Continental growth is episodic, and arc-continental margin has importance for the formation of continental crust in the Shyok Suture Zone (SSZ). To shed light on the petrogenesis of mantle derived orthogneiss and hybrid source derived leucogranites, a detailed geochemical study has been conducted on granitoids which are exposed between the Shyok-Darbuk of the Pangong transpressional zone. The Shyok-Darbuk is a complex zone, marked by migmatization, crustal anatexis, in-situ emplacement of various granitoids within metapelites and orthogneiss. Major and trace element data have been used in this paper to classify the granitoids to estimate the possible source regions and tectonic environment of magma generation and emplacement. The metaluminous Hbl-Bt orthogneiss (OG) of Eocene to Late-Cretaceous age show chemical characteristics typical of Andean-type granitoids. The late phase granitoids (porphyritic granites, coarse leucogranites, two-mica±garnet bearing leucogranite dyke swarms) of Miocene age have generated from the intracrustal partial melting of hybrid magma source, involving predominantly of orthogneiss (derived from mantle source) and subordinate amounts of metapelites (crustal source). The generation of these crustally-derived magma bodies has also been promoted by an influx of externally derived aqueous fluids. Further, the variation of felsic melts from leucogranodiorite (metaluminous) to leucogranite (peraluminous), calls for the geochemical heterogeneity, largely due to protolith internal heterogeneity at source. The leucosome of migmatites and the common leucogranites of the nearby Darbuk pluton are coeval, which record melt flow syntectonically through the deforming crust. The various leucosome magma channels in the migmatites are considered to merge and link-up with each other during their ascent to upper crustal levels, resulting in feeding stocks and plutons. In the Shyok-Darbuk corridor of the Pangong range it is thus envisaged that, the fundamental role in the growth of continental crust, witnessed tectonism that span from initial arc-continent to continent-continent collision regimes.