Pepsin Levels Research Articles

Serum pepsin and tubeless gastric analysis as predictors of stomach cancer. A 10-year follow-up study, Hiroshima.

Abstract From 1959 to 1962, 6859 Japanese clinic subjects had assays of serum peptic activity (referred to as in this study). By 1969 the incidence of stomach cancer was three times higher among men whose pepsin levels had been below 200 μg per milliliter (tyrosine equivalents). A similar trend was not as clear among the women with low pepsins. In 1959, 1251 persons had Diagnex Blue (DB) tests for stomach acidity. There was, over the next 10 years, a significantly higher age-adjusted incidence of stomach cancer among those whose Diagnex Blue tests had been abnormal. A subgroup of 695 persons had both pepsin and Diagnex Blue testing. Those with both low serum pepsin levels and abnormal Diagnex Blue tests comprised only 3.5 per cent of the group but constituted over 30 per cent of the stomach cancers diagnosed. None of these results could be attributed to an effect of atomic-bomb radiation.

The relationship between blood pepsin level, ABO blood group, and secretor status.

Article1 April 1962The Relationship between Blood Pepsin Level, ABO Blood Group, and Secretor StatusJAMES C. NIEDERMAN, M.D., EDWARD C. GILBERT, M.D., HOWARD M. SPIRO, M.D.JAMES C. NIEDERMAN, M.D.Search for more papers by this author, EDWARD C. GILBERT, M.D.Search for more papers by this author, HOWARD M. SPIRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-564 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAssociations between specific diseases and certain hereditary characteristics are becoming increasingly apparent. In particular, the relationship between blood groups and peptic ulcer disease has been amply documented. In 1954, Aird, Bentall, Mehigan, and Fraser Roberts (1) emphasized the increased incidence of blood group O among adult males with duodenal ulcer; further observations revealed that those patients with duodenal ulcer who subsequently required operation accounted to a large extent for this blood group O excess (2). Clinical studies have demonstrated the additional physiologic importance of secretion of mucopolysaccharide ABH substances into body fluids, especially those of the stomach (3). A significantly...

Peptic ulcer in pregnancy; a serial study of gastric secretion during pregnancy.

This is a young woman in whom gastric acid and pepsin levels decreased to low values during the course of her pregnancy. Some correlation between emotional states and gastric secretory levels was observed. The case is presented because it is the first to be recorded where gastric aspiration was carried out during pregnancy in an ulcer patient.

Confirmation of achylia by radioactive B 12 uptake and blood pepsin measurement

The unstimulated phase of gastric secretion was studied by comparing the twenty-four-hour urinary radioactive B 12 test (of Schilling) and the blood pepsin level in thirty-seven patients. Many gradations and variations between normal gastric secretion (adequate intrinsic factor and gastric acid with normal blood pepsin level) to complete gastric atrophy (absent intrinsic factor and gastric acid with low blood pepsin levels) were found. Factors involved in these variations are discussed. In general, a normal urinary radioactive vitamin B 12 excretion will be found in patients with a blood pepsin level above 350 units, but the converse is not always true.

Effect of histamine on gastric peptic secretion in man.

PARENTERAL administration of histamine leads to a marked outpouring of acid and a transient rise in pepsin concentration in the gastric juice. Whether this rise in pepsin concentration is the result of stimulation of pepsin production or whether it represents the "washout" of preformed pepsinogen has been a matter of dispute. Most recorded opinion favors the concept that the parietal cells pour acid out into a canaliculus from which pepsinogen, previously secreted by the chief cells, is passively carried. Previous conclusions about the meaning of blood pepsin levels in relation to gastric secretion have been based in part on this . . .

Duodenal ulcer in one of identical twins.

Summary A case of peptic ulcer in one 46-year-old male identical twin has been presented. Both subjects have strikingly similar backgrounds and character structure; passive, shy, dependent, anxious, semiskilled workers. The twin with the ulcer began to have symptoms during a near-psychotic breakdown in his wife when she was having an affair with another man and threatened to kill their children. The patient's difficulty with his wife, though somewhat diminished, has persisted since the onset of illness and so have the ulcer symptoms. In contrast, is his brother's marriage to a motherly woman who dependably manages the family affairs. Both patients have high blood pepsin levels, but show on interview and psychological testing, modest but real differences in their responses to stressful circumstances. This paper serves as a demonstration of the use of identical twins in the study of psychosomatic disorders, and illustrates techniques of examining hypotheses concerning these disorders in this unusual setting.

The relation of blood pepsin to gastric secretion, with particular reference to anacidity and achylia

Summary 1. In a general way, the level of blood pepsin rises with increasing gastric juice concentration of pepsin, in patients with free acid. Blood pepsin i 2. At low levels of gastric secretion, or with specific stimulation or inhibition, there is no parallelism between blood pepsin and gastric acid; activ 3. Extragastric factors, of which uremia is most prominent, affect the blood pepsin and the uropepsin levels and should be taken into account in the clinical 4. Nevertheless, the blood pepsin is of clinical interest in the delineation of the peptic ulcer diathesis; and of physiologic interest in pointing to the d

慢性胃炎に関する研究

The author has determined pepsin in the chronic gastritis by Bucher, Grossman, Ivy method and compared with it in the other stomach diseases.1) The fasting pepsin level; 87.3 P. U.Hb in the gastric ulcer, 54.8 P. U.Hb in the stomach cancer, 102.0 P. U.Hb in the gastric ulcer, and 183.6 P. U.Hb (the highest in all) in the duodenal ulcer. Pepsin has been proved even in the case of achlorhydria in the chronic gastritis.2) Gastric secretion by the use of its stimilants (Histamine, Insulin, Vagostigmin, Caffeine, and dried bonito extract) increased in the pepsin level in every case, and was marked especially by the vagus stimulant. Pepsin level was considerably elevated in some of the hypochlorhydria in the chronic gastritis and especially by the vagus stimulant. Acidity and pepsin level, in general, went side by side on the use of the stimulants excepting histamine, and those relation was definite in the caffeine and in the dried bonito extract. The elevation of the pepsin level was much higher than that of the acidity, in insulin and in vagostigmin.

X-ray irradiation and conservative surgery in the treatment of chronic duodenal ulcer

Summary 1. A description has been given of the effects of X-ray irradiation of the stomach in 28 patients suffering from chronic duodenal ulcer. 2. In 10 patients irradiation was given alone (1500 r gastric tissue dose over three weeks) and a temporary fall of acid and pepsin secretion with relief of symptoms was produced. However, in 5 patients symptoms returned between eight and twenty-five months later. 3. In 16 patients surgical removal of the ulcerated duodenum and the adjacent gastric antrum was performed (antroduodenectomy), followed by irradiation with 2000 r (g.t.d.) over three weeks; in 2 other patients irradiation was given two months before antroduodenectomy. These patients have been followed for periods ranging between three and eleven months; in none have symptoms of recurrent ulceration occurred and complications and untoward after-effects have been minimal. 4. Irradiation produced a fall in acid and pepsin secretion to low levels or zero and histological changes in the mucosa which were clearly demonstrated in serial gastric biopsies. With a dose of 1500 r return to former acid and pepsin levels and histological appearance usually occurred in six to twelve months. With the larger tissue dose (2000 r) a tendency to return was recorded, but it is too early to judge whether return will be to the pre-irradiation state. 5. The changes in the function and appearance of the gastric mucosa were produced with regularity. It is considered that close attention to the details of posture and X-ray dosage is largely responsible for these results. The techniques used have been described. 6. Using these techniques a fall in acid and pepsin secretion can be produced in a patient with gastric hypersecretion in the absence of any medication and without serious interruption of his work. In the present series radiation sickness was minimal. 7. In conjunction with the operation of antroduodenectomy irradiation has produced satisfactory relief of symptoms in cases of severe chronic duodenal ulcer. However, our experience is limited with regard to numbers of cases and time of follow-up.