SUMMARY: Comparison of the results of treatment with epiduralinjection of procaine alone with that of procaine plus Depo-Medrone in patients with unilateral sciatica showed no definite difference between the two groups. Of 48 patients, there was improvement in about 70 %, whichever solution was used. However, it is of interest that in patients with a long history of severe sciatica the injection of procaine plus Depo-Medrone appeared to give better results. This finding should be noted, and a further comparative trial in this group is worth undertaking. LUMBAR disc lesions with nerve-root compression are common, and epidural injections have been used therapeutically, with alleged benefit, for many years (Cathelin, 1901; Viner, 1928; Evans, 1930). During the last ten years, epidural injections of local anaesthetic (Coomes, 1961; Cyriax, 1969), corticosteroid (Barry and Kendall, 1962; Harley, 1967), or saline (Davidson, 1961), separately or in combination (Goebert, 1960; Brown, 1960; Goldie, 1968), have attracted some interest. Previous papers have produced claims for the effectiveness of these preparations. In particular, there has been a suggestion that injection of corticosteroid is of special benefit. The object of this paper is to compare the results, in patients with sciatica, of epidural injection of procaine alone with those of injection of procaine plus Depo-Medrone, and to show, from a practical point of view, if it is worth while adding a corticosteroid to the local anaesthetic solution. To my knowledge, no previous comparison has been recorded. MATERIAL Forty-eight consecutive patients were treated with epidural local anaesthesia during the past six months; 36 were males and 12 females. The ages ranged from 19 to 71 years, with a mean of 40 · 6 years. Patients were selected with moderate or severe unilateral sciatica, thought to be caused by an intervertebral disc lesion, with or without neurological signs, before or after other conservative treatments