Objectives This study analyzes the relationship between nursing students' learning motivation, academic self-efficacy, medication calculation confidence, and medication calculation anxiety to confirm the interrelationship between them. Methods The study was conducted on 120 second-year nursing students taking pharmacotherapy nursing classes. A structured questionnaire was used to measure learning motivation, academic self-efficacy, medication calculation confidence, and medication calculation anxiety, and the collected data were analyzed using descriptive statistics, t-test, analysis of variance (ANOVA), and Pearson correlation coefficient using the SPSS 25.0 program. Results Department satisfaction was shown to be a characteristic that showed significant differences in learning motivation, academic self-efficacy, medication calculation confidence, and medication calculation anxiety. Learning motivation showed a significant positive correlation with academic self-efficacy and medication calculation confidence, and a significant negative correlation with medication calculation anxiety. Academic self-efficacy did not have a significant correlation with medication calculation confidence, but showed a negative correlation with medication calculation anxiety. In addition, a negative correlation was confirmed between medication calculation confidence and medication calculation anxiety. Conclusions The results of this study confirmed that there was a close correlation between learning motivation, academic self-efficacy, medication calculation confidence, and medication calculation anxiety. This suggests that learning-related factors are significantly related to nursing students' medication calculation ability. Therefore, systematic research on the status of medication education and the level of medication calculation by grade level is necessary in nursing undergraduate courses, and it is necessary to develop a systematic curriculum to improve medication calculation ability.
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