ABSTRACT As education evolves from traditional lecture-style teaching to more interactive and collaborative methods using information and communication technologies, student response systems (SRS) have become increasingly popular in both offline and online classes. However, despite the attention given to SRS’s potential to enhance active learning, it remains unclear whether their implementation leads to improved learning. Therefore, the objective of this study is to conduct a systematic literature review using the mixed methods methodology to identify and confirm relevant learning outcomes associated with SRS, such as classroom dynamics, understanding, classroom performance, remembering, and likeness. In addition, bibliometric analysis enables us to uncover the trend and intellectual dynamics in the SRS literature. The study aims to investigate the impact of SRS on different learning outcomes and discuss the implications of the findings.