In this study, applying the theories on case-based learning, we have built a new set of 30 case studies used in teaching and learning for some contents of Module S1.4: Physical basis of life activities and applications in medicine according to the competency-based training program of Hanoi Medical University. A set of 30 case studies accompanied by 150 multiple choice questions (MCQ) is designed to suit each corresponding teaching method such as Lectures (LEC), Seminar (SEM), and Team Based Learning (TBL). The feedback from students shows that 97.1% of students agreed that the content of the cases is suitable with the goals and content of each corresponding lesson; 95.3% of students said that the situations all have a clinical context, promoting the attractiveness of the lesson. The content of the set of situations in the topic is completely new and has been built and used by lecturers of Medical Physics, Hanoi Medical University in teaching students of Hanoi Medical University recently.