Length Of Group Research Articles

Cationic dyes and their use for the quantitative extraction-photometric determination of higher carboxylic acids

Cationic dyes of various natures have been investigated in order to select a dye that is stable under strongly alkaline conditions and applicable for the quantitative extraction-photometric determination of higher carboxylic acids. The nature of the dye, solvent, the length of the hydrocarbon radical of carboxylic acids and the pH of the aqueous phase for the extraction of ionic associates of higher carboxylic acids with cationic dye with pyronin G were experimentally studied. The study substantiates the practical application of the cationic dye pyronin G as an effective reagent for the quantitative extraction-photometric determination of higher carboxylic acids.

Effect of pre-sowing treatments on germination and growth of French bean (Phaseolus vulgaris L.)

The experiment was laid out to study the effect of pre-sowing treatments with growth regulators viz. Indole acetic acid (IAA), Salicylic acid (SA) and Gibberellin acid (GA3) with different concentrations like 50 ppm and 100 ppm on physiological and growth attributes of French bean. The seeds treated with growth regulators for 8 hrs. And 12 hrs. Duration along with three replications of treatments. The experimental approaches like plot size 2.5×2.5 m, spacing 45×15 cm and ridge & furrow planting method used and transplanting followed. The significantly maximum germination percentage (95.95%) recorded with 100 ppm concentration of IAA in this seeds soaked for 12 hrs. (T6) which was better over control (87.17%). The maximum change in seed diameter (0.86 cm) was noticed in T6 i.e. seeds treated with IAA 100 ppm concentration and soaked for 12 hrs. And minimum recorded in control (0 cm). The better length of radical (9.03 cm) when seeds treated with 100 ppm concentration of GA3 and soaked for 12 hrs. (T4). The minimum days taken to emergence (5.11 days) occurred with T6 i.e. seeds treated with 100 ppm IAA and soaked for 12 hrs. Over control. The results revealed that significant change in growth attributes of French bean like maximum plant height (66.46 cm), number of branches per plant (7.85), minimum days taken to 50% flowering (31.15 days) recorded when seeds treated with 100 ppm GA3 and soaked for 12 hrs. (T4) over control or water treated seeds.

The correlation between the surface-active characteristics of SAFOL 23 – alcohol – water systems and the length of the alkyl radical of the alcohol

The effect of isobutyl and isoamyl alcohols on the surface-active characteristics of SAFOL 23 nonionic sur-factant was studied. The surface tension isotherms (STI) of an aqueous solution of surfactant and its water-alcohol compositions are obtained. The structure of mixed micelles and the values of the surfactant interac-tion factor in the micelle, based on the STIs of SAFOL 23 – alcohol – water systems, were calculated. The dependence of surface activity on the SAFOL 23: alcohol ratio passes through a maximum, which is associat-ed with the transition of alcohol from co-surfactant to co-solvent due to the increase in its quantity. The wet-ting process of high dispersed polytetrafluoroethylene (PTFE) by SAFOL 23 – alcohol – water compositions was studied, contact angle isotherms were constructed. The PTFE surface was hydrophilized by compositions at ratios which comply with surface activity maximum. SAFOL 23 is more adsorbed on the surface of the sol-id phase than on the liquid-gas interface. The appending of alcohol into an aqueous solution of surfactant changes the ratio between hydrophilic and lipophilic groups of the composition, which affects cloud point. It significantly expands the range of application of surfactants and allows the use of SAFOL 23 as a solubilizer, emulsifier and wetting agent.

Fungicidal and Bactericidal Activity of the Alkyl-Substituted Guanidine-Containing Oligomers

Biocides are widely used in medicine and various industries to protect against a number of harmful microorganisms. Organic quaternary ammonium and guanidine-containing compounds, the biological action of which is based on membrane-toxic properties, are used as bactericidal preparations. The aim of this work was to study the bactericidal and fungicidal activities of the synthesized oligomeric alkylsubstituted guanidinium bromides with different radicals -C3H7, -C7H15, -C10H21, against different isolates of heterotrophic bacteria and microscopic fungi. Methods. The synthesis of alkyl-substituted guanidiniumcontaining oligomers was performed in two stages. In the first stage, alkyl-substituted guanidine was obtained by the reaction of guanidine, previously converted by alkali from the salt form to the base form by the base and alkyl bromides (Alk=-C3H7 (propyl), -C7H15 (heptyl), -C10H21 (decyl)) in methanol at a temperature of 50°C and a molar ratio of 1:1. The second carried out the reaction between aromatic oligoepoxide DER-331 and alkyl-substituted guanidine in methanol at a temperature of 50°C for 2–3 hours and a molar ratio of 1:2. Bacteria were grown on meat-peptone agar for 48 hours at a temperature of 28±2°С. Test cultures of micromycetes were cultured on agar beer wort (6°B), incubated for 14 days in a thermostat at a temperature of 28±2°C. Antimicrobial activity of newly synthesized alkyl-substituted guanidinium-containing oligomers was determined by standard disco-diffusion method (method of disks on agar) and fungicidal activity was determined by the method of holes in agar. Results. Oligomeric alkylsubstituted guanidinium bromides with different radicals composed -C3H7, -C7H15, -C10H21- synthesized by the reaction of guanidine alkyl bromides with aromatic oligoepoxydes. It was found that alkyl-substituted guanidinium-containing oligomers at a concentration of 1–3% inhibited the growth of Escherichia coli 475, Pseudomonas aeruginosa 465, Klebsiella pneumonia 479, Pseudomonas pseudoalcaligenes 109, Staphylococcus aureus 451, E. faecalis 422, Rhodococcus erythropolis 102, Bacillus subtilis 138 and most of the studied micromycetes – Aureobasidium pullulans F-41430, Paecilomyces variotii F-41432, Penicillium funiculosum F-41435, Penicillium ochrochloron F-41431, Scopulariopsis brevicaulis F-41434, Trichoderma viride F-41437, Candida albicans F-41441, Aspergillus flavus F-41442, Aspergillus niger F-41448, Penicillium sp. F-41447. Conclusions. Antimicrobial and fungicidal properties significantly depend on the length of the alkyl radical, with increasing of its length the diameter of the zone of bacterial and micromycetes growth retardation increases.10.15407/microbiolj82.06.054

Chemiluminescent Reaction of N-Octyl Luminol with a Hypochlorite Ion in a Micellar Medium

We study the effect of surfactants having a different charge and length of the hydrocarbon radical on the intensity and kinetic laws of the model chemiluminescent reaction of a hydrophobic analogue of luminol, N-octyl luminol. The effect of the solution pH and the charge, structure, and concentration of surfactants on the intensity of the chemiluminescence is assessed, and the kinetic laws of the chemiluminescent reaction are determined.

MODIFICATION OF OLIGOESTER MALEINATE BY ALKYL ESTER OF N-MALEINIMIDOBENZOIC ACID

When using products from unsaturated polyester resins (NPS), often increased requirements for thermal and chemical resistance are raised. Increasing the thermal stability of the PS is possible due to the modification of resins by polymerization compounds, which can copolymerize with both oligoether maleinate and styrene. One of such effective additives is N-phenylmaleinimides. The paper presents the results of modification of unsaturated polyester grade PN-1 UT with alkyl ethers n-maleinimidobenzoic acid. The properties of terpolymers are investigated. The effect of substituents of the aromatic group with N-phenylmaleinimides on the properties of terpolymers was investigated. It is also of interest to study the effect of substituents of the aromatic group in N-phenylmaleinimide on the properties of modified polymers. It is shown that terpolymers due to their maleinimides are superior in strength and thermomechanical properties of the copolymers of oligoestermaleinate and styrene. The increase in the size of the hydrocarbon radical substituents of the aromatic group of maleinimides contributes to the increase of the thermo-and physico-mechanical properties of terpolymers. It is also shown that the glass transition temperature of polymers depends on the content of maleinimides, as well as on the structure of the aromatic group. With an increase in the content of maleinimides (up to 5 wt. %) there is an increase in the glass transition temperature and the beginning of the destructive flow. The greatest increase in glass transition temperature (30 °C) is observed at a content of 3 wt. % butyl ether of n-maleimidobenzoic acid. The increase in the length of the hydrocarbon radical (С5Н11 and С8Н17) of the ester group of n-maleimidobenzoic acid leads to the appearance of a plasticizing effect. Synthesized terpolymers can be recommended as binders in the production of heat-resistant composite materials, in particular, fiberglass.

Synthesis and Study of the Properties of Amphiphilic Poly-N-Vinylpyrrolidone with Terminal Thioalkyl Groups

Poly-N-vinylpyrrolidone-based amphiphilic polymers, which can be used as drug carriers, were prepared by radical polymerization with a thiol-type chain transfer agent. The polymers did not contain sequences of hydrophilic and hydrophobic fragments in the main chain. Molecules contained only one hydrophilic and one hydrophobic fragment linked by a covalent bond. This facilitated the self-organization of macromolecules into micelles in aqueous media. The critical micelle concentration and its dependence on the molecular weight of the diblock copolymers and the length of the hydrophobic radical were determined

Germination and seedling growth of rice (Oryza sativa L.) as affected by varying concentrations of loom-dye effluent

Indiscriminate discharge of industrial effluent has become a serious problem for the agro-ecological environment in most of the areas of Bangladesh. The effects of loom-dye effluents on seed germination and early seedling growth of rice (Oryza sativa L.) were investigated by conducting an experiment in the laboratory of the Department of Agricultural Chemistry of Bangladesh Agricultural University, Mymensingh. Three types of loom-dye effluents were applied in sterilized petridishes at different loading ratios. Seven treatments (i.e., T0, T1, T2, T3, T4, T5 and T6 with 0, 5, 10, 25, 50, 75 and 100% effluent, respectively) of each effluent were used following completely randomized design (CRD) and replicated three times. Subsequently, Pb, Fe, Zn, Mn and Cr accumulation were also investigated in the harvested rice seedlings. Rice seed showed a significant difference in germination percentage with varying levels of effluent application at different days after setting of germination. The decreased seed germination rate and seedling growth of rice were observed with increased concentration of loom-dye effluents. The highest germination speed (97.8%) was obtained from control whereas the lowest germination speeds were obtained from T5 of black, and T6 of both black and violet effluents. Phytotoxic effects of loom-dye effluents on germination and radical length were extreme at 100% effluent concentration having the order of black > violet > pink. The maximum radical length (6.4 cm) and plumule length (7.5 cm) were observed with T1 of pink dye effluent whereas the minimum length of radical and plumule were obtained from T6 treatment of the effluents. The highest fresh weight (39.8 mg petridish–1), dry weight (5.7 mg petridish–1) and seedling vigor index (746.7%) were also observed from T1 of pink dye effluent. The maximum uptake of Pb, Fe, Mn and Zn was 0.48, 3.81, 0.79 and 0.13 μg g−1, respectively. The uptake of Cr was below the detectable limit. Total heavy metal accumulation in rice was in the following order: Fe>Mn>Pb>Zn>Cr. Results showed that the higher concentration of loom-dye effluent showed the higher toxic effects on different parameters of germination and early seedling growth compared with the lower effluent concentrations.
 J. Bangladesh Agril. Univ. 17(2): 153–160, June 2019

Epoxy antifriction wollastonite-filled materials

Introduction. Domestic mineral natural-origin filler ‘wollastonite’, also known as calcium methyl silicate, is widely used as a base for wear-resisting epoxy antifriction materials. Due to anisodiametric shape of its particles, wollastonite functions as a micro reinforcement fibre enhancing adhesion strength and wear resistance of epoxy compositions, improving their antifriction properties, especially when organomodifying by quaternary ammonium salts. In this regard, the investigation of the impact of chemical composition of such surfactants as quaternary ammonium salts on the properties of epoxy compound materials presents utmost interest for researchers developing low-friction materials. Materials and methods. Epoxy diane resin ED-20 was hardened with aminoalkylphenol AF-2. Content of epoxy hardener was determined by equimolar ratio of epoxy groups to amine groups. Domestic wollastonite of the grade Miwoll 10-97 was used as filler, particle length to the diameter correlated as 15:1. The wollastonite surface was activated with surfactants belonging to domestically produced quaternary ammonium salts. Wear resistance of specimens was tested by means of the vertical optical caliper IZV-1. Friction coefficient was estimated with the assistance of the computer-automated frictional machine CSM Instruments Tribometer. Adhesion strength of glue joint was determined as per GOST 28840-90 standard. Two bars of sheet aluminium were used as glued surfaces as per GOST 14759-69 standard. Results. Reduction of wear of epoxy coatings when modified with micro reinforcing wollastonite can be explained by the increase of cross-linking degree of the polymer. The length of alkyl radical of quaternary ammonium salts used for wollastonite surface activation affects the intervals between the epoxy links. As the quaternary ammonium salt chain length is growing, wear of epoxy materials is reducing. Introduction of the wollastonite containing metallic oxides in the epoxy composites increases wear resistance and adhesion strength and reduces coating friction coefficients. Conclusions. Hardened with the AF-2 and filled with the wollastonite of the Miwoll 10-97 grade, the epoxy compound materials have enhanced wear resistance and adhesion strength and lower friction coefficient. The best result is observed when applying wollastonite modified with a surfactant belonging to the class of quaternary ammonium salts. The wollastonite can be used for practical purposes as a perspective reinforcing agent for epoxy materials with improved wear resistance, enhanced adhesion to metals and reduced friction coefficient.

Effect of the Composition of the Lubricating Medium on the Structure of Surface Layers Formed by the Friction of a Servovite Film

The tribological characteristics of a brass–steel friction pair in aqueous solutions of saturated carboxylic acids are studied. With an increase in the length of the carbon radical in the acid molecule used as the organic component of the lubricant composition upon the friction of brass on steel, the coefficient of friction decreases and wear reduces. A servovite film is found to form on tribocoupled surfaces during frictional interaction. In the series of monobasic carboxylic acids R–COOH (R = CnH2n + 1, n = 0–5) used as a lubricating medium, from formic acid to caproic acid, the roughness of the film surface decreases and its continuity increases. The servovite film is formed by copper nanoclusters of predominantly ellipsoidal shape up to 40 nm in height, tightly packed and directed along the slip of the counterbody.

Shrimp shells, Chitin and chitosan powders effect on growth of Lycopersicon esculentum and their ability to induce resistance against Fusarium oxysporum f.sp. radicis-lycopersici attack

The potential of co-products of shrimp shells on the germination parameters, growth, and for inducing defense reactions in tomato (Lycopersicon esculentum) plants inoculated with Fusarium oxysporum f.sp. radicis-lycopersici (FORL) was investigated in vitro and in vivo.It was found that chitosan at 50mg/l increased the germination percentage by 2.66%; the shrimp shells powder at 50mg/l was best in increasing the length of radical and length and weight of hypocotyl in vitro. In Vivo, chitosan at 50mg/l increased length, fresh/dry weight of aerial and radicle parts compared to control. An inhibition of FORL growth in vitro was obtained by addition of chitosan at 100mg/l. In addition, chitin at 25 mg/l decreased the foliar alteration index by 73.34% compared to control.

Effects of three Bacillus strains on growth promoting and rhizosphere soil microflora of tomato.

The effects of Bacillus Bs10, Ba12 and Bl10 on tomato growth and soil rhizosphere microorganisms were determined by Petri dish germination test and pot experiments. The results showed that Bs10, Ba12 and Bl10 exhibited remarkable promoting effect on the length of hypocotyl and radical, as well as the growth of plants. The length, surface area and volume of tomato roots increased significantly after treatment with Bacillus stains, the numbers and proportions of soil bacteria also increased markedly, while those of soil fungi decreased. The numbers of the dominant bacteria and fungi were changed, withBacillus methylotrophicus being much higher in root zone soil, surface soil and neouchi, while the plant pathogens Fusarium solani and Fusarium oxysporum decreased significantly in root zone soil and root surface soil. These results suggested that the addition of Bs10, Ba12 and Bl10 could improve the micro-ecosystem of the root domain of tomato, which might play an important role in growth promoting and disease prevention on tomato plants.

Allelopathic effects of mesquite (Prosopis juliflora) aqueous extracts on seeds germination and seedlings growth of alfalfa, sesame and sorghum

Abstract. Omer HHM, Mohammed IS. 2017. Allelopathic effects mesquite (Prosopis juliflora) aqueous extracts on seeds germination and seedling growth of alfalfa, sesame and sorghum. Cell Biol Dev 1: 51-54. Mesquite plant [Prosopis juliflora (Swartz) DC] is an invasive tree or shrub native to South America. Unfortunately, the plant threatens biodiversity and agriculture due to deliberate distribution within Sudan. Furthermore, this plant has an allopathic potential that may be caused by falling leaves, fruits, root exudates, or plant leachates. These allelochemicals may inhibit the germination and growth of agricultural crops. This study was conducted in the Laboratory of Plant Pathology, College of Agricultural Studies, Sudan University of Science and Technology, Khartoum, in January-February 2016. The aim of this study was to elucidate the potential of allopathic effects of aqueous extract of different parts of mesquite plant, i.e., leaves, fruits, bark, and roots, on germination and early seedlings growth of alfalfa, sesame, and sorghum. The results indicated that the aqueous extracts of different parts of the mesquite plant significantly ( P ? 0. 05) inhibited the seeds' germination and reduced the early growth of the seedlings. These suggest that the inhibitory substance (s) were widely distributed in mesquite plants but to varying extents. Moreover, fruits and leaves extracts were more pronounced and consistent than bark and roots. That could be attributed to the mesquite fruits and leaves aqueous extracts containing more water-soluble allelochemicals than roots and bark. They gave 0.0% germination in alfalfa and sesame and 47.6-86.7% in sorghum, respectively, compared to control. At the same time, the length of hypocotyl and radical was reduced to 0.0 cm and up to 2.7 cm depending on the efficacy of extract and the response of the test crop. Thus, it is recommended to study the nature of inhibitors to determine whether allelopathic is the cause of the extraordinary success of mesquite on the flat plains of agricultural land in Sudan.

Diet and feeding strategy of the forkbeard Phycis phycis (Pisces: Phycidae) from the Portuguese continental coast

The diet and feeding behaviour of the forkbeard Phycis phycis was studied based on 246 stomachs collected between May 2011 and April 2012 from a commercial fleet operating off the central west coast of Portugal. A total of 44 prey items were identified in the stomachs which were merged into major groups to avoid problems with low expected frequencies. The following taxonomic categories were considered: non-decapod Crustacea, Caridea, Anomura, Munida spp., Processa spp., Brachyura, Pisces, Trisopterus luscus. In order to investigate possible diet differences between fish size classes, a cluster analysis was performed using the mean abundance of each prey group by forkbeard 5 cm length class, and three length groups (LG) were obtained: <22.5, 27.5–37.5 and >42.5 cm. Seasonally, Caridea was the main prey group during winter and autumn while Pisces was predominant during the rest of the year. Caridea was the most important prey group for LG1 and LG2 while in LG3 Pisces was the principal one. The forkbeard feeding behaviour may be characterized as presenting a shift pattern from a more generalist diet (small Crustacea, mainly Caridea) in the young adults to a more specialist strategy (teleosts) in the adults.

1-ALKYL-3-METHYL-4-HYDROXYIMINO-2-PYRAZOLINE-5-ONES AS EXTRACTION REAGENTS

With nitrosation of the corresponding 1-R-3-methylpyrazole-5-one (R = C4H9, C5H11, C6H13, C7H15, C8H17, C6H5) in acidic aqueous methanolic medium at 0-5 °C a series of 1-alkyl-3-methyl-4-hydroxyimino-2-pyrazolin-5-ones with a yield of 72-85% were synthesized. The compounds are soluble in CHCl3, C2H4Cl2, C6H5CH3, i-C4H9OH, CCl4, C2H5OH, slightly soluble in C6H14, H2O. They can be recrystallized from a mixture of C6H14: C6H5CH3 = 5: 1 or isooctane. The structure of the compounds was confirmed by the data of ECR, IR, Raman spectroscopy and TLC data. The interphase distribution of oxyiminopyrazolones between chloroform and aqueous solutions was studied as a function of pH. In alkaline media, the reagents completely transferred into the aqueous phase. In acidic solutions, up to 1 mol/l HCl, the compounds are in the organic phase. The maximum values of the partition coefficient are observed for the reagents with the maximum length of the aliphatic radical. The effect of the length of aliphatic radical at the first position of the pyrazoline ring on their extraction properties were studied by example of extraction of nickel and copper (II) ions. The length of the radical does not affect the composition of the recoverable complexes of nickel and copper (II). In all cases the ratio is close to 1:2. Extraction proceeds through a cation-exchange mechanism. Replacement of the phenyl radical in the first position of the pyrazoline ring by an aliphatic resulted to the increase in partition constants of the reagents between chloroform and aqueous solutions. The range of pH values of the maximum extraction of elements was widened. The capacity of the extractant for metals also increased. At the same time, the pH50 extraction values remained practically unchanged. In the case of 0.05 mol/l solution of 1-phenyl-3-methyl-4-oxyimino-2-pyrazolin-5-one in chloroform, when the extract was saturated with the metal ion, precipitation of the complex was observed.For citation:Lesnov A.E., Pavlov P.T., Pustovik L.V., Sarana I.A. 1-Alkyl-3-methyl-4-hydroxyimino-2-pyrazoline-5-ones as extraction reagents. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 5. P. 30-36.

Reaction of 3-carene with perfluoroalkanoic acids

The addition of perfluoroalkanoic acids to 3-carene involves opening of the cyclopropane ring at the peripheral bonds with formation of a mixture of isomeric p-menth-1-en-8-yl and m-menth-1-en-8-yl perfluoroalkanoates. The reaction rate decreases as the length of the perfluoroalkyl radical of the acid increases. Trichloroacetic acid reacted with 3-carene at a lower rate than does trifluoroacetic acid, but the products are analogous p-menth-1-en-8-yl and m-menth-1-en-8-yl trichloroacetates.

Antibacterial Activity of Imidazolium-Based Ionic Liquids Investigated by QSAR Modeling and Experimental Studies.

Predictive QSAR models for the inhibitors of B. subtilis and Ps. aeruginosa among imidazolium-based ionic liquids were developed using literary data. The regression QSAR models were created through Artificial Neural Network and k-nearest neighbor procedures. The classification QSAR models were constructed using WEKA-RF (random forest) method. The predictive ability of the models was tested by fivefold cross-validation; giving q(2) = 0.77-0.92 for regression models and accuracy 83-88% for classification models. Twenty synthesized samples of 1,3-dialkylimidazolium ionic liquids with predictive value of activity level of antimicrobial potential were evaluated. For all asymmetric 1,3-dialkylimidazolium ionic liquids, only compounds containing at least one radical with alkyl chain length of 12 carbon atoms showed high antibacterial activity. However, the activity of symmetric 1,3-dialkylimidazolium salts was found to have opposite relationship with the length of aliphatic radical being maximum for compounds based on 1,3-dioctylimidazolium cation. The obtained experimental results suggested that the application of classification QSAR models is more accurate for the prediction of activity of new imidazolium-based ILs as potential antibacterials.

Enzymatic Synthesis of Fatty Esters by Lipase from Porcine Pancreas

An enzymatic synthesis of aliphatic esters of butyric acid in the waterless environment of organic solvent hexane was carried out with use of the enzyme preparation lipase from porcine pancreas. Aliphatic alcohols with different length of hydrocarbon radical (C4-C11) were used as substrates. Conversion of the esters depending on time of the process and concentration of the enzyme was defined at 30°C of the process. It was found that an increase in length of the hydro carbonic radical of alcohol and branching of a chain complicated enzymatic synthesis. For the lower alcohols the conversion reach more than 90%.

Sedimentation of coal particles in lower aliphatic alcohols and the stability of alcohol–coal suspensions

The sedimentation of coal particles in lower aliphatic alcohols from the methanol–pentanol series was studied. It was demonstrated that, in the metamorphism series, the alcohol–coal suspensions based on brown coal and anthracite are the most and least stable, respectively. It was found that the stability of the coal suspensions increases with the length of a hydrocarbon radical in the alcohol molecules. It was established that the sedimentation of coal particles in dilute alcohol–coal suspensions obeys Stokes’ law. The sedimentation of coal particles in concentrated alcohol–coal suspensions is of structural nature and strongly depends on interactions between the particles through a liquid layer. In this case, the most stable suspensions are those in which the surface tension of a dispersion medium approaches the surface tension of coal and a difference between the polarities of a dispersed phase and a dispersion medium decreases.

ПРОТИЗАПАЛЬНА АКТИВНІСТЬ ЕСТЕРІВ ІБУПРОФЕНУ ПРИ ТРАНСДЕРМАЛЬНОМУ ВВЕДЕННІ

The goal of this study was to investigate the anti-inflammatory activity of ibuprofen esters ointment after their transdermal application on the model of carrageenan-induced inflammation in experimental animals. In this paper, we have studied the transdermal delivery of ibuprofen esters with methyl, ethyl, octyl and heptyl radicals.The anti-inflammatory activity was assessed on the basis of inhibition of paw edema induced by the injection of 0.2 ml of 0.2 % solution of carrageenan (an edematogenic agent) into the subplantar region of the hind paw of the rat. The ointments were consisted of PEG -1500 , PEO -400 and 1,2- propylene glycol in the following proportions: 4 : 2: 3 and consisted 5% of ibuprofen esters. For comparison, 5% ibuprofen ointment (cream Dolhit) was used. Paw volumes were measured at the beginning of the experiment with a plethysmometer. As a result of the study, it was shown that the level of anti-inflammatory activity ointment with ibuprofen esters with different length of radical in transdermal delivery was not different from anti-inflammatory activity of the commercial referent drug - ibuprofen ointment and in some cases, were more active.We shown that the transdermal delivery of methyl, ethyl and heptyl esters of ibuprofen reduces the level of white blood cells in the blood of experimental rats to the level of physiological norm at the 4th day, after a significant level increase in the acute phase of inflammation.