced by stimulus factors and may not generalize to the use of speech cues in specific frequency regions.

Audibility and Spectral-Ripple Discrimination Thresholds as Predictors of Word Recognition with Nonlinear Frequency Compression.

Nonlinear frequency compression (NFC) lowers high-frequency sounds to a lower frequency and is used to improve high-frequency audibility. However, the efficacy of NFC varies widely-while some individuals benefit from NFC, many do not. Spectral resolution is one factor that might explain individual benefit from NFC. Because individuals with better spectral resolution understand more speech than those with poorer spectral resolution, it was hypothesized that individual benefit from NFC could be predicted from the change in spectral resolution measured with NFC relative to a condition without NFC. This study aimed to determine the impact of NFC on access to spectral information and whether these changes predict individual benefit from NFC for adults with sensorineural hearing loss (SNHL). Present study is a quasi-experimental cohort study. Participants used a pair of hearing aids set to the Desired Sensation Level algorithm (DSL m[i/o]). Participants were 19 adults with SNHL, recruited from the Boys Town National Research Hospital Participant Registry. Participants were seated in a sound-attenuating booth and then percent-correct recognition of words, and spectral-ripple discrimination thresholds were measured for two different conditions, with and without NFC. Because audibility is known to influence spectral-ripple thresholds and benefit from NFC, audibility was quantified using the aided speech intelligibility index (SII). Linear mixed models were generated to predict word recognition using the aided SII and spectral-ripple discrimination thresholds. While NFC did not influence percent-correct word recognition, participants with higher (better) aided SII and spectral-ripple discrimination thresholds understood more words than those with either a lower aided SII or spectral-ripple discrimination threshold. Benefit from NFC was not predictable from a participant's aided SII or spectral-ripple discrimination threshold. We have extended previous work on the effect of audibility on benefit from NFC to include a measure of spectral resolution, the spectral-ripple discrimination threshold. Clinically, these results suggest that patients with better audibility and spectral resolution will understand speech better than those with poorer audibility or spectral resolution; however, these results are inconsistent with the notion that individual benefit from NFC is predictable from aided audibility or spectral resolution.

Wide-Bandwidth Soft Vibrotactile Interface Using Electrohydraulic Actuator for Haptic Steering Wheel Application

This letter presents a novel soft vibrotactile interface with a wide acceleration bandwidth that can be applied to a curved surface, such as a steering wheel. This haptic interface utilizes the surface charge-inducing characteristic of polyvinyl chloride (PVC) gel and adopts a design where hydraulic pressure is induced upon actuation. This working principle significantly increases the output force of the device, which enables a high-performance haptic interface. In addition, the small contact angle due to its curved shape was analyzed as an important parameter for high-frequency performance. Results showed that the proposed haptic interface can generate sufficient acceleration performance (>3 G) over a broad frequency range (90-700 Hz) with a maximum value near 6 G. Due to this high performance, user test participants could certainly feel the generated vibration with a sensation level of 22.5-44.8 dB from 10-360 Hz at 3 kV.

Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold.

Spinal cord injury (SCI) often results in an inhibitory environment at the injury site. In our previous studies, transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI. Based on these preclinical studies, collagen scaffolds loaded with the patients' own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients. Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years. No serious adverse events related to functional scaffold transplantation were observed. Among the patients with acute SCI, five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder. Additionally, four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction. Among patients with chronic SCI, 16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site. Nearly half of the patients with chronic cervical SCI developed enhanced finger activity. These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI.

J receptor activity in idiopathic pulmonary hypertension and its expected change in the presence of pulmonary bed vasodilators

Juxtapulmonary receptors (J) lying in the lung parenchyma are stimulated naturally by any condition that produces interstitial oedema, transient increases in interstitial volume and pressure or raised pulmonary capillary pressure. There is no information available about the level of their stimulation in patients with idiopathic pulmonary hypertension (IPH) who have high levels of pulmonary artery systolic pressures.The aim of the present study therefore was to find the level of these receptors activity in these patients at their prevailing pulmonary artery systolic pressures. This was done by the established method of determining the dose of i.v. lobeline that gives rise to threshold levels of sensations in the upper chest areas and accelerates respiration. In IPH patients it was found to be as high as 31.6 ± 5.6 μg/kg i.e., twice as much as that known for healthy individuals which is 15 μg/kg. This shows an enhanced stimulation of J receptors in IPH patients.Expectedly when pulmonary artery systolic pressure falls with pulmonary bed vasodilator medication given to IPH patients, a reduction in the natural stimulus of J receptors would also occur leading to a fall in their activity and hence that of the quantum of their reflexes of respiratory acceleration and inhibition of exercise. This finding provides the first insight of a neural mechanism that could be influenced to produce its effects when pulmonary artery systolic pressure falls by pulmonary vasodilator medication.

The Influence of Sensation Level on Speech-Evoked Envelope Following Responses.

To evaluate sensation level (SL)-dependent characteristics of envelope following responses (EFRs) elicited by band-limited speech dominant in low, mid, and high frequencies. In 21 young normal hearing adults, EFRs were elicited by 8 male-spoken speech stimuli-the first formant, and second and higher formants of /u/, /a/ and /i/, and modulated fricatives, /∫/ and /s/. Stimulus SL was computed from behaviorally measured thresholds. At 30 dB SL, the amplitude and phase coherence of fricative-elicited EFRs were ~1.5 to 2 times higher than all vowel-elicited EFRs, whereas fewer and smaller differences were found among vowel-elicited EFRs. For all stimuli, EFR amplitude and phase coherence increased by roughly 50% for every 10 dB increase in SL between ~0 and 50 dB. Stimulus and frequency dependency in EFRs exist despite accounting for differences in audibility of speech sounds. The growth rate of EFR characteristics with SL is independent of stimulus and its frequency.

Low-sound-level auditory processing in noise-exposed adults

Early signs of noise-induced hearing damage are difficult to identify, as they are often confounded by factors such as age, audiometric thresholds, or even music experience. Much previous research has focused on deficits observed at high intensity levels. In contrast, the present study was designed to test the hypothesis that noise exposure causes a degradation in low-sound-level auditory processing in humans, as a consequence of dysfunction of the inner hair cell pathway. Frequency difference limens (FDLs) and amplitude modulation depth discrimination (MDD) were measured for five center frequencies (0.75, 1, 3, 4 and 6 kHz) at 15 and 25 dB sensation level (SL), as a function of noise exposure, age, audiometric hearing loss, and music experience. Forty participants, aged 33-75 years, with normal hearing up to 1 kHz and mild-to-moderate hearing loss above 2 kHz, were tested. Participants had varying degrees of self-reported noise exposure, and varied in music experience. FDL worsened as a function of age. Participants with music experience outperformed the non-experienced in both the FDL and MDD tasks. MDD thresholds were significantly better for high-noise-exposed, than for low-noise-exposed, participants at 25 dB SL, particularly at 6 kHz. No effects of age or hearing loss were observed in the MDD. It is possible that the association between MDD thresholds and noise exposure was not causal, but instead was mediated by other factors that were not measured in the study. The association is consistent, qualitatively, with a hypothesized loss of compression due to outer hair cell dysfunction.

Understanding of “Feeling” and “Self-Consciousness” on the Border of the XIX–XX Centuries and M. Loewy’s Concept of Depersonalization

The aimwas to review the understanding of the phenomena of “feeling” and “self-consciousness” in the concepts of the leading European scientists at the second half of XIX — beginning of the XX centuries.Method:H.R. Lotze, I.M. Sechenov, A. Bain, W. Wundt, G. Stoerring, Th. Lipps, K. Oesterreich, E. Kraepelin and some others are analyzed.Conclusion:while Th. Lipps, H.R. Lotze, W. Wundt and K. Oesterreich were striving for strict differentiation of the notions of “sensations” and “feelings”, A. Bain, I.M. Sechenov, G. Stoerring were not following an effi cient distinction of these phenomena. H.R. Lotze, I.M. Sechenov, A. Bain distinguished in the consciousness and self-consciousness the affective and intellectual components; Th. Lipps considered as the core of self-consciousness the feelings that were very manifold and accompanied different mental acts including the act of perception: “perceptions feeling”. G. Stoerring paid attention to the lack of the feeling of activity by depersonalization, and the Austrian psychiatrist and neurologist M. Loewy elaborated the concept of “ubiquitous” “action feelings” (Actionsgefuehle) that exist outside of “pleasure — displeasure” modality. According to M. Loewy’s concept every mental act is accompanied normally by two “feelings of act”: general and specifi c, in the abnormal case one or both of them may disappear. The clinical description of weakening or loss of the action feelings: impulse feeling, perception feeling of vital sensation, perception feelings of sensations from organs of sense, “feelings of the feeling process”, “thinking feeling”, M. Loewy accomplished by “personalizing” approach to the account of one of his patient, Russian female student. M. Loewy considered the depersonalization disorders in this case as a symbolic neurosis according to S. Freud and as a psychasthenia according to P. Janet. Although E. Kraepelin defi ned selfconsciousness as merely cognitive phenomenon he interpreted depersonalization as a kind of emotional disturbance including the disorders on the level of sensations in the frames of light depressive phase of the manic-depressive illness. The M. Loewy’s concept of the “action feelings” can be applied not only for the understanding of “neurotic” depersonalization but also for depersonalization cases on the ground of depressive and mixed phase affective states.

Meta-Learning for Fake News Detection Surrounding the Syrian War

In this manuscript, we pursue the automatic detection of fake news reporting on the Syrian war using machine learning and meta-learning. Our model is based on a suite of features that include a given article's linguistic style, its level of subjectivity, sensationalism and sectarianism, the strength of its attribution, as well as its consistency with other news articles from the same ``media camp'' and reporting on the same single large-scale event detected from a timeline of the Syrian war. To train our model, we use FA-KES, a fake news dataset about the Syrian war, consisting of 804 articles roughly balanced between true and fake . We explore a suite of basic machine learning models as well as the model-agnostic meta-learning algorithm (MAML) suitable for few-shot learning, using datasets of a modest size. Our feature importance analysis confirms that our collection of features specific to the Syrian war are indeed very important predictors for the output label. Our meta-learning model achieves the best performance improving upon the baseline approaches that are trained exclusively on text features in FA-KES in about 20% inaccuracy, 15% in F1-measure, and 30% in AUC. It also achieves more robust probabilistic outcomes and higher top k precision and recall than the vanilla machine learning models.

Experimental investigation of standard effective temperature (SET*) adapted for human walking in an indoor and transitional thermal environment

Thermal indices are widely used to predict the human body's thermal sensation indoors and outdoors, with standard effective temperature (SET*) being the most commonly used index. Although SET* has been well-proven in predicting indoor static thermal comfort, it has not yet proven its applicability in thermal comfort and dynamic condition assessments outdoors. Refers to verify the application of SET* in both an indoor and transitional space, experiments were conducted in the badminton hall of Guangzhou University (representing the indoor space) and the overhead floor of the experimental building of Guangzhou University (representing the transition space). Thirty healthy college students were first asked to walk for 20 min at four walking speeds and then to rest for 10 min. During the whole process, environmental parameters and the mean thermal sensation vote (MTSV) were recorded. Thereafter, the relationship between MTSV and the calculated SET* was established; notably, the applicability of the SET* prediction model in the transitional space was significantly better than that in the indoor space during walking. An improved SET* prediction model and the corresponding thermal stress categories are proposed to predict the dynamic thermal sensation, which is suitable for either walking indoors or in transitional spaces. From the linear regression equation in the improved model, it was obtained that the thermal comfort interval (MTSV falling within ±0.5) represented by α SET* is 24–37.5 °C. In addition, through Probit regression analysis, the thermal sensation level corresponding to the improved SET* (α SET*) was determined.

Outdoor comfort level improvement in the traffic waiting areas by using a mist spray system: An experiment and questionnaire study

Outdoor hot environment in summer affects human health seriously, and it is very difficult to be improved by air-conditioning equipment. However, some outdoor activities are unavoidable and taking the public transportation is the main way, especially for medium and low-income population, so improving thermal environment in urban transportation waiting areas is necessary and significant. Based on this, the mist spray system was considered to improve the human thermal comfort in the urban transportation waiting areas. A bus station model was established to analyze the influence of the mist spray system through experimental test and questionnaire. The results showed air temperature was reduced obviously, while thermal comfort was well improved in the mist spray system. The average air temperatures were decreased by 2.6 °C, 2.1 °C and 3.3 °C in the head, the nasal cavity, and the chest, respectively. Human thermal sensation was increased from 1.44 (between slightly hot and hot) to 0.33 (slightly higher than neutrality), while thermal comfort was improved from −1.13 (slightly uncomfortable) to 0.76 (slightly comfortable). And female and obese participants had more sensitivity on thermal sensation and comfort level. And the mist spray system could be used widely in practice due to its wide acceptability of 76 %.

The comparison of gains prescribed for digital behind-the-ear hearing aids using the manufacturer-specific and conventional prescriptive formulas

Background and Aim: There are several prescriptive formulas for covering a variety of hearing loss, each of which applies relatively different amplifications at different frequencies. This study aims to compare the gains prescribed for digital behind-the-ear (BTE) hearing aids by the Desired Sensation Level Multi-Stage [Input/Output] (DSLm[I/O]), National Acoustic Laboratories-non linear2 (NAL-NL2) and manufacturer-specific formulas at different levels of input intensity. Methods: The gain values in 12-channel BTE hearing aids prepared from four companies (Oticon, Phonak, ReSound and Siemens) were measured at three levels of input intensity (45, 65, and 85 dB SPL) and at a frequency range of 250−8000 Hz for two moderately severe flat and mild sloping to severe hearing losses by using the DSLm[I/O], NAL-NL2 and manufacturerspecific formulas in the Frye FP35 test box. Results: There was no significant difference between the four selected hearing aids in terms of prescribed gain values using the prescriptive formulas (p > 0.05). Conclusion: The DSLm[I/O] formula prescribes higher gain in the 12-channel BTE hearing aids from Oticon, Phonak and Siemens companies at all input intensities and frequencies for moderately severe flat and mild sloping to severe hearing losses compared to the NAL-NL2 formula and manufacturer-specific formulas (Voice Aligned Compression (VAC), Adaptive Phonak, Connexx Fit and audiogram+). Keywords: National acoustic laboratories-non linear2; desired sensation level multi-stage [input/output]; gain; frequency; intensity levels

Effects of non-thermal atmospheric pressure plasma on palatal wound healing of free gingival grafts: a randomized controlled clinical trial.

The aim of this trial was to evaluate the effects of non-thermal atmospheric pressure plasma (NAPP) on wound healing, epithelization, local pain, bleeding, and alteration of sensation in palatal donor site. Forty patients with inadequate attached gingiva were included in the study. Patients were divided into two groups: (i) NAPP group (Free gingival graft [FGG] + NAPP) and (ii) control group (FGG alone). NAPP was performed immediately after the operation and on days 3 and 7. Pain, bleeding, and the amount of medication were recorded by patients every day. Epithelization in donor site, alteration of sensation and color match were assessed weekly for 2 months. Inter-group comparisons of continuous variables by time were performed with two-way repeated measures ANOVA test and a general linear model. Categorical variables were compared using Chi-square exact test. A p value of < 0.05 was considered significant. At week 2, the number of patients with complete epithelization was greater in the NAPP group compared to the control group (p < 0.05). Additionally, color match in donor site was better in the NAPP group than in the control group (p < 0.05) during the first five follow-up assessments. No significant difference was found between the two groups with regard to bleeding, pain level, drug use, and alteration of sensation. The NAPP application increased the epithelization and accelerated the wound healing process although it did not decrease the level of pain and sensation. Our data suggested that the NAPP application may help epithelization and thus may shorten the recovery time after oral surgeries.

Vitamin B and Zinc Supplements and Capsaicin Oral Rinse Treatment Options for Burning Mouth Syndrome.

Background and Objectives: Burning mouth syndrome (BMS) is an enigmatic, idiopathic, chronic, often painful clinical entity, where patients experience oral burning without clear clinical changes on the oral mucosa. There are yet to be well established standardized and validated definitions, diagnostic criteria or classifications for burning mouth syndrome. The aim of this study is to determine whether vitamin B complex and zinc supplements or 0.02% topical capsaicin rinse, can help alleviate BMS pain/burning levels. The objectives: (1) Gather data before and after treatment with vitamin B complex and zinc supplements (2) After the vitamin B complex and zinc protocol gather data before and after treatment with 0.02% topical capsaicin rinse (3) Data analysis and assessment for both treatment methods. Materials and Methods: 89 patients took part in the vitamin B and zinc supplement treatment regimen, out of those 20 patients took part in the capsaicin rinse treatment regimen. Before and after each treatment pain/burning levels were determined using the Visual analogue scale, salivary flow was also determined. Results: Both treatment methods showed statistically significant data in reducing pain/burning levels. There were no statistically significant changes in the salivary flow after any treatment. Conclusion: vitamin B and zinc supplement therapy and topical capsaicin rinse therapy can be an effective way to decrease pain/burning sensation levels in patients with BMS. More research should be conducted to determine the benefit of either vitamin B and zinc supplement therapy or topical capsaicin rinse therapy, so that BMS patients have treatment options, that have as few side-effects as possible.

Cutaneous sensation of electrical stimulation waveforms

BackgroundSkin sensation is the primary factor limiting the intensity of transcranial electrical stimulation (tES). It is well established that different waveforms generate different sensations, yet transcranial stimulation has been limited to a relatively small number of prototypical waveforms. ObjectiveWe explore whether alternative stimulation waveforms could substantially reduce skin sensation and thus allow for stronger intensities in tES. MethodsWe systematically tested a range of waveforms in a series of 6 exploratory experiments stimulating human adults on the forearm and in one instance on the head. Subjects were asked to rate skin sensation level on a numerical scale from “none” to “extreme”. ResultsHigh frequency (>1 kHz) monophasic square wave stimulation was found to decrease in sensation with increasing duty cycle, baseline, and frequency, but the sensation was never lower than for constant current stimulation. For the purpose of injecting a net direct current (DC), a constant current is optimal. For stimulation with alternating current (AC), sensation decreased with increasing frequency, consistent with previous reports. Amplitude modulation did not reduce sensation below stimulation with constant AC amplitude, and biphasic square waveforms produced higher sensation levels than biphasic sinusoidal waveforms. Furthermore, for DC stimulation, sensation levels on the arm were similar to those reported on the head. ConclusionOur comparisons of various waveforms for monophasic and biphasic stimulation indicate that conventional DC and AC waveforms may provide the lowest skin sensations levels for transcutaneous electrical stimulation. These results are likely generalizable to tES applications.

Relationships between subjective taste sensations and electrogustometry

<h3>Objectives</h3> The purpose of this study was to examine the relationships between subjective taste sensations and electrogustometry (EGM) results in patients with taste disorders according to the presence of burning mouth symptoms. <h3>Methods</h3> Forty-six patients (11 men, 53.5 ± 19.5 years; 35 women, 52.9 ± 12.9 years) with taste disturbances as a chief complaint were included. They were asked to complete a questionnaire including subjective taste sensations of 4 basic taste qualities and the pattern of taste disorders such as ageusia, hypogeusia, and dysgeusia. EGM was performed to measure detection thresholds of the chorda tympani, glossopharyngeal, and greater petrosal nerve areas in both sides. To examine the influence of burning mouth symptoms, they were divided into 2 groups: patients with (20 patients; 2 men and 18 women) and without (26 patients; 9 men and 17 women) burning mouth symptoms. The Mann-Whitney <i>U</i> or Kruskal-Wallis test was used to compare variables between the groups. The chi-square test or Fisher exact test for categorical variables and the Spearman correlation analysis for continuous variables were used to investigate associations. <h3>Results</h3> There were no significant differences in age and sex distribution according to the presence of burning mouth symptoms. Compared with the patients with burning mouth symptoms, those without burning mouth symptoms reported significantly lower levels of subjective taste sensations in all taste qualities and showed higher correlation levels between subjective taste sensations and EGM thresholds. Hypogeusia was the most common in both groups. Dysgeusia was more common than ageusia in the patients with burning mouth symptoms and vice versa in those without burning mouth symptoms. The pattern of taste disorders also showed more significant associations with the levels of subjective taste sensations in the patients without burning mouth symptoms than those with burning mouth symptoms. <h3>Conclusions</h3> Patients with taste disorder without burning mouth symptoms had a more severe level of taste disturbances than those with burning mouth symptoms. The pathophysiology of taste disturbances could differ according to the presence of burning mouth symptoms.

Dynamic monocyte chemoattractant protein-1 level as predictors of perceived pain during first and second phacoemulsification eye surgeries in patients with bilateral cataract

BackgroundThe purpose of the study was to investigate whether dynamic monocyte chemoattractant protein-1 (MCP-1) level might be as predictors of perceived pain during the first and second phacoemulsification eye surgeries in patients with bilateral cataract.MethodsConsecutive bilateral cataract patients undergoing bilateral sequential phacoemulsification were retrospectively enrolled. Patients’ preoperative anxiety score and intraoperative pain score were registered. Aqueous humor samples were obtained during surgery. MCP-1 level in the aqueous humor was measured by enzyme linked immunosorbent assay (Elisa). Patients were assigned to seven subgroups based on the interval between first-eye and second-eye cataract surgery. Comparisons were performed for a subjective sensation and MCP-1 levels among different subgroups.Resultspain score during second-eye surgery was significantly higher than during first-eye surgery. Whereas there was no statistical difference in anxiety score between both surgeries. Result from subgroups comparison showed that the visual analog scale (VAS) pain score was statistically greater in 1-group and 6-group during the second eye surgery. Anxiety score did not statistically differ in subgroups. Additionally, the second-eye MCP-1 level was significantly higher at week 1and 6 intervals. Preoperative MCP-1 level was positively correlated with perceiving pain score during both surgeries.ConclusionsMCP-1 level in aqueous humor significantly correlated with perceived pain during cataract surgery. Dynamic MCP-1 level could function as predictors of perceived pain during the first and second phacoemulsification eye surgeries in patients with bilateral cataract, which might support clinicians in treatment optimization and clinical decision-making.

Weakened Cochlear Nonlinearity During Human Aging and Perceptual Correlates.

As humans age, compressive nonlinearity-a hallmark of healthy cochlear function-changes. The nonlinear distortion-component of the distortion product otoacoustic emission (DPOAE) provides a noninvasive gauge of cochlear nonlinearity. Earlier published work has suggested that weakened nonlinearity begins in middle age; the current work extends this investigation into the eight decade of life using advanced DPOAE data collection and analysis methods as well as multiple metrics of nonlinearity, including a test of loudness scaling. The 2f1-f2 DPOAE was recorded in 20 young adults, 25 middle-aged adults and 32 older adults from f2 = 0.78 to 9.4 kHz with primary tones (f2/f1 = 1.22) swept upward at a rate of 0.5 octave/sec. Only frequencies with audiometric thresholds ≤20 dB HL were included in the analysis and to the extent possible, ears were audiometrically matched to eliminate hearing threshold as a contributing factor to the observed age effects. Input/output functions were generated for the separated distortion-component of the DPOAE to probe compressive nonlinearity of the cochlea, and ipsilateral suppression of the DPOAE was conducted to probe two-tone suppression. To investigate the perceptual effects of weakening nonlinearity on loudness perception, the same subjects performed categorical loudness scaling. Age effects on both DPOAE and loudness scaling variables were assessed, and correlations were conducted between key OAE and perceptual metrics. Age × Frequency ANOVAs revealed that the compression knee of the DPOAE I/O function occurred at higher stimulus levels in both groups of older adults compared to young adults, suggesting an expanded linear range with aging; also, the compressive slope (growth beyond the knee point) was steeper in older-adults compared to young adults. These results were most notable at high frequencies. ANOVAs including age and auditory threshold as factors confirmed that the age effect observed was independent of threshold. Additionally, in smaller subsets of subjects with audiometrically matched data, these same trends persisted, further ruling out hearing threshold as an influential factor. The growth of DPOAE ipsilateral suppression was shallower near 4 kHz in middle-aged and older adults compared to young adults and elevated suppression thresholds were observed. Results of categorical loudness scaling showed steeper growth of loudness for older adults and, at fixed sensation levels (dB SL), the older-adult group rated tones as louder than did their young-adult counterparts, suggesting abnormal loudness growth and perception. Several correlations between the compression knee of the DPOAE I/O function and key metrics of loudness scaling were significant and accounted for up to one-third of the variance. Results indicate that the aging cochlea begins to show weakened nonlinearity in middle age and it progressively weakens further into senescence. The perceptual impact of weakened nonlinearity during aging is manifested as abnormal loudness judgments; that is, in older-adult ears, a tone considered comfortable or medium in young-adult ears can be considered loud. The biophysical origin of this weakened nonlinearity is not known. It is hypothesized to reflect aging-related damage to, or loss of, outer hair cells and their stereocilia. More work is warranted to better define the perceptual impact of a linearized cochlear response in older adults and to consider how this deficit might impact the fitting of hearing aids and other intervention strategies.

Failure to Perceive Change: From Neurons to Social Networks

Humans are fundamentally bad at perceiving change which is not expected to be present based on prior experience of the organism. Change blindness and inattentional blindness are striking such examples of failure to notice changes in a visual scene. This has been observed in other sensory systems including auditory and somatosensory. In conditions of crisis, whether it is a global crisis such as the COVID-19 pandemic or a local crisis such as Hurricane Katrina, profound changes in structure and function of previously static environmental elements occur and trickle down to each neighborhood, street corner, and individual person’s life. In such conditions of flux and instability, susceptibility to micro-perceptual failures such as change and inattentional blindness may be heightened. These phenomena occur at millisecond to seconds time scale, at the level of initial sensations and first level perceptions, however are linked to multimodal associative brain-wide processes. Here we review the evidence for, and develop a line of argument that following propositions hold true in conditions of crisis: (1) Frequency of change blindness events and related failures of micro-perceptions may be higher; (2) accumulation of micro-perceptual failures of a single sensory system such as vision can impact complex cognitive processes such as reasoning, reality-based belief, and judgment occurring over longer time scales and brain-wide networks; and (3) same failures of micro-perceptions across individuals in a population may have impact on faulty consensus assessments of reality of situation and missed opportunities for solution building on group or collective level.