Vocal Cord Lesions Research Articles

Measuring Oxidative DNA Damage With 8-Hydroxy-2'-Deoxyguanosine Levels in Patients With Laryngeal Cancer.

8-Hydroxy-2'-deoxyguanosine is a biomolecule associated with DNA damage. We evaluated oxidative stress and DNA damage in patients with laryngeal cancer by measuring 8-hydroxy-2'-deoxyguanosine levels. This study enrolled 117 subjects, including 64 controls and 53 patients who had benign vocal cord lesions or laryngeal cancer. The benign excised lesions, tumor tissue, noncancerous laryngeal tissue, blood, and urine were subjected to high-performance liquid chromatography, and 8-hydroxy-2'-deoxyguanosine levels were compared between groups. Blood and urine 8-hydroxy-2'-deoxyguanosine levels in patients with laryngeal carcinoma were significantly higher than in the controls ( P = .00002, P = .00001). The 8-hydroxy-2'-deoxyguanosine level was significantly higher in tumor tissues than in non-tumor tissue and benign vocal cord lesion tissues ( P = .00002, P = .000001). We determined that laryngeal cancer was associated with oxidative stress, which may be quantified by measuring 8-hydroxy-2'-deoxyguanosine. For a patient with a suspicious laryngeal lesion, 8-hydroxy-2'-deoxyguanosine levels in blood and urine can provide advance information about the likely diagnosis.

Hoarseness: A Serious but Neglected Symptom.

Introduction: Hoarseness is an abnormal change in voice and is related to disorders in the vocal cords. Causes of hoarseness include:- Laryngitis, voice abuse, benign vocal cord lesions, vocal haemorrhage, Laryngopharyngeal reflux, Laryngeal cancer, etc. Hoarseness should be seen and evaluated promptly in hospital by an otolaryngologist within one week in children and about ten days in adults. However, most patients and even Physicians do not reasons or believe hoarseness is a serious enough problem to present early in hospital. Results: Two hundred and thirty patients were evaluated within the study period. Male to Female ratio of 1.53:1 was observed. 120 patients presented in hospital within 0-1year, 70 patients within 2 years, 25 patients within 3-4 years and 15 patients within 5 years and above. Most common cause of hoarseness was the common cold-60 cases, followed by Laryngitis-35 cases and Laryngeal cancer accounted for 25 cases. Conclusion: Hoarseness is a serious symptom that should be taken seriously by both the patient and the physician and be promptly evaluated in hospital as it may result from a malignant condition like laryngeal cancer.

Risk Factors of Voice Disorders and Impact of Vocal Hygiene Awareness Program Among Teachers in Public Schools in Egypt

Even though many studies have explored the problem of voice disorders among teachers worldwide, this problem is still not adequately studied in Egypt. The following study was conducted to investigate the risk factors of voice disorders among an Egyptian sample of school teachers, to measure the effect of a vocal hygiene awareness program on them, and to investigate their vocal cord lesions. One hundred fifty-six teachers working in public schools and 180 administrative workers in the Faculty of Medicine in the same city participated in this study. They completed a self-administered questionnaire investigating voice disorders, and were subjected to a voice awareness program and a clinical examination. Voice-related symptoms and Voice Handicap Index were statistically significantly higher among teachers compared with the control subjects. Work duration and high frequency of classes per week of ≥15 were the most statistically significant indicators influencing a teacher's voice. Three months after application of vocal hygiene awareness program, the teachers who were studied showed a statistically significant increase in their awareness about vocal hygiene tips. Egyptian teachers working in public schools are dealing with classes that include a great number of students per class. They also have to deal with unprofessional facilities and limited assisting resources. Therefore, they are highly exposed to the risk of voice-related disorders. Increasing awareness about healthy behavior with the voice in their occupations will help in improving their quality of work and in minimizing any permanent impairments and/or disability.

Relationship between the presence of videolaryngoscopic signs suggestive of laryngopharyngeal reflux and voice disorders in teachers.

To analyze the relationship between the presence of videolaryngoscopic signs suggestive of laryngopharyngeal reflux (LPR) and voice disorder (VD) in teachers. this is a cross-sectional study with convenience sample and inclusion criteria as subjects 18 years or older, be a teacher female, seek care with complaint of VD and/or LPR. The exclusion criteria included smoking and presence of respiratory changes. All subjects concluded the following instruments: Vocal Production Condition - Teacher (VPC-T), including the Screening Index for Voice Disorder (SIVD); and Voice Handicap Index (VHI). Speech samples were collected for voice perceptual assessment and all of them were submitted to otorhinolaryngology review. We evaluated 121 teachers, with a mean age of 43 years and 7.8 class hours per day. Only 24.0% of the teachers did not have vocal cord lesions and 42.1% had videolaryngoscopic signs suggestive of LPR. In the group of teachers with presence of Signs suggestive of LPR, the most common symptoms of SIVD were dry throat, hoarseness, throat clearing; the average VHI was 17.9 points. There was no association between voice disorder and presence of videolaryngoscopic signs suggestive of LPR. The independent factors for the LPR in the multiple binary logistic regression analysis were age and VHI score (tertile: 13-20). There was no association between VD and LPR, but between age and VHI score.

Awake videolaryngoscopic intubation in a pregnant patient with a large vocal cord lesion

SummaryWe describe the case of a 39‐year‐old female, 29 weeks pregnant who required urgent excision of a large laryngeal lesion. This was symptomatic, almost completely obstructing her glottis and creating a ball‐valve effect. Rapid progression of the lesion made the patient increasingly dyspnoeic and stridulous over the course of 2 weeks from presentation until surgery. Due to pregnancy‐related challenges and additional risks of complete airway obstruction, we conducted an awake videolaryngoscopic intubation supplemented with Transnasal Humidified Rapid‐Insufflation Ventilatory Exchange (THRIVE) for oxygenation.We discuss the anaesthetic challenges and management of this case, in particular this patient's airway pathology in the context of pregnancy. An overview of laryngeal pathology under the influence of pregnancy hormones is also presented.

Experience of Varied Presentation of Chronic Progressive Disseminated Histoplasmosis in Immunocompetent Patients: A Diagnostic Conundrum.

We report two cases of chronic progressive disseminated histoplasmosis with unusual and rare clinical picture in a patient with no underlying risk factor. One 50-year-old male, presented with hoarseness of voice, chronic cough, with a history of nonresponding anti-tubercular therapy, revealed mucocutaneous lesions on examination. Fungating vocal cord lesions were visualized on bronchoscopy, raised suspicion of carcinoma. The second case, a 22-year-old female, referred to hospital with suspected vasculitis, with complaints of “off and on” fever with decreased oral intake, arthralgia, who later developed generalized nodular skin eruptions. On investigation, human immunodeficiency virus test was found to be negative in both the cases. Histopathological findings of skin biopsy, adrenal and bone marrow aspirates raised suspicion, whereas fungal cultures confirmed Histoplasma infection. Although diagnosis was delayed, but both of them were successfully treated with amphotericin B.

Correlations between Videostroboscopy and Constant Light Examination with Intraoperative Findings and Histopathology—Our Experience

Objective: To assess the role of stroboscopy in the diagnosis of vocal cord lesions. Study Design: Prospective interventional study. Setting: Academic tertiary care medical centre. Materials and Methods: 50 patients with complaints of hoarseness of voice were clinically evaluated and diagnosis was made using Rigid Videolaryngoscopy, Flexible Videolaryngoscopy and Videostroboscopy. Patients underwent microlaryngeal surgery and a final diagnosis made with histopathological examination. The intra-operative findings and the final histopathological diagnosis were compared with the diagnosis made with rigid, flexible videolaryngoscopy and stroboscopy. Results: Intra-operative findings correlated with stroboscopic findings in 84% of patients, with fibreopticlaryngo-pharyngoscopic diagnosis in 54% of patients and with rigid video-laryngoscopy in 46% of patients. Videostroboscopy showed the highest diagnostic co-relation on histopathology (80%) as compared to rigid videoendoscopy (56%) and flexible videolaryngoscopy (58%). Videostroboscopy also elucidated vocal fold abnormalities that were missed on rigid or flexible laryngoscopic examinations. Conclusion: Videostroboscopy is a valuable complement to a thorough vocal history and physical examination. Videostroboscopy is superior to constant light laryngeal examination in diagnosis of vocal cord lesions.

Outcome Analysis in Patients with Benign Vocal Fold Lesions

ABSTRACT Introduction Benign vocal cord lesions cause significant dysphonia by disrupting the normal vibratory function of the vocal fold mucosa. Multidimensional assessment of voice characteristics allows for an accurate analysis of voice impairment and can be used to assess the outcome of different treatment modalities. Aims To evaluate the outcome in patients treated for benign vocal fold lesions using multidimensional voice assessment Materials and methods Thirty adult patients with benign vocal fold lesions were treated according to standard protocols and followed up for 6 months. Voice was evaluated by visual analog scale (VAS), GRBAS (grade, roughness, breathiness, asthenia, strain) scale, maximum phonation time (MPT), S/Z ratio, and acoustic parameters using PRAAT. Pre- and posttreatment voice was compared. Results Benign lesions observed were vocal polyps (16), vocal nodules (7), vocal fold cysts (5), vocal cord papilloma (1), and sulcus vocalis (1). Mean VAS rating improved from 7.5 to 2 at 3 months and 1.6 at 6 months. Mean GRBAS score improved from 7.5 to 2.96 at 3 months and 2.3 at 6 months. Maximum phonation time increased from 9.43 seconds to 14.16 seconds at 3 months and 14.46 seconds at 6 months. S/Z ratio reduced from 1.37 to 1.16 at 3 months and 1.15 at 6 months. Jitter reduced from 1.81 to 1% at 3 months and 0.97% at 6 months; shimmer decreased from 6.07 to 2.19% at 3 months and to 2.03% at 6 months. Harmonic-to-noise ratio values improved from 8.01 to 10.78 dB at 3 months and 10.96 dB at 6 months; mean F0 increased from 207.27 to 217.89 Hz at 3 months and 219.65 Hz at 6 months. Conclusion A single measurement of voice cannot be used as a reliable outcome measure. Perceptual, aerodynamic, acoustic, and self-analysis together allow a multidimensional assessment of voice characteristics. How to cite this article Virmani N, Sharma A, Dabholkar J. Outcome Analysis in Patients with Benign Vocal Fold Lesions. Int J Phonosurg Laryngol 2016;6(1):8-13.

Medrobotics Flex System for Laryngeal Surgery: A Feasible Study in Two Cadavers

ABSTRACT Objective To report the feasibility of Medrobotics Flex® System for laryngeal surgery. Materials and methods Cadaver study in research laboratory. Results The Medrobotics Flex System was utilized with the Medrobotics Flex Retractor to evaluate robotic laryngeal surgery in a cadaver model. Two surgeons using two cadavers tested the robotic system to expose the larynx and facilitate robotic airway surgery using the Flex Instruments. In both cadavers, these procedures were performed transorally with excellent visualization: supraglottoplasty, arytenoidectomy, epiglottectomy, vocal cord lesion excision, posterior cordotomy, hemilaryngectomy, and endoscopic anterior/posterior cricoid split. Laryngeal cleft repair was limited by availability of suture to close the interarytenoid band. Laryngeal exposure was rated as “excellent” by both surgeons using the robotic platform. Conclusion Robotic surgery for the head and neck, while still in relative infancy, remains one of the newest platforms for the otolaryngologist. Currently available robotic platforms, while adapted to head and neck and airway surgery, were not designed for this purpose and pose challenges in size and accessibility to the larynx. The Flex System is specifically designed for head and neck and laryngeal surgery. This system provides outstanding visualization of hard to access areas in the larynx and hypopharynx. The flexible surgical instruments used with the Flex System allow for reasonable surgical exposure and technique. The Flex System may provide an improved robotic experience for transoral laryngeal and head and neck surgery. How to cite this article Roy S, Naqvi SHS, Karni RJ. Medrobotics Flex System for Laryngeal Surgery: A Feasible Study in Two Cadavers. Int J Head Neck Surg 2016;7(4):204-206.

Can videostroboscopy predict early glottic cancer? A systematic review and meta-analysis.

Correct assessment of patients with a glottic lesion is crucial for ensuring proper treatment in cases of cancer or premalignancy and for avoiding unnecessary surgery. For years, videostroboscopy (VS) has been the gold standard for assessing such lesions, but diagnostic difficulties have been described. We aim to estimate the diagnostic accuracy of VS in differentiating early glottic cancer from noninvasive lesions by conducting a systematic review and meta-analysis of published studies. PubMed and Embase databases were searched without restrictions on publication date. A systematic review and subsequent meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched the literature for publications on stroboscopic diagnosis of cancer or premalignant lesions on the vocal cords. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of VS were calculated, and bubble and summary receiver operating characteristics plots were created. A meta-analysis was conducted on five studies with a total of 307 patients. The sensitivities of VS within the single studies ranged from 86% to 100% and specificities ranged from 7% to 93%. The meta-analysis showed that the sensitivity of the combined results was 0.96 (95% confidence interval [CI]: 0.89-0.98), and the specificity was 0.65 (95% CI: 0.21-0.93). VS is able to identify almost all patients with cancer, but only approximately two-thirds of patients with noninvasive lesions are correctly identified as not having cancer. Further research concerning assessment of patients with vocal cord lesions is needed. NA Laryngoscope, 126:2079-2084, 2016.

Adult onset xanthogranuloma presenting as laryngeal mass

Histiocytic disorders can be classified according to the distribution pattern of the lesions and the organs involved. Non-Langerhans-cell histiocytosis is a rare group of diseases that have varied clinical presentations ranging from isolated masses to diffuse systemic eruptions. We discuss a patient who initially presented with a vocal cord lesion and was ultimately diagnosed with adult onset xanthogranuloma.

VALUE OF LARYNGEAL ULTRASOUND IN COMPARISON TO VOCAL CORD VIDEO STROPOSCOPY IN DIAGNOSIS OF VARIOUS LARYNGEAL LESIONS

Background: Video stroposcopy is useful in diagnosis of various laryngeal lesion. Laryngeal ultrasound is also used as a beneficial tool in this diagnosis. Objectives: The main aim of this study was to evaluate the value of laryngeal ultrasound in comparison to vocal cord stroposcopy in diagnosis of different laryngeal lesions. Patients and Methods: This study which was carried out between August 2014 and April 2015 in Radio diagnosis and Otorhinolaryngology Departments, Al-Zahraa University Hospital, Egypt. The study included groups of thirty patients who had complaints related to the larynx as hoarseness of voice, stridor, chronic cough, chocking attacks or neck swelling. These patients were referred from the ENT outpatient clinic. All the patients of the study group were subjected to both laryngeal ultrasound and vocal cord stroposcopy. Results: Twelve patients (40%) were normal, two patients (6.6%) had vocal fold palsy, four patients (13,3 %) had vocal fold nodules, three (10%) had vocal fold polyp, two (6.6%) had vocal fold hypertrophy, two (6.6%) had intrarytenoid edema, one (3.3%) had anterior commissure mass enchroaching upon the right vocal cord, one (3.3%) had submandibular swelling and three (10%) had multinodular goitre. Conclusion: Laryngeal ultrasound can be used in diagnosis in different vocal cord lesions. It can be used as a complementary tool to vocal cord stroposcopy in diagnosis of vocal cord lesions.

Polypoid laryngeal inflammatory myofibroblastic tumors: misleading lesions: description of six cases showing ALK overexpression.

Laryngeal inflammatory myofibroblastic tumors (IMTs) are rarely reported in the literature but may be underrecognized. To better characterize their features, we report a series of six cases. The clinicopathologic findings, including immunohistochemistry, fluorescence in situ hybridization (FISH) analysis, and follow-up, were evaluated and a review of the literature was performed. These cases presented as small polypoid vocal cord or ventricular band lesions, with a more advanced mean age at diagnosis (49 years) than typically reported in other localizations. Apart from one secondary revision surgery, no complementary treatment and no recurrences were observed. Histologically, various morphologic features were seen. All tumors were spindle cell proliferations on a myxoid background with more or less atypia and significant inflammatory infiltrate. All six cases showed anaplastic lymphoma kinase (ALK) immunohistochemical expression. FISH rearrangement was present in four of six cases. Only two cases were initially diagnosed as IMT. According to our series, laryngeal IMTs are easily misdiagnosed. They have a good prognosis, and ALK immunohistochemistry should be carried out to assess this diagnosis when spindle cell proliferations are observed in this localization.

A Few Unusual Cases of Benign Laryngeal Lesions - Our Experience

Introduction: Benign laryngeal lesions may have some uncommon presentations. 
 Aims: The aim was to identify unusual benign vocal cord lesions and review their management and follow up. 
 Material and methods: The records of the patients presenting with different benign vocal cord lesions were reviewed retrospectively. Confirmed cases of vocal cord paralysis and malignancy were excluded from the study. Nine cases were imcluded in this study. Clinical findings, investigation reports, treatment and outcome were analysed. 
 Results: Most of the patients were from 18 years to 52 years (66%). Most common presenting feature was hoarseness of voice (89%) followed by respiratory distress (33%) . Microlaryngeal surgeries were done in 7 patients (78%) and 2 patients (22%) were managed conservatively. 
 Conclusion: Diagnosis of benign vocal cord lesions may sometimes be difficult. Careful history, attention to the anatomy and the probable variations in presentation of the benign lesions of larynx, thorough clinical examination and different diagnostic tools are essential for satisfactory management.

Day surgery for vocal fold lesions using a double-bent 60-mm Cathelin needle.

Day surgery for vocal cord lesions overcomes the disadvantages of laryngomicrosurgery under general anesthesia. We present our experience with treatment of vocal fold lesions using a long double-bend Cathelin needle that can access all parts of the vocal cords. A 23G, 60-mm-long Cathelin needle was bent twice by 45(o) at a distance of 1 and 2 cm from the tip, and was attached to a syringe. Under topical anesthesia and nasal endoscopy of the laryngopharynx, the needle was inserted percutaneously perpendicular to the skin, the direction of insertion being altered when the bends in the needle reached the skin surface. This allows the tip of the needle to access all parts of the glottis, allowing the performance of procedures such as biopsies, excision of lesions, and injection into the vocal folds. Between January 2011 and December 2013, we used this technique to perform vocal fold procedures in 566 patients presenting for treatment of spasmodic dysphonia (412 cases, 73 %) and other vocal fold lesions. Only minor complications, such as hematoma (3 patients, 0.5 %) and slight bleeding from the puncture site in the epiglottic vallecula (all patients, 100 %), which ceased spontaneously within 10 min, were seen. Erroneous puncture occurred in three patients (0.5 %) and the puncture had to be repeated in 38 patients (6.7 %). The procedure was completed successfully in all cases (100 %). Surgery for vocal fold lesions under topical anesthesia using our double-bend Cathelin needle technique is simple, safe, and useful.

Metastatic Calcification of the True Vocal Folds in the Setting of Renal Failure

Objectives: (1) Present a case of metastatic calcinosis of the true vocal cords. (2) Discuss the pathogenesis, diagnosis, and treatment strategies for this condition. Methods: This is a case report of a 52-year-old male with a history of end-stage renal disease and tobacco abuse who presented to clinic with complaints of dysphagia, cough, and subtle voice changes. Transnasal fiberoptic laryngoscopy revealed bilateral patches of leukoplakia on the anterior third of the vocal cords. After a 3-month period of conservative management with a proton pump inhibitor and serial scope examinations, the lesions were noted to be slowly enlarging. It was determined that an excisional biopsy should be performed to rule out malignancy. The patient underwent micro-suspension direct laryngoscopy with microflap excision of the bilateral vocal cord lesions. Results: Surgical pathology revealed benign squamous mucosa with calcinosis, parakeratosis, and submucosal hyalinization. These findings were characteristic of metastatic calcification. Review of the patient’s medical records confirmed ongoing phosphorous dysregulation. Metastatic calcinosis of the true vocal fold is a very rare finding, with only 2 other reported cases in the literature. Conclusions: In patients suffering from end-stage renal disease, dysregulation of calcium and phosphate levels may lead to deposition of calcium in many types of soft tissue, including the true vocal cords. Examination findings may mimic dysplastic lesions, and this diagnosis should be considered in patients with chronic kidney disease.

Assessment of malignant and non-malignant lesions of the vocal cord using videostroboscopy

Background: Videostroboscopy has evolved as the most practical and useful technique for clinical evaluation of the viscoelastic properties of the phonatory mucosa. It is most useful in identifying the laryngeal pathologies of the vocal fold cover. Aim: To assess the malignant and non-malignant pathologies of the vocal cord by using videostroboscopy. Materials and Methods: The study was carried out on 105 cases, with various complaints of change in voice and hoarseness, in the Department of ENT, VMKVMC., Salem, between March 2011 and June 2013. The stroboscopic examination was carried out after the history, routine ENT examination, and indirect laryngoscopic examination were conducted. All statistical analyses were conducted using the SPSS version 16. The Chi-square was applied to assess the significance value. The level of significance in each calculation was 0.05. Results: A total of 105 patients, with various pathologies, were included in this study. Their ages ranged between 16 and 80 years, and the mean age was 49.7 years. Sixty-seven (63.8%) cases were male and 38 (36.2%) were female. Hoarseness of voice was found to be the major complaint among the study group, followed by a high-pitched voice and dyspnea. Vocal abuse was found be a major factor for nodule, vocal cyst, and polyps. Smoking and tobacco/gutkha chewing was found to be associated with most of the other malignant vocal cord lesions. Chronic laryngitis, polyp, and congestion had shown a statistically significant association with complete glottis closure. Vocal cord cancer, polyp, and cyst had shown significant association with asymmetry of the vocal cord, whereas, acute and chronic laryngitis, nodule, abductor palsy, and congestion had shown a significant relationship with symmetry of the vocal cord. Conclusion: Videostroboscopy is most useful in identifying and differentiating malignant and non-malignant vocal fold pathologies.

A comparison of histopathological results of conventional surgery and transoral radiofrequency ablation in early stage laryngeal carcinoma

This study aims to compare histopathological results of conventional surgery and transoral radiofrequency ablation in patients with early stage laryngeal carcinoma. Between January 2006 and May 2010, 36 patients (34 males, 2 females; mean age 61.6 years; range 43 to 77 years) who underwent partial laryngectomy in our clinic were retrospectively analyzed. All patients were randomized to partial laryngectomy with radiofrequency ablation or conventional surgery. Hoarseness due to early stage T1 and selected T2N0 vocal cord lesions was an indication for surgery. Of 20 patients receiving conventional surgery, 14 underwent partial laryngectomy, while six patients underwent cordectomy for the excision of tumors. Tumors were excised by transoral radiofrequency ablation in 16 patients. We observed thermal artifacts in four patients undergoing conventional surgery and in 13 patients undergoing transoral radiofrequency ablation. There was also hemorrhage in 16 patients undergoing conventional surgery and in seven patients undergoing transoral radiofrequency ablation. Histopathological examination revealed that the surgical margins were safe in 10 patients after radiofrequency ablation. The specimens obtained from six patients showed thermal artifacts which complicated histopathological examination. Sixteen (80%) of 20 conventional surgery patients and nine (56%) of 16 radiofrequency ablation patients had safe surgical margins. In radiofrequency ablation, the surgical zone must be larger than in conventional surgery due to the high risk of tissue damage and complicated histopathological examination.

Using image processing technology and mathematical algorithm in the automatic selection of vocal cord opening and closing images from the larynx endoscopy video

The human larynx is an important organ for voice production and respiratory mechanisms. The vocal cord is approximated for voice production and open for breathing. The videolaryngoscope is widely used for vocal cord examination. At present, physicians usually diagnose vocal cord diseases by manually selecting the image of the vocal cord opening to the largest extent (abduction), thus maximally exposing the vocal cord lesion. On the other hand, the severity of diseases such as vocal palsy, atrophic vocal cord is largely dependent on the vocal cord closing to the smallest extent (adduction). Therefore, diseases can be assessed by the image of the vocal cord opening to the largest extent, and the seriousness of breathy voice is closely correlated to the gap between vocal cords when closing to the smallest extent. The aim of the study was to design an automatic vocal cord image selection system to improve the conventional selection process by physicians and enhance diagnosis efficiency. Also, due to the unwanted fuzzy images resulting from examination process caused by human factors as well as the non-vocal cord images, texture analysis is added in this study to measure image entropy to establish a screening and elimination system to effectively enhance the accuracy of selecting the image of the vocal cord closing to the smallest extent.

Characteristics of polypoid lesions in patients undergoing microsurgery of the larynx

Summary Introduction: Dysphonia is the main symptom of lesions that affect the vocal tract. Many of those lesions may require surgical treatment. Polyps are one of the most common forms of vocal cord lesions and the most prevalent indication for laryngeal microsurgery. There are different types of polyps, and their different characteristics can indicate different prognosis and treatments. Aim: To conduct a comparative study of polypoid lesions (angiomatous and gelatinous) in patients undergoing laryngeal microsurgery via an electronic protocol. Method: We prospectively evaluated 93 patients diagnosed with vocal fold polyps; the polyps were classified as angiomatous or gelatinous. Results: In total, 93 patients undergoing laryngeal microsurgery were diagnosed with vocal fold polyps. Of these, 63 (64.74%) had angiomatous and 30 (32.26%) gelatinous polyps. Most patients with angiomatous polyps were men; their polyps were frequently of medium size, positioned in the middle third of the vocal fold, and accompanied by minimal structural alterations (MSA). In contrast, the majority of patients with gelatinous polyps were women; their polyps were smaller, positioned in the middle and posterior third of the vocal fold, and were not accompanied by MSA. Both types of polyps were more frequently located on the right vocal fold. Conclusion: Angiomatous polyps were more frequently encountered than gelatinous polyps. In addition, correlations between polyp type and sex, polyp size, position, location, and the presence of MSA were observed. Different surgical techniques were used, but the postoperative results were similar and satisfactory after speech therapy.