Levels Of Disturbance Research Articles

Longitudinal patterns of behavioral and psychological symptoms of dementia in community‐dwelling older people

AbstractBackgroundBehavioral and psychological symptoms of dementia (BPSD) exhibit fluctuate by symptoms. This can cause difficulty for caregivers in addressing symptoms and a greater care burden. Few studies have analyzed the longitudinal course of multiple BPSD together. We aimed to identify the trajectory groups of 12 BPSD symptoms and assess the predictors of trajectory group membership.MethodData were drawn from the National Alzheimer’s Coordinating Center Uniform Data Set comprising participants who were followed up approximately annually in the United States. We examined home‐dwelling participants who were followed‐up for at least 1 year from 2015 to 2020. Individuals with cognitive decline (Clinical Dementia Rating of more than 0.5 and diagnosis of mild cognitive impairment or dementia) were included (n = 1,585). Twelve symptoms of BPSD were measured using the Neuropsychiatric Inventory. We used group‐based multi‐trajectory models to identify latent trajectory groups. Multinomial logistic regression analysis was conducted to assess participants’ characteristics at baseline associated with trajectory groups.ResultAmong participants, mean age was 75.7 years, median annual number of visits was 3 (interquartile range: 2‐5 visits), 44% were female, 74% lived with their spouse/partner, and 38% were able to live independently. Four trajectory groups were identified. One group showed relatively higher levels of all symptoms across years. In two groups, moderate levels of agitation, irritability, and depression, and moderate levels of apathy, appetite disturbances, and hallucinations were observed. The fourth group exhibited lower levels of all symptoms. Multinomial logistic regression models revealed that, compared with the lower‐level group, older age was associated with lower odds of other group membership. The level of dependence and cognitive decline were associated with higher odds of other group membership, although their interaction indicated lower odds. Male was a predictor of higher‐level group. Living with someone was a predictor for a group with moderate levels of apathy, appetite disturbances, and hallucinations.ConclusionWe identified at least four trajectories in 12 BPSD symptoms over 5 years, and their common and specific predictors among community‐dwelling people with dementia. Inferring individual group membership using these predictors may be helpful for determining appropriate measures for addressing expected BPSD.

Optimizing functional zoning for Dalingshan Forest Park in China through microcosmic human disturbance evaluation.

Human disturbance stands as a prominent factor influencing the ecological environment within natural protected areas. Presently, the issue of balancing human activities and ecological preservation has emerged as a critical concern in the construction of China's natural protected area system. Functional zoning serves as the cornerstone of natural protected area management and represents a pivotal tool in achieving this equilibrium. This study endeavors to introduce a set of functional zoning methods for natural protected areas based on human disturbance assessments. Utilizing Dalingshan Forest Park in Dongguan city which is known for its significant human disturbances as a case study, field surveys were conducted to identify various types of small-scale and understory-hidden human disturbances, such as residential areas, roads, tourist areas, forestry areas, and energy facilities. Subsequently, a microcosmic human disturbance model tailored to forested areas was developed using the analytic hierarchy process. By integrating the findings of macrocosmic human disturbance assessments conducted concurrently by the research group, a functional zoning plan for Dalingshan Forest Park was proposed. The results show that ecological conservation zones within the park should be established in three specific areas, primarily in regions with low-level microcosmic human disturbance (levels 1 and 2) and terrain fluctuations ≥110 m. In contrast, the rational use zone is notably influenced by tourist infrastructure and road networks, predominantly located in regions with high human activity, such as popular tourist destinations and areas with road classifications and vehicular traffic. The microcosmic human disturbance assessment method proposed in this study enhances the rationality and accuracy of natural protected area functional zoning. It provides a more scientifically grounded research approach for similar studies concerning natural protected area functional zoning and contributes valuable insights for the further advancement of China's efforts in the integration and optimization of natural protected areas.

Systemic Oxidative Stress Parameters in Skin Cancer Patients and Patients with Benign Lesions

Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells and tissues and the capacity of a biological system to eliminate these reactive substances. Systemic oxidative stress biomarkers in plasma, serum, urine, or red blood cells have been found to be elevated in many diseases, including skin cancer. UV radiation (UVR) induces damage to biomolecules that enter the bloodstream, reinforcing systemic oxidative stress. On the other hand, pre-existing systemic oxidative stress does not supply the skin with the adequate micronutrients and antioxidant resources to ameliorate the skin’s antioxidant defense against UVR. In both scenarios, skin cancer patients are exposed to oxidative conditions. In the case of warts, oxidation is linked to chronic inflammation, while impaired cutaneous antioxidant defense could ineffectively deal with possible oxidative stimuli from viral agents, such as HPV. Therefore, the aim of our study is to evaluate the existing data on systemic oxidative stress in skin diseases such as non-melanoma skin cancer (NMSC), basal-cell carcinoma (BCC), squamous-cell carcinoma (SCC), and melanoma as well as benign lesions such as actinic keratosis (AK), sebaceous keratosis (SK), and warts. Previous studies have demonstrated that patients with NMSC, melanoma, AK, and warts (both genital and non-genital) are subjected to severe oxidative stress, indicated by disturbed antioxidant enzyme levels, accumulated oxidized proteins and lipid products, and, to a lesser extent, lower concentrations of micronutrients. Interestingly, medical history of NMSC or melanoma as well as stage of skin cancer and treatment approach were found to affect systemic oxidative stress parameters. In the case of warts (both genital and non-genital), high oxidative stress levels were also detected, and they were found to be aligned with their recalcitrant character.

Determinants of plant community along environmental gradients in Geramo forest, the western escarpment of the rift valley of Ethiopia.

Detailed information on plant community types, distribution, and their relationships with various environmental gradients is crucial for understanding forest dynamics and sustainable forest management because plant community types are influenced by various environmental factors. Thus, this study was conducted to investigate plant community types and species diversity in relation to various environmental gradients in Geramo Forest, which is a remnant forest in the western escarpment of the Rift Valley of Ethiopia. Vegetation data were collected in 96 nested plots (20 × 20 m2 and five 1 ×1 m2) laid systematically at a distance of 250 m along 16 line transects, which were laid 300 m apart. Environmental and disturbance variables were also collected from each main plot. Agglomerative hierarchical cluster analysis and Canonical correspondence analysis (CCA) with R software were used to identify plant community types and analyze the relationship between plant community types and environmental variables, respectively. The Shannon Wiener diversity index was used to compute species diversity among community types. Five significantly different (p ≤ 0.001) plant community types were identified. The CCA results showed that species diversity and community composition among different community types were significantly influenced by altitude, disturbance, soil organic carbon, slope, soil available phosphorus, and pH, which revealed the compounded effect of various environmental factors on species richness, diversity, and evenness among plant community types. The study also identified a significant level of anthropogenic disturbance and a strong reliance of the local community on the forest in the research area. Therefore, it is recommended that sustainable forest conservation interventions be implemented through awareness creation and the promotion of community-based approaches.

Psychological disturbances encountered by selected undergraduates studying at the University of Ruhuna, Sri Lanka during the Covid-19 pandemic: a cross-sectional study

University undergraduates are increasingly recognized as a vulnerable population with a higher level of psychological disturbances. During the Covid-19 pandemic, universities closed all over the world, resulting in the psychological well-being of this population being severely affected across the globe. This study examined the prevalence of stress, anxiety, and depressive symptoms encountered by undergraduates of the selected five faculties at the University of Ruhuna in Southern Sri Lanka due to the Covid-19 pandemic, its associated factors, and the correlations between stress, anxiety, and depressive symptoms. An online, cross-sectional, descriptive study was conducted among undergraduates using pre-tested, self-administered questionnaires from the randomly selected five faculties: Allied Health Sciences, Engineering, Humanities and Social Sciences, Management and Finance, and Medicine. Undergraduates were invited to complete the Google Form. Socio-demographic details and a 21-item Depression, Anxiety, and Stress Scale (21-DASS) were used for data collection. Stress, anxiety, and depressive symptoms were evaluated using a Sinhala version of the 21-DASS scale. Ethical permission was granted by the Ethics Review Committee of the Faculty of Allied Health Sciences, University of Ruhuna. Among the 359 undergraduates, the majority were represented by females (62.1%). The mean age of the sample was 23.67 years (SD ± 1.6). Stress, anxiety, and depressive symptoms were found to be prevalent in 53.7%, 41.8%, and 63.8% of undergraduates respectively. Younger and female undergraduates had more impact on psychological issues than their counterparts. It revealed a significant positive correlation between anxiety and depressive symptoms (r = 0.646, p < .001), anxiety and stress (r = 0.868, p < .001), and stress and anxiety (r = 0.786, p < .001). Most undergraduates experienced considerable levels of stress, anxiety, and depressive symptoms during the Covid-19 as increasing stress, anxiety, or depressive symptoms, tend to increase all types of psychological disturbances. The development of mental health among undergraduates is essential and needs innovative strategies to improve the psychological well-being of undergraduates. The initiation of a stress management programme and expanded available counseling services are also important. Further studies are needed to be conducted on the extended topic of how the Covid-19 era is affecting the psychological well-being of undergraduates from different universities (state/non-state), locations, and different study departments.

Status and Influencing Factors of Body Image Disturbance in Patients With Hemifacial Spasm: A Quantitative and Qualitative Study

Patients diagnosed with hemifacial spasm (HFS) often experience significant facial changes that affect their body image and potentially have a negative impact on their physical and psychological well-being. This study therefore seeks to identify the current state of body image of Chinese patients with HFS, analyze the factors that influence it, and further explore their experiences based on their level of body image disturbance (BID) using a mixed methods approach. A mixed-methods study was conducted between January 2021 and June 2023. Phase I encompassed the completion of questionnaires by 124 participants. Subsequently, in Phase II, in-depth interviews were conducted with 15 individuals selected from Phase I to gain deeper insights into their specific experiences with BID. Patients afflicted with HFS achieved Body Image Scale scores 9.00 (0.00, 12.00). Age, anxiety, depression, and fear of negative evaluation were identified as predictors of exacerbated BID (P < 0.05). Qualitative research predominantly centered on 2 primary themes: the experiences and outward manifestations of BID in HFS patients. These individuals expressed dissatisfaction with their appearance, apprehensions about being the focus of attention, and instances of social avoidance. Owing to varying degrees of anxiety, depression, and apprehension about external evaluation, individuals grappling with HFS are susceptible to experiencing BID. Consequently, when devising interventions, it is imperative to conduct a comprehensive assessment of the patient's condition and implement targeted measures aimed at ameliorating body image, ultimately enhancing the overall quality of life for the patient.

An intermediate level of disturbance with customary agricultural practices increases species diversity in Maya community forests in Belize

Across the planet, Indigenous societies control, use, and manage large tracts of tropical forest that are crucial for combating climate change. Here we investigate whether customary Indigenous agricultural practices can increase forest species diversity using swidden (aka, slash-and-burn) agriculture. We examine the community lands surrounding two Q’eqchi’ Maya villages in southern Belize using high-resolution multispectral imagery that we collected with drones, ground truth data related to land use and history, and a plant and tree biodiversity survey. We use computational methods including simulation and Bayesian modeling to analyze the relationship between spectral diversity, forest diversity, and landscape disturbance. Our key result, replicated in both villages, is that the highest level of spectral diversity (a proxy for forest diversity) is associated with an intermediate level of forest disturbance. In conclusion, we suggest that concepts from complex adaptive systems can provide an important conceptual framework for understanding how ecosystem enhancement can emerge from customary Indigenous land use practices.

Effects of dispersed and aggregated retention on epiphytic microarthropod assemblages: A northern hardwood forest case study

Epiphytic lichens and bryophytes provide important habitat for microarthropods, yet little work has documented epiphytic microarthropod assemblages. Further, the response of epiphytes and their associated microarthropod communities to varying levels of forest disturbance and cutting intensity are not well known. We conducted a case study to provide an initial community description of epiphyte-dwelling microarthropods in Adirondack northern hardwoods, and to assess potential for impacts of aggregated and dispersed patterns of reserve tree retention to these communities. In total, 79 families of microarthropods were identified in the 0.14 m2 of samples. Late summer average daily maximum temperatures were 3.2 °C higher in the shelterwood, and three years following treatments the per-unit area dry weight of the bole-associated bryophyte Neckera pennata was 34 % lower in the shelterwood. Microarthropod richness and density were distinctly greater in epiphyte substrates at the base of trees, and were reduced in the shelterwood. Several indicator taxa were identified within the basal bryophytes in the reserve treatment, and in both bryophytes the microarthropod assemblages were more homogenous in the shelterwood. A few mobile and heavily sclerotized taxa persisted in shelterwood substrates, especially in the lichens which lacked 3-dimensional structure. This case study revealed a diverse community of microarthropods in northern hardwood forests that were structured by epiphyte type, height on tree and, potentially, by canopy removal, and suggests conservation value of aggregated tree retention when applying even-age regeneration methods with respect to epiphytic bryophytes, lichens, and their associated invertebrates.

Parenting Style in Single-parent Family Influence on the Development of Adolescent Depression

Parenting styles have been shown through empirical studies to be a central determinant in the depression of youth throughout the past decades. This review examines the two most dominant negative parenting styles in single-parent families and explores how single parents with two negative parenting styles contribute to adolescent depression. Based on the special economic constraints and excessive parenting responsibilities, single parents are apt to adopt authoritarian parenting and neglect parenting styles, in which authoritarian parenting styles presenting restrictive rules and harsh punishments will lead to low-level parenting self-esteem and high levels of emotional disturbances for teenagers. Also, neglectful parenting styles which are characterized by fewer parental involvements will significantly impair the adolescents disability to express and manage emotions. The conclusion is that authoritarian parenting style and neglectful parenting style negatively influence adolescent depression in single-parent families. This review provides a perspective on the impact of single-parent family background on adolescent depression. Future research should focus on how to help parents develop appropriate parenting styles to decrease the risks of suffering depression for adolescents.

Effect of seaweed canopy disturbance on understory microbial communities on rocky shores

IntroductionThe collapse of macroalgal habitats is altering the structure of benthic communities on rocky shores globally. Nonetheless, how the loss of canopy-forming macroalgae influences the structure of epilithic microbial communities is yet to be explored. MethodsHere, we used experimental field manipulations and 16S-rRNA-gene amplicon sequencing to determine the effects of macroalgal loss on the understory bacterial communities and their relationship with epiphytic bacteria on macroalgae. Beds of the fucoid Hormosira banksii were exposed to different levels of disturbance resulting in five treatments: (i) 100% removal of Hormosira individuals, (ii) 50% removal, (iii) no removal, (iv) a procedural control that mimicked the removal process, but no Hormosira was removed and (v) adjacent bare rock. Canopy cover, bacterial communities (epilithic and epiphytic) and benthic macroorganisms were monitored for 16 months.ResultsResults showed that reductions in canopy cover rapidly altered understory bacterial diversity and composition. Hormosira canopies in 50% and 100% removal plots showed signs of recovery over time, but understory epilithic bacterial communities remained distinct throughout the experiment in plots that experienced full Hormosira removal. Changes in bacterial communities were not related to changes in other benthic macroorganisms.DiscussionThese results demonstrate that understory epilithic bacterial communities respond rapidly to environmental disturbances at small scales and these changes can be long-lasting. A deeper knowledge of the ecological role of understory epilithic microbial communities is needed to better understand potential cascading effects of disturbances on the functioning of macroalgal-dominated systems.

Fine‐scale interplay between decline and growth determines the spatial recovery of coral communities within a reef

As coral reefs endure increasing levels of disturbance, understanding recovery patterns of reef‐building hard corals is paramount to assessing the sustainability of these ecosystems. At local scales, coral recovery slows down; however, it's unclear how this trend propagates across spatial scales due to the inherent complexity of coral dynamics. In this paper, we aimed to learn about fine scale heterogeneity of coral dynamics and explore implications for assessing coral recovery at larger spatial scales. We developed a spatio‐temporal statistical model to estimate long‐term trajectories of three types of corals and predict their recovery patterns at unobserved locations within a reef. Then, model predictions were used to derive metrics that capture the interplay between coral growth and decline from disturbance(s) across time, space and growth morphology. This model is developed in the context of a substantive case study at Heron Reef using a high spatio‐temporal resolution dataset. Our results revealed that successful coral community recoveries took place in different habitats of Heron Reef and associated with various reasons. Branching corals recovered in the southern slope, due to fast growth in locations that were previously abundant. Plate corals flourished in the northern slope due to fast growth, despite a large decline and low baseline cover. They also recovered in the southern slope but in this case there was both a low decline and baseline cover. At Heron Reef, the recovery of coral communities followed specific conditions that were acting at a fine scale in a complex and heterogeneous way within habitat. This implies that capturing the variability of fine‐scale coral dynamics is an important first step to detect accurate signals of coral recovery at larger spatial scales. The approach proposes here can be further extend to the scale of a reef and beyond enabling assessment of recovery patterns representative at management scales.

Prevalence and determinants of occupational injuries among small-scale industry workers in sub-saharan Africa. A systematic review and meta-analysis

Occupational injuries are manifestations of diseases because of different exposure in the workplace like Small-Scale cement factories, tanneries, textile and/or street sweeping, and woodworkers all of which affect the health condition and productivity. In sub-Saharan Africa, several primary studies were conducted regarding the magnitude of occupational injuries with a prevalence of 68.89% in street sweepers and determinant factors with inconsistent results. This meta-analysis aimed to the pooled prevalence of occupational injuries and their associated factors in Sub-Saharan Africa among workers working in small-Scale industries. PubMed, African Journals Online, Google Scholar, Cochrane Library, and Direct Google were systematically searched to identify primary studies. Three authors performed data abstraction and quality assessment for each included study independently. Cochran’s Q-statistic and I-squared statistics were used to check heterogeneity. The random-effects models were used to estimate the pooled prevalence and associated factors of occupational injuries. Publication bias was checked by funnel plot and Egger’s test, and also sensitivity analyses were performed. 20 primary studies with 7,235 study participants were included in the Systematic review and meta-analysis of the pooled prevalence of occupational injuries among Small-Scale industry workers in Sub-Saharan Africa. The pooled prevalence of overall occupational injuries among Small-scale industry workers in Sub-Saharan Africa was 53.23% (95% CI= 44.71, 61.74). Training, Sleeping disturbance, and Educational level were significantly associated with occupational injuries. In this review, the pooled prevalence of occupational injuries was high. The findings of this study dictate the need for the implementation of workplace safety measures. Special attention is required for employees with lower educational levels and training.

Estimating the spatial amplification of damage caused by degradation in the Amazon.

The Amazon rainforests have been undergoing unprecedented levels of human-induced disturbances. In addition to local impacts, such changes are likely to cascade following the eastern-western atmospheric flow generated by trade winds. We propose a model of spatial and temporal interactions created by this flow to estimate the spread of effects from local disturbances to downwind locations along atmospheric trajectories. The spatial component captures cascading effects propagated by neighboring regions, while the temporal component captures the persistence of local disturbances. Importantly, all these network effects can be described by a single matrix, acting as a spatial multiplier that amplifies local forest disturbances. This matrix holds practical implications for policymakers as they can use it to easily map where the damage of an initial forest disturbance is amplified and propagated to. We identify regions that are likely to cause the largest impact throughout the basin and those that are the most vulnerable to shocks caused by remote deforestation. On average, the presence of cascading effects mediated by winds in the Amazon doubles the impact of an initial damage. However, there is heterogeneity in this impact. While damage in some regions does not propagate, in others, amplification can reach 250%. Since we only account for spillovers mediated by winds, our multiplier of 2 should be seen as a lower bound.

The comparison of dispersal rate between invasive and native species varied by plant life form and functional traits

A long dispersal distance is widely used to indicate high invasiveness, but it ignores the temporal dimensions of plant invasion. Faster dispersal rates (= distance/time) of invasive species than native ones have been widely used in modeling species invasion and planning control management. However, the comparison of dispersal rate between invasive and native plants, particularly for dispersal on a local or landscape scale, has not been tested with a comprehensive dataset. Moreover, both the effects of plant functional traits on the dispersal rate and variation in the functional-trait effects between invasive and native plants remain elusive. Compiling studies from 30 countries globally, we compared seed dispersal rates (km/year) on a local or landscape scale between 64 observations of invasive and 78 observations of native plants given effects of plant life forms, disturbance levels, and measurement methods. Furthermore, we compared the effects of functional traits on dispersal rate between invasive and native species. We found that: (1) Trait values were similar between the invasive and native plants except for the greater height of woody native plants than woody invasive ones; (2) Compared within the same plant life form, the faster dispersal rates of invasive species were found in herbaceous plants, not in woody plants, and disturbance level and measurement methods did not affect the rate comparison; (3) Plant height and seed length had significant effects on dispersal rates of both invasive and native plants, but the effect of leaf dry matter content (LDMC) was only significant on herbaceous invasive plants. The comparison of dispersal rate between invasive and native plants varied by plant life form. The convergent values but divergent dispersal effects of plant traits between invasive and native species suggest that the trait effects on invasiveness could be better understood by trait association with key factors in invasiveness, e.g., dispersal rate, than the direct trait comparison between invasive and native plants.

Active flutter suppression of nonlinear fin-actuator system via inverse system and immersion and invariance method

Structural nonlinearities such as freeplay will affect the stability and even flight safety of the fin-actuator system. There is a lack of a practical method for designing Active Flutter Suppression (AFS) control laws for nonlinear fin-actuator systems. A design method for the AFS controller of the nonlinear all-movable fin-electromechanical actuator system is established by combining the inverse system and the Immersion and Invariance (I&I) theory. First, the composite control law combining the inverse system principle and internal model control is used to offset the nonlinearity and dynamics of the actuator, so that its driving torque can follow the ideal signal. Then, the ideal torque of the actuator is designed employing the I&I theory. The unfavorable oscillation of the fin is suppressed by making the output torque of the actuator track the ideal signal. The simulation results reveal that the proposed AFS method can increase the flutter speed of the nonlinear fin-actuator system with freeplay, and a set of controller parameters is also applicable for wider freeplay within a certain range. The power required for the actuator does not exceed the power that can be provided by the commonly used aviation actuator. This method can also resist a certain level of noise and external disturbance.

2 The Longitudinal Relationship Between Concussion History, Years of Football Participation, and Alcohol Use Among Former National Football League (NFL) Players: an NFL-LONG Study

Objective:It has been posited that alcohol use may confound the association between greater concussion history and poorer neurobehavioral functioning. However, while greater alcohol use is positively correlated with neurobehavioral difficulties, the association between alcohol use and concussion history is not well understood. Therefore, this study investigated the cross-sectional and longitudinal associations between cumulative concussion history, years of contact sport participation, and health-related/psychological factors with alcohol use in former professional football players across multiple decades.Participants and Methods:Former professional American football players completed general health questionnaires in 2001 and 2019, including demographic information, football history, concussion/medical history, and health-related/psychological functioning. Alcohol use frequency and amount was reported for three timepoints: during professional career (collected retrospectively in 2001), 2001, and 2019. During professional career and 2001 alcohol use frequency included none, 1-2, 3-4, 5-7 days/week, while amount included none, 12, 3-5, 6-7, 8+ drinks/occasion. For 2019, frequency included never, monthly or less, 2-4 times/month, 2-3 times/week, &gt;4 times/week, while amount included none, 1-2, 3-4, 5-6, 7-9, 10+ drinks/occasion. Scores on a screening measure for Alcohol Use Disorder (CAGE) were also available at during professional career and 2001 timepoints. Concussion history was recorded in 2001 and binned into five groups: 0, 1-2, 3-5, 6-9, 10+. Depression and pain interference were assessed via PROMIS measures at all timepoints. Sleep disturbance was assessed in 2001 via separate instrument and with PROMIS Sleep Disturbance in 2019. Spearman’s rho correlations tested associations between concussion history and years of sport participation with alcohol use across timepoints, and whether poor health functioning (depression, pain interference, sleep disturbance) in 2001 and 2019 were associated with alcohol use both within and between timepoints.Results:Among the 351 participants (Mage=47.86[SD=10.18] in 2001), there were no significant associations between concussion history or years of contact sport participation with CAGE scores or alcohol use frequency/amount during professional career, 2001, or 2019 (rhos=-.072-.067, ps&gt;.05). In 2001, greater depressive symptomology and sleep disturbance were related to higher CAGE scores (rho=.209, p&lt;.001; rho=.176, p&lt;.001, respectively), while greater depressive symptomology, pain interference, and sleep disturbance were related to higher alcohol use frequency (rho=.176, p=.002; rho=.109, p=.045; rho=.132, p=.013, respectively) and amount/occasion (rho=.215, p&lt;.001; rho=.127, p=.020; rho=.153, p=.004, respectively). In 2019, depressive symptomology, pain interference, and sleep disturbance were not related to alcohol use (rhos=-.047-.087, ps&gt;.05). Between timepoints, more sleep disturbance in 2001 was associated with higher alcohol amount/occasion in 2019 (rho=.115, p=.036).Conclusions:Increased alcohol intake has been theorized to be a consequence of greater concussion history, and as such, thought to confound associations between concussion history and neurobehavioral function later in life. Our findings indicate concussion history and years of contact sport participation were not significantly associated with alcohol use cross-sectionally or longitudinally, regardless of alcohol use characterization. While higher levels of depression, pain interference, and sleep disturbance in 2001 were related to greater alcohol use in 2001, they were not associated cross-sectionally in 2019. Results support the need to concurrently address health-related and psychological factors in the implementation of alcohol use interventions for former NFL players, particularly earlier in the sport discontinuation timeline.

Environmental filtering of life‐history trait diversity in urban populations of Arabidopsis thaliana

Abstract The challenges to which plants are exposed in urban environments represent, in miniature, the challenges plants face as a result of global environmental change. Hence, urban habitats provide a unique opportunity to assess whether processes of local adaptation are taking place despite the short temporal and geographical scales that characterize the Anthropocene. We quantified the ecological diversity of urban habitats hosting Arabidopsis thaliana populations. Using plant community indicators, we show that these patches differ in their levels of soil nutrient content and disturbance. Accordingly, plants in each patch displayed a range of flowering time, size and fitness. Using a deep sampling approach coupled with reduced genome sequencing, we demonstrate that most individuals can be assigned to a limited set of clonal lineages; the genetic diversity of these lineages is a sample of the diversity observed in western European populations of the species, indicating that established urban populations originate from a broad regional pool of lineages. We assessed the genetic and phenotypic diversity of these lineages in a set of common garden experiments. We report marked genetic differences in life‐history traits, including time of primary and secondary dormancy as well as of flowering. These genetic differences in life‐history traits are not randomly distributed but sorted out by ecological differences among sites of origin. Synthesis. Our study shows that the genetically diverse phenology of a regional Arabidopsis thaliana gene pool is not randomly distributed but filtered by heterogeneity in the urban environment. To our knowledge, this report is the first to show a pattern indicative of environmental filtering enhancing local genetic adaptation within urban environments. We conclude that environmental filtering helps maintain functional diversity within species.

Histomorphological and histomorphometric evaluation of the therapeutic role of sulforaphane on the hypothalamic-pituitary-ovarian axis in polycystic ovary syndrome rats via its potential anti-inflammatory and anti-oxidant activities

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance. Sulforaphane (SFN) is a widely distributed isothiocyanate found in cruciferous vegetables. This study investigated the role of SFN on the hypothalamic-pituitary-ovarian axis in PCOS rats. Twenty-four female rats randomized into group A control received 2 ml of normal saline. Group B received 4 mg/kg body weight (bwt) I.P of estradiol valerate (EV) on the first day, groups C received 100 mg/kg bwt of SFN orally, and Group D received I.P 4 mg/kg bwt of EV follow by 100 mg/kg bwt of SFN orally. All administrations were done once daily for 30 days. Final body weight, estrous cycle, ovarian weight, blood glucose, serum sex hormones levels, serum lipid profile, ovarian antioxidants assay, ovarian inflammatory cytokines, and ovary and pituitary histology were assessed.The PCOS rats exhibited the characteristic features of PCOS. Disturbed ovarian cyclicity, histopathological alterations, decreased the number of healthy follicles and corpora lutea and increased degenerated and cystic follicles were detected by light microscopic studies. A significant increase in final body weight, ovarian weight, blood glucose, sex steroids hormone levels, and antioxidant assays in PCOS rats. Sulforaphane reduces the elevated level of serum sex steroids hormone, lipid profile, ovarian diameter, and cysts and restores healthy follicles in PCOS rats. SFN reduces the upraised levels of ovarian oxidant and inflammatory cytokines and increases the suppressed antioxidant enzymes.Sulforaphane thus ameliorates the disturbed hormonal levels, lipid profile, and antioxidant status in PCOS rats through its antioxidant and anti-inflammatory capacity.

Spatial marine meiofauna variations in areas undergoing different disturbance levels on the Amazon coast

Spatial marine meiofauna variations in areas undergoing different disturbance levels on the Amazon coast

Congruence between vascular plants and bryophytes in response to ecological conditions in sustainably managed temperate forests (taxonomic- and trait-based levels)

Vascular plant species (VP) and bryophytes (B) constitute a significant portion of forest biodiversity and respond to both management intensity and natural disturbances within forests. In this study, we investigated the cross-taxa congruence between understorey VP and B at both diversity and composition levels across a wide range of sustainably managed forests in Slovenia. The taxonomic and functional characteristics of the selected plant groups were studied, with a particular emphasis on ground-dwelling species. We employed a trait-based approach to examine the functional characteristics. On average, the species richness of B in sustainably managed temperate forests increased with the corresponding number of VP. Furthermore, a moderate positive correlation in species composition between the studied groups of ground-dwelling organisms was also observed. The ground-dwelling VP and B were congruent in terms of trait-based composition, which was influenced by soil reaction and nutrients and light availability, while trait-based diversity was only slightly similar in response to moisture. A negative correlation between the composition of stress-tolerant VP and B hemeroby was found, indicating forest environments with a low level of disturbance. This is likely due to the sustainable management of Slovenian forests, where climate change and natural disturbances have intensified in recent years. A cross-taxon comparison of the two groups at four different levels, namely taxonomic-based diversity and composition and trait-based diversity and composition, revealed varying degrees of congruence. It is therefore important to monitor the status and temporal trends of both groups from different aspects to draw reliable conclusions.