You have accessJournal of UrologyProstate Cancer: Basic Research (II)1 Apr 2013313 LOW FAT FISH OIL (LFFO) DIET DECREASES PRO-INFLAMMATORY EICOSANOIDS AND PROSTATE CANCER CELL CYCLE PROGRESSION (CCP) SCORE IN MEN UNDERGOING RADICAL PROSTATECTOMY J. Bryant Byrd, Colette Galet, Sevan Stepanian, Kiran Gollapudi, Susanne M. Henning, Tristan Grogan, David Elashoff, David Heber, Pinchas Cohen, and William J. Aronson J. Bryant ByrdJ. Bryant Byrd Los Angeles, CA More articles by this author , Colette GaletColette Galet Los Angeles, CA More articles by this author , Sevan StepanianSevan Stepanian Los Angeles, CA More articles by this author , Kiran GollapudiKiran Gollapudi Los Angeles, CA More articles by this author , Susanne M. HenningSusanne M. Henning Los Angeles, CA More articles by this author , Tristan GroganTristan Grogan Los Angeles, CA More articles by this author , David ElashoffDavid Elashoff Los Angeles, CA More articles by this author , David HeberDavid Heber Los Angeles, CA More articles by this author , Pinchas CohenPinchas Cohen Los Angeles, CA More articles by this author , and William J. AronsonWilliam J. Aronson Los Angeles, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1698AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In a prospective randomized trial we previously showed that a 4-6 week LFFO diet resulted in increased prostate tissue omega-3 fatty acid levels and reduced prostate cancer proliferation (Ki67). We sought to determine if the LFFO diet (compared to a western diet (WD)) affected serum fatty acids and pro-inflammatory eicosanoid levels as well as prostate cancer CCP score, and if changes in serum fatty acids and inflammatory factors predict antiproliferative effects in prostate cancer tissue. METHODS Pre and post intervention serum fatty acids and eicosanoids (leukotriene B4 (LTB4) and 15-S-Hydroxyeicosatetraenoic acid (15S-HETE)) were measured by gas chromatography and ELISA. Prostate cancer CCP score (an independent predictor of prostate cancer progression and mortality following radical prostatectomy) was measured by RT-PCR. The relationship between serum fatty acids and pro-inflammatory factors, and prostate cancer proliferation was evaluated using partial correlations controlling for pathological gleason score, weight loss and race. RESULTS Serum omega-6 fatty acids and 15S-HETE levels were significantly reduced whereas serum omega-3 levels were significantly increased in the LFFO group relative to the WD group (Table 1). The prostate cancer CCP score was significantly lower in the LFFO prostatectomy tissue compared to the WD prostatectomy tissue. The post-intervention serum omega-6/omega-3 ratio positively correlated with the radical prostatectomy prostate cancer proliferation (Ki67) and CCP score (R=0.51; p<0.01 and R=0.4; p=0.02 respectively). The 15-S-HETE change positively correlated with tissue Ki67 (R=0.48; p<0.01) while LTB4 change correlated with the CCP score (R=0.4; p=0.02). CONCLUSIONS A 4-6 week LFFO diet decreased serum 15S-HETE and prostate cancer tissue CCP score. Further prospective studies are needed to evaluate serum omega-6/omega-3 ratio, 15S-HETE or LTB4 levels as surrogate biomarkers for prostate cancer proliferation. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e127 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information J. Bryant Byrd Los Angeles, CA More articles by this author Colette Galet Los Angeles, CA More articles by this author Sevan Stepanian Los Angeles, CA More articles by this author Kiran Gollapudi Los Angeles, CA More articles by this author Susanne M. Henning Los Angeles, CA More articles by this author Tristan Grogan Los Angeles, CA More articles by this author David Elashoff Los Angeles, CA More articles by this author David Heber Los Angeles, CA More articles by this author Pinchas Cohen Los Angeles, CA More articles by this author William J. Aronson Los Angeles, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...