Left-sided Heart Disease Research Articles

Morphologic significance of left atrial involvement

Left atrial involvement, defined as the terminal negativity of the P wave in Lead V 1 of 1 mm. or more in depth and a duration of 0.04 second or more, was evaluated in 270 autopsied cases with the use of a chamber dissection technique for the determination of atrial and ventricular hypertrophy. Left atrial involvement was present in the following: 35 (44.3 per cent) of 79 hearts with left atrial hypertrophy, 31 (34.8 per cent) of 89 hearts with right atrial hypertrophy, 32 (22.4 per cent) of 143 hearts without atrial hypertrophy, 52 (44.4 per cent) of 117 hearts with left ventricular hypertrophy, 17 (34.7 per cent) of 49 hearts with right ventricular hypertrophy, 9 (11.5 per cent) of 78 hearts without anatomic evidence of atrial or ventricular hypertrophy, and 3 (3.8 per cent) of 78 hearts without anatomic evidence of atrial or ventricular hypertrophy or any clinical or postmortem findings of cardiopulmonary disease. Left atrial involvement has a significant correlation with left atrial hypertrophy (p < 0.01) and left ventricular hypertrophy (p < 0.001). Left atrial involvement was frequently noted to be transient. The presence of left atrial involvement on the ECG appears to be the result of many factors including left-sided heart disease, left atrial hypertrophy, left ventricular hypertrophy, increases in left atrial volume or pressure, and possibly intra-atrial conduction delays.

The Effect of Left-Sided Heart Disease on Blood Flow Through the Lung Capillaries.

s1 May 1968The Effect of Left-Sided Heart Disease on Blood Flow Through the Lung Capillaries.Grant de J. Lee, F.R.C.P., Nicholas KaratzasGrant de J. Lee, F.R.C.P.Search for more papers by this author, Nicholas KaratzasSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1157_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLung capillary blood flow, using the N2O-body plethysmograph method, was measured simultaneously with pulmonary artery, pulmonary wedge, and left atrial pressures during routine cardiac catheterization to study changes in capillary flow due to alterations in pulmonary arterial and pulmonary venous impedance. Normally the compliant arterial system stores up to 67% of the stroke volume during systole for delivery to the capillaries during diastole. In pulmonary arterial hypertension this is reduced, and the increased arteriolar resistance reduces the pulsatility of capillary flow. An inverse relationship between pulmonary arterial resistance and capillary pulsatility has been found. The pulmonary veins are even more... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oxford, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1157-1158KeywordsBlood flowCapillariesCatheterizationDiastoleLungsPulmonary arteriesPulmonary hypertensionStrokeSystoleVeins ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...

The current status of pulmonary embolism and pulmonary vascular disease in relation to pulmonary hypertension

The mechanism and pattern of pulmonary hypertension and pulmonary vascular disease has been compared in pulmonary embolism and in chronic obliterative pulmonary hypertension due to other causes, in left-sided heart disease, in association with left to right intracardiac shunt and in chronic lung disease.

Transseptal left heart catheterization.

From the experiences with "transseptal left heart catheterization" in 40 patients, this method has been proven to be relatively simple and safty in techniques. Therefore, the procedure can be carried out by any physician trained in the usual techniques of right heart catheterization. As the Brockenbrough method has had advantages over the Ross method in techniques and applications, the author would like to recommend the use of the Brockenbrough method hereafter. In this report, clinical application of this method to dilution method was demonstrated with relation to left atrial pressure. Further application of this method to the hemodynamic study will contribute to clarify the pathologic physiology of the left-sided heart disease.

Radiological contrast studies of the left heart.

1. The indications for contrast studies of the left side of the heart and ascending aorta are listed. 2. The various techniques of retrograde catheterisation of the ascending aorta and left ventricle of the heart are discussed together with their difficulties and complications. 3. The results of left ventricular angiocardiography and arteriography of the ascending aorta, in relation to leftsided heart disease in a variety of congenital and acquired lesions, are presented and analysed.