Abstract
The role of various sulphydryl compounds in protective mechanisms against acute ethanol toxicity has been investigated in the mouse. Intraperitoneal administration of varying doses of ethanol (0–6 g/kg as 20 per cent, w/v solutions) produced a linear dose response reduction in hepatic reduced glutathione (GSH) levels. The time scale of this effect suggested that GSH depletion occurred as a consequence of hepatic damage rather than contributing towards it. It was also demonstrated that the sulphydryl compounds β-mercaptoethylamine-HCl, cysteine and methionine significantly increased the survival rate of mice given a lethal dose of ethanol.
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