Lethal Doses Of Ethanol Research Articles

Dexamethasone protection against the acute lethality of ethanol in mice.

The administration of dexamethasone (DXM, 2.00 mg/kg) 1 h prior to the injection of lethal doses of ethanol was found to offer complete protection against ethanol toxicity at doses up to 5.25 g/kg and partial protection using higher doses. It is suggested that DXM central action might be involved in the protection against ehanol toxicity.

A possible protective role for sulphydryl compounds in acute alcoholic liver injury

The role of various sulphydryl compounds in protective mechanisms against acute ethanol toxicity has been investigated in the mouse. Intraperitoneal administration of varying doses of ethanol (0–6 g/kg as 20 per cent, w/v solutions) produced a linear dose response reduction in hepatic reduced glutathione (GSH) levels. The time scale of this effect suggested that GSH depletion occurred as a consequence of hepatic damage rather than contributing towards it. It was also demonstrated that the sulphydryl compounds β-mercaptoethylamine-HCl, cysteine and methionine significantly increased the survival rate of mice given a lethal dose of ethanol.