Lepore Trait Research Articles

The synthesis of alpha, beta, and delta peptide chains by reticulocytes from subjects with thalassemia or hemoglobin Lepore.

Abstract The incorporation of radioactive amimo acids into the α and β chains of hemoglobin A, the α and δ chains of hemoglobin A 2 , and the α and non-α chains of hemoglobin Lepore by reticulocytes from nonhemoglobinopathic, Lepore trait, and thalassemic patients has been compared. Significant imbalance of α and β chain production was detected only in thalassemic subjects. This was characteristic of thalassemia minor as well as thalassemia major. The relative rates of δ chain production were greater than those of β thalassemia chains. There was little depression of the synthesis of the non-α chains of hemoglobin Lepore relative to α chain formation in vitro by reticulocytes from patients heterozygous for hemoglobin Lepore when compared with control subjects.

Study on nine families with haemoglobin Lepore in Campania: Hb Lepore trait, heterozygosity for Hb Lepore and beta-thalassaemia, homozygosity for Hb Lepore.

Study on nine families with haemoglobin Lepore in Campania: Hb Lepore trait, heterozygosity for Hb Lepore and beta-thalassaemia, homozygosity for Hb Lepore.

A New Hereditary Hemoglobinopathy (the Lepore Trait) and Its Interaction with Thalassemia Trait

Abstract A new hemoglobinopathy, termed the "Lepore trait," is described. The Lepore trait is characterized by an altered erythrocyte morphology, resembling classical thalassemia trait,[unknown] and by the presence of a hitherto unreported abnormal hemoglobin occurring in low concentration (10-12% of the total hemoglobin). The trait is transmitted as if due to a single gene defect. Simultaneous inheritance of the Lepore trait and classical thalassemia trait occurred in one member of the pedigree studied and resulted in a severe hemolytic anemia clinically indistinguishable from thalassemia major. On the basis of the erythrocyte morphology, the clinical findings, and the electrophoretic studies, it is conjectured that the Lepore trait may be more closely related to thalassemia than to the other abnormal hemoglobin syndromes.