Background Students' physical and psychological well-being, particularly with a focus on depression, is a significant public health concern. Objective This study aims to explore the level of depression among health students at Al-Quds University. Methods In this assay, a cross-sectional study using a self-reporting questionnaire was conducted. To evaluate the degree of depression among students, the Beck Depression Inventory (BDI-II) was used. The sample comprised 357 students from Al-Quds University in the West Bank. Results The results of the study showed that depression impacted 40.3% of the subjects. Of these, 32% experienced moderate to severe depression symptoms, 24% had thoughts or wishes related to suicide, and 6.7% believed that death was the answer to their issues. The findings demonstrated that there were statistically significant variations in depression based on gender, age, study year, study geographical area, place of residence, level of religiosity, and thoughts of death (p < 0.05). Conclusion To protect their well-being, mental health professionals should advise students to seek assistance and therapy. University administrators should assist students in learning time management and stress-reduction strategies so they can finish their assignments and fulfill other course obligations.