The present study envisions the influences of land use dynamics on the spatial trend of groundwater depth levels over a period of two decades in the south region of NCT Delhi, India. The findings have inferred that among five major LULC categories, built-up has shown a sprawling trend (+2.17 km2/year) from the north, northeastern, and central portions to the confined patches observed in the south and southwest fringes of South Delhi from 2001 to 2021. Likewise, vegetation class has also witnessed significant increment (+1.91 km2/year) to the peripheral boundary, i.e., southern, southwest/eastern fringes, and central portions under recent initiatives of city forests, plantation drives, and urban green spaces programs. On the contrary, a negative rate of change has been observed in fallow land (-2.78 km2/year), agriculture (-1.22 km2/year), and water bodies (-0.07 km2/year). LULC transition matrix has also showed prominent conversion of fallow land into vegetation and built-up class, and change of vegetation into built-up, and fallow land category. Subsequently, corresponding LULC maps have been superimposed with long-term trends of groundwater depth levels (as spatial contours). For entire South Delhi region, depth to water levels ranged from 2.02 to 66.45 meters below ground level (mbgl) where shallower depths followed a negative trend and remain persistent throughout the time period in north and northeastern fringes. Higher fluctuations in groundwater depletion with positive trends directly get influenced with allied land use transitions such as a steady increase in built-up area and steeper depth levels (> 40 mbgl) as observed in central, southwestern, and southern parts. Moreover, buffer peripheries in the proximity of groundwater monitoring stations viz., Hauz Khas, Pushp Vihar, Jamali, Gadaipur, and Bhatti Kalan have observed deeper groundwater levels allied to built-up expansion. Thus, groundwater depletion trends can be ascribed to the incessant conversion of recharging areas into impervious zones along with uneven distribution of groundwater usage and supply. Conversely, expanding vegetative land has also shown improved groundwater depth levels. Therefore, land use influences must be managed in the long run for ensuring sustainable management of groundwater resources.