Herein we report on 3 clinical cases of pilomatrixoma, discussing the diagnosis and clinical and histologic features, as well as treatment. Pilomatrixoma is a benign tumor of the skin, originating from within the hair follicle matrix, and represents 0.12% of skin tumors. The lesion has its peak incidence in the first and sixth decades of life, being more common in women. Patients reported to the service presenting with nodular lesions as their chief complaint. Clinical examination revealed painless, firm, fluctuating nodule on palpation. Locations of the lesions were: left preauricular region, left zygomatic region and right mandibular angle. The patients ranged in age from 10 to 30 years. Two cases had fine needle aspiration procedure, but only 1 had cytopathologic suggestion of pilomatrixoma. Excisional biopsy was performed in 3 cases with histopathologic diagnosis confirmation. Patients were followed-up without recurrence for 6 to 24 months.
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