Control Levels Research Articles

The dance of power and responsibility: understanding the multilevel government influence on CSR practices in Chinese state-owned enterprises

ABSTRACT This study investigates how multilevel government influences the corporate social responsibility (CSR) practices of state-owned enterprises (SOEs). Using the control rights theory, we illustrate how the supervisor (the provincial government) utilizes residual control rights allocated by the principal (the central government) to exert both top-down binding and bottom-up buffering effects on the CSR practices of their agents (local governments and SOEs). Our findings reveal a U-shaped relationship between government control levels and SOEs’ CSR practices, with administrative intervention reinforcing this trend and fiscal decentralization leading to an inverted U-shaped relationship. These insights highlight complex inter-governmental dynamics influencing SOEs’ CSR practices.

Effects of acute hypoxia and reoxygenation on the coelomic fluid of Phascolosoma esculenta: Oxidative stress and transcriptome analysis

Phascolosoma esculenta is an economically species inhabiting a soft substrate of mud in the intertidal zone, which is bad breathability, especially during the prolonged heavy rainstorms, that will bring hypoxia environment to P. esculenta. In this study, the negative impact of hypoxia on P. esculenta was firstly studied. The results showed that there were no P. esculenta died post 7 days hypoxia. However, P. esculenta surface became black after hypoxia stress and changed to brown after reoxygenation. The body cavity fluid’s total antioxidant capacity (T-AOC) showed notable increases at 48 h, 120 h, and 168 h post hypoxia stress and returned to the control level after reoxygenation. The contents of malondialdehyde (MDA) increased significantly at 24 h, 48 h, and 96 h but decreased substantially after reoxygenation. The activity of lactate dehydrogenase (LDH) increased during the hypoxia but decreased significantly after reoxygenation. Transcriptomic analysis was performed and a total of 55.26 GB of clean data were collected, 362 DEGs were obtained based on FPKM values, including 77 DEGs between control and hypoxia groups, 48 DEGs between control and reoxygenation groups, and 237 DEGs between hypoxia and reoxygenation groups. DEGs are enriched in pathways associated with immune system, carbon metabolism, apoptosis, ribosome and ion transport. These data enriched the molecular mechanism of invertebrate hypoxia tolerance and provided genetic material reference for future breeding of hypoxia-tolerant P. esculenta and other aquatic species.

Therapeutic Potential of Methanolic Stem Extract of Costus afer on Serum Uric Acid, Tumor Necrosis Factor-alpha (TNF-α), and Interleukin-6 (IL-6) Levels in Monosodium Urate (MSU)-Induced Gouty Arthritis in Wistar Rats

The therapeutic potential of methanolic stem extracts of Costus afer was investigated to evaluate their effects on serum uric acid, TNF-α, and IL-6 levels, which are the key biomarkers associated with inflammatory and metabolic disorders like gouty arthritis. Qualitative and quantitative phytochemical analysis of C. afer indicated the presence of flavonoids, alkaloids, phenol, anthraquinone and glycosides, these bioactive compounds have been implicated for numerous medicinal uses and as such the therapeutic potentials of the extract were investigated by administering varying doses (100 mg/kg, 200 mg/kg, and 400 mg/kg) of the extract to a Wistar rat model with induced gouty arthritis and assessing its impact compared to a control group and an untreated MSU group. The results revealed that the extracts significantly reduced ( serum uric acid levels in a dose-dependent manner, with the high dose achieving a reduction below the control level. Additionally, the extracts effectively decreased ( TNF-α and IL-6 levels, indicating potent anti-inflammatory properties. The high dose exhibited the most substantial reduction in these biomarkers, underscoring the extract’s therapeutic potential. These findings support the traditional use of C. afer and provide scientific validation for its application in managing hyperuricemia and inflammatory conditions.

The Impact of Polydimethylsiloxane as a Herbicide Adjuvant for Weed Control in the Lime Citrus × aurantifolia (Christm.) Swingle Plot

The objective of this research was to evaluate the effect of polydimethylsiloxane (PDMS) CH3[Si(CH3)2O]nSi(CH3)3 as an adjuvant in bioherbicides and synthetic herbicides (chemicals) for weed (Johnson grass S. halepense and star grass Cynodon sp.) management in the lime plot. A total of 20 treatments were conducted, which included bioherbicides and synthetic herbicides, each with three replications, the dose was 50% more polydimethylsiloxane and 100% according to the product label. The experimental design was a randomized block design, with a factorial arrangement with three factors: A (products) with 10 levels, B (adjuvants) with 2 levels and C (evaluation dates) with 5 levels, each block consisted of an area of 5 m by 4 m. The assessment was carried out periodically, every week (5 evaluations), the scale proposed by EWRS was used. The results were in percentages and a 3-factor factor analysis was performed, where A (products) = 10 levels, B (adjuvants) = 2 levels and C (evaluation dates) = 5 levels, and the mean comparison test with Tukey (α ≤ 0.05), using SAS software. According to the results obtained, a significant difference is only presented between factors A (products) and B (adjuvants) (P < .0001). In factor A, the highest levels in weed control were glyphosate, diuron + carfentrazone and ammonium glufosinate with an average of 80.8, 74.0 and 70.8%, respectively. Regarding the interaction between the factors, only the A*B factors were present (P < .0001), only in the glyphosate, BH2 and diuron were the treatments with the highest interaction when using the 50% dose + polydimethylsiloxane as an adjuvant at a dose of 2 ml per 1 L of water with 76.2, 72.93 and 71.33%, respectively. The date when the treatments had the highest weed control effect was at the second and third week. These results underline the effect of polydimethylsiloxane to optimize the use of herbicides, not only in combination with chemical herbicides, but also with bioherbicides, offering an efficient and economic alternative for weed management (Johnson grass S. halepense and star grass Cynodon sp.).

Brønsted acid-catalyzed selective alkylation of tetrazoles with acetone

The alkylation of tetrazole and acetone under the catalysis of TfOH has been shown to be an efficient process with high levels of regioselective control. This protocol features simple and readily accessible starting materials, unique reaction mechanism, excellent compatibility with diverse functional groups.

Fractional order slide mode droop control for simultaneous voltage and frequency regulation of AC microgrid

AbstractThis research proposes the application of fractional‐order sliding mode control (FOSMC) at the primary controller level to improve the stability of an islanded microgrid by adjusting its voltage and frequency. The control strategies used in the microgrid are performed in two levels (primary and secondary) in the islanded mode. Practically, most previous studies have worked to improve the primary controller. Droop control is one of the most commonly used methods at the primary level and is adopted in this study as well. The sliding mode control (SMC) strategy is normally used to control linear equations. Thus, the non‐linear microgrid equations were transformed into some linear ones using the input‐output feedback linearization technique. Further, a fractional sliding surface was acquainted. The sliding surface and FOSMC were designed to reject system uncertainties and organize the voltage and frequency. Design parameters were chosen using the Lyapunov stability theorem. The validation of the proposed method using Simulink‐MATLAB confirms its effectiveness in enhancing level power sharing, regulating frequency, and maintaining voltage stability across the system.

Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis.

Motor systems operate over a range of frequencies and relative timing (phase). We studied the role of the hyperpolarization-activated inward current (Ih) in regulating these features in the pyloric rhythm of the stomatogastric ganglion (STG) of the crab, Cancer borealis, as temperature was altered from 11°C to 21°C. Under control conditions, rhythm frequency increased monotonically with temperature, while the phases of the pyloric dilator (PD), lateral pyloric (LP), and pyloric (PY) neurons remained constant. Blocking Ih with cesium (Cs+) phase advanced PD offset, LP onset, and LP offset at 11°C, and the latter two further advanced as temperature increased. In Cs+ the frequency increase with temperature diminished and the Q10 of the frequency dropped from ~1.75 to ~1.35. Unexpectedly in Cs+, the frequency dynamics became non-monotonic during temperature transitions; frequency initially dropped as temperature increased, then rose once temperature stabilized, creating a characteristic 'jag'. Interestingly, these jags persisted during temperature transitions in Cs+ when the pacemaker was isolated by picrotoxin, although the temperature-induced change in frequency recovered to control levels. Overall, these data suggest that Ih plays an important role in maintaining smooth transitory responses and persistent frequency increases by different mechanisms in the pyloric circuitry during temperature fluctuations.

Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis

Motor systems operate over a range of frequencies and relative timing (phase). We studied the role of the hyperpolarization-activated inward current (Ih) in regulating these features in the pyloric rhythm of the stomatogastric ganglion (STG) of the crab, Cancer borealis, as temperature was altered from 11°C to 21°C. Under control conditions, rhythm frequency increased monotonically with temperature, while the phases of the pyloric dilator (PD), lateral pyloric (LP), and pyloric (PY) neurons remained constant. Blocking Ih with cesium (Cs+) phase advanced PD offset, LP onset, and LP offset at 11°C, and the latter two further advanced as temperature increased. In Cs+ the frequency increase with temperature diminished and the Q10 of the frequency dropped from ~1.75 to ~1.35. Unexpectedly in Cs+, the frequency dynamics became non-monotonic during temperature transitions; frequency initially dropped as temperature increased, then rose once temperature stabilized, creating a characteristic ‘jag’. Interestingly, these jags persisted during temperature transitions in Cs+ when the pacemaker was isolated by picrotoxin, although the temperature-induced change in frequency recovered to control levels. Overall, these data suggest that Ih plays an important role in maintaining smooth transitory responses and persistent frequency increases by different mechanisms in the pyloric circuitry during temperature fluctuations.

What patients with kidney stones believe about their condition.

Patients' beliefs about their illness are of central importance in understanding how a person adjusts to their condition and adheres to self-management recommendations. No previous studies have set out to quantitatively examine Illness beliefs in patients with kidney stones (KS). 112 patients with radiological confirmation of KS (59% male, mean (x̄) age = 50.1 years [sd14.15 years], 50.5% previous surgical treatment) attending for clinical consultation completed the Brief-Illness Perception Questionnaire alongside a range of demographic and illness related variables. Template analysis was undertaken on the free text responses of patients' beliefs about what had caused their KS. Almost a third (31.2%) of patients did not know what had caused their KS. Of those who cited a cause, dietary factors, fluid intake, medical risk factors (e.g. Inflammatory bowel disease), genetics, and psychological factors were ranked as the most important. Patients generally believed they had a reasonable understanding of KS (x̄=6.32 [sd3.21]), but reported poor levels of personal control over their KS (x̄=2.90 [sd2.93]) and high confidence in the effectiveness of treatments (x̄=8.64 [sd1.90]). Patients with a recurrence believed KS had a significantly greater impact on their life (z=-2.56, p = 0.01) and had greater emotional consequences (z=-2.77, p < 0.01). Perceptions of poor personal control over KS and a strong belief in medical/surgical treatment was evident regardless of first or recurrent stone, gender, age, previous surgical management of KS or time since diagnosis. Results highlight the need to actively increase patients' perceptions of personal control in the management and prevention of KS.

Affect in Literary Translations: What is at Stake for the Author and the Translator

This article explores the relationships between authors, translators, and readers within the context of literature and translation. Emphasising the reciprocal influence between texts, it delves into the desire of writers to control the interpretation of their works during translation. The examination extends to the hierarchy within literature and translation, questioning whether a translated text can be considered an autonomous entity and if translators can be acknowledged as authors considering the transformative nature of translation and the subjective, creative processes involved. The article also sheds light on the emotional and affective aspects involved in the translation process, highlighting the recurring theme of trust and the fear of translatorial non-compliance. Through examples, it demonstrates how authors can actively engage in the translation process to safeguard their narrative nuances. Case studies, including instances involving Umberto Eco, Guillermo Cabrera Infante, Carlos Fuentes, and Günter Grass, illustrate various levels of authorial control and collaboration. The discussion expands to the global literary landscape, emphasising the dominance of certain languages and the dynamics between the literary centre and periphery. Ultimately, it raises fundamental questions about authorship, control, and the transformative power of translation in shaping the “world republic of letters”. The article investigates the multifaceted dynamics between authors and translators, examining collaboration along a continuum from carte blanche to conflictual relationships. The extent of an author’s involvement in the translation process is explored, questioning the reasons behind some authors’ keen interest in ensuring accurate translations. The power imbalances within collaborations are scrutinised, raising questions about the translator’s agency. The article concludes with reflections on the challenges and potential pitfalls of authors participating in the translation of their own works, emphasising the inherent plurality of interpretations in the act of translation.

A Liquid Chromatography‐Tandem Mass Spectrometry Bioanalytical Method Development and Validation for the Determination of Pacritinib in Plasma

ABSTRACTThe primary objective of the current work is to establish and verify an accurate and linear liquid chromatography‐electrospray ionization‐tandem mass spectrometry procedure for quantifying Pacritinib. An effective chromatographic resolution was obtained using the Hypersil Gold (50 × 4.6 mm, 2.1 µm) C18 column. The mobile phase is a mixture of methanol, 0.1% formic acid, and acetonitrile in the proportion of 20:15:65 (%v/v/v). The procedure involved closely monitoring executed ionic transitions of m/z 473.1/376.2 for Pacritinib and 584.26/101.1 for Brigatinib internal standard in multiple reaction monitoring mode. A strong correlation value (r2) of 0.9997 is associated with the linear plot regression line, which can be represented as y = 0.0001x − 0.0008. The relative standard deviation (RSD) results for the matrix effect were 3.63% and 3.57%, respectively, when the quality control (QC) level was low and high, respectively. Over the course of the study, the percentage average recoveries for Pacritinib were found to be 103.27% in high QC, 97.59% in medium QC, and 94.28% in low QC, respectively. The values that were obtained for the QC samples (0.378, 1.058, 7.56, and 11.34 µg/mL) varied from 2.00% to 4.03%. The developed method was useful for evaluating Pacritinib in biological samples for the purposes of QC, forensics, and bioavailability investigations for individuals.

CONTRIBUIÇÕES DA ALIMENTAÇÃO FUNCIONAL NO TRATAMENTO DIETOTERAPICO EM PACIENTES COM DIABETES MELLITUS 2

Type 2 diabetes mellitus is a chronic metabolic condition that affects millions of people worldwide. In this context, the importance of a proper diet is crucial for managing this disease. The main objective of this research was to analyze the importance of functional foods in the management of type 2 diabetes, focusing on how these foods can contribute to glycemic control and improve the quality of life for patients. The research was conducted through a literature review covering the period from 2014 to 2024. The consulted databases included Scielo, Google Scholar, and Lilacs, analyzing recent studies on the effects of functional foods on type 2 diabetes, focusing on their bioactive compounds. The findings indicate that many functional foods possess properties that help modulate the glycemic response, as well as reduce the risk of complications associated with diabetes. Including these foods in the diet can promote healthier eating habits. The results of this research highlight the importance of functional foods as a valuable strategy in treating type 2 diabetes mellitus. These foods not only help control blood glucose levels but also contribute to preventing complications associated with the disease. Integrating functional foods into patients' daily diets can significantly improve their metabolic health and quality of life.

A new herbal anesthetic agent for common carp (Cyprinus carpio) sedation and anesthesia: nutmeg (Myristica fragrans) essential oil.

In aquaculture, interest in natural essential oils is increasing alongside synthetic anesthetic agents. In this context, the anesthetic efficacy of nutmeg essential oil, which had not been previously tested, was investigated in common carp (Cyprinus carpio). The study, conducted using three different concentrations (800 μL/L "LC", 1,200 μL/L "MC", and 1,400 μL/L "HC"), found that induction times were <3 min for MC and HC, while LC had a longer induction time, exceeding acceptable levels. Within the first 4 h, white blood cells, red blood cells, hemoglobin, and hematocrit levels increased to >5 103/μL, >1 106/μL, >6 g/dL, and >12%, respectively. However, they returned to control levels after 8 h. Histological signs were more severe with higher concentrations, and necrosis was only observed in the HC group. Alkaline comet assay results showed DNA migration only in the HC group. According to the PROMETHEE multi-criteria decision-making model, the LC concentration is suitable for sedation, while the MC concentration should be used for deep anesthesia. The current study demonstrates that nutmeg essential oil can be used as an alternative to commercial synthetic anesthetic agents.

How parties can shape their competence reputations: Issue attention, position and performance

AbstractIssue ownership is an important determinant of the vote, and it is electorally beneficial for parties to build a strong reputation on their core issues. Even though issue ownership has already been studied extensively in the party literature, we know less about how citizens form ownership perceptions. We contribute to this literature by means of two studies on the connection between party behaviour and perceptions of issue ownership, with an empirical focus on issue competence reputations of parties. In Study 1, we combine party‐level information about issue attention, positions and performance with data on competence perceptions from a wide range of national election studies. Study 2 is a pre‐registered conjoint experiment designed to examine the causal link between party behaviour and perceived competence. Our results point to significant effects for all three hypothesised sources of competence reputations. Moving beyond previous work that has argued that competence reputations are mostly stable over time, after accounting for the variation due to parties' popularity, our results show that they fluctuate in the short term and that parties have some level of control over how they are perceived.

Do the results of the OXYGEN trial change if analyzed as “as-treated?”: A secondary analysis of the OXYGEN trial

ObjectiveTo determine if the results of the OXYGEN trial changed using an “as-treated” approach instead of the original “intention-to-treat” approach. The multi-center randomized controlled OXYGEN trial aimed to determine the effectiveness of high FiO2 in decreasing infection rates for high-risk tibial plateau, tibial pilon, and calcaneus fractures. MethodsA secondary analysis of a multi-center randomized controlled trial conducted at 29 US trauma centers was performed. A total of 1231 patients aged 18–80 years with tibial plateau, tibial pilon, or calcaneus fractures thought to be at elevated risk of infection were enrolled. Patients were randomly assigned to receive inspired oxygen at a concentration of 80 % FiO2 (treatment) or 30 % FiO2 (control). Adherence was defined using two different criteria. Criterion 1 required at least 80 % of the surgery time ≤40 % FiO2 for the control group or ≥70 % FiO2 for the treatment group. Criterion 2 required at least 80 % of surgery time within 20–40 % (control) or 70–90 % FiO2 (treatment). The primary outcome was surgical site infection (SSI) within 182 days of definitive fracture fixation. Secondary outcomes were deep and superficial surgical site infections within 90, 182, and 365 days of definitive fixation. ResultsUnder Criterion 1, the primary outcome occurred in 7 % (38/523) and 10 % (49/471) of patients in the treatment and control groups, respectively (p = 0.10). Deep infection occurred in 30 (6 %) treatment and 30 (6 %) control patients (p = 0.75). Superficial infection occurred in 9 (2 %) treatment and 20 (4 %) control patients (RR, 0.41; p = 0.03). Using Criterion 2, the primary outcome occurred in 7 % (36/498) of treatment and 10 % (48/468) of control patients (p = 0.12). Deep infection occurred in 28 (6 %) treatment and 29 (6 %) control patients (p = 0.81). Superficial infection occurred in 9 (2 %) treatment and 20 (4.3 %) control patients (RR = 0.43; p = 0.03). ConclusionsWhen re-analyzing based on which patients actually received high or control levels of perioperative oxygen fraction, the results are somewhat consistent with the original “intent-to-treat” analysis. Specifically, high perioperative oxygen lowered the risk of superficial SSI but did not affect deep infections.

Methods for the accelerated creation of updated high-quality flax seeds in primary seed production

Relevance. The creation of high-quality oilseed flax seeds using new plant breeding methods is an imperative principle with the advent of better crop seed production. Current methods for creating such seeds continue to be complicated and laborious. In this regard, the development of more advanced methods for obtaining renewed seeds with a high level of manifestation of sowing, various types and morphophysiological properties is relevant and has practical importance.Methods. The experiments were carried out in accordance with the methods of planting, conducting field experiments with flax, and methodological recommendations for seed production of oil flax. The assessment of sowing quality and seed material was carried out in accordance with the current certification system , varietal quality — by the soil control method.Results. The high efficiency of creating updated oilseed flax seeds using the method of plant selection during the growing season — from the beginning to the end of full flowering, which allowed for a significant increase in their yield to 61.5%, compared with the control. Selection of plants in the interval from the beginning to the end of full flowering ensured the preservation of the sowing qualities of the created seeds at the control level — selection according to the current method, as well as increasing the uniformity of indicators of the morphophysiological properties of seeds, including the uniformity of seed sprouts along the length by 4.6%. The selection method with the removal of plants atypical in morphological charakteristics compared with the control allowed to increase the yield of updated oilseed flax seeds by 29.7%, improve their morphophysiological properties. The varietal quality of the updated seed material for all methods of its creation was characterized by the absence of atypical seeds in color and minor differences between the options in the uniformity of varietal characteristics.

Does Camouflaging Cause Reduced Quality of Life? A Co-Twin Control Study.

Camouflaging has been proposed to have a detrimental effect on quality of life, yet previous research has not accounted sufficiently for potential confounding by genetic and shared environmental factors. The current study utilized a co-twin control design providing stringent control for a range of confounders to investigate the hypothesis that camouflaging autistic traits has a negative impact on quality of life. The sample included 140 individual twins from 42 monozygotic (MZ) and 28 dizygotic (DZ) twin-pairs, enriched for participants with neurodevelopmental conditions including 22 autistic participants. All twins provided self-reports of camouflaging and quality of life. Autistic participants and specifically autistic females displayed increased camouflaging behaviors compared to non-autistic participants. Across the sample, higher levels of camouflaging were associated with reduced quality of life, surviving adjustment for confounding effects of autistic traits, ADHD, sex, and age. Within DZ- as well as MZ-pairs, which provide the highest level of control for unmeasured confounders, twins who camouflaged more reported lower quality of life compared to their co-twins, consistent with a causal influence of camouflaging on quality of life. Our results strengthen previous claims purporting camouflaging behaviors as a risk factor for reduced quality of life.

Functional screen for mediators of onco-mRNA translation specificity.

Oncogenic protein dosage is tightly regulated to enable cancer cells to adapt and survive. Whether this is regulated at the level of translational control and the key factors in cis and trans remain unknown. The Myc oncogene is a central paradigm of an exquisitely regulated oncogene and a major driver of pancreatic ductal adenocarcinoma (PDAC). Using a functional genome-wide CRISPRi screen in PDAC cells, we identified activators of selective MYC translation through its 5' untranslated region (5'UTR) and validated four RNA binding proteins (RBPs), including epitranscriptome modifiers. Among these RBPs, our top hit was RBM42, which is highly expressed in PDAC and predicts poor survival. Combining polysome sequencing and CLIP-seq analyses, we find that RBM42 binds and selectively regulates the translation of MYC and a precise, yet vital suite of pro-oncogenic transcripts, including JUN and EGFR . Mechanistically, employing IP-mass spectrometry analysis, we find that RMB42 is a novel ribosome-associated protein (RAP). Using DMS-Seq and mutagenesis analysis, we show that RBM42 directly binds and remodels the MYC 5'UTR RNA structure, facilitating the formation of the translation pre-initiation complex. Importantly, RBM42 is necessary for human PDAC cell growth and fitness and PDAC tumorigenesis in xenograft mouse models in a Myc-dependent manner in vivo . In PDAC patient samples, RBM42 expression is correlated with Myc protein levels and transcriptional activity. This work transforms our understanding of the translational code in cancer and offers a new therapeutic opening to target the expression of oncogenes.

Adaptive stereotactic radiosurgery for cerebral metastases of non-small cell lung cancer: a retrospective study

INTRODUCTION: Non-small cell lung cancer (NSCLC) is a common cause of brain metastases (BM). Adaptive stereotactic radiosurgery (ASRS) may be a useful option in the treatment of patients with large unresectable brain metastases (BM), but to date there are only a limited number of studies evaluating the effectiveness of this method.OBJECTIVE: To analyze the effectiveness of ASRS in patients with large BM NSCLC not subject to surgical resection.MATERIAL AND METHODS: We retrospectively analyzed data from 37 patients suffering from NSCLC with 45 large (&gt;2 cm in diameter, volume &gt;4 cm3) unresectable BM treated with the Gamma Knife Perfexion model using two- and three-fraction ASRS. Of these, 14 foci (31.1%) were metastases of squamous cell lung cancer, 31 (68.9%) were metastases of adenocarcinoma. The median volume of lesions treated with ASRS was 9.8 (range 4.6–30.6 cm3). The dynamics of volume changes between fractions and the cumulative incidence of local relapses (CILR) were studied, and ROC analysis was performed for the tumor volume parameter. Intracranial progression-free survival (iPFS) and overall survival (OS) were assessed. Statistics: To establish statistical significance of differences for related variables, the Wilcoxon test for pairwise comparisons and the Friedman test for three or more groups were used. The Kaplan-Meier method was used to calculate local control, PFS, and OS rates. The log-rank test was used to compare survival data in two groups.RESULTS: The median follow-up period was 19.4 months. With two-fraction ASRS, the median volume of metastasis decreased by 28.6% by the second session, with three-fraction — by 40.0% by the third session. The 1-year and 2-year CILR rates were 8.6±6.1%, respectively; 26.1±12.3%. In ROC analysis, the area under the curve (AUC) for tumor volume was 0.80 (95% CI 0.6– 1.0) with an optimal cutoff of 18.5 cm3. The differences in CILR between the groups with metastasis volume &lt;18.5 cm3 and ≥18.5 cm3 were statistically significant (p&lt;0.001). Median iPFS was 8.3 (95% CI 5.9–10.7) months, 1-year iPFS was 33.5±8.1%;2-year — 7.8±5.2%. Median OS was 13.2 (95% CI 9.0–17.4) months; 1-year OS — 52.9±8.7%, 2-year — 22.4±8.8%.DISCUSSION: Using two- and three-fraction ASRS, we delivered doses to large BM sufficient for a high level of local control with an acceptable risk of neurotoxicity: 1-year local control was 91.4%; 2-year — 73.9%; the incidence of radionecrosis is 8.5%. A statistically significant effect of lesion volume ≥18.5 cm3 on the risk of local recurrence was found. The iPFS and OS indicators after ASRS can be considered satisfactory for this group of patients.CONCLUSION: ASRS is an effective and perhaps optimal strategy for the treatment of large unresectable BM in patients with NSCLC, but comparison with other modern radiotherapy modalities such as stereotactic hypofractionated radiotherapy and WBRT with simultaneous integrated boost is needed.

Rapid Aircraft Wake Vortex Identification Model Based on Optimized Image Object Recognition Networks

Wake vortices generated by aircraft during near-ground operations have a significant impact on airport safety during takeoffs and landings. Identifying wake vortices in complex airspaces assists air traffic controllers in making informed decisions, ensuring the safety of aircraft operations at airports, and enhancing the intelligence level of air traffic control. Unlike traditional image recognition, identifying wake vortices using airborne LiDAR data demands a higher level of accuracy. This study proposes the IRSN-WAKE network by optimizing the Inception-ResNet-v2 network. To improve the model’s feature representation capability, we introduce the SE module into the Inception-ResNet-v2 network, which adaptively weights feature channels to enhance the network’s focus on key features. Additionally, we design and incorporate a noise suppression module to mitigate noise and enhance the robustness of feature extraction. Ablation experiments demonstrate that the introduction of the noise suppression module and the SE module significantly improves the performance of the IRSN-WAKE network in wake vortex identification tasks, achieving an accuracy rate of 98.60%. Comparative experimental results indicate that the IRSN-WAKE network has higher recognition accuracy and robustness compared to common recognition networks, achieving high-accuracy aircraft wake vortex identification and providing technical support for the safe operation of flights.