Major and minor element analyses of 496 natural volcanic glass samples from 141 locations along the superfast spreading (150 mm/yr) East Pacific Rise (EPR), 13°–23°S, and near‐ridge seamounts comprise 212 chemical groups. We interpret these groups to represent the average composition of individual lava flows or groups of closely related flows. Groups slightly enriched in K2O (T‐MORB) are distributed variably along the axis, in contrast to the Galapagos Spreading Center where T‐MORB are extremely rare. This result is consistent with the interpretation that T‐MORB magmas arise from low‐melting temperature, K‐rich heterogeneities in the subaxial EPR mantle. The Galapagos Spreading Center, which is migrating to the west in an absolute reference frame, is underlain by mantle previously processed and depleted in the T‐MORB component during melting events giving rise to earlier EPR magmas. Excluding T‐MORB, there are nearly monotonic, twofold increases in K/Ti and K/P of axial lavas from 23°S to 13°S. From 22°S to 17°S these gradients correlate with isotopic ratios, but north of 17°S there is a reversal of isotopic gradients, indicating (recent?) decoupling of the isotopic and minor element ratios in the subaxial mantle. A strong, southward increase in degree of differentiation for approximately 200 km north of the large offset at 20.7°S correlates with a gradient in bathymetry, consistent with previous interpretations that this offset is propagating to the south. Samples from recently abandoned ridges associated with this dueling propagator mainly carry the distinctive, evolved fractionation signatures of rift propagation, suggesting that propagating rift tips have been abandoned preferentially to failing rift tips. Glass compositional variations south of this offset are consistent with rift failure on the southern limb within 40 km of the offset, and possibly also south of 22°S; the latter region may be affected by deformation accompanying northward growth of the Easter Microplate. Near‐ridge seamounts on the Pacific Plate between 18°–19°S comprise two distinct populations: those aligned approximately parallel to the spreading direction are extremely variable in major element composition, but consistently enriched in Sr relative to nearby axial lavas; smaller seamounts aligned approximately parallel to the direction of absolute plate motion are uniformly depleted in minor elements and Sr relative to axial lavas. The degree of differentiation of axial lavas between 18°–19°S can be related to the structural development of the rift axis and/or vigor of hydrothermal activity of individual segments. Glass compositional variations indicate that magmatic segmentation occurs on several different scales at the superfast spreading rate of this area. Primary magmatic segmentation mainly reflects mantle source variations, the boundaries of which correlate with the largest physical offsets in the rise axis between the Easter Microplate and Garrett Transform Zone. A secondary magmatic segmentation, defined by the along‐axis continuity of similar parental magma compositions or liquid lines of descent, occurs with a length scale varying from 11 to 185 km, with an average of 69 ±57 (1σ) km. The boundaries of these segments mainly occur at overlapping spreading centers. All first‐, second‐ and third‐order physical offsets correspond to secondary magmatic segment boundaries, but some secondary magmatic segment boundaries also occur at small, fourth‐order ridge axis discontinuities. The secondary magmatic segments define the length scale of mantle melting variations, mainly variations in extent of melting, but not the scale of melt extraction processes that feed the axis. This scale must be smaller than that of the secondary magmatic segments and probably corresponds to the length scale of fourth‐order physical discontinuities along axis. There is a good positive correlation of average secondary magmatic segment length with spreading rate for four well‐sampled areas varying from 20 to 150 mm/yr. Secondary magmatic segments also become more variable in axial length with increasing spreading rate. The average lengths of secondary magmatic segments are smaller than those predicted by gravitational instability considerations at all spreading rates. Superposed on the axial magmatic segmentation are variations reflecting subaxial magmatic temperature, defined by extent of magmatic differentiation, which bears little systematic relation to physical or other kinds of magmatic segmentation. At 13°–23°S, the length scale of this variation is 217±60 (1σ) km, approximately corresponding to the wavelength of “rolls” in the gravity field observed off‐axis. Taken together, the various kinds and scales of magmatic variations observed for this superfast spreading ridge suggest that regional temperature of the upwelling asthenosphere, magma supply to the axis, and crustal magmatic temperature reflect independent, regionally decoupled processes.