Blood Hemoglobin Levels Research Articles

Physiotypic variations lead to variations within the normal range for red blood cells and haemoglobin levels in a healthy human population: An evaluation using generalised additive modelling and hierarchical structure analysis.

Haematological parameters have been used for a long time for clinical evaluations, however the dynamics of these parameters has not been studied at length, in healthy populations. We aim to understand the dependence of haematological parameters on human physiotypes. Using an age and gender restricted healthy human (male) population (n = 100), we attempt to analyse the dynamics of haemoglobin and red blood cells, with reference to age, height and weight of individuals. Using advanced generalised additive modelling and classical hierarchical structural analysis we aim to establish relationships between these parameters and human physiotypes. We demonstrate that definitive relationships can be established for number of red blood cells, haemoglobin levels, RDW-CV, RDW-SD and weight, height and age of individuals. This study provides a proof of principle, that haematological parameters are dependent on physiotypic variation, within the normal ranges in a healthy population. It may also be noted that there is a definitive influence of height, weight and age on normal ranges and stratification by these factors might therefore make reference intervals narrower, in turn, possibly allowing more precise clinical decisions based on the complete blood count (CBC).

Acceptance and Levels of Iron Gyoyam (Spinach Gyoza) as an Alternative Snack to Prevent Anemia in Young Women

Anemia is a condition in which blood hemoglobin levels are lower than normal in certain age and gender groups. Hemoglobin is the pigment in the blood that carries carbon dioxide and oxygen around the body. To confirm the results of a study on the acceptability and iron content of Gyo Yam (spinach dumplings) as an alternative snack to anticipate anemia in young women. Because this type of research aims to study the effect of one variable on other variables, or to test whether there is a change between one variable and another. This type of research is true experimental research. In this study, a laboratory test was conducted to test the formulation using the method used, namely ICP-OES (Inductively Coupled Plasma-Omission Spectroscopy) to measure iron levels. Result, each dumpling weighs 50 grams and contains 2.2 milligrams of iron.Conclusion, Gyoyam (Spinach Gyoza) Formula 3 can be used as an alternative snack to prevent anemia in young women.

Geographic inequalities and determinants of anaemia among preeclamptic women: a cross-sectional sample-based study in Bangladesh

BackgroundAnaemia among preeclamptic (PE) women is a major undefined health issue in Bangladesh. This study explored the risk factors associated with anaemia and mapped the regional influences to understand the geographical inequalities.MethodsData from 180 respondents were prospectively collected from the Preeclampsia ward of Dhaka Medical College Hospital (DMCH), Bangladesh. Anaemia was defined as a blood haemoglobin level less than 11.0 g/dl. Preeclampsia was defined as systolic blood pressure (SBP) ≥ 140 mmHg and diastolic blood pressure (DBP) ≥ 90 mmHg with proteinuria. Factors associated with anaemia were explored using the chi-square test. Logistic regression (LR) was done to determine the level of association with the risk factors.ResultsAmong the participants, 28.9% were identified as having early onset and 71.1% reported late onset of PE. 38.9% of the subjects were non-anaemic, whereas mild, moderate, and severe anaemia was found among 38.3%, 17.8%, and 5% of patients respectively. The following factors were identified; including age range 25–34 (OR: 0.169, p < 0.05), a lower education level (OR: 3.106, p < 0.05), service-holder mothers (OR: 0.604, p < 0.05), pregnancy interval of less than 24 months (OR: 4.646, p < 0.05), and gestational diabetes mellitus (OR: 2.702, p < 0.05). Dhaka district (IR: 1.46), Narayanganj district (IR: 1.11), and Munshiganj district (IR: 0.96) had the highest incidence rates.ConclusionDeterminants of anaemia must be considered with importance. In the future, periodic follow-ups of anaemia should be scheduled with a health care program and prevent maternal fatality and fetus morbidity in patients with PE.

Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L.

Anemia is a widespread global health concern necessitating effective, accessible, and natural interventions. The potential of medicinal plants to address anemia has garnered significant interest. Among these plants, parsley (Petroselinum crispum (Petroselinum crispum) L.) stands out as an edible and herbal-based option for combating anemia. Aim of the study: This study investigated the potential of P. crispum (PC-Ext) as an emerging antianemic product, focusing on its physicochemical attributes, antioxidant properties, and mineral profile. Both qualitative and quantitative analyses of the phenolic compounds in P. crispum were conducted by using high-performance liquid chromatography with a diode array detector (HPLC-DAD). Anemia was induced in rats by intravenous injections of phenylhydrazine, administered at a dose of 40 mg/kg for two consecutive days. The antianemic activity of PC-Ext was assessed at a dose of 500 mg/kg twice daily for 5 weeks by estimating blood parameters, such as serum iron and ferritin. Additionally, the osmotic fragility test measured the capacity of red blood cells to withstand osmotic shock of various concentrations of saline. Aqueous extract of P. crispum was rich in phytochemical compounds, including syringic acid, quercetin, catechin, gallic acid, and luteolin. The findings demonstrate the effectiveness of P. crispum in ameliorating phenylhydrazine-induced reductions in red blood cell count (RBCs), hemoglobin (Hb), and hematocrit (HCT) levels. Consequently, PC-Ext exhibits significant activity against phenylhydrazine-induced anemia in rats, as demonstrated by its ability to prevent hemolysis. Iron estimation within PC-Ext further confirms its utility in addressing both iron deficiency and ferritin-deficiency anemia. Therefore, PC exhibits a favorable effect against both types of anemia, iron deficiency, and hemolysis. The results of this study provide robust scientific validation for ethnomedicinal use and the potential utility of P. crispum, positioning it as a promising source for future pharmaceutical development.

Optimal level of dietary arginine enhances growth performance, haemato-biochemical status, metabolic responses and growth-related gene expression of GIFT juveniles reared in inland saline water

The effects of arginine levels in diets on growth performance, survival, and haemato-biochemical responses and gene expression of genetically improved farmed tilapia (GIFT) juveniles raised in inland saline water (ISW) of 10 ppt were evaluated through a 60-day growth trial. Seven isoproteinaceous (⁓320 g protein/kg), isolipidic (80 g/kg) and isoenergetic (16.8 MJ DE/kg) diets with graded levels of arginine viz. A10 (10 g/kg), A12.5 (12.5 g/kg), A15 (15.0 g/kg), A17.5 (17.5 g/kg), A20 (20.0 g/kg), A22.5 (22.5 g/kg) and A25 (25.0 g/kg) were prepared. Acclimated GIFT juveniles (3.75 ± 0.017 g) were randomly assigned into seven treatments in triplicate with 15 fish/replicate and fed with respective diets thrice a day on a satiation basis. The percent weight gain, specific growth rate, protein efficiency ratio, whole carcass protein, tissue alanine and aspartic acid aminotransferase activities, serum total protein, albumin and globulin concentration and expression of IGF-1 & IGF-1R genes of fish significantly increased, while feed conversion ratio significantly decreased with increasing arginine in the diet up to 17.5 g/kg and decreased thereafter. Additionally, white blood cell count increased with rising arginine levels in the diet. However, body indices, survival, whole carcass lipid, total ash and essential amino acids contents, activities of digestive and antioxidant enzymes, serum glucose level and blood haemoglobin level and red blood cell count of fish remained unchanged for different treatments. Based on broken-line regression and second order polynomial regression models in relation to hepatic IGF-1 gene expression and percent weight gain, the dietary optimal arginine level was found to be 15.97 and 16.76 g/kg and 17.06 and 17.41 g/kg, respectively with the optimum range of 15.97 to 17.41 g/kg for successful culture of GIFT in ISW of 10 ppt salinity.

Analysis of Viral Load Factors in Sweet Potato Leaf (Ipomoea batatas) Increases Blood Hemoglobin Levels of Adolescents in Pesantren Ainul Yaqin Jambi City

Anemia among teenagers occurs when their dietary intake fails to meet their iron requirements, necessitating iron supplementation. Typically, iron supplements are derived from Fe tablets, often inducing symptoms like nausea and dark-colored stools, which are unpopular among teenagers. One alternative local food source rich in iron are sweet potato leaves. However, the iron content in sweet potato leaves is not widely recognized by the public. This study aims to evaluate the efficacy of incorporating sweet potato (Ipomoea Batatas) leaves into the diet of teenagers at the Ainul Yaqin Islamic Boarding School in Jambi City, with the objective of increasing their blood iron levels. This research employed a quasi-experimental design utilizing a two-group pre-test-post-test methodology. A sample of 50 individuals was selected based on homogeneity in their daily food consumption at the Ainul Yaqin Islamic boarding school in Jambi City. Hb stick examination instruments and Easy Touch Hb scales were utilized to measure the weight of sweet potato leaves. Participants were administered sweet potato leaves for a period of 10 days. The average Hb level before treatment was 11.828 g/dl for the treatment group and 14.949 g/dl for the control group. Following treatment, the average Hb level increased to 13.392 g/dl for the treatment group and 14.532 g/dl for the control group. The treatment group exhibited a notable increase of 1.56 g/dl in Hb levels, whereas the control group saw a marginal increase of only 0.04 g/dl. These results indicate a significant effect of sweet potato leaves in elevating blood hemoglobin levels, with a p-value of 0.00. Anemia among teenage girls can be prevented by incorporating sweet potato leaves into their diet as a vegetable twice a week at the Ainul Yaqin Islamic boarding school. This affordable option offers numerous benefits and taps into local wisdom. Keywords: Sweet potato leaf, haemoglobin, Anemia, Adolescent

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review).

Retinopathy of prematurity (ROP) is a retinopathy caused by abnormal proliferation of blood vessels in premature infants. It can lead to retinal detachment and, in severe cases, blindness, rendering ROP a critical condition. Advances in neonatal medicine have improved survival rates of low birth weight and low gestational age infants. However, this progress has also led to a rise in incidence of ROP. Currently, premature birth, low birth weight and high postpartum oxygen levels are independent risk factors for ROP. Other factors include mode of delivery, multiple births, anemia, blood transfusion, maternal pregnancy factors, neonatal bronchopulmonary dysplasia, use of surfactants, arterial ductus arteriosus and necrotizing enterocolitis. Laboratory indicators in premature infants such as platelet count, levels of blood glucose, inflammatory cells, lipid and hemoglobin and blood transfusion may also be associated with ROP. However, the etiology and pathogenesis of ROP are not fully understood. A number of factors may influence the onset and progression of ROP, including decreased platelet counts, decreased hemoglobin levels, increased white blood cell counts, increased blood glucose levels, and disorders of lipid metabolism. The present study reviewed the effects of platelet count, hemoglobin, blood glucose, inflammatory cells and factors, blood lipids, and plasma metabolic pathways on ROP.

Risk factors associated with wheezing in severe pediatric community-acquired pneumonia: a retrospective study.

Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated with the development of wheezing pneumonia and its clinical features are not fully characterized, especially in children with severe pneumonia. We retrospectively recruited 1434 pediatric patients diagnosed with severe pneumonia between April 2012 and September 2019 in Fujian Maternity and Child Health Hospital. The medical records regarding demographic information, clinical manifestations, radiographic/laboratory findings, and complications were collected. Based on the presence or absence of wheezing symptoms and signs, subjects were divided into wheezing cohort (N.=684) and non-wheezing cohort (N.=750), and their clinical data were compared. Multivariate cox regression analysis was performed to identify independent risk factors of wheezing. Demographic features including gender, weigh, onset season, birth weight, full-term birth or not, history of pneumonia were significantly associated with the occurrence of wheezing in severe CAP (P<0.05). Specifically, male gender, onset seasons in autumn/winter, and absence of a history of pneumonia were identified as independent risk factors of wheezing in multivariate analysis (P<0.05). As for clinical features, wheezing cohort differed from the non-wheezing one in terms of clinical manifestation (higher incidence of cough and breathless, but lower incidence of fever), laboratory finding (higher levels of red blood cells, hemoglobin, and albumin and lower levels of total or indirect bilirubin and creatine), pathogen detection (higher incidence of respiratory syncytial viral infection), and clinical complications (lesser risk of sepsis and hydrothorax) (P<0.05). Severe CAP with wheezing is a special clinical entity of severe pneumonia in children, which has specific risk factors and differ from non-wheezing pneumonia in terms of clinical features and etiologic pathogens.

MODERN APPROACHES TO THE PHARMACOTHERAPY OF ANEMIA

Anemia is a common blood disorder characterized by a decrease in the number of red blood cells or hemoglobin levels, leading to symptoms such asfatigue, weakness, and shortness of breath. Pharmacotherapy plays a crucial role in managing anemia by addressing underlying causes and restoring normal hemoglobin levels. This article explores the current state of pharmacological treatments for anemia, including erythropoiesis-stimulating agents, iron supplements, and newer innovative therapies such as erythroid maturation agents. It also discusses the challenges and future directions in the field of anemia pharmacotherapy.

Effects of chlorpyriphos on haematological parameters in freshwater fish Anabas testudineus

Haematological measures are frequently employed as stress indicators in fish and to evaluate their overall health. This study evaluated the sublethal effects of the organophosphate insecticide chlorpyriphos on a number of haematological parameters in freshwater fish, specifically Anabas testudineus. Based on comparisons between control and experimental groups exposed to sublethal amounts of chlorpyrifos (0.125 and 0.250) at 7, 14, and 21 days, the effect was evaluated. Red blood cell counts, haemoglobin levels, WBC, and thrombocyte counts were found to decline as chlorpyrifos concentrations and days increased. White blood cell counts rose on the seventh day of exposure but fell on the fourteenth and twenty-first days when chlorpyrifos concentrations rose. According to the study, chlorpyrifos had a major negative effect on the fish's health, and haematological measures might be used as a diagnostic tool to determine whether A. testudineus has been exposed to chlorpyrifos.. KEYWORDS :A. testudineus, Chlorpyrifos, haemoglobin, Rbc, Wbc, haematological.

High Doses of Dexamethasone Improved Hemoglobin Levels Lowered by Corona Virus in COVID-19 Infected Patients

Corona virus an infectious disease caused by SARS–CoV-2 virus that lower hemoglobin level leading to worsening of the conditions. The respiratory symptoms are treated by steroids and patients are rapidly recovered. Objective: To study the effect of high and low doses of dexamethasone on hemoglobin level in COVID-19 infected patients. Methods: This experimental study was carried out in Rawal Institute of Health Sciences, Islamabad and Pakistan Institute of Medical Sciences, Islamabad between May 2021 to Sep 2021 on 100 adult male and female of COVID-19 patients having blood hemoglobin level &lt; 10 g/dl. For different doses of dexamethasone patients were divided into two groups of 50 patients in each group. Blood samples were taken on day 01 and day 15 for hemoglobin analysis. Mean and standard deviation of both groups was calculated and p-value of &lt; 0.05 was considered significant. Results: At the time of admission 74% of the patients had a cough, 89% of the patients presented with fever, 98% had increased heart rate whereas 100% of the patients presented with the complaint of fatigue. Mean Hemoglobin (Hb) levels of both groups were compared on day 01 and day 15 respectively. The comparison of Hb levels showed a significant difference on day 15, there was a marked increase in Hb levels in the group which was taking 12mg/day of dexamethasone as compared to the group which was taking 6mg/day of dexamethasone (P-value &lt;0.05). Conclusions: Administration of high doses of Dexamethasone caused a pronounced increase in hemoglobin levels in COVID-19 patients

Kegiatan Skrining Pemeriksaan Hemoglobin dan Hematokrit terhadap Penyakit Anemia pada Kelompok Lanjut Usia di Panti Werda Hana

Anemia in the elderly is a common condition characterized by a decrease in red blood cells or hemoglobin levels, causing various health problems. Anemia is defined as a hemoglobin level below 13 g/dL in men and 12 g/dL in women. Various factors, such as inadequate nutritional intake, chronic inflammation, and kidney disease, often cause anemia in this population. Untreated anemia impacts quality of life, increases hospitalization rates, the risk of falls, and cognitive decline, and is independently associated with higher mortality from cardiovascular stress. This activity uses the PDCA (Plan-Do-Check-Action) method to screen and treat anemia in elderly participants Hana Nursing Home. We conducted complete blood tests on 61 respondents to evaluate their hematological profile. The blood test results revealed an average hematocrit of 36.15% for the participants, and anemia in 11 (18.03%) men and 19 (31.15%) women. Routine hemoglobin screening and effective management are essential for early detection and intervention, thereby improving the quality of life of the elderly. Keywords: Anemia, Elderly, Hemoglobin, Hematocrit

Different concentrations of high fructose corn syrup in broiler diet cause different effects on selected hematological parameters

This study was aimed to explore how the consumption of high fructose corn syrup (HFCS) affects blood parameters of broilers. Total 120 chickens were divided into three groups including 4 subgroups in each with free access to food and water for 42 days. The control group received no additional treatment, while the second and third groups were fed diets containing 5% or 10% HFCS, respectively. On the last day, broilers were euthanized, and 5 mL blood samples were collected for hematological analyses. Results indicated no significant differences in red blood cell (RBC) or hemoglobin (HGB) levels between the control and 5% or 10% HFCS- treated groups. However, 10% HFCS treatment significantly increased packed cell volume (PCV) and mean corpuscular volume (MCV), while 5%-HFCS increased mean corpuscular hemoglobin (MCH) and decreased mean corpuscular hemoglobin concentration (MCHC) compared to the control group. Total leukocyte counts (TLC) and monocyte values remained unaffected by HFCS treatments. Notably, 5% HFCS treatment increased basophil, heterophil, and heterophil/lymphocyte ratio while decreasing lymphocyte. Conversely, 10% HFCS treatment reduced eosinophil and heterophil, increasing lymphocyte counts. In conclusion, our study suggests that dietary fructose intake can modify certain hematological parameters, potentially serving as early indicators of future systemic or metabolic issues.

#2505 PTEN ablation in osteocytes exacerbates anemia in mice with subtotal nephrectomy

Abstract Background and Aims The identification of novel roles for bone as a principal endocrine organ has grown in recent decades, being now recognized for its contribution to the regulation of numerous systemic functions. In previous studies, we observed that 5/6Nx mice with osteocytic deletion of phosphatase and tensin homolog (PTEN), exhibited higher bone volume in 5/6Nx mice, consistent with studies under normal renal conditions. However, we also noted a decrease in blood hemoglobin levels, prompting further exploration. This study aims to elucidate the causative actions by which specific PTEN deletion in osteocytes influences red blood cell (RBC) homeostasis and to identify its possible involvement in anemia development. Method To achieve this goal, we used mice with targeted PTEN deletion in osteocytes (PTEN Ocy-cKO) by crossing DMP1-Cre ± and PTENflox/flox mice, subjected to subtotal nephrectomy (5/6Nx) at 2 months of age. Two weeks post-surgery, bone and blood samples were collected for plasma biochemistry, blood count, RBC membrane integrity, and preliminary bone+bone marrow proteomic analysis. Cre-negative mice and animals with normal renal function were included as controls. Results Our findings revealed that PTEN Ocy-cKO mice, under both normal and reduced renal function conditions, showed higher bone volume than corresponding controls. In terms of blood homeostasis, PTEN Ocy-cKO mice with normal renal function showed splenomegaly and a lower number of circulating RBCs. Notably, PTEN Ocy-cKO mice undergoing 5/6Nx experienced a profound decrease in RBC number in only two weeks, independent of renal erythropoietin expression. Further exploration ruled out bone marrow failure as a cause, as the erythroid progenitor (CD45-CD71+Ter119+) population remained similar in both groups. Extramedullary hematopoiesis was observed in the spleen, in addition to increased circulating reticulocyte number in the PTEN Ocy-cKO mice. Finally, altered RBC membrane protein patterns in PTEN Ocy-cKO mice suggested reduced mechanical/osmotic resistance. Preliminary proteomic analysis identified downregulation of Slc4a1 (Band3) and Phosphofructokinase (Pfkm), whose deficiencies have been previously linked to anemia. Conclusion In conclusion, our results propose that osteocytes contribute to RBC homeostasis through a pathway downstream of PTEN, and open a new avenue for understanding anemia in chronic kidney disease and a potential target for future treatments.

Edukasi Gizi Tentang Anemia Pada Remaja Putri di SMA Negeri 1 Batang Kuis

&lt;p&gt;&lt;em&gt;Iron deficiency anemia can have an impact on young women, such as getting tired quickly, reducing the body's resistance to infectious diseases, reducing body fitness, reducing concentration and learning achievement, reducing the immune system and disrupting physical growth. Iron deficiency anemia during adolescent girls in turn leads adolescent girls to anemia in later pregnancy.&lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;em&gt;The aim of this activity is to increase knowledge about anemia so that teenage girls can prevent anemia&lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;em&gt;Community service implemented at SMA Negeri 1 Batang Kuis. Activities that have been implemented: Obtain permission from headmaster, measuring nutritional status, checking blood hemoglobin levels, carrying out counseling using LCD tools and booklets. Participants were 50 students from SMA N 1 Batang Kuis&lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;em&gt;The implementation results showed that 22% of the female students' nutritional status was very thin and underweight, 20% of the female students' nutritional status was overweight and 22% of the female students were anemic. There was an increase in female students' knowledge about anemia by 3.52 points from 9.2 points before counseling to 12.72 points after counseling. Likewise, attitudes increased by 4.26 points from 50.78 points to 55.0 points. The resulting output: Published in the Community Service journal&lt;/em&gt;&lt;/p&gt;

The clinical significance of TAT, PIC, TM, and t-PAIC in vascular events of BCR/ABL-negative myeloproliferative neoplasms

Predicting the likelihood vascular events in patients with BCR/ABL1-negative myeloproliferative neoplasms (MPN) is essential for the treatment of the disease. However, effective assessment methods are lacking. Thrombin-antithrombin complex (TAT), plasmin-α2- plasmininhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC) are the new direct indicators for coagulation and fibrinolysis. The aim of this study was to investigate the changes of these four new indicators in thrombotic and hemorrhagic events in BCR/ABL1-negative MPN. The study cohort of 74 patients with BCR/ABL negative myeloproliferative disorders included essential thrombocythemia, polycythemia vera, and primary myelofibrosis (PMF). A panel of 4 biomarkers, including TAT, PIC, TM, and t-PAIC were determined using Sysmex HISCL5000 automated analyzers, whereas fibrin/fibrinogen degradation products (FDP), D-dimer and Antithrombin III (ATIII) were analyzed using Sysmex CS5100 coagulation analyzer. A total of 24 (32.4%) patients experienced thrombotic events and hemorrhagic events occurred in 8 patients (10.8%). Compared to patients without hemorrhagic-thrombotic events, patients with thrombotic events had higher fibrinogen (FIB) level, FDP level and lower ATIII activity, while patients with hemorrhagic events had lower white blood cell count and hemoglobin level, higher FDP level (P < 0.05). Patients with a JAK2V617F mutation were more likely to experience thrombotic events (P < 0.05). In addtion, patients with thrombotic events had higher TAT, PIC, TM, and t-PAIC levels than patients without hemorrhagic-thrombotic events (P < 0.05), whereas patients with hemorrhagic events had a lower median value in TAT and TM (no statistical difference, P > 0.05). Patients with higher TAT, TM and t-PAIC were more likely to experience thrombotic events (P < 0.05), and only TAT was positively correlated with thrombotic events (Spearman r =0.287, P = 0.019). TAT, PIC, TM, and t-PAIC combined with ATIII and FDP have a certain value for predicting thrombosis in patients with BCR/ABL1-negative MPN. These 6 parameters are worth further exploration as predictive factors and prognostic markers for early thrombotic events.

Impact of anemia on incidence of perioperative lower limb deep vein thrombosis in patients undergoing total hip arthroplasty

To explore the impact of anemia on the incidence of perioperative lower limb deep vein thrombosis (DVT) in patients undergoing total hip arthroplasty (THA). A retrospective analysis was conducted on clinical data of 1 916 non-fracture patients who underwent THA between September 2015 and December 2021, meeting the selection criteria. Among them, there were 811 male and 1 105 female patients, aged between 18 and 94 years with an average of 59.2 years. Among the patients, 213 were diagnosed with anemia, while 1 703 were not. Preoperative DVT was observed in 55 patients, while 1 861 patients did not have DVT preoperatively (of which 75 patients developed new-onset DVT postoperatively). Univariate analysis was performed on variables including age, gender, body mass index (BMI), diabetes, hypertension, history of tumors, history of thrombosis, history of smoking, revision surgery, preoperative D-dimer positivity (≥0.5 mg/L), presence of anemia, operation time, intraoperative blood loss, transfusion requirement, and pre- and post-operative levels of red blood cells, hemoglobin, hematocrit, and platelets. Furthermore, logistic regression was utilized for multivariate analysis to identify risk factors associated with DVT formation. Univariate analysis showed that age, gender, hypertension, revision surgery, preoperative levels of red blood cells, preoperative hemoglobin, preoperative D-dimer positivity, and anemia were influencing factors for preoperative DVT ( P<0.05). Further logistic regression analysis indicated that age (>60 years old), female, preoperative D-dimer positivity, and anemia were risk factors for preoperative DVT ( P<0.05). Univariate analysis also revealed that age, female, revision surgery, preoperative D-dimer positivity, anemia, transfusion requirement, postoperative level of red blood cells, and postoperative hemoglobin level were influencing factors for postoperative new-onset DVT ( P<0.05). Further logistic regression analysis indicated that age (>60 years old), female, and revision surgery were risk factors for postoperative new-onset DVT ( P<0.05). The incidence of anemia is higher among patients with preoperative DVT for THA, and anemia is an independent risk factor for preoperative DVT occurrence in THA. While anemia may not be an independent risk factor for THA postoperative new-onset DVT, the incidence of anemia is higher among patients with postoperative new-onset DVT.

Comprehensive analysis of the clinical manifestations and hematological parameters associated with secondary immune thrombocytopenia in patients with primary Sjögren syndrome: An observational study.

Primary Sjögren Syndrome (pSS) is a chronic autoimmune disease that primarily affects exocrine glands and can lead to various extraglandular manifestations, including secondary immune thrombocytopenia (ITP). Understanding the clinical and hematological differences in pSS patients with and without secondary ITP is crucial for improved patient management and treatment strategies. This retrospective study, conducted from January 2020 to December 2023, involved a cohort of pSS patients, dividing them into 2 groups: those with secondary ITP and those without. Patients were evaluated using the European League Against Rheumatism Sjögren Syndrome Disease Activity Index (ESSDAI), EULAR Sjögren Syndrome Patient-Reported Index (ESSPRI), Health Assessment Questionnaire, and other hematological parameters. Inclusion criteria were based on the American-European Consensus Group or ACR/EULAR classification criteria for pSS. Exclusion criteria included other autoimmune or hematological disorders, prior splenectomy, recent blood transfusions, and lack of informed consent. Statistical analysis was performed using SPSS software, with various tests applied to analyze the data, including logistic regression to identify risk factors for secondary ITP. Significant differences were noted in fatigue, lymphadenopathy, arthritis, mean age, and ESSDAI scores between the secondary ITP and non-secondary ITP groups. Patients with secondary ITP exhibited higher platelet counts, more prevalent lymphopenia, higher immunoglobulin G (IgG) levels, lower complement 3 levels, and reduced white blood cell and hemoglobin levels. Logistic regression analysis identified lymphadenopathy as a risk factor and arthritis as a protective factor for the development of secondary ITP. The study reveals distinct clinical and hematological characteristics in pSS patients with secondary ITP, suggesting a higher disease activity in this subset. These findings underscore the need for further exploration of these associations to develop more precise treatment approaches for pSS, focusing on preventing secondary ITP and improving patient outcomes.

Astragalus membranaceus Treatment and Clinical Care Pathways for Inflammation and Oxidative Stress Management in Hemodialysis

This study aimed to investigate the effects of Astragalus membranaceus (AM) treatment combined with clinical care pathways (CCP) on inflammation and oxidative stress response in hemodialysis (HD). This study comprised the establishment of an animal model for HD and the enrollment of 60 maintenance HD patients. Rats were categorized into control + HD and AS-IV + HD groups, while patients were randomly allocated to control + CCP or AM + CCP groups. In the animal model, Astra-galoside IV (AS-IV), a primary active component of AM, was administered to HD rats to assess dialysis efficiency and examine inflammatory and oxidative stress markers. For patients, assessments of hematological and biochemical parameters, inflammatory and oxidative stress markers, and health-related quality of life (HRQoL) were conducted before and after a 6-month intravenous infusion of AM injection. In the rat model, AS-IV significantly enhanced dialysis efficiency and decreased levels of inflammatory factors and oxidative stress markers compared to the control + HD group. In patients, significant improvements in white blood cell count (WBC), hemoglobin (HGB), hematocrit (HCT), and albumin (ALB) levels in the AM + CCP group after 6 months when compared to the control + CCP group, with the reduced inflammation and oxidative stress response. Additionally, various dimensions of HRQoL showed significant improvements in the AM + CCP group compared to the control + CCP group. Astragalus membranaceus, when integrated into clinical care pathways, holds potential as an adjunctive therapy for individuals undergoing hemodialysis.

Genotypic Variations in Exercise-Induced Hemoglobin Oxygen Desaturation in Sickle Cell Disease: The Role of Hemoglobin Levels

Background: Sickle cell disease (SCD) presents abnormal hemoglobin S (HbS) and frequent vaso-occlusive crises. Previous studies reveal exercise intolerance in SCD patients. However, the role of exercise-induced hemoglobin oxygen desaturation (EIHOD) and its predictors remains unclear. This study investigates EIHOD in adult SCD patients, focusing on potential predictors, aligning with the hypothesis that EIHOD is prevalent and varies across genotypes, with hemoglobin as a predictor. Methods: A cross-sectional study was conducted on adult patients with HbSS and HbSC genotypes in a steady state at the Korle-Bu Teaching Hospital, Ghana. Clinical, hematological, and haemolytic markers were assessed. Lung function was evaluated through spirometry, and a six-minute walk test (6MWT) was performed to assess EIHOD. Logistic regression was used to identify predictors of EIHOD. We hypothesis that, EIHOD is common in SCD, varying across genotypes, with hemoglobin predicting its occurrence. Results: The prevalence of EIHOD was 41% in HbSS patients and 36.1% in HbSC patients. No significant differences were observed in age, white blood cell count, platelet count, hemolytic markers, hemoglobin levels, or lung function parameters between SCD patients with and without EIHOD. In the logistic regression model, none of the variables predicted EIHOD in HbSS patients. In HbSC patients, reduced hemoglobin was the only predictor of EIHOD (OR=0.551; 95% CI=0.315-0.964; p-value= 0.037). Discussion: The study highlights a high prevalence of EIHOD within the HbSS genotype, emphasizing the importance of hemoglobin levels as a predictor of EIHOD in SCD. Contrarily, hemolytic markers and lung function were not predictors of EIHOD across either genotype. These results suggest the potentially heightened significance of EIHOD-related complications in patients with the HbSS genotype. Conclusion: EIHOD is common in SCD, more so in HbSS. Reduced hemoglobin predicts EIHOD in HbSC. Lung function and hemolytic markers don't. Understanding the impact of EIHOD in SCD may guide interventions to improve exercise tolerance and reduce complications in this population. No Funding. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.