Objective: To describe the clinical, radiological and neuropathological manifestations, response to treatment, and prognosis of non-meningothelial disorders diagnosed at the community hospital. Background Leptomeningeal and dural involvement as detected by neuroimaging is problematic to diagnose because of the broad differential diagnosis. However, it frequently requires an aggressive diagnostic approach as exact diagnosis is crucial for appropriate treatment and prognosis. Design/Methods: We retrospectivelly indentified nine patients with rare leptomeningeal disorders, treated in our facility over the last eight years. All diagnoses were pathologically confirmed. Collected data included demographics, neurological symptoms, radiographic and biopsy/autopsy findings. Results: Two patients were diagnosed with disseminated primary diffuse leptomeningeal gliomatosis, three with isolated CNS lymphoma involving meninges or dura, one with Rosa-Dorfman disease, one inflammatory myofibroblastic tumor, and two with granulomatous disorder. Among the patients with lymphoma, two had diffuse large B cell lymphoma and one had marginal zone lymphoma (MALToma). Patients with leptomeningeal gliomatosis had progressive course with fatal outcome. Neurological manifestations included encephalopathy, cognitive decline and subsequent paraparesis. One patient required placement of ventriculo-peritoneal shunt for acute hydrocephalus. The other patients, including lymphoma cases, responded well to treatment and so far all but one have remained in remission. In this group, clinical manifestations included headaches and seizures that were controlled on anticonvulsants. Conclusions: Based on our experience, uncommon leptomeningeal and dural disorders need to be aggressively investigated as treatment of some disorders can be successful. Neurologists in a community based practice should have a high level of clinical awareness and be familiar with a variety of leptomeningeal disorders othe than infection and leptomeningeal spread from metastatic cancer. Disclosure: Dr. Bronstein has nothing to disclose. Dr. Pinsky has nothing to disclose. Dr. Danesh has nothing to disclose. Dr. Khoiny has nothing to disclose. Dr. Petrovic has nothing to disclose.