Adequate training recovery is essential for optimization of muscle performance, injury prevention, and avoiding overtraining. Consequently, athletes may benefit from interventions that accelerate recovery processes. PURPOSE: To evaluate the effects of concurrent supplementation with branched-chain amino acids (BCAA), β-hydroxy-β-methylbutyrate (HMB), and glutamine on recovery from weightlifting. METHODS: Fourteen trained participants (mean ± SD: age = 21 ± 2 y) completed two protocols (treatment and placebo), each consisting of two resistance bouts separated by 24 h rest. Sessions consisted of three sets to failure at an 8 - 12 repetition maximum load for six exercises. Muscle pain and ratings of perceived exertion (RPE) were assessed after each set using a 100-mm visual analog scale (VAS). Residual pain and ratings of perceived recovery (RPR) were assessed 24 h after initial workouts. Treatment included one 6-g BCAA plus glutamine (BCAA + G) supplement (Leucine, 2.5 g; Valine, 1.5 g; Isoleucine, 1 g; Glutamine, 1 g) and one 1-g dose of HMB respectively consumed 1 h or 30 min before exercise, and another BCAA + G immediately after exercise. An additional HMB supplement was ingested after 2 h and 6 h of recovery. Sugar pills replaced supplements as a placebo, and the order was randomized, counter-balanced, and double-blind. RESULTS: Treatment enhanced second-day performance for the leg extension (11 ± 1 vs. 10 ± 3; p = .03), latissimus pull-down (11 ± 2 vs. 10 ± 1; p = .02), and total repetitions (62 ± 5 vs. 59 ± 7; p = .03). Reduced residual pain (29 ± 19 vs. 40 ± 23; p = .01) and pain during the leg press (37 ± 14 vs. 45 ± 21; p = .04) and shoulder press (39 ± 17 vs. 47 ± 24; p = .04) were observed with treatment. RPE on the second day was reduced under the treatment for the leg press (55 ± 20 vs. 62 ± 16; p = .02) and leg extension (53 ± 20 vs. 61 ± 19; p = .03) exercises. RPR were similar between conditions (p > .05). CONCLUSIONS: Combined ingestion of BCAA, HMB, and glutamine may enhance muscle recovery 24 h after an exhaustive resistance bout. Reduced muscle pain and RPE under the treatment may have attributed to enhanced performance during subsequent workouts. Additional research is necessary to understand the effects of chronic supplementation and the mechanisms associated with individual supplements.