Level Of Fructosamine Research Articles

Clinical availability of serum fructosamine measurement in diabetic patients with uremia. Use as a glycemic index in uremic diabetes.

Serum fructosamine levels were investigated in patients with uremia undergoing various modes of treatment. The serum fructosamine levels correlated positively with the blood glucose levels determined a week or two earlier. The fructosamine levels were significantly affected by the protein concentration, and those corrected for protein concentrations had a closer correlation to the blood glucose levels than did the uncorrected levels. The corrected fructosamine levels were not significantly different between healthy volunteers and nondiabetic patients with uremia on conservative treatment. In an in vitro system, fructosamine concentrations were hardly affected by urea, which is known to influence the level of hemoglobin A1. These results suggest that serum fructosamine measurement can provide us with reliable information on a short-term glycemic condition, even in azotemic patients. To be more precise, the serum level of fructosamine corrected for protein concentration can be an excellent glycemic index which is not susceptible to over- or dehydration and is of high clinical value, especially in the management of diabetic patients with chronic renal failure.

Hemoglobin A 1 and serum fructosamine levels in hyperthyroidism

The severity, prevalence and pathogenesis of abnormalities of carbohydrate metabolism in hyperthyroidism are incompletely defined. The extent of glycosylation of proteins provides an objective, retrospective index of glycemic control. We have measured the percent hemoglobin A 1, random plasma glucose level and serum concentrations of fructosamine, total protein and albumin in hyperthyroid and euthyroid subjects attending a hospital-based thyroid clinic. A significant ( p = 0.002) increase in the mean value for hemoglobin A 1 and a significant ( p = 0.0003) decrease in the mean values for fructosamine were found in the hyperthyroid group. The lower mean fructosamine value in the hyperthyroid group was attributed to a concomitant decline in the mean albumin concentration ( p = 0.001). The mean value for glucose tended to be higher in the hyperthyroid group, but the difference did not reach significance at the 0.05 level ( p = 0.09). The finding of a higher mean hemoglobin A 1 concentration in hyperthyroid patients compared to euthyroid subjects is new evidence for a persistent abnormality in glycemic regulation in most thyrotoxic patients.